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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Investigar en pacientes con traumatismo craneoencef&#225;lico grave y moderado &#40;TCE&#41;&#44; hemodin&#225;micamente estables&#44; la relaci&#243;n entre los valores arteriales de &#225;cido l&#225;ctico &#40;AL&#41; en las primeras 48 horas con la evoluci&#243;n y complicaciones del TCE&#44; y conocer qu&#233; factores de riesgo se relacionan con valores anormales de AL&#46;</p> <span class="elsevierStyleSectionTitle">Material y m&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudio observacional&#44; pros-pectivo&#44; de cohorte&#44; de 210 pacientes adultos con TCE grave y moderado&#46; Conseguida la estabilizaci&#243;n hemodin&#225;mica del paciente&#44; se realiz&#243; una determinaci&#243;n basal de AL&#44; que se repiti&#243; cada 12 horas durante las primeras 48 horas y&#44; posteriormente&#44; cada 24 horas hasta la normalizaci&#243;n de los valores de AL&#46; Los pacientes se clasificaron en dos grupos&#58; Grupo 1 &#40;AL &#60; 2&#44;2<span class="elsevierStyleHsp" style=""></span>mmol&#47;L&#41; sin hipoperfusi&#243;n oculta &#40;HO&#41;&#44; y grupo 2 &#40;AL &#8805; 2&#44;2<span class="elsevierStyleHsp" style=""></span>mmol&#47;L&#41; con HO&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">115 pacientes &#40;57&#44;76&#37;&#41; se catalogaron como grupo 1&#44; y 95 pacientes &#40;45&#44;24&#37;&#41; como grupo 2&#46; En el an&#225;lisis univariante de los factores de riesgo para AL &#8805; 2&#44;2<span class="elsevierStyleHsp" style=""></span>mmol&#47;L mostraron significaci&#243;n estad&#237;stica todos los &#237;ndices generales de gravedad del TCE &#91;Glasgow Coma Scale &#40;GCS&#41;&#44; Injury Severity Score &#40;ISS&#41;&#44; Trauma Score Revisado &#40;TSR&#41; y Acute Physiology and Chronic Health Evaluation &#40;APACHE&#41; II&#93;&#44; la hipotensi&#243;n arterial&#44; hipoxemia&#44; anemia&#44; hiper-glucemia&#44; hipotermia y la mayor incidencia de administraci&#243;n de noradrenalina&#46; Asimismo&#44; en el grupo 1 se objetiv&#243; un mayor porcentaje en la TAC de ingreso de lesiones tipo II &#40;53&#44;91&#37; vs&#46; 38&#44;94&#37;&#41; &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;03&#41;&#46; En el an&#225;lisis multivariante de regresi&#243;n log&#237;stica&#44; s&#243;lo dos factores se asociaron de forma independiente a valores elevados de AL&#58; APACHE II en las primeras 24 horas&#58; OR 1&#44;12 &#40;IC 95&#37; 1&#44;06&#8211;1&#44;196&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;0001&#41; y volumen de l&#237;quidos total infundido en las primeras 48 horas&#58; OR 1&#44;09 &#40;IC 95&#37; 1&#44;02&#8211;1&#44;16&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;0001&#41;&#46; El grupo 2 se asoci&#243;&#44; con significaci&#243;n estad&#237;stica&#44; a una mayor tasa de infecciones &#40;63&#44;2&#37; vs 47&#44;8&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;026&#41;&#44; y al aumento de la estancia en UCI&#46; &#91;mediana &#40;percentil 25&#8211;75&#41;&#93; &#91;13&#44;29 &#40;7&#44;11&#8211;21&#44;22&#41; d&#237;as vs&#46; 8&#44;78 &#40;4&#44;40&#8211;16&#44;72&#41; d&#237;as&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;018&#93;&#46; Aunque fue m&#225;s alto el porcentaje de hipertensi&#243;n intracraneal y mortalidad en el grupo 2&#44; no se constat&#243; significaci&#243;n estad&#237;stica&#46; El aumento de AL&#44; en el an&#225;lisis multivariante&#44; no se comport&#243; como factor independiente de riesgo para las complicaciones estudiadas&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La existencia de HO en pacientes con TCE graves y moderados&#44; con valores de presi&#243;n arterial postreanimaci&#243;n seg&#250;n las recomendaciones actuales&#44; se asocia a una mayor gravedad del TCE manifestada por el APACHE II y por el volumen de l&#237;quidos administrado en las primeras 48 horas&#46; La HO en el TCE conlleva un aumento de la tasa de infecciones y de la estancia en UCI&#46;</p>"
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        "titulo" => "Summary"
        "resumen" => "<span class="elsevierStyleSectionTitle">Objectives</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To determine the correlation between blood lactic acid levels in the first48 hours and outcome&#44; in hemodynamically stable patients&#44; with moderate or severe head injury &#40;HI&#41;&#44; and to investigate the risk factors associated with abnormal lactate levels&#46;</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A prospective observational study&#44; in 210 adults patients with moderate or severe head injury&#46; When the patients were hemodynamically stable&#44; blood lactate concentrations were measured once on admission&#44; twice daily during the first 2 days and once daily until lactate levels were normalized&#46; The whole group 210 patients were divided into 2 groups&#46; Group 1&#58; &#40;LA &#60; 2&#44;2<span class="elsevierStyleHsp" style=""></span>mmol&#47;L&#41; patients without occult hypoperfussion &#40;OH&#41;&#44; and group 2&#58; &#40;LA &#8805; 2&#44;2<span class="elsevierStyleHsp" style=""></span>mmol&#47;L&#41; patients with OH&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">One hundred and fifteen patients &#40;57&#44;76&#37;&#41; were categorized as group 1&#44; and 95 patients &#40;45&#44;24&#37;&#41; as group 2&#46; In the univariate analysis of risk factors for blood lactate &#8805; 2&#44;2<span class="elsevierStyleHsp" style=""></span>mmol&#47;L the following variables showed statistical significance&#58; severity of the head injury measured by several scales &#91;Glasgow Coma Scale &#40;GCS&#41;&#44; Injury Severity Score &#40;ISS&#41;&#44; Revised Trauma Score &#40;RTS&#41; and Acute Physiology and Chronic Health Evaluation &#40;APACHE&#41; II&#93;&#44; arterial hypotension&#44; hypoxemia&#44; anaemia&#44; hyperglucemia&#44; hypothermia&#44; a greater incidence of norepinephrine infusion&#44; and the higher percentage of type II lesions in the head computerized tomography at admission showed in the group 1 &#40;53&#44;91&#37; vs&#46; 38&#44;94&#37;&#41; &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;03&#41;&#46; In the multiple logistic regression analysis only two variables were risk independently associated