TY - JOUR T1 - Endoscopic versus open surgery in patients with malignant sinonasal tumours and brain invasion. A case series study JO - Neurocirugía (English edition) T2 - AU - Caballero-García,Joel AU - Cuétara Lugo,Elizabeth Bárbara AU - Lence-Anta,Juan Jesús AU - Gonzáles Fernández,Nélido AU - Hidalgo-Gonzáles,Adolfo AU - Kindelán-Agustín,Grisel SN - 25298496 M3 - 10.1016/j.neucie.2021.04.005 DO - 10.1016/j.neucie.2021.04.005 UR - https://revistaneurocirugia.com/en-endoscopic-versus-open-surgery-in-articulo-S2529849621000393 AB - ObjectivesTo determine the safety, effectiveness and perioperative costs of endonasal endoscopic approach in brain invasive malignant sinonsal tumours patients. Materials and methodsThis was a case series bidirectional study; that included 30 brain invasive malignant sinonsal tumours patients treated by endonasal endoscopic approach (2015–2017) and 53 by open surgery (2010–2015). Propensity score matching was used to compensate the prognostic factors; in a sample of 50 patients (25 per group). Primary response variables was local control and 3-years overall survival. Perioperative cost variables were analyzed. ResultsA number of 50 patients were included after matching (25 in each therapeutic group). The age average was 55 years and male proportion was 62%. Squamous cell carcinoma and grade II lesions were the most represented in the sample. Endonasal endoscopic approach reduced surgical time in 1 h 20 min, transfusion needs in 5.5 fold and hospitalization in 19 days; in comparison with open technique. Oncologic control based on surgical free margins, local control, overall survival and progression free survival after three years was higher when the resection was performed endoscopically. Functional status was enhanced and complications diminished by using endoscopic approach. Saving was estimated in $7 355.18 per patient. ConclusionsEndonasal endoscopic approach represents a safe, effective and economic procedure in selected patients with malignant sinonasal tumors and brain invasion. ER -