Tratamiento de los gliomas mediante virus oncolíticos: revisión de la literatura
Oncolytic viral terapy of gliomas: review of the literature
I. Arrese
, P. González, P. Miranda, A. Pérez-Núñez, B. Pascual, R.D. Lobato
Servicio de Neurocirugía, Hospital Universitario 12 de Octubre, Madrid
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"apellidos" => "Arrese" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "P." "apellidos" => "González" ] 2 => array:2 [ "nombre" => "P." "apellidos" => "Miranda" ] 3 => array:2 [ "nombre" => "A." "apellidos" => "Pérez-Núñez" ] 4 => array:2 [ "nombre" => "B." "apellidos" => "Pascual" ] 5 => array:2 [ "nombre" => "R.D." "apellidos" => "Lobato" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Neurocirugía, Hospital Universitario 12 de Octubre, Madrid" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Correspondencia postal: Servicio de Neurocirugía, Hospital Universitario 12 de Octubre, Avda de Córdoba s/n, 28041 Madrid." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Oncolytic viral terapy of gliomas: review of the literature" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2004-05-20" "fechaAceptado" => "2004-06-22" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec158839" "palabras" => array:3 [ 0 => "Virus oncolíticos" 1 => "Glioma" 2 => "Biología molecular" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec158840" "palabras" => array:3 [ 0 => "Oncolytic viruses" 1 => "Glioma" 2 => "Molecular biology" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Los gliomas son los tumores cerebrales primarios más frecuentes. Los tratamientos tradicionales se han basado en la cirugía, la radioterapia y la quimioterapia. Pese al avance en estas terapias, el pronóstico de estos tumores ha permanecido casi constante durante los últimos años. Dada la ausencia de mejoría en el pronóstico, los últimos avances en técnicas de biología molecular han abierto un nuevo campo de investigación para el desarrollo de nuevos tratamientos, y dentro de ellos, se ha evaluado el uso de virus oncolíticos en diferentes ensayos. En esta revisión discutimos los avances ocurridos en el uso de terapias basadas en estos agentes anticancerosos.</p>" ] "en" => array:2 [ "titulo" => "Summary" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Gliomas are the most frequent primary tumors of the brain. The standard treatment includes surgery, radiotherapy and chemotherapy, but the outcomes of patients with these tumors have remained nearly unchanged for past years. Hopefully, recent advances in molecular biology are rising new clinical expectation for patients with brain tumors. Among the novel techniques in this new fleld of research a new fleld of research, the use of oncolytic viruses has been explored in different trials during last years. In the present review we analyze the advances in the understanding of the oncolytic viral therapy of gliomas.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Arrese, I; González, P.; Miranda, P.; Pérez-Núñez, A.; Pascual, B.; Lobato, R.D.: Tratamiento de los gliomas mediante viras oncolíticos: revisión de la literatura. Neurociragía 2005; 16: 158–168.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:66 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| año/Mes | Html | Total | |
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| 2015 Marzo | 14 | 19 | 33 |
| 2015 Febrero | 19 | 14 | 33 |
| 2015 Enero | 12 | 14 | 26 |
| 2014 Diciembre | 26 | 22 | 48 |
| 2014 Noviembre | 15 | 12 | 27 |
| 2014 Octubre | 19 | 21 | 40 |
| 2014 Septiembre | 16 | 22 | 38 |
| 2014 Agosto | 19 | 13 | 32 |
| 2014 Julio | 11 | 13 | 24 |
| 2014 Junio | 22 | 28 | 50 |
| 2014 Mayo | 28 | 26 | 54 |
| 2014 Abril | 16 | 18 | 34 |
| 2014 Marzo | 21 | 28 | 49 |
| 2014 Febrero | 13 | 21 | 34 |
| 2014 Enero | 15 | 11 | 26 |
| 2013 Diciembre | 18 | 21 | 39 |
| 2013 Noviembre | 18 | 16 | 34 |
| 2013 Octubre | 17 | 19 | 36 |
| 2013 Septiembre | 27 | 20 | 47 |
| 2013 Agosto | 35 | 20 | 55 |
| 2013 Julio | 30 | 26 | 56 |
| 2013 Junio | 25 | 19 | 44 |
| 2013 Mayo | 14 | 25 | 39 |
| 2013 Abril | 16 | 18 | 34 |
| 2013 Marzo | 20 | 19 | 39 |
| 2013 Febrero | 11 | 14 | 25 |
| 2013 Enero | 16 | 17 | 33 |
| 2012 Diciembre | 15 | 15 | 30 |
| 2012 Noviembre | 2 | 14 | 16 |
| 2012 Octubre | 0 | 1 | 1 |
| 2012 Septiembre | 0 | 2 | 2 |
| 2012 Enero | 9 | 0 | 9 |
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