with elevated blood lactate concentration&#58; APACHE II in the first 24 hours&#58; OR 1&#44;12 &#40;95&#37; IC 1&#44;06&#8211;1&#44;196&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;0001&#41; and the first 48-hours total fluid infusion volumes&#58; OR 1&#44;09 &#40;95&#37; IC 1&#44;021&#44;16&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;0001&#41;&#46; The infection rate &#40;63&#44;2&#37; vs 47&#44;8&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;026&#41;&#44; and length of ICU stay &#91;mediana &#40;percentil 25&#8211;75&#41;&#93; &#91;13&#44;29 &#40;7&#44;11&#8211;21&#44;22&#41; days vs&#46; 8&#44;78 &#40;4&#44;40&#8211;16&#44;72&#41; days&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;018&#93; were significantly higher in patients with blood lactate &#8805; 2&#44;2<span class="elsevierStyleHsp" style=""></span>mmol&#47;L &#40;group 2&#41;&#46; Although&#44; the percentage of intracranial hypertension and mortality was higher in the group 2&#44; there was no significant difference&#46; In the multivariate analysis&#44; the increase of blood lactate concentration&#44; was not independently associated as a risk factor with studied complications&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The presence of OH in patients with moderate or severe head injury&#44; with postres uscitation arterial pressure&#44; according to present recommendations&#44; is associated with a more severe head injury&#44; showed by APACHE II and the total fluid infusion volumes in the first 48 hours&#46; OH in head injury increases the infection rate and length of ICU stay&#46;</p>"
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                          "etal" => true
                          "autores" => array:3 [
                            0 => "M&#46;H&#46; Bishop"
                            1 => "W&#46;C&#46; Shoemaker"
                            2 => "P&#46;L&#46; Appel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Crit Care Med"
                        "fecha" => "1993"
                        "volumen" => "21"
                        "paginaInicial" => "56"
                        "paginaFinal" => "63"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8420731"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The golden our and the silver day&#58; detection and correction of occult hypoperfusion within 24 hours improves outcome from major trauma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "O&#46; Blow"
                            1 => "L&#46; Magliore"
                            2 => "J&#46; Claridge"
                            3 => "K&#46; Butler"
                            4 => "S&#46; Jeffrey"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Trauma"
                        "fecha" => "1999"
                        "volumen" => "47"
                        "paginaInicial" => "964"
                        "paginaFinal" => "969"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10568731"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Factores pron&#243;sticos en el traumatismo craneoencef&#225;lico grave"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "G&#46;R&#46; Boto"
                            1 => "P&#46;A&#46; G&#243;mez"
                            2 => "J&#46; De la Cruz"
                            3 => "R&#46; Diez Lobato"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurocirug&#237;a"
                        "fecha" => "2004"
                        "volumen" => "15"
                        "paginaInicial" => "233"
                        "paginaFinal" => "247"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15239010"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Relationship between injury severity and lactate levels in severely injured patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "O&#46; Cerovi"
                            1 => "V&#46; Golubovi"
                            2 => "A&#46; pec-Marn"
                            3 => "B&#46; Krem"
                            4 => "G&#46; Vidmar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00134-003-1753-8"
                      "Revista" => array:6 [
                        "tituloSerie" => "Intensive Care Med"
                        "fecha" => "2003"
                        "volumen" => "29"
                        "paginaInicial" => "1300"
                        "paginaFinal" => "1305"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12904861"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A revision of the Trauma Score"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "H&#46;R&#46; Champion"
                            1 => "W&#46;J&#46; Sacco"
                            2 => "W&#46;S&#46; Copes"
                            3 => "D&#46;S&#46; Gann"
                            4 => "T&#46;A&#46; Gennarelli"
                            5 => "M&#46;E&#46; Flanagan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Trauma"
                        "fecha" => "1989"
                        "volumen" => "29"
                        "paginaInicial" => "623"
                        "paginaFinal" => "629"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2657085"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The role of secondary brain injury in determining outcome from severe head injury"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "R&#46;M&#46; Chesnut"
                            1 => "L&#46;F&#46; Marshall"
                            2 => "M&#46;R&#46; Klauber"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Trauma"
                        "fecha" => "1993"
                        "volumen" => "34"
                        "paginaInicial" => "216"
                        "paginaFinal" => "222"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8459458"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Detection of early ischemia in severe head injury by means of arteriovenous lactate differences and jugular bulb oxygen saturation&#46; Relationship with CPP&#44; severity indexes and outcome&#44; Preliminary analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A&#46; Chieregato"
                            1 => "M&#46; Marchi"
                            2 => "R&#46; Zoppellari"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Neurochir"
                        "fecha" => "2002"
