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        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">El absceso cerebral es un proceso supurativo focal en el par&#233;nquima cerebral que todav&#237;a presenta una elevada mortalidad&#46; El resultado est&#225; altamente relacionado con un tratamiento precoz y adecuado&#46; Para valorar dicho tratamiento revisamos los abscesos cerebrales tratados en nuestro Servicio en los &#250;ltimos 14 a&#241;os</p> <span class="elsevierStyleSectionTitle">Material y m&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Presentamos una revisi&#243;n de los 60 pacientes con diagn&#243;stico de absceso cerebral pi&#243;geno tratados en el Servicio de Neurocirug&#237;a del Hospital Infanta Cristina entre Enero de 1990 y Febrero de 2004&#44; prestando atenci&#243;n a la epidemiolog&#237;a&#44; cl&#237;nica&#44; etiolog&#237;a&#44; microbiolog&#237;a&#44; tratamiento y resultado final&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La relaci&#243;n hombre&#47;mujer es 5&#46;6&#47;1&#44; con una edad media de 47 a&#241;os&#59; el origen de la infecci&#243;n m&#225;s frecuente es el hemat&#243;geno&#44; seguido de las infecciones contiguas&#44; con un 22&#37; de abscesos de origen desconocido&#59; los g&#233;rmenes m&#225;s frecuentes son los cocos Gram positivos &#40;44&#37;&#41;&#44; con una importante presencia de g&#233;rmenes anaerobios &#40;40&#37;&#41;&#59; en un 39&#37; de los casos las infecciones son mixtas&#59; las modalidades de tratamiento fueron la punci&#243;n de los abscesos para aspiraci&#243;n-drenaje&#44; la cirug&#237;a abierta&#44; con o sin resecci&#243;n capsular&#44; y el tratamiento m&#233;dico exclusivo&#46; 52 pacientes &#40;86&#46;7&#37;&#41; curaron sin secuelas y 4 &#40;6&#44;7&#37;&#41; fallecieron&#46; Aunque los resultados de ambos tipos de tratamiento quir&#250;rgico son similares&#44; el drenaje del absceso requiri&#243; en un 20&#37; de los casos un segundo proceder quir&#250;rgico&#44; mientras que la craneotom&#237;a lo precis&#243; s&#243;lo en el 10&#37;&#59; la estancia media en nuestro hospital fue mucho menor en los abscesos tratados mediante drenaje que en los tratados mediante cirug&#237;a abierta &#40;13 vs 26 d&#237;as&#41;&#59; la mortalidad fue mayor en pacientes con bajo nivel de conciencia al ingreso y en mayores de 70 a&#241;os&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Consideramos que la menor estancia media del drenaje del absceso&#44; unido a su alta eficacia y su baja morbilidad&#44; hacen aconsejable su uso como tratamiento de primera elecci&#243;n&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Brain abscess is a focal suppurative process in the brain parenchyma that still carries high mortality rates&#46; Outcome is closely related with a correct and early management&#46; In order to evaluate this management we have reviewed the brain abscesses treated in our Department during the last 14 years&#46;</p> <span class="elsevierStyleSectionTitle">Material and Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">The authors present a retrospective series of 60 consecutive patients with pyogenic brain abscess treated between January of 1990 and February of 2004 paying attention to the epidemiology&#44; etiology&#44; clinical data&#44; microbiology&#44; treatment modalities and outcome</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The male to female rate was 5&#46;6 to 1&#46; The average age was 47 years&#46; Hematogenous spread was most frequent&#44; followed by contiguous spread&#46; In 22&#37; of the cases&#44; the origin was unknown&#46; Regarding the causative pathogens&#44; Gram positive cocci are the most frequent &#40;44&#37;&#41;&#44; with a 40&#37; incidence of anaerobics&#46; A mixed infection occurred in 39&#37; of the abscesses&#46; Three modalities of treatment were used&#58; non surgical&#44; catheter drainage-aspiration and surgical excision&#46; Outcome was excellent in 52 patients &#40;86&#46;7&#37;&#41; and 4 patients &#40;6&#46;7&#37;&#41; died&#46; Although outcome was similar in both surgical modalities&#44; drainage-aspiration required a second procedure in 20&#37; of the cases while this was necessary in only 10&#37; of the patients with abscess excision&#46; Length of admission was shorter in the drainageaspiration group than in the excision group &#40;13 and 26 days respectively&#41;&#46; Mortality was higher in patients with low level of consciousness and age over 70 years&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The shorter admission time associated with drainage-aspiration of brain abscesses together with its high efficacy and low morbidity suggests that drainageaspiration should be used as the first mode of treatment&#46;</p>"
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                        "tituloSerie" => "Rev Clin Esp"
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                        "paginaFinal" => "419"
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                          0 => array:2 [
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                    0 => array:1 [
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                        "tituloSerie" => "Br J Neurosurg"
                        "fecha" => "1994"
                        "volumen" => "8"
                        "paginaInicial" => "447"
                        "paginaFinal" => "455"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7811410"
                            "web" => "Medline"
                          ]
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                            3 => "L&#46; Nuteanu"
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                    ]
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                        "tituloSerie" => "Child&#39;s Nery Syst"
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                        "paginaInicial" => "309"
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                      "LibroEditado" => array:4 [
                        "titulo" => "Neurological Surgery"
                        "paginaInicial" => "3191"
                        "paginaFinal" => "3220"
                        "serieFecha" => "1996"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Brain abscess"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46;A&#46; Habib"
                            1 => "T&#46; Mozaffar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Neurol"
