Journal Information
Vol. 31. Issue 1.
Pages 47-51 (January - February 2020)
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Vol. 31. Issue 1.
Pages 47-51 (January - February 2020)
Caso clínico
Sarcoma granulocítico del sistema nervioso central: reporte de 2 casos y revisión de la literatura
Central nervous system granulocytic sarcoma: Report of 2 cases and review of the literature
Augusto Vilariñoa,
Corresponding author
augustovilarino@gmail.com

Autor para correspondencia.
, Rodrigo Carrasco Morob, Fidel P. Sosaa, Luis Ley Urzaizb, Maria de los Ángeles Vicentec
a Servicio de Neurocirugía, Hospital Alemán de Buenos Aires, Buenos Aires, Argentina
b Servicio de Neurocirugía, Hospital Ramón y Cajal, Madrid, España
c Servicio de Hematología, Hospital Alemán de Buenos Aires, Buenos Aires, Argentina
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Resumen

Los sarcomas granulocíticos son neoplasias sólidas compuestas de células mieloides inmaduras, de localización extramedular, asociadas a síndromes mieloproliferativos. La afectación del sistema nervioso central es muy infrecuente y puede desarrollarse tras un periodo de remisión completa, coexistir con o preceder a la enfermedad sistémica, siendo esta el elemento fundamental que orienta el diagnóstico radiológico y marca el pronóstico. En este trabajo, presentamos 2 casos de sarcoma granulocítico intracraneal, verificados desde el punto de vista patológico tras ser tratados mediante cirugía, y discutimos sus características clínicas, diagnósticas, terapéuticas y pronósticas tras realizar una revisión bibliográfica de la literatura científica destacada publicada hasta la fecha.

Palabras clave:
Cloroma
Sarcoma granulocítico
Sarcoma mieloide
Sistema nervioso central
Abstract

Granulocytic sarcomas are solid, extramedullary-located neoplasms composed of immature myeloid cells, associated with myeloproliferative syndromes. Central nervous system involvement is very rare and may develop either after complete remission, coexist with or precede the systemic disease, being the last one that guides the radiological diagnosis and marks the prognosis. In this work, we report 2 pathologically-verified cases of intracranial granulocytic sarcoma treated by surgical means. Their clinical, diagnostic, therapeutic and prognostic features are discussed in the light of the most relevant scientific literature published to date.

Keywords:
Chloroma
Granulocytic sarcoma
Myeloid sarcoma
Central nervous system

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