                        "volumen" => "81"
                        "numero" => "Suppl"
                        "paginaInicial" => "289"
                        "paginaFinal" => "293"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Persistent occult hypoperfusion is associated with a significant increase in infection rate and mortality in major trauma patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46;A&#46; Cladrige"
                            1 => "T&#46;D&#46; Crabtree"
                            2 => "S&#46;J&#46; Pelletier"
                            3 => "K&#46; Butler"
                            4 => "R&#46;G&#46; Sowyer"
                            5 => "J&#46;S&#46; Young"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Trauma"
                        "fecha" => "2000"
                        "volumen" => "48"
                        "paginaInicial" => "8"
                        "paginaFinal" => "14"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10647559"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Occult hypoperfusion is associated with increased morbidity in patients undergoing early femur fracture fixation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A&#46;C&#46; Crowl"
                            1 => "J&#46;S&#46; Young"
                            2 => "S&#46; Jeffrey"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Trauma"
                        "fecha" => "2000"
                        "volumen" => "48"
                        "paginaInicial" => "260"
                        "paginaFinal" => "267"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10697084"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lactate production by the lungs in acute lung injury"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "D&#46; De Backer"
                            1 => "J&#46; Creteur"
                            2 => "H&#46; Zhang"
                            3 => "M&#46; Norrenberg"
                            4 => "J&#46;L&#46; Vincent"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.156.4.9701048"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "1997"
                        "volumen" => "156"
                        "paginaInicial" => "1099"
                        "paginaFinal" => "1104"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9351608"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lactic acidosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "D&#46; De Backer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00134-003-1746-7"
                      "Revista" => array:6 [
                        "tituloSerie" => "Intensive Care Med"
                        "fecha" => "2003"
                        "volumen" => "29"
                        "paginaInicial" => "699"
                        "paginaFinal" => "702"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12682722"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "CDC definitions for nosocomial infections"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46;S&#46; Garner"
                            1 => "W&#46;R&#46; Jarvis"
                            2 => "T&#46;G&#46; Emori"
                            3 => "T&#46;C&#46; Horan"
                            4 => "J&#46;M&#46; Hughes"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Infect Control"
                        "fecha" => "1988"
                        "volumen" => "16"
                        "paginaInicial" => "128"
                        "paginaFinal" => "140"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2841893"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lactic acidosis during sepsis is related to increase pyruvate production&#44; no deficits in tissue oxygen availability"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46;C&#46; Gore"
                            1 => "F&#46; Jahoor"
                            2 => "J&#46;M&#46; Hibbert"
                            3 => "E&#46;J&#46; DeMaria"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Surg"
                        "fecha" => "1996"
                        "volumen" => "224"
                        "paginaInicial" => "97"
                        "paginaFinal" => "102"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8678625"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "APACHE II&#46; A severity of disease classification system"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "W&#46;A&#46; Knaus"
                            1 => "D&#46;P&#46; Wagner"
                            2 => "E&#46;A&#46; Draper"
                            3 => "J&#46;E&#46; Zimmerman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Crit Care Med"
                        "fecha" => "1985"
                        "volumen" => "13"
                        "paginaInicial" => "818"
                        "paginaFinal" => "829"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3928249"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Impact of ICP instability and hypotension on outcome in patients with severe head trauma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A&#46; Marmarou"
                            1 => "R&#46;L&#46; Anderson"
                            2 => "J&#46;D&#46; Ward"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurosurg"
                        "fecha" => "1991"
                        "volumen" => "75"
                        "numero" => "Suppl"
                        "paginaInicial" => "S28"
                        "paginaFinal" => "S36"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A new classification of head injury based on computerized tomography"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "L&#46;F&#46; Marshall"
                            1 => "S&#46;B&#46; Marshall"
                            2 => "M&#46;R&#46; Klauber"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurosurg"
                        "fecha" => "1991"
                        "volumen" => "75"
                        "numero" => "Suppl"
                        "paginaInicial" => "S59"
                        "paginaFinal" => "S66"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Post-injury multiple organ failure"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "F&#46;A&#46; Moore"
                            1 => "E&#46;E&#46; Moore"
