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                        "paginaFinal" => "230"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1540138"
                            "web" => "Medline"
                          ]
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                      "titulo" => "Noninvasive differentiation of tumors with the use of localized H-l MR spectroscopy in vivo&#44; initial experience in patients with cerebral tumors"
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                          "autores" => array:3 [
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                            1 => "J&#46; Frahm"
                            2 => "M&#46;L&#46; Gyngell"
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                        "tituloSerie" => "Radiology"
                        "fecha" => "1989"
                        "volumen" => "172"
                        "paginaInicial" => "541"
                        "paginaFinal" => "548"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2748837"
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                      "titulo" => "Correlation of Myo-inositol levels and grading of cerebral astrocytoma"
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                        "paginaFinal" => "1649"
                        "link" => array:1 [
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                      "titulo" => "Magnetic Resonance Spectroscopy Diagnosis of Neurological Diseases"
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                          "autores" => array:3 [
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                        "paginaInicial" => "675"
                        "paginaFinal" => "686"
                        "link" => array:1 [
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1438744"
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                        "paginaFinal" => "276"
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                        "tituloSerie" => "J Comput Assist Tomogr"
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                        "paginaFinal" => "504"
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                      "titulo" => "The origin of lactate inperitumoral edema as measured by proton-magnetic resonance spectroscopic imaging"
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            12 => array:3 [
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              "etiqueta" => "13&#46;"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Serial proton MR spectroscopic imaging of recurrent malignant gliomas after Gamma-Knife radiosurgery"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "E&#46; Graves"
                            1 => "S&#46;J&#46; Nelson"
                            2 => "D&#46; Vigneron"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "AJ N R"
                        "fecha" => "2001"
                        "volumen" => "22"
                        "paginaInicial" => "613"
                        "paginaFinal" => "624"
                        "itemHostRev" => array:3 [
                          "pii" => "S0140673600010217"
                          "estado" => "S300"
                          "issn" => "01406736"
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                ]
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            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Differentiation of tuberculous from pyogenic brain abscesse with in vivo proton MR spectroscopy and magnetization transfer imaging"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "R&#46;K&#46; Gupta"
                            1 => "D&#46;K&#46; Vatsal"
                            2 => "N&#46; Husain"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "AJ N R"
                        "fecha" => "2001"
                        "volumen" => "22"
                        "paginaInicial" => "1503"
                        "paginaFinal" => "1509"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Proton magnetic resonance spectroscopy of cerebrospinal fluid as an aid in neurological diagnosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; Hiraoka"
                            1 => "I&#46; Miura"
                            2 => "M&#46; Hattori"
                            3 => "I&#46; Tominaga"
                            4 => "K&#46; Kushida"
                            5 => "M&#46; Maeda"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Biol Pharm Bull"
                        "fecha" => "1994"
                        "volumen" => "17"
                        "paginaInicial" => "1"
                        "paginaFinal" => "14"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8148794"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Differentiationbetweenhigh-grade glioma and metastatic brain tumor using single-voxel proton MR spectroscopy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46; Ishimaru"
                            1 => "M&#46; Morikawa"
                            2 => "S&#46; Iwanaga"
                            3 => "M&#46; Kaminogo"
                            4 => "M&#46; Ochi"
                            5 => "K&#46; Hayashi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Eur Radio"
                        "fecha" => "2001"
                        "volumen" => "11"
                        "paginaInicial" => "1784"
                        "paginaFinal" => "1791"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "In vivo single-voxel proton MR spectroscopy in brain lesions with ring-like enhancement"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "T&#46; Kimura"
                            1 => "K&#46; Sako"
                            2 => "T&#46; Gotoh"
                            3 => "K&#46; Tanaka"
                            4 => "T&#46; Tanaka"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "NMR Biomed"
                        "fecha" => "2001"
                        "volumen" => "14"
                        "paginaInicial" => "339"
                        "paginaFinal" => "349"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11599032"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Singlevoxel proton MR spectroscopy of nonneoplastic brain lesions suggestive of aneoplasm"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "H&#46;G&#46; Krouwer"
                            1 => "T&#46; Kim"
                            2 => "S&#46;D&#46; Rand"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "AJNR"
                        "fecha" => "1998"
                        "volumen" => "19"
                        "paginaInicial" => "1695"
                        "paginaFinal" => "1703"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9802493"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hl-NMRS of high grade astrocytomas&#58; mobile lipid accumulation in necrotic tissue"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46;C&#46; Kuesel"
