TY - JOUR T1 - Experience with the radiosurgical treatment of brain metastases JO - Neurocirugía (English edition) T2 - AU - Fernández-de Aspe,Pablo AU - Fernández-Quinto,Alejandro AU - Guerro-Moya,Andrea AU - Arán-Echabe,Eduardo AU - Varela-Pazos,Ana AU - Peleteiro-Higuero,Paula AU - Cascalla-Caneda,Luis AU - Gelabert-González,Miguel SN - 25298496 M3 - 10.1016/j.neucie.2016.06.001 DO - 10.1016/j.neucie.2016.06.001 UR - https://revistaneurocirugia.com/en-experience-with-radiosurgical-treatment-brain-articulo-S2529849616300041 AB - ObjectiveTo analyse the survival rate of a cohort of patients with intracranial metastases treated with radiosurgery, and to determine the factors that influence the results. Patients and methodRetrospective analysis performed on a cohort of 126 patients undergoing radiosurgery for brain metastases. Patients treated with surgery before or after radiosurgery were excluded. Survival is analysed based on clinical (age, sex, primary tumour), radiological (number, location and volume of lesions), and radiotherapy factors (treatment dose, holocraneal radiation). Univariate and multivariate analyses were performed to determine significant prognostic factors. ResultsA total of 225 brain metastases in 126 patients, with a mean age of 59.8±11.6years, were treated between February 2008 and April 2015. The mean survival was 8.2 months. The overall survival rates at 6months, 1year, and 2years were 60.3%, 31.5%, and 12.8%, respectively. Lung (59.5%) and breast (14.3) were the most common primary tumours, and the most common site for metastases was the cerebral hemisphere (77%) and the average volume was 10.35cc (0.2–43.5). Significant survival factors were: age under 60 (p=0.046), female (p<0.001), breast cancer (p<0.001), KPS >80 (p=0.001), SIR6 >5 (p=0.031), and GPA ≥2.5 (p=0.003). ConclusionsRadiosurgery is an appropriate technique for the treatment of brain metastases, and the main prognostic factors include being age under 65, female, breast cancer, and good scores on Karnofsky, SIR, and GPA scales. ER -