                            2 => "J&#46;B&#46; Haenel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:5 [
                        "titulo" => "Trauma"
                        "paginaInicial" => "1205"
                        "paginaFinal" => "1218"
                        "edicion" => "3&#170;"
                        "serieFecha" => "1996"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Utilidad del doppler transcraneal en la fase precoz del traumatismo craneoencef&#225;lico"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "F&#46; Murillo Cabezas"
                            1 => "D&#46; Arteta Arteta"
                            2 => "J&#46;M&#46; Flores Cordero"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurocirug&#237;a"
                        "fecha" => "2002"
                        "volumen" => "13"
                        "paginaInicial" => "196"
                        "paginaFinal" => "208"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12148164"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Early biochemical changes and severity of injury on man"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "W&#46;L&#46; Oppenheim"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Trauma"
                        "fecha" => "1980"
                        "volumen" => "20"
                        "paginaInicial" => "135"
                        "paginaFinal" => "140"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7354495"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Rinc&#243;n-Ferrari&#44; M&#46;D&#46;&#44; Flores-Cordero&#44; J&#46;M&#46;&#44; Leal-Noval&#44; S&#46;R&#46;&#44; et al&#46;&#58; Impact of ventilator-associated pneumoma in patients with severe head injury&#46; J Trauma &#40;in press&#41;&#46;"
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Early goal-directed therapy in the treatment of severe sepsis and septic shock"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "E&#46; Rivers"
                            1 => "B&#46; Nguyen"
                            2 => "S&#46; Havstad"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa010307"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2001"
                        "volumen" => "345"
                        "paginaInicial" => "1368"
                        "paginaFinal" => "1377"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11794169"
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                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Metabolic correlates of oxygen debt predict posttrauma early acute respiratory distress syndrome and the related cytokine response"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
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                      ]
                    ]
                  ]
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                      "Revista" => array:6 [
                        "tituloSerie" => "J Trauma"
                        "fecha" => "2000"
                        "volumen" => "49"
                        "paginaInicial" => "392"
                        "paginaFinal" => "403"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11003314"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The predictive value of cerebral anaerobic metabolism with cerebral infarction after head injury"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "C&#46; Robertson"
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                            3 => "R&#46;K&#46; Narayan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3171/jns.1987.67.3.0361"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurosurg"
                        "fecha" => "1987"
                        "volumen" => "67"
                        "paginaInicial" => "361"
                        "paginaFinal" => "368"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3612268"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib26"
              "etiqueta" => "26&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Assessment of coma and impaired consciousness&#58; A practical Scale"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "G&#46; Teasdale"
                            1 => "B&#46; Jennnet"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1974"
                        "volumen" => "2"
                        "paginaInicial" => "81"
                        "paginaFinal" => "84"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2567876"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
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              "etiqueta" => "27&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The value of blood lactate monitoring in clinical practice"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "J&#46;L&#46; Vincent"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Updated in lntensive Care and Emergency Medicine"
                        "paginaInicial" => "260"
                        "paginaFinal" => "272"
                        "serieFecha" => "1991"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
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Existencia de hipoperfusión oculta sistémica en el traumatismo craneoencefálico. Estudio preliminar
Evidence of occult systemic hypoperfussion in head injured patients. Preliminary study
F. Murillo-Cabezas
, R. Amaya-Villar, Mª.D. Rincón-Ferrari, J.M. Flores-Cordero, S. García-Gómez, Mª.A. Muñoz-Sánchez
Servicio de Cuidados Críticos y Urgencias. Hospitales Universitarios Virgen del Rocío. Sevilla
J. Valencia-Anguita*
* Servicio de Neurocirugía. Hospitales Universitarios Virgen del Rocío. Sevilla