                        "fecha" => "2001"
                        "volumen" => "58"
                        "paginaInicial" => "1302"
                        "paginaFinal" => "1304"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11493176"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intracranial suppurative disease&#46; Early presumptive diagnosis and successful treatment without surgery"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "H&#46;S&#46; Heineman"
                            1 => "J&#46;L&#46; Braude Al Osterholm"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA"
                        "fecha" => "1971"
                        "volumen" => "218"
                        "paginaInicial" => "1542"
                        "paginaFinal" => "1547"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5171140"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Brain abscess&#58; clinical analysis of 53 cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "P&#46;T&#46; Kao"
                            1 => "H&#46;K&#46; Tseng"
                            2 => "C&#46;P&#46; Liu"
                            3 => "S&#46;C&#46; Su"
                            4 => "C&#46;M&#46; Lee"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Microbiol Inmunol Infect"
                        "fecha" => "2003"
                        "volumen" => "36"
                        "paginaInicial" => "129"
                        "paginaFinal" => "136"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Surgical treatment of nocardial brain abscesses"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "G&#46;Y&#46; Lee"
                            1 => "R&#46;T&#46; Daniel"
                            2 => "B&#46;P&#46; Brophy"
                            3 => "P&#46;L&#46; Reily"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurosurgery"
                        "fecha" => "2002"
                        "volumen" => "51"
                        "paginaInicial" => "668"
                        "paginaFinal" => "671"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12188944"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diagnosis and management of brain abscess"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "C&#46;M&#46; Loftus"
                            1 => "R&#46;K&#46; Osenbach"
                            2 => "J&#46; Biller"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Neurosurgery"
                        "paginaInicial" => "3285"
                        "paginaFinal" => "3298"
                        "serieFecha" => "1996"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bacteriology of abscesses of the central nervous system&#58; a multicentre prospective study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46; de Louvois"
                            1 => "P&#46; Gortavai"
                            2 => "R&#46; Hurley"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Br Med J"
                        "fecha" => "1977"
                        "volumen" => "15"
                        "paginaInicial" => "981"
                        "paginaFinal" => "984"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pyogenic infective disease of the brain and spinal cord"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "W&#46; Macewen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:3 [
                        "paginaInicial" => "333"
                        "paginaFinal" => "334"
                        "serieFecha" => "1893"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Nocardial brain abscess&#58; treatment strategies and factors influencing outcome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46;N&#46; Mamelak"
                            1 => "W&#46;G&#46; Obana"
                            2 => "J&#46;F&#46; Flaherty"
                            3 => "M&#46;L&#46; Rosemblum"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurosurgery"
                        "fecha" => "1994"
                        "volumen" => "35"
                        "paginaInicial" => "622"
                        "paginaFinal" => "631"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7808604"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Improved management of multiple brain abscesses&#58; a combined surgical and medical approach"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46;N&#46; Mamelak"
                            1 => "T&#46;J&#46; Mampalam"
                            2 => "W&#46;G&#46; Obana"
                            3 => "M&#46;L&#46; Rosemblum"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurosurgery"
                        "fecha" => "1995"
                        "volumen" => "36"
                        "paginaInicial" => "76"
                        "paginaFinal" => "86"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7708172"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Trends in the management of bacterial brain abscesses&#58; a review of 102 cases over 17 years"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "T&#46;J&#46; Mampalam"
                            1 => "M&#46;L&#46; Rosemblum"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurosurgery"
                        "fecha" => "1988"
                        "volumen" => "23"
                        "paginaInicial" => "451"
                        "paginaFinal" => "458"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3200375"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Experience with 88 consecutive cases of brain abscess"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "H&#46; Morgan"
                            1 => "M&#46;W&#46; Wood"
                            2 => "F&#46; Murphey"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3171/jns.1973.38.6.0698"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurosurg"
                        "fecha" => "1973"
                        "volumen" => "38"
                        "paginaInicial" => "698"
                        "paginaFinal" => "704"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4541198"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Absceso cerebral&#46; Revisi&#243;n de 60 casos"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "J&#46;M&#46; Ortega"
                            1 => "R&#46; D&#237;ez Lobato"
                            2 => "J&#46;M&#46; Aguado"
                            3 => "J&#46; Dom&#237;nguez"
