Comparación de la eficacia del pentobarbital y el tiopental en el control de la hipertensión intracraneal refractaria. Resultados preliminares en una serie de 20 pacientes
Comparison of the effectiveness of pentobarbital and thiopental in patients with refractory intracranial hypertension. Preliminary report of 20 patients
J. Pérez-Bárcena
, J. Homar, J.M. Abadal, J. Ibáñez
Servicio de Medicina Intensiva. Hospital Son Dureta. Palma Mallorca. Departament de Cirurgia. Universitat Autónoma. Barcelona
Departament de Cirurgia. Universitat Autónoma. Barcelona
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Resultados preliminares en una serie de 20 pacientes" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "5" "paginaFinal" => "12" ] ] "autores" => array:2 [ 0 => array:4 [ "autoresLista" => "J. Pérez-Bárcena, J. Homar, J.M. Abadal, J. Ibáñez" "autores" => array:4 [ 0 => array:3 [ "nombre" => "J." "apellidos" => "Pérez-Bárcena" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "J." "apellidos" => "Homar" ] 2 => array:2 [ "nombre" => "J.M." "apellidos" => "Abadal" ] 3 => array:2 [ "nombre" => "J." "apellidos" => "Ibáñez" ] ] "afiliaciones" => array:2 [ 0 => array:1 [ "entidad" => "Servicio de Medicina Intensiva. Hospital Son Dureta. Palma Mallorca. Departament de Cirurgia. Universitat Autónoma. Barcelona" ] 1 => array:1 [ "entidad" => "Departament de Cirurgia. Universitat Autónoma. 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"apellidos" => "Sahuquillo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">****</span>" "identificador" => "aff0030" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Servicios de Análisis Clínicos. Hospital Son Dureta. Palma Mallorca" "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0015" ] 1 => array:3 [ "entidad" => "Servicios de de Neurología. Hospital Son Dureta. Palma Mallorca" "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0020" ] 2 => array:3 [ "entidad" => "Servicio de Medicina Interna. Hospital Son LLatzer. Palma Mallorca" "etiqueta" => "<span class="elsevierStyleSup">***</span>" "identificador" => "aff0025" ] 3 => array:3 [ "entidad" => "Servicio de Neurocirugía. Hospital Valí d’Hebrón. Barcelona" "etiqueta" => "****" "identificador" => "aff0030" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Comparison of the effectiveness of pentobarbital and thiopental in patients with refractory intracranial hypertension. Preliminary report of 20 patients" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2004-05-25" "fechaAceptado" => "2004-08-18" "PalabrasClave" => array:2 [ "es" => array:2 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec158694" "palabras" => array:4 [ 0 => "Traumatismo craneal" 1 => "Hipertensión intracraneal" 2 => "Pentobarbital" 3 => "Tiopental" ] ] 1 => array:4 [ "clase" => "abr" "titulo" => "Abreviaturas" "identificador" => "xpalclavsec158695" "palabras" => array:13 [ 0 => "APACHE" 1 => "FSC" 2 => "GCS" 3 => "HIC" 4 => "ISS" 5 => "LCR" 6 => "PIC" 7 => "SAPS" 8 => "SNC" 9 => "TAM" 10 => "TC" 11 => "TCE" 12 => "VSC" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key word" "identificador" => "xpalclavsec158693" "palabras" => array:4 [ 0 => "Head injury" 1 => "Intracranial hypertension" 2 => "Pentobarbital" 3 => "Thiopental" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Comparar la eficacia del pentobarbital y tiopental en el control de la hipertensión intracraneal (HIC) refractaria a las medidas de primer nivel, según las Guías de Práctica Clínica de la “Brain Trauma Foundation”, en pacientes con traumatismo craneoencefálico (TCE) grave.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudio prospectivo de cohorte, aleatorizado, de intervención terapéutica comparativa entre dos fármacos: pentobarbital y tiopental. La muestra fue seleccionada a partir de los pacientes que sufrieron un TCE grave (Glasgow Coma Scale GCS, postresucitación, ≤8 puntos o deterioro neurológico en la primera semana post traumatismo) y que presentaron HIC (PIC >20<span class="elsevierStyleHsp" style=""></span>mmHg) refractaria al tratamiento convencional, de acuerdo con las Guías de Práctica Clínica de la “Brain Trauma Foundation”. Además de comprobar la eficacia en el control de la PIC, también se recogieron los efectos secundarios del tratamiento.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se presentan los resultados de los primeros 20 pacientes reclutados, de los cuales diez recibieron tiopental y diez pentobarbital. No hubo diferencias estadísticamente significativas en las características básales de los pacientes (edad, sexo, índices de gravedad y comorbilidades). Tampoco hubo diferencias respecto al GCS de ingreso (tiopental seis puntos; pentobarbital siete puntos; P<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,26) ni en la tomografía craneal computarizada de ingreso, según la clasificación del “Traumatic Coma Data Bank”.</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">En el grupo de tiopental se controló la PIC en cinco casos y en el grupo de pentobarbital en dos pacientes (P<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,16). Cinco pacientes tratados con tiopental fallecieron y ocho en el grupo de pentobarbital (P<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,16).</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">No hubo diferencias significativas entre ambos grupos respecto a la incidencia de hipotensión arterial (P<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>l) o complicaciones infecciosas.