                            1 => "G&#46;R&#46; Sutherland"
                            2 => "W&#46; Halliday"
                            3 => "I&#46;C&#46; Smith"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "NMR Biomed"
                        "fecha" => "1994"
                        "volumen" => "7"
                        "paginaInicial" => "149"
                        "paginaFinal" => "155"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8080717"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Human brain tumors&#58; spectral pattems detected with localizaed H-l MR spectroscopy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "H&#46; Kugel"
                            1 => "W&#46; Heindel"
                            2 => "R&#46;I&#46; Ernestos"
                            3 => "J&#46; Bunke"
                            4 => "R&#46; du Mesnil"
                            5 => "G&#46; Friedmann"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1148/radiology.183.3.1584924"
                      "Revista" => array:6 [
                        "tituloSerie" => "Radiology"
                        "fecha" => "1992"
                        "volumen" => "183"
                        "paginaInicial" => "701"
                        "paginaFinal" => "709"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1584924"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Atlas de tecnolog&#237;a de la resonancia magn&#233;tica"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "J&#46; Lafuente"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:3 [
                        "fecha" => "2000"
                        "editorial" => "Mallinckrodt"
                        "editorialLocalizacion" => "Madrid"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Lanfermann&#44; H&#46;L&#46;&#44; Kugel&#44; H&#46;&#44; Heindel&#44; W&#46;&#44; Herhorz&#44; K&#46;&#44; Heiss&#44; W&#46;D&#46;&#44; Lacker&#44; K&#46;&#58; Metabolic changes in acute and subacute cerebral infarctions&#58; Findings at proton MR spectroscopic imaging&#46; Radiology 196&#58; 203&#8211;210&#46;"
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23&#46;"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Lantos&#44; P&#46;L&#46;&#44; Vanderberg&#44; S&#46;R&#46;&#44; Kleihues&#44; P&#46;&#58; Tumours of the nervous system&#46; En&#58; Graham DI&#44; Lantos PL&#46; Greenfield&#39;s Neuropathology&#46; 7a ed&#46; Arnold&#46; London&#46;"
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "High grade gliomas and solitary metastases&#46; differentiation by using perfusi&#243;n and proton spectroscopic MR imaging"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Law"
                            1 => "S&#46; Cha"
                            2 => "E&#46;A&#46; Knopp"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1148/radiol.2223010558"
                      "Revista" => array:6 [
                        "tituloSerie" => "Radiology"
                        "fecha" => "2002"
                        "volumen" => "222"
                        "paginaInicial" => "715"
                        "paginaFinal" => "721"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11867790"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "MR Spectroscopy&#46; Clinical tool or Research Probe&#63; &#40;Revisited&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "R&#46;E&#46; Lenkinski"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S1076-6332(03)80680-3"
                      "Revista" => array:6 [
                        "tituloSerie" => "Acad Radiol"
                        "fecha" => "2001"
                        "volumen" => "8"
                        "paginaInicial" => "567"
                        "paginaFinal" => "570"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11450956"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
              "etiqueta" => "26&#46;"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Maheshwari&#44; S&#46;R&#46;&#44; Fatterpekar&#44; G&#46;M&#46;&#44; Castillo&#44; M&#46; y Mukherji&#46;&#58; Proton MR spectroscopy of the brain&#46; Seminars in ultrasound&#44; CT and MRI 2000&#59; 21&#58; 434&#8211;451&#46;"
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib27"
              "etiqueta" => "27&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Preliminary assessment of turbo spectroscopic imaging for targeting in brain biopsy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46;J&#46; Martin"
                            1 => "H&#46; Liu"
                            2 => "W&#46;A&#46; Hall"
                            3 => "Ch&#46; Truwit"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "AJNR"
                        "fecha" => "2001"
                        "volumen" => "22"
                        "paginaInicial" => "959"
                        "paginaFinal" => "968"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11337343"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib28"
              "etiqueta" => "28&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical application of proton magnetic resonance spectroscopy in the diagnosis of intracranial mass lesions"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "W&#46; Mbller-Hartmann"
                            1 => "S&#46; Hermingaus"
                            2 => "T&#46; Krings"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00234-001-0760-0"
                      "Revista" => array:6 [
                        "tituloSerie" => "Neuroradiology"
                        "fecha" => "2002"
                        "volumen" => "44"
                        "paginaInicial" => "371"
                        "paginaFinal" => "381"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12012120"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib29"
              "etiqueta" => "29&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Areview of chemical issues in Hl NMR spectroscopy&#58; N-acetylL-aspartate&#44; creatine and choline"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "B&#46;L&#46; Miller"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "NMR Biomed"
                        "fecha" => "1991"
                        "volumen" => "4"
                        "paginaInicial" => "47"
                        "paginaFinal" => "52"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1650241"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib30"
              "etiqueta" => "30&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Brain abscess and glioblastoma identified by combined proton magn&#233;tico resonance spectroscopy and diffusion-weighted magn&#233;tico resonance imaging-two case reports"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46; Nakaiso"
