TY - JOUR T1 - SIXTO OBRADOR SENEC PRIZE 2019: Utility of diffusion tensor imaging as a prognostic tool in moderate to severe traumatic brain injury. Part II: Longitudinal analysis of DTI metrics and its association with patient's outcome JO - Neurocirugía (English edition) T2 - AU - Castaño-Leon,Ana M. AU - Cicuendez,Marta AU - Navarro-Main,Blanca AU - Munarriz,Pablo M. AU - Paredes,Igor AU - Cepeda,Santiago AU - Hilario,Amaya AU - Ramos,Ana AU - Gómez,Pedro A. AU - Lagares,Alfonso SN - 25298496 M3 - 10.1016/j.neucie.2020.03.001 DO - 10.1016/j.neucie.2020.03.001 UR - https://revistaneurocirugia.com/en-sixto-obrador-senec-prize-2019-articulo-S2529849620300095 AB - Background and objectivesTraumatic axonal injury is the main cause of the cognitive and neuropsychological situation of patients after head trauma (TBI). Additionally, there are some evidences about the dynamic evolution of traumatic axonal injury. Although the diffusion tensor MRI (DTI) sequence is considered a useful technique for modifying the extent of the traumatic axonal injury, few studies have evaluated the longitudinal changes in the characteristics of the DTI and its relation to evolution of patients. Materials and methodsWe performed a prospective observational study in 118 patients with moderate to severe TBI. The study included clinical outcome assessment based on the Glasgow Outcome Scale Extended and serial DTI studies in the early subacute setting (<60 days) and 6 and 12 months after injury. Fractional anisotropy, axial and radial diffusivities were measured in the 3 portions of corpus callosum (genu, body, splenium) at each time point and compared to normalised values from an age-matched control group. Longitudinal fractional anisotropy analysis and its correlation with patient improvement was also done by non-parametric testing and ordinal regression analysis. ResultsAlthough dynamic changes in DTI characteristics have been detected in the 3 portions of corpus callosum, patients continue to show lower fractional anisotropy and axial diffusivities values and higher radial diffusivities values compared to controls at the end of the period of study. We have also found differences in the pattern of DTI metrics change between subgroups of patients according with their favourable outcome. ConclusionsThe temporal profile of the change in DTI characteristics seems to provide important information about the clinical recovery of patients after TBI. ER -