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Investigar en pacientes con traumatismo craneoencef&#225;lico grave y moderado &#40;TCE&#41;&#44; hemodin&#225;micamente estables&#44; la relaci&#243;n entre los valores arteriales de &#225;cido l&#225;ctico &#40;AL&#41; en las primeras 48 horas con la evoluci&#243;n y complicaciones del TCE&#44; y conocer qu&#233; factores de riesgo se relacionan con valores anormales de AL&#46;</p> <span class="elsevierStyleSectionTitle">Material y m&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudio observacional&#44; pros-pectivo&#44; de cohorte&#44; de 210 pacientes adultos con TCE grave y moderado&#46; Conseguida la estabilizaci&#243;n hemodin&#225;mica del paciente&#44; se realiz&#243; una determinaci&#243;n basal de AL&#44; que se repiti&#243; cada 12 horas durante las primeras 48 horas y&#44; posteriormente&#44; cada 24 horas hasta la normalizaci&#243;n de los valores de AL&#46; Los pacientes se clasificaron en dos grupos&#58; Grupo 1 &#40;AL &#60; 2&#44;2<span class="elsevierStyleHsp" style=""></span>mmol&#47;L&#41; sin hipoperfusi&#243;n oculta &#40;HO&#41;&#44; y grupo 2 &#40;AL &#8805; 2&#44;2<span class="elsevierStyleHsp" style=""></span>mmol&#47;L&#41; con HO&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">115 pacientes &#40;57&#44;76&#37;&#41; se catalogaron como grupo 1&#44; y 95 pacientes &#40;45&#44;24&#37;&#41; como grupo 2&#46; En el an&#225;lisis univariante de los factores de riesgo para AL &#8805; 2&#44;2<span class="elsevierStyleHsp" style=""></span>mmol&#47;L mostraron significaci&#243;n estad&#237;stica todos los &#237;ndices generales de gravedad del TCE &#91;Glasgow Coma Scale &#40;GCS&#41;&#44; Injury Severity Score &#40;ISS&#41;&#44; Trauma Score Revisado &#40;TSR&#41; y Acute Physiology and Chronic Health Evaluation &#40;APACHE&#41; II&#93;&#44; la hipotensi&#243;n arterial&#44; hipoxemia&#44; anemia&#44; hiper-glucemia&#44; hipotermia y la mayor incidencia de administraci&#243;n de noradrenalina&#46; Asimismo&#44; en el grupo 1 se objetiv&#243; un mayor porcentaje en la TAC de ingreso de lesiones tipo II &#40;53&#44;91&#37; vs&#46; 38&#44;94&#37;&#41; &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;03&#41;&#46; En el an&#225;lisis multivariante de regresi&#243;n log&#237;stica&#44; s&#243;lo dos factores se asociaron de forma independiente a valores elevados de AL&#58; APACHE II en las primeras 24 horas&#58; OR 1&#44;12 &#40;IC 95&#37; 1&#44;06&#8211;1&#44;196&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;0001&#41; y volumen de l&#237;quidos total infundido en las primeras 48 horas&#58; OR 1&#44;09 &#40;IC 95&#37; 1&#44;02&#8211;1&#44;16&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;0001&#41;&#46; El grupo 2 se asoci&#243;&#44; con significaci&#243;n estad&#237;stica&#44; a una mayor tasa de infecciones &#40;63&#44;2&#37; vs 47&#44;8&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;026&#41;&#44; y al aumento de la estancia en UCI&#46; &#91;mediana &#40;percentil 25&#8211;75&#41;&#93; &#91;13&#44;29 &#40;7&#44;11&#8211;21&#44;22&#41; d&#237;as vs&#46; 8&#44;78 &#40;4&#44;40&#8211;16&#44;72&#41; d&#237;as&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;018&#93;&#46; Aunque fue m&#225;s alto el porcentaje de hipertensi&#243;n intracraneal y mortalidad en el grupo 2&#44; no se constat&#243; significaci&#243;n estad&#237;stica&#46; El aumento de AL&#44; en el an&#225;lisis multivariante&#44; no se comport&#243; como factor independiente de riesgo para las complicaciones estudiadas&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La existencia de HO en pacientes con TCE graves y moderados&#44; con valores de presi&#243;n arterial postreanimaci&#243;n seg&#250;n las recomendaciones actuales&#44; se asocia a una mayor gravedad del TCE manifestada por el APACHE II y por el volumen de l&#237;quidos administrado en las primeras 48 horas&#46; La HO en el TCE conlleva un aumento de la tasa de infecciones y de la estancia en UCI&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objectives</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To determine the correlation between blood lactic acid levels in the first48 hours and outcome&#44; in hemodynamically stable patients&#44; with moderate or severe head injury &#40;HI&#41;&#44; and to investigate the risk factors associated with abnormal lactate levels&#46;</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A prospective observational study&#44; in 210 adults patients with moderate or severe head injury&#46; When the patients were hemodynamically stable&#44; blood lactate concentrations were measured once on admission&#44; twice daily during the first 2 days and once daily until lactate levels were normalized&#46; The whole group 210 patients were divided into 2 groups&#46; Group 1&#58; &#40;LA &#60; 2&#44;2<span class="elsevierStyleHsp" style=""></span>mmol&#47;L&#41; patients without occult hypoperfussion &#40;OH&#41;&#44; and group 2&#58; &#40;LA &#8805; 2&#44;2<span class="elsevierStyleHsp" style=""></span>mmol&#47;L&#41; patients with OH&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">One hundred and fifteen patients &#40;57&#44;76&#37;&#41; were categorized as group 1&#44; and 95 patients &#40;45&#44;24&#37;&#41; as group 2&#46; In the univariate analysis of risk factors for blood lactate &#8805; 2&#44;2<span class="elsevierStyleHsp" style=""></span>mmol&#47;L the following variables showed statistical significance&#58; severity of the head injury measured by several scales &#91;Glasgow Coma Scale &#40;GCS&#41;&#44; Injury Severity Score &#40;ISS&#41;&#44; Revised Trauma Score &#40;RTS&#41; and Acute Physiology and Chronic Health Evaluation &#40;APACHE&#41; II&#93;&#44; arterial hypotension&#44; hypoxemia&#44; anaemia&#44; hyperglucemia&#44; hypothermia&#44; a greater incidence of norepinephrine infusion&#44; and the higher percentage of type II lesions in the head computerized tomography at admission showed in the group 1 &#40;53&#44;91&#37; vs&#46; 38&#44;94&#37;&#41; &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;03&#41;&#46; In the multiple logistic regression analysis only two variables were risk independently associated with elevated blood lactate concentration&#58; APACHE II in the first 24 hours&#58; OR 1&#44;12 &#40;95&#37; IC 1&#44;06&#8211;1&#44;196&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;0001&#41; and the first 48-hours total fluid infusion volumes&#58; OR 1&#44;09 &#40;95&#37; IC 1&#44;021&#44;16&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;0001&#41;&#46; The infection rate &#40;63&#44;2&#37; vs 47&#44;8&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;026&#41;&#44; and length of ICU stay &#91;mediana &#40;percentil 25&#8211;75&#41;&#93; &#91;13&#44;29 &#40;7&#44;11&#8211;21&#44;22&#41; days vs&#46; 8&#44;78 &#40;4&#44;40&#8211;16&#44;72&#41; days&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;018&#93; were significantly higher in patients with blood lactate &#8805; 2&#44;2<span class="elsevierStyleHsp" style=""></span>mmol&#47;L &#40;group 2&#41;&#46; Although&#44; the percentage of intracranial hypertension and mortality was higher in the group 2&#44; there was no significant difference&#46; In the multivariate analysis&#44; the increase of blood lactate concentration&#44; was not independently associated as a risk factor with studied complications&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The presence of OH in patients with moderate or severe head injury&#44; with postres uscitation arterial pressure&#44; according to present recommendations&#44; is associated with a more severe head injury&#44; showed by APACHE II and the total fluid infusion volumes in the first 48 hours&#46; OH in head injury increases the infection rate and length of ICU stay&#46;</p>"