                            1 => "M&#46; Uno"
                            2 => "M&#46; Harada"
                            3 => "T&#46; Kageji"
                            4 => "O&#46; Takimoto"
                            5 => "S&#46; Nagairo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Neurol Med Chir &#40;Tokyo&#41;"
                        "fecha" => "2002"
                        "volumen" => "42"
                        "paginaInicial" => "346"
                        "paginaFinal" => "348"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib31"
              "etiqueta" => "31&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Proton magnetic resonance imaging in patients with gl&#237;al tumors&#58; a multicenter study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "W&#46;G&#46; Negendank"
                            1 => "R&#46; Sauter"
                            2 => "R&#46; Truman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3171/jns.1996.84.3.0449"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurosurg"
                        "fecha" => "1996"
                        "volumen" => "84"
                        "paginaInicial" => "449"
                        "paginaFinal" => "458"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8609557"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib32"
              "etiqueta" => "32&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Human brain tumors&#58; assessment with in vivo proton MR spectroscopy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "D&#46; Ott"
                            1 => "J&#46; Hennig"
                            2 => "T&#46; Ernst"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1148/radiology.186.3.8430183"
                      "Revista" => array:6 [
                        "tituloSerie" => "Radiology"
                        "fecha" => "1993"
                        "volumen" => "186"
                        "paginaInicial" => "745"
                        "paginaFinal" => "752"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8430183"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib33"
              "etiqueta" => "33&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diagn&#243;stico diferencial de tumors cerebrales &#8220;in vitro&#8221; por espectroscopia de resonancia magn&#233;tica de prot&#243;n&#46; M&#233;todo de los cocientes espectrales"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46;M&#46; Pascual"
                            1 => "F&#46; Carceller"
                            2 => "S&#46; Cerd&#225;n"
                            3 => "J&#46;M&#46; Roda"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Neurocirug&#237;a"
                        "fecha" => "1998"
                        "volumen" => "9"
                        "paginaInicial" => "4"
                        "paginaFinal" => "10"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib34"
              "etiqueta" => "34&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Characterization of intracranial mass lesions with in vivo proton MR spectroscopy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "H&#46; Poptani"
                            1 => "R&#46;K&#46; Gupta"
                            2 => "R&#46; Roy"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "AJNR"
                        "fecha" => "1995"
                        "volumen" => "16"
                        "paginaInicial" => "1593"
                        "paginaFinal" => "1603"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7502961"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib35"
              "etiqueta" => "35&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Magnetic resonance spectroscopy guided brain tumor resection&#46; differentiation between recurren glioma and radiation change in two disgnostically difficult cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46;C&#46; Preul"
                            1 => "R&#46; Leblanc"
                            2 => "Z&#46; Caramanos"
                            3 => "R&#46; Kasrai"
                            4 => "S&#46; Narayanan"
                            5 => "D&#46;L&#46; Arnold"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Can J Neurol Sci"
                        "fecha" => "1998"
                        "volumen" => "25"
                        "paginaInicial" => "13"
                        "paginaFinal" => "22"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9532276"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib36"
              "etiqueta" => "36&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Accuracy of single-voxel proton MR spectroscopy in distinguishing neoplastic from nonneoplastic brain lesions"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "S&#46;D&#46; Rand"
                            1 => "R&#46; Prost"
                            2 => "V&#46; Haughton"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "AJNR"
                        "fecha" => "1997"
                        "volumen" => "18"
                        "paginaInicial" => "1695"
                        "paginaFinal" => "1704"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9367317"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib37"
              "etiqueta" => "37&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Correlations between magnetic resonance spectroscopy and imageguided histopathology&#44; with special attention to radiation necrosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "J&#46;P&#46; Rock"
                            1 => "D&#46; Hearshen"
                            2 => "L&#46; Scarpace"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurosurgery"
                        "fecha" => "2002"
                        "volumen" => "51"
                        "paginaInicial" => "912"
                        "paginaFinal" => "920"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12234397"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib38"
              "etiqueta" => "38&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Nonhistological diagnosis of human cerebral tumors by 1 H magnetic resonance spectroscopy and aminoacid analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "J&#46;M&#46; Roda"
                            1 => "J&#46;M&#46; Pascual"
                            2 => "F&#46; Carceller"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Cancer Res"
                        "fecha" => "2000"
                        "volumen" => "6"
                        "paginaInicial" => "3983"
                        "paginaFinal" => "3993"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11051247"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib39"
              "etiqueta" => "39&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "MR spectroscopy and the biochemical basis of neurological disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "T&#46;M&#46; Rudkin"