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">los resultados preliminares de este estudio indican que el tiopental podría ser más eficaz que el pentobarbital en el control de la HIC refractaria a las medidas de primer nivel. Dichos resultados confirman la evidencia experimental que indica que los mecanismos neuroprotectores de ambos fármacos son distintos y justifican el continuar aumentando el tamaño muestral de nuestro estudio para poder definir mejor la eficacia de ambos fármacos.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">To assess the effectiveness of pentobarbital and thiopental to control raised intracranial pres-sure (ICP), refractory to first level measures, in patients with severe traumatic brain injury.</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Prospective, randomized study to compare the effectiveness between two treat-ments: pentobarbital and thiopental. The patients will be selected from those admitted to the Intensive Care Unit with a severe traumatic brain injury (postresusci-tation Glasgow Coma Scale equal or less than 8 points) and raised ICP (ICP>20<span class="elsevierStyleHsp" style=""></span>mmHg) refractory to first level measures according to the Brain Trauma Foundation guidelines. The adverse effeets of both treatments were also collected.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">We present the results of the first 20 patients included. Ten received pentobarbital and the other ten thiopental. There were no statistically significance differences in patients’characteristics (age, sex, severity of the trauma at admission and comorbilities). There were no differences between both groups neither in the Glasgow Coma Scale at admission (thiopental six points; pentobarbital seven points; P=0,26) ñor in the admission Cranial Tomography, according to the Trau-matic Coma Data Bank classiñcation.</p><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Thiopental treatment controlled raised ICP in flve cases and pentobarbital in two cases (P=0,16). Five patients in the thiopental group died and eight in the pentobarbital group (P=0,16).</p><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">There were no statistically differences between both groups regarding to the presence of hypotension (P=l) or infectious complications.</p><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Conclusions. These preliminary results indícate that thiopental could be more effective than pentobarbital in patients with refractory intracranial hypertension. These results support previous experimental ñndings that show that both treatments are not equal and justify to continué this study.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Pérez-Barcena, J.; Barceló, B.; Homar, J.; Abadal, J.M.; Molina, F.J.; de la Peña, A.; Sahuquillo, J.; Ibáñez, J.: Comparación de la eficacia del pentobarbital y el tiopental en el control de la hipertensión intracraneal refractaria. Resultados preliminares en una serie de 20 pacientes. Neurocirugía 2005; 16:5–13.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:21 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The American Association of Neurological Surgeons. The Joint Section on Neurotrauma and Critical Care. Critical pathway for the treatment of established intracranial hypertension" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "The Brain Trauma Foundation" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1089/neu.2000.17.537" "Revista" => array:6 [ "tituloSerie" => "J. Neurotrauma" "fecha" => "2000" "volumen" => "17" "paginaInicial" => "537" "paginaFinal" => "538" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10937898" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The American Association of Neurological Surgeons. The Joint Section on Neurotrauma and Critical Care. Use of barbirurates in the control of intracranial hypertension" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "The Brain Trauma Foundation" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1089/neu.2000.17.527" "Revista" => array:6 [ "tituloSerie" => "J. Neurotrauma" "fecha" => "2000" "volumen" => "17" "paginaInicial" => "527" "paginaFinal" => "530" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10937896" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of barbirurates on hydroxyl radicáis, lipid peroxidation, and hypoxic cell death in human NT2-N neurons" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "R. Almaas" 1 => "O.D. Saugstad" 2 => "D. Pleasure" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Anesthesiology" "fecha" => "2000" "volumen" => "92" "paginaInicial" => "764" "paginaFinal" => "774" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10719955" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Thiopentone and methohexital, but not pentobarbitone, reduce early focal cerebral ischemic injury in rats" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "D.J. Colé" 1 => "L.M. Cross" 2 => "J.C. Drummond" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/BF03016699" "Revista" => array:6 [ "tituloSerie" => "Can. J. Anaesth." "fecha" => "2001" "volumen" => "48" "paginaInicial" => "807" "paginaFinal" => "814" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11546724" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The free radical pathology and the microcirculation in the major central nervous system disorders" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "H.B. Demopoulos" 1 => "E.S. Flamm" 2 => "D.D. Pietronigro" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Acta Physiol Scand." "fecha" => "1980" "volumen" => "492" "numero" => "Suppl" "paginaInicial" => "91" "paginaFinal" => "119" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cerebral protection: are all barbirurates created equal?