Journal Information
Vol. 19. Issue 4.
Pages 343-349 (January 2008)
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Vol. 19. Issue 4.
Pages 343-349 (January 2008)
Giant cell glioblastoma: review of the literature and illustrated case
Glioblastoma de células gigantes: revisión de la literatura e ilustración de un caso
Visits
1985
J.M. Valle-Folgueral, L. Mascarenhas
, J.A. Costa, C. Alegria
Neurosurgery Service. São Marcos Hospital. Braga. Portugal
F. Vieira*, J. Soares-Fernandes**, P. Beleza***
* Anatomic Pathology Service. São Marcos Hospital. Braga. Portugal
** Neuroradiology Service. São Marcos Hospital. Braga. Portugal
*** Neurology Service. São Marcos Hospital. Braga. Portugal
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Summary

Giant cell glioblastoma is an infrequent variety of glioblastoma (5% of the cases). It has deserved a separate category in the World Health Organization classification of grade IV tumors. The clinical, imaging, histological and immunohistochemical characteristics, and the genetic alterations are reviewed. Treatment and prognosis are discussed and updated. The case of a patient that survived 19 months and died of spinal leptomeningeal metastases is illustrated.

Keywords:
Giant cell glioblastoma
Leptomeningeal metastases
Surgery
Temozolomide
Radiotherapy
Resumen

El glioblastoma de células gigantes es una variante rara dentro de los glioblastomas (5% de los casos). En la clasificación de la Organización Mundial de la Salud esta entidad ha merecido una categoría aparte en los tumores de grado IV. Se revisan las características clínicas, radiológicas, histológicas, inmunohistoquímicas y las alteraciones genéticas que caracterizan este tumor. El tratamiento y el pronóstico son discutidos aportando información actualizada. Finalmente se presenta un caso clínico ilustrado, en el cual el paciente sobrevivió durante 19 meses, falleciendo como consecuencia de una diseminación espinal leptomeníngea.

Palabras clave:
Glioblastoma de células gigantes
Metástasis leptomeníngeas
Cirugía
Temozolomida
Radioterapia

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