                            1 => "D&#46;L&#46; Arnold"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:3 [
                        "titulo" => "Magnetic Resonance Imaging of the Brain and Spine"
                        "edicion" => "3a ed&#46;"
                        "serieFecha" => "2002"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            39 => array:3 [
              "identificador" => "bib40"
              "etiqueta" => "40&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Noninvasive evaluation of malignancy of brain tumors with proton MR spectroscopy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "H&#46; Shimizu"
                            1 => "T&#46; Kumabe"
                            2 => "T&#46; Tominaga"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "AJNR"
                        "fecha" => "1996"
                        "volumen" => "17"
                        "paginaInicial" => "737"
                        "paginaFinal" => "747"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8730195"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            40 => array:3 [
              "identificador" => "bib41"
              "etiqueta" => "41&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased choline signal coinciding with malignant degeneration of cerebral gliomas&#46; a serial proton magnetic resonance spectroscopy imaging study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "G&#46; Tedeschi"
                            1 => "N&#46; Lundbom"
                            2 => "R&#46; Raman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3171/jns.1997.87.4.0516"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurosurg"
                        "fecha" => "1997"
                        "volumen" => "87"
                        "paginaInicial" => "516"
                        "paginaFinal" => "524"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9322842"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            41 => array:3 [
              "identificador" => "bib42"
              "etiqueta" => "42&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Single-voxel proton brain spectroscopy exam &#40;PROBEISV&#41; in patients with primary brain tumors"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "R&#46;D&#46; Tien"
                            1 => "P&#46;H&#46; Lai"
                            2 => "J&#46;S&#46; Smith"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "MR"
                        "fecha" => "1996"
                        "volumen" => "167"
                        "paginaInicial" => "201"
                        "paginaFinal" => "209"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            42 => array:3 [
              "identificador" => "bib43"
              "etiqueta" => "43&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Characterization of lipis from human brain tissues by multinuclear magnetico resonance spectroscopy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "V&#46; Tugnoli"
                            1 => "M&#46;R&#46; Tosi"
                            2 => "A&#46; Tinti"
                            3 => "A&#46; Trinchero"
                            4 => "G&#46; Bottura"
                            5 => "G&#46; Fini"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/bip.10005"
                      "Revista" => array:6 [
                        "tituloSerie" => "Biopolymers"
                        "fecha" => "2001"
                        "volumen" => "62"
                        "paginaInicial" => "297"
                        "paginaFinal" => "306"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11857268"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            43 => array:3 [
              "identificador" => "bib44"
              "etiqueta" => "44&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Proton nuclear magnetic resonance spectroscopy unambiguosly identifies different neural cell types"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46; Urenjak"
                            1 => "S&#46;R&#46; Williams"
                            2 => "D&#46;G&#46; Gadian"
                            3 => "M&#46; Noble"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurosci"
                        "fecha" => "1993"
                        "volumen" => "13"
                        "paginaInicial" => "981"
                        "paginaFinal" => "989"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8441018"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            44 => array:3 [
              "identificador" => "bib45"
              "etiqueta" => "45&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Proton MR spectroscopy of pediatric brain metabolic disorders"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "Z&#46;J&#46; Wang"
                            1 => "R&#46;A&#46; Zimmerman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Neurimag Clin North Am"
                        "fecha" => "1998"
                        "volumen" => "8"
                        "paginaInicial" => "1"
                        "paginaFinal" => "27"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
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Vol. 15. Núm. 3.
Páginas 258-268 (enero 2004)
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Vol. 15. Núm. 3.
Páginas 258-268 (enero 2004)
Aplicaciones clínicas de la espectroscopia de protón por resonancia magnética in vivo en el estudio de los astrocitomas: estado actual
Clinical applications of in vivo proton magnetic resonance spectroscopy in the study of astrocytomas: state of the art
Visitas
3861
J.C. Méndez-Cendón
Sección de Neurorradiología. Servicio de Radiodiagnóstico. Hospital Virgen de la Salud. Complejo Hospitalario de Toledo
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Resumen

Se realiza una revisión de la literatura sobre el estado actual de las aplicaciones de la espectroscopia por resonancia magnética en el diagnóstico y caracterización de los astrocitomas cerebrales, haciendo especial hincapié en su utilidad en la determinación prequirúrgica del grado tumoral de las lesiones y en el diagnóstico diferencial con otros tumores y procesos pseudotumorales.

Palabras clave:
Espectroscopia
Resonancia magnética
Astrocitomas
Abreviaturas:
aa
Ala
Cho
Cr
GC
Glx
Lac
Lip
mI
NAA
Summary

We review the current state in literature of the use of magnetic resonance spectroscopy in the assessment and characterization of cerebral astrocytomas. Special attention will be paid to the presurgical grading of astrocytomas and to the role of spectroscopy in differentiating these tumors from other neoplastic and nonneoplastic brain lesions.

Key words:
Spectroscopy
Magnetic resonance
Astrocytomas

Artículo

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