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Vol. 27. Issue 5.
Pages 237-244 (September - October 2016)
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Vol. 27. Issue 5.
Pages 237-244 (September - October 2016)
Artículo de revisión
Aneurismas cerebrales no rotos: controversias sobre el cribado poblacional
Unruptured cerebral aneurysms: Controversies on population screening
Pedro David Delgado Lopez
Corresponding author
pedrodl@yahoo.com

Autor para correspondencia.
, José Manuel Castilla Díez, Vicente Martín Velasco
Servicio de Neurocirugía, Hospital Universitario de Burgos, Burgos, España
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Tables (4)
Tabla 1. Factores relacionados con el desarrollo, crecimiento y rotura de los aneurismas cerebrales
Tabla 2. Datos epidemiológicos relativos al riesgo de ser portador y tratarse de un aneurisma incidental
Tabla 3. Circunstancias en las que está justificado realizar cribado de aneurismas cerebrales no rotos
Tabla 4. Propuesta de protocolo de estudio de factibilidad y cuestiones generales a tener en cuenta en el diseño de un estudio de cribado poblacional de aneurismas no rotos mediante angiorresonancia magnética en función de la revisión bibliográfica realizada51
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Resumen

La idea de cribado poblacional de aneurismas no rotos es interesante dado que, a pesar de los avances en los tratamientos quirúrgico y endovascular, la mortalidad debido a la hemorragia subaracnoidea aneurismática se encuentra en torno al 30%. El cribado está justificado cuando la morbimortalidad asociada al tratamiento (marcadamente menor en aneurismas no rotos frente a los rotos) es inferior al riesgo inherente a ser portador de un aneurisma. A día de hoy, este balance no parece favorecer el cribado a nivel poblacional, aunque sí está justificado en subpoblaciones de alto riesgo de desarrollo o rotura de aneurismas. En esta revisión se analizan los requisitos necesarios para implementar un cribado, en qué situaciones estaría justificado, qué se puede esperar del tratamiento (en términos de efectividad, morbilidad y coste) y qué cuestiones medicolegales son relevantes y condicionan la utilidad del mismo. Proponemos un esquema de estudio que explore la utilidad del cribado poblacional mediante angiorresonancia.

Palabras clave:
Aneurisma cerebral
Cribado
Pronóstico
Hemorragia subaracnoidea
Clipado
Embolización
Abstract

The idea of population screening of unruptured intracranial aneurysms is interesting because, despite recent advances in surgical and endovascular treatment, the mortality related to aneurismal subarachnoid haemorrhage reaches 30%. Screening is justified whenever the morbidity and mortality of the treatment (markedly lower for unruptured compared to ruptured aneurysms) overcomes the inherent risk of harbouring a brain aneurysm. Although, at present, this balance does not seem to favour population-based screening, it is justified in certain sub-populations with an increased risk of rupture. In this review, an analysis is made of the requirements for implementing a screening program, when would it be justified, what is to be expected from treatment (in terms of effectiveness, morbidity and costs), and what medical-legal issues are relevant and to determine the usefulness of the program. A study protocol is proposed aimed at examining the usefulness of population screening for brain aneurysms by magnetic resonance angiography.

Keywords:
Cerebral aneurysm
Screening
Prognosis
Subarachnoid haemorrhage
Clipping
Coiling

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