TY - JOUR T1 - Early atypical malignant transformation of diffuse low-grade astrocytoma: The importance of genotyping JO - Neurocirugía (English edition) T2 - AU - Valente Aguiar,Pedro AU - Sousa,Osvaldo AU - Silva,Roberto AU - Vaz,Rui AU - Linhares,Paulo SN - 25298496 M3 - 10.1016/j.neucie.2020.09.001 DO - 10.1016/j.neucie.2020.09.001 UR - https://revistaneurocirugia.com/en-early-atypical-malignant-transformation-diffuse-articulo-S2529849621000551 AB - Diffuse astrocytoma (WHO grade II) has classically been considered a slow growing tumour, typically affecting young adults, with tendency for late malignant conversion. We describe a case of early atypical malignant transformation of diffuse astrocytoma seventeen months after complete surgical removal, as an intraventricular high-grade glioma (HGG). Retrospective laboratory findings for the presence of IDH 1/2 (isocitrate dehydrogenase) mutations were negative. There is growing evidence that IDH-wildtype (wt) astrocytomas behave more aggressively, therefore identifying IDH-mutation status should be mandatory in order to determine disease prognosis and guide treatment course. ER -