      ]
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    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara">Murillo-Cabezas&#44; F&#46;&#59; Amaya-Villar&#44;R&#46;&#59; Rinc&#243;n-Ferrari&#44; M&#170;&#46;D&#46;&#59; Flores-Cordero&#44; J&#46;M&#46;&#59; Valencia-Anguita&#44; J&#46;&#59; Garc&#237;a-G&#243;mez&#44; S&#46;&#59; Mu&#241;oz-S&#225;nchez&#44; M&#170;&#46;A&#46;&#58; Existencia de hipoperfusi&#243;n oculta sist&#233;mica en el traumatismo craneoencef&#225;lico&#46; Estudio Preliminar&#46; Neurocirug&#237;a 2005&#59; 16&#58; 323&#8211;332&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Bibliograf&#237;a"
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        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:27 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "The Brain Trauma Foundation&#46; The American Association of Neurological Surgeons"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1089/neu.2000.17.471"
                      "Revista" => array:7 [
                        "titulo" => "The Joint Section on Neurotrauma and Critical Care&#46; Resuscitation of blood pressure and oxygenation"
                        "tituloSerie" => "J Neurotrauma"
                        "fecha" => "2000"
                        "volumen" => "17"
                        "paginaInicial" => "471"
                        "paginaFinal" => "478"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10937889"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The Injury Severity Score&#58; a method for describing patients with multiple injuries and evaluating emergency care"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46;P&#46; Baker"
                            1 => "B&#46; O&#8217;Neill"
                            2 => "W&#46; Haddon"
                            3 => "W&#46;B&#46; Long"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Trauma"
                        "fecha" => "1974"
                        "volumen" => "14"
                        "paginaInicial" => "187"
                        "paginaFinal" => "196"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4814394"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Relationship between supranormal circulatory values&#44; time delays&#44; and outcome in severely traumatized patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "M&#46;H&#46; Bishop"
                            1 => "W&#46;C&#46; Shoemaker"
                            2 => "P&#46;L&#46; Appel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Crit Care Med"
                        "fecha" => "1993"
                        "volumen" => "21"
                        "paginaInicial" => "56"
                        "paginaFinal" => "63"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8420731"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The golden our and the silver day&#58; detection and correction of occult hypoperfusion within 24 hours improves outcome from major trauma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "O&#46; Blow"
                            1 => "L&#46; Magliore"
                            2 => "J&#46; Claridge"
                            3 => "K&#46; Butler"
                            4 => "S&#46; Jeffrey"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Trauma"
                        "fecha" => "1999"
                        "volumen" => "47"
                        "paginaInicial" => "964"
                        "paginaFinal" => "969"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10568731"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Factores pron&#243;sticos en el traumatismo craneoencef&#225;lico grave"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "G&#46;R&#46; Boto"
                            1 => "P&#46;A&#46; G&#243;mez"
                            2 => "J&#46; De la Cruz"
                            3 => "R&#46; Diez Lobato"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurocirug&#237;a"
                        "fecha" => "2004"
                        "volumen" => "15"
                        "paginaInicial" => "233"
                        "paginaFinal" => "247"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15239010"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Relationship between injury severity and lactate levels in severely injured patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "O&#46; Cerovi"
                            1 => "V&#46; Golubovi"
                            2 => "A&#46; pec-Marn"
                            3 => "B&#46; Krem"
                            4 => "G&#46; Vidmar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00134-003-1753-8"
                      "Revista" => array:6 [
                        "tituloSerie" => "Intensive Care Med"
                        "fecha" => "2003"
                        "volumen" => "29"
                        "paginaInicial" => "1300"
                        "paginaFinal" => "1305"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12904861"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A revision of the Trauma Score"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "H&#46;R&#46; Champion"
                            1 => "W&#46;J&#46; Sacco"
                            2 => "W&#46;S&#46; Copes"
                            3 => "D&#46;S&#46; Gann"
                            4 => "T&#46;A&#46; Gennarelli"
                            5 => "M&#46;E&#46; Flanagan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Trauma"
