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        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Presentamos un estudio de investigaci&#243;n de car&#225;cter experimental&#44; realizando autoinjertos de la corteza cerebral frontal en 70 ratas albinas en diferentes per&#237;odos evolutivos &#40;neonatos&#44; adolescentes y adultos&#41;&#46; En los animales adultos y adolescentes&#44; se procedi&#243; a la t&#233;cnica de transplante diferido &#40;produciendo la cavidad una semana&#44; antes de realizar el implante&#41;&#44; mientras que en los neonatos&#44; se procedi&#243; al implante en un mismo tiempo&#46; Todos los animales fueron sacrificados a las tres y seis semanas&#44; mediante perfusi&#243;n intracardiaca&#44; para proceder a los estudios morfol&#243;gicos haciendo uso de la t&#233;cnica de hematoxilina-eosina&#44; Nissl y de inmunohistoqu&#237;mica &#40;PFG&#41;&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Los resultados obtenidos descartaban la supervivencia de c&#233;lulas neuronales&#44; aunque se comprob&#243; la presencia de c&#233;lulas gliales en la cavidad del implante en los adultos y adolescentes&#44; mientras que en el grupo de los neonatos se observ&#243; la presencia de c&#233;lulas neuronales en el &#225;rea del implante&#44; tanto a las tres como a las seis semanas&#46;</p>"
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Vol. 2. Núm. 1.
Páginas 25-30 (enero 1991)
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Vol. 2. Núm. 1.
Páginas 25-30 (enero 1991)
Auto-injertos del cortex cerebral. Estudio experimental
Visitas
1455
A. Faleh, L. Carreira, R. Carrillo
Servicio de Neurocirugía. Hospital General Ntra. Sra. del Pino. Las Palmas
A. Cabello*, J. Rejidro**, A. Escobar**
* Servicio de Neuropatología. Hospital 12 de Octubre. Madrid
** Departamento de Morfología. Facultad de Medicina. Las Palmas
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Resumen

Presentamos un estudio de investigación de carácter experimental, realizando autoinjertos de la corteza cerebral frontal en 70 ratas albinas en diferentes períodos evolutivos (neonatos, adolescentes y adultos). En los animales adultos y adolescentes, se procedió a la técnica de transplante diferido (produciendo la cavidad una semana, antes de realizar el implante), mientras que en los neonatos, se procedió al implante en un mismo tiempo. Todos los animales fueron sacrificados a las tres y seis semanas, mediante perfusión intracardiaca, para proceder a los estudios morfológicos haciendo uso de la técnica de hematoxilina-eosina, Nissl y de inmunohistoquímica (PFG).

Los resultados obtenidos descartaban la supervivencia de células neuronales, aunque se comprobó la presencia de células gliales en la cavidad del implante en los adultos y adolescentes, mientras que en el grupo de los neonatos se observó la presencia de células neuronales en el área del implante, tanto a las tres como a las seis semanas.

Palabras clave:
Transplante neuronal
autoinjertos
corteza cerebral
Summary

We present an investigation study, using autologous graft of frontal cortex in 70 rats, with different ages (newboro, adolescent and adult). In adults and adolescents we used the «Cavity technique» with one week between the cavity procedure and the implantation. In the newborn group we implanted in one time (extraction and implantation) from the left side to the right side.

After a survival period of 3 and 6 weeks the animals were sacrificed for morfological study (hematoxilineosine, Nissl and inmmunohystochemical techniques).

In adult and adolescent groups, we did not observe neuron survival, but we found sorne glial tissue in the cavity of the implantation. In the newboro group, we found in half of the cases neuronal ceIls from the host.

Key words:
Neuronal transplant
autologous
brain cortex

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