                            4 => "J&#46; Ayerbe"
                            5 => "H&#46; Sandoval"
                            6 => "J&#46;J&#46; Rivas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Neurocirug&#237;a"
                        "fecha" => "1992"
                        "volumen" => "3"
                        "paginaInicial" => "125"
                        "paginaFinal" => "130"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Post-traumatic brain abscess&#58; experience of 36 patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "R&#46; Patir"
                            1 => "S&#46; Sood"
                            2 => "R&#46; Bhatia"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Neurosurg"
                        "fecha" => "1995"
                        "volumen" => "9"
                        "paginaInicial" => "29"
                        "paginaFinal" => "35"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7786422"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Decadron in the treatment of cerebral abscess"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "G&#46;R&#46;C&#46; Quartey"
                            1 => "J&#46;A&#46; Johnston"
                            2 => "B&#46; Rozdilsky"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3171/jns.1976.45.3.0301"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurosurg"
                        "fecha" => "1976"
                        "volumen" => "45"
                        "paginaInicial" => "301"
                        "paginaFinal" => "310"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/948016"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Predictors of mortality in brain abscess"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "H&#46;U&#46; Qureshi"
                            1 => "A&#46;A&#46; Habib"
                            2 => "A&#46;A&#46; Siddiqui"
                            3 => "T&#46; Mozaffar"
                            4 => "A&#46;R&#46; Sarwari"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Pak Med Assoc"
                        "fecha" => "2002"
                        "volumen" => "52"
                        "paginaInicial" => "111"
                        "paginaFinal" => "116"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12071065"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evaluation and treatment of patients with central nervous system infections"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "K&#46;L&#46; Roos"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Textbook of neurological surgery"
                        "paginaInicial" => "567"
                        "paginaFinal" => "578"
                        "serieFecha" => "2003"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Controversies in the management of brain abscess"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46;L&#46; Rosemblum"
                            1 => "T&#46;J&#46; Mampalam"
                            2 => "V&#46;G&#46; Ponds"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Neurosurg"
                        "fecha" => "1986"
                        "volumen" => "33"
                        "paginaInicial" => "603"
                        "paginaFinal" => "632"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3791819"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Developments in the treatment and prognosis of multiple cerebral abscesses"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46; Rousseaux"
                            1 => "F&#46; Lesoin"
                            2 => "A&#46; Destee"
                            3 => "M&#46; Jomin"
                            4 => "H&#46; Petit"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurosurgery"
                        "fecha" => "1985"
                        "volumen" => "16"
                        "paginaInicial" => "304"
                        "paginaFinal" => "308"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3982607"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of dexamethasone on experimental brain abscess"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "K&#46;A&#46; Schroeder"
                            1 => "P&#46;E&#46; McKeever"
                            2 => "D&#46;R&#46; Schaberg"
                            3 => "J&#46;T&#46; Hoff"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3171/jns.1987.66.2.0264"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurosurg"
                        "fecha" => "1987"
                        "volumen" => "66"
                        "paginaInicial" => "264"
                        "paginaFinal" => "269"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3806206"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
              "etiqueta" => "26&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Stereotactic management of bacterial brain abscesses"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "S&#46; Shahzadi"
                            1 => "A&#46;M&#46; Lozano"
                            2 => "M&#46; Bernstein"
                            3 => "A&#46; Guha"
                            4 => "R&#46;R&#46; Tasker"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Can J Neurol Sci"
                        "fecha" => "1996"
                        "volumen" => "23"
                        "paginaInicial" => "34"
                        "paginaFinal" => "39"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8673960"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib27"
              "etiqueta" => "27&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Multiloculated pyogenic brain abscess&#58; experience with 25 patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
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Vol. 17. Núm. 1.
Páginas 23-33 (enero 2005)
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Vol. 17. Núm. 1.
Páginas 23-33 (enero 2005)
Abscesos piógenos encefálicos. Nuestra experiencia en 60 casos consecutivos
Pyogenic brain abscesses: experience with 60 consecutive cases
Visitas
1661
M. Ortega-Martínez
, J.M. Cabezudo, I. Fernández-Portales, L. Gómez-Perals, J.A. Rodríguez-Sánchez, L. García-Yagüe, L.F. Porras, L.M. Lorenzana, F. Ugarriza, M. Pineda-Palomo, L.M. Bernal-García
Servicio de Neurocirugía. Hospital Regional Universitario Infanta Cristina. Badajoz
Este artículo ha recibido
Información del artículo
Resumen
Introducción