                        "fecha" => "1989"
                        "volumen" => "29"
                        "paginaInicial" => "623"
                        "paginaFinal" => "629"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2657085"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The role of secondary brain injury in determining outcome from severe head injury"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "R&#46;M&#46; Chesnut"
                            1 => "L&#46;F&#46; Marshall"
                            2 => "M&#46;R&#46; Klauber"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Trauma"
                        "fecha" => "1993"
                        "volumen" => "34"
                        "paginaInicial" => "216"
                        "paginaFinal" => "222"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8459458"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Detection of early ischemia in severe head injury by means of arteriovenous lactate differences and jugular bulb oxygen saturation&#46; Relationship with CPP&#44; severity indexes and outcome&#44; Preliminary analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A&#46; Chieregato"
                            1 => "M&#46; Marchi"
                            2 => "R&#46; Zoppellari"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Neurochir"
                        "fecha" => "2002"
                        "volumen" => "81"
                        "numero" => "Suppl"
                        "paginaInicial" => "289"
                        "paginaFinal" => "293"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Persistent occult hypoperfusion is associated with a significant increase in infection rate and mortality in major trauma patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46;A&#46; Cladrige"
                            1 => "T&#46;D&#46; Crabtree"
                            2 => "S&#46;J&#46; Pelletier"
                            3 => "K&#46; Butler"
                            4 => "R&#46;G&#46; Sowyer"
                            5 => "J&#46;S&#46; Young"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Trauma"
                        "fecha" => "2000"
                        "volumen" => "48"
                        "paginaInicial" => "8"
                        "paginaFinal" => "14"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10647559"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Occult hypoperfusion is associated with increased morbidity in patients undergoing early femur fracture fixation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A&#46;C&#46; Crowl"
                            1 => "J&#46;S&#46; Young"
                            2 => "S&#46; Jeffrey"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Trauma"
                        "fecha" => "2000"
                        "volumen" => "48"
                        "paginaInicial" => "260"
                        "paginaFinal" => "267"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10697084"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lactate production by the lungs in acute lung injury"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "D&#46; De Backer"
                            1 => "J&#46; Creteur"
                            2 => "H&#46; Zhang"
                            3 => "M&#46; Norrenberg"
                            4 => "J&#46;L&#46; Vincent"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.156.4.9701048"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "1997"
                        "volumen" => "156"
                        "paginaInicial" => "1099"
                        "paginaFinal" => "1104"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9351608"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lactic acidosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "D&#46; De Backer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00134-003-1746-7"
                      "Revista" => array:6 [
                        "tituloSerie" => "Intensive Care Med"
                        "fecha" => "2003"
                        "volumen" => "29"
                        "paginaInicial" => "699"
                        "paginaFinal" => "702"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12682722"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "CDC definitions for nosocomial infections"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46;S&#46; Garner"
                            1 => "W&#46;R&#46; Jarvis"
                            2 => "T&#46;G&#46; Emori"
                            3 => "T&#46;C&#46; Horan"
                            4 => "J&#46;M&#46; Hughes"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Infect Control"
                        "fecha" => "1988"
                        "volumen" => "16"
                        "paginaInicial" => "128"
                        "paginaFinal" => "140"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2841893"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lactic acidosis during sepsis is related to increase pyruvate production&#44; no deficits in tissue oxygen availability"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46;C&#46; Gore"
                            1 => "F&#46; Jahoor"
                            2 => "J&#46;M&#46; Hibbert"
                            3 => "E&#46;J&#46; DeMaria"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Surg"
                        "fecha" => "1996"
                        "volumen" => "224"
                        "paginaInicial" => "97"
                        "paginaFinal" => "102"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8678625"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "APACHE II&#46; A severity of disease classification system"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "W&#46;A&#46; Knaus"
                            1 => "D&#46;P&#46; Wagner"
                            2 => "E&#46;A&#46; Draper"
                            3 => "J&#46;E&#46; Zimmerman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Crit Care Med"
                        "fecha" => "1985"
                        "volumen" => "13"
                        "paginaInicial" => "818"
