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Vol. 14. Issue 1.
Pages 46-51 (January 2003)
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Vol. 14. Issue 1.
Pages 46-51 (January 2003)
Oligoastrocitoma con diferenciación en células en anillo de sello. Estudio morfológico, ultraestructural e inmunohistoquímico
Oligoastrocytoma with signet-ring cell differentiation. A morphological, ultrastructural and immunohistochemical study
D. Ramos, M. Cerdá-Nicolás
Corresponding author
jose.m.cerda@uv.es

Correspondencia postal: Departamento de Patología. Facultad de Medicina. Av. Blasco Ibáñez, 17. 46010, Valencia.
, C. López-Ginés, M. Pérez-Bacete, A. Llombart-Bosch
Departamento de Patología. Hospital Clínico Universitario. Facultad de Medicina. Universidad de Valencia. Valencia
P. Roldán*, J. Molla*, F. Talamantes*, J. Barberá*
* Departamento de Cirugía. Neurocirugía. Hospital Clínico Universitario. Facultad de Medicina. Universidad de Valencia. Valencia
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Resumen

Presentamos un caso de tumor glial mixto (oligoastrocitoma) con células en anillo de sello. Esta diferenciación celular es rara en tumores gliales del sistema nervioso central. En este estudio analizamos las características morfológicas, ultraestructurales e inmunohistoquímicas del tumor. Las células neoplásicas con características morfológicas en anillo de sello mostraban expresión de GFAP, S-100 y vimentina. En la discusión consideramos el diagnóstico diferencial con otros tumores primarios del sistema nervioso central, así como con metástasis cerebrales de neoplasias con diferenciación en células en anillo de sello.

Palabras clave:
Oligoastrocitoma
Células en anillo de sello
Histopatología
Summary

We present a case of a mixed glial tumor (oligoastrocytoma) with signetring cells. This cellular feature is a rare differentiation in glial tumors of the central nervous system. Histological, immunohistochemical and ultrastructural findings have been analyzed. Signet-ring cells showed intense expression with GFAP, S-100 and vimentin. A differential diagnosis with other primary brain tumors and cerebral metástases with signet-ring cell differentiation was discussed.

Key words:
Oligoastrocytoma
Signet-ring cells
Histopathology

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