El absceso cerebral es un proceso supurativo focal en el parénquima cerebral que todavía presenta una elevada mortalidad. El resultado está altamente relacionado con un tratamiento precoz y adecuado. Para valorar dicho tratamiento revisamos los abscesos cerebrales tratados en nuestro Servicio en los últimos 14 años

Material y métodos

Presentamos una revisión de los 60 pacientes con diagnóstico de absceso cerebral piógeno tratados en el Servicio de Neurocirugía del Hospital Infanta Cristina entre Enero de 1990 y Febrero de 2004, prestando atención a la epidemiología, clínica, etiología, microbiología, tratamiento y resultado final.

Resultados

La relación hombre/mujer es 5.6/1, con una edad media de 47 años; el origen de la infección más frecuente es el hematógeno, seguido de las infecciones contiguas, con un 22% de abscesos de origen desconocido; los gérmenes más frecuentes son los cocos Gram positivos (44%), con una importante presencia de gérmenes anaerobios (40%); en un 39% de los casos las infecciones son mixtas; las modalidades de tratamiento fueron la punción de los abscesos para aspiración-drenaje, la cirugía abierta, con o sin resección capsular, y el tratamiento médico exclusivo. 52 pacientes (86.7%) curaron sin secuelas y 4 (6,7%) fallecieron. Aunque los resultados de ambos tipos de tratamiento quirúrgico son similares, el drenaje del absceso requirió en un 20% de los casos un segundo proceder quirúrgico, mientras que la craneotomía lo precisó sólo en el 10%; la estancia media en nuestro hospital fue mucho menor en los abscesos tratados mediante drenaje que en los tratados mediante cirugía abierta (13 vs 26 días); la mortalidad fue mayor en pacientes con bajo nivel de conciencia al ingreso y en mayores de 70 años.

Conclusiones

Consideramos que la menor estancia media del drenaje del absceso, unido a su alta eficacia y su baja morbilidad, hacen aconsejable su uso como tratamiento de primera elección.

Palabras clave:
Abscesos cerebrales
Escisión
Infección intracraneal
Punción-aspiración
Abreviaturas:
BGN
GOS
LCR
SNC
TC
VSG
Summary
Introduction

Brain abscess is a focal suppurative process in the brain parenchyma that still carries high mortality rates. Outcome is closely related with a correct and early management. In order to evaluate this management we have reviewed the brain abscesses treated in our Department during the last 14 years.

Material and Methods

The authors present a retrospective series of 60 consecutive patients with pyogenic brain abscess treated between January of 1990 and February of 2004 paying attention to the epidemiology, etiology, clinical data, microbiology, treatment modalities and outcome

Results

The male to female rate was 5.6 to 1. The average age was 47 years. Hematogenous spread was most frequent, followed by contiguous spread. In 22% of the cases, the origin was unknown. Regarding the causative pathogens, Gram positive cocci are the most frequent (44%), with a 40% incidence of anaerobics. A mixed infection occurred in 39% of the abscesses. Three modalities of treatment were used: non surgical, catheter drainage-aspiration and surgical excision. Outcome was excellent in 52 patients (86.7%) and 4 patients (6.7%) died. Although outcome was similar in both surgical modalities, drainage-aspiration required a second procedure in 20% of the cases while this was necessary in only 10% of the patients with abscess excision. Length of admission was shorter in the drainageaspiration group than in the excision group (13 and 26 days respectively). Mortality was higher in patients with low level of consciousness and age over 70 years.

Conclusions

The shorter admission time associated with drainage-aspiration of brain abscesses together with its high efficacy and low morbidity suggests that drainageaspiration should be used as the first mode of treatment.

Key words:
Brain abscess
Drainage-aspiration
Excision
Intracranial infection

Artículo

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