                        "paginaFinal" => "829"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3928249"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Impact of ICP instability and hypotension on outcome in patients with severe head trauma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A&#46; Marmarou"
                            1 => "R&#46;L&#46; Anderson"
                            2 => "J&#46;D&#46; Ward"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurosurg"
                        "fecha" => "1991"
                        "volumen" => "75"
                        "numero" => "Suppl"
                        "paginaInicial" => "S28"
                        "paginaFinal" => "S36"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A new classification of head injury based on computerized tomography"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "L&#46;F&#46; Marshall"
                            1 => "S&#46;B&#46; Marshall"
                            2 => "M&#46;R&#46; Klauber"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurosurg"
                        "fecha" => "1991"
                        "volumen" => "75"
                        "numero" => "Suppl"
                        "paginaInicial" => "S59"
                        "paginaFinal" => "S66"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Post-injury multiple organ failure"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "F&#46;A&#46; Moore"
                            1 => "E&#46;E&#46; Moore"
                            2 => "J&#46;B&#46; Haenel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:5 [
                        "titulo" => "Trauma"
                        "paginaInicial" => "1205"
                        "paginaFinal" => "1218"
                        "edicion" => "3&#170;"
                        "serieFecha" => "1996"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Utilidad del doppler transcraneal en la fase precoz del traumatismo craneoencef&#225;lico"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "F&#46; Murillo Cabezas"
                            1 => "D&#46; Arteta Arteta"
                            2 => "J&#46;M&#46; Flores Cordero"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurocirug&#237;a"
                        "fecha" => "2002"
                        "volumen" => "13"
                        "paginaInicial" => "196"
                        "paginaFinal" => "208"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12148164"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Early biochemical changes and severity of injury on man"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "W&#46;L&#46; Oppenheim"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Trauma"
                        "fecha" => "1980"
                        "volumen" => "20"
                        "paginaInicial" => "135"
                        "paginaFinal" => "140"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7354495"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Rinc&#243;n-Ferrari&#44; M&#46;D&#46;&#44; Flores-Cordero&#44; J&#46;M&#46;&#44; Leal-Noval&#44; S&#46;R&#46;&#44; et al&#46;&#58; Impact of ventilator-associated pneumoma in patients with severe head injury&#46; J Trauma &#40;in press&#41;&#46;"
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Early goal-directed therapy in the treatment of severe sepsis and septic shock"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "E&#46; Rivers"
                            1 => "B&#46; Nguyen"
                            2 => "S&#46; Havstad"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa010307"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2001"
                        "volumen" => "345"
                        "paginaInicial" => "1368"
                        "paginaFinal" => "1377"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11794169"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Metabolic correlates of oxygen debt predict posttrauma early acute respiratory distress syndrome and the related cytokine response"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46; Rixen"
                            1 => "J&#46;H&#46; Siegel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Trauma"
                        "fecha" => "2000"
                        "volumen" => "49"
                        "paginaInicial" => "392"
                        "paginaFinal" => "403"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11003314"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The predictive value of cerebral anaerobic metabolism with cerebral infarction after head injury"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "C&#46; Robertson"
                            1 => "R&#46;G&#46; Grossman"
                            2 => "J&#46;C&#46; Goodman"
                            3 => "R&#46;K&#46; Narayan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3171/jns.1987.67.3.0361"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurosurg"
                        "fecha" => "1987"
                        "volumen" => "67"
                        "paginaInicial" => "361"
                        "paginaFinal" => "368"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3612268"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
              "etiqueta" => "26&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Assessment of coma and impaired consciousness&#58; A practical Scale"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "G&#46; Teasdale"
                            1 => "B&#46; Jennnet"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1974"
                        "volumen" => "2"
                        "paginaInicial" => "81"
                        "paginaFinal" => "84"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2567876"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib27"
              "etiqueta" => "27&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The value of blood lactate monitoring in clinical practice"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "J&#46;L&#46; Vincent"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Updated in lntensive Care and Emergency Medicine"
                        "paginaInicial" => "260"
                        "paginaFinal" => "272"
                        "serieFecha" => "1991"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
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