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.C. Drummond" 1 => "P.M. Patel" 2 => "D.J. Colé" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Anesthesiology" "fecha" => "1996" "volumen" => "85" "paginaInicial" => "1504" "paginaFinal" => "1505" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8968211" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "High-dose barbirurate control of elevated intracranial pressure in patients with severe head injury" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "H.M. Eisenberg" 1 => "R.F. Frankowski" 2 => "C.F. Contant" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1988.69.1.0015" "Revista" => array:6 [ "tituloSerie" => "J. Neurosurg." "fecha" => "1988" "volumen" => "69" "paginaInicial" => "15" "paginaFinal" => "23" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3288723" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Survey of critical care management of comatose, head-injured patients in the United States" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "J. Ghajar" 1 => "R.J. Hariri" 2 => "R.K. Narayan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Crit Care Med." "fecha" => "1995" "volumen" => "23" "paginaInicial" => "560" "paginaFinal" => "567" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7874910" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The contractile responses of isolated dog cerebral and extracerebral arteries to oxybarbirurates and thiobarbirurates" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "Y. Hatano" 1 => "K. Nakamura" 2 => "S. Moriyama" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Anesthe siology" "fecha" => "1998" "volumen" => "71" "paginaInicial" => "80" "paginaFinal" => "86" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The intracranial pressure during barbital narcosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.S. Horsley" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1937" "volumen" => "1" "paginaInicial" => "141" "paginaFinal" => "143" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2563055" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Survey of intensive care of severely head injured patients in the United Kingdom" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "D.R. Jeevaratnam" 1 => "D.K. Menon" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "BMJ" "fecha" => "1996" "volumen" => "312" "paginaInicial" => "944" "paginaFinal" => "947" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8616307" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Alterations in cerebral blood flow, oxygen metabolism, and electrical activity produced by high dose sodium tbiopental" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "N.F. Kassell" 1 => "P.W. Hitchon" 2 => "M.K. Gerk" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurosurgery" "fecha" => "1980" "volumen" => "7" "paginaInicial" => "598" "paginaFinal" => "603" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6782503" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Role of intracranial pressure monitoring and barbiturate therapy in malignant intracranial hypertension. Case report" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "L.F. Marshall" 1 => "D.A. Bruce" 2 => "L. Bruno" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J. Neurosurg." "fecha" => "1977" "volumen" => "47" "paginaInicial" => "481" "paginaFinal" => "484" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/894354" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A new classification of head injury based on computerized tomography" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "L.F. Marshall" 1 => "S.B. Marshall" 2 => "M.R. Klauber" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Neurosurg" "fecha" => "1991" "volumen" => "75" "paginaInicial" => "S14" "paginaFinal" => "S20" ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Barbirurate control of intracranial hypertension in head injury and other conditions: iatrogenic coma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "L.F. Marshall" 1 => "H.M. Shapiro" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Acta Neurol. Scand." "fecha" => "1977" "volumen" => "64" "numero" => "Suppl" "paginaInicial" => "156157" ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The outcome with aggressive treatment in severe head injuries. Part I: the significance of intracranial pressure monitoring" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "L.F. Marshall" 1 => "R.W. Smith" 2 => "H.M. Shapiro" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J. Neuro surg." "fecha" => "1979" "volumen" => "50" "paginaInicial" => "20" "paginaFinal" => "25" ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Highdose barbiturate therapy in humans: a clinical review of 60 patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.A. Rockoff" 1 => "L.F. Marshall" 2 => "H.M. Shapiro" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/ana.410060303" "Revista" => array:6 [ "tituloSerie" => "Ann. Neurol." "fecha" => "1979" "volumen" => "6" "paginaInicial" => "194" "paginaFinal" => "199" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/534417" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nitric oxide-induced cytotoxicity attenuation by thiopentone sodium but not pentobarbitone sodium in primary brain cultures" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "S. Shibuta" 1 => "J. Kosaka" 2 => "T. Mashimo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/sj.bjp.0701884" "Revista" => array:6 [ "tituloSerie" => "Br. J. Pharmacol." "fecha" => "1998" "volumen" => "124" "paginaInicial" => "804" "paginaFinal" => "810" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9690874" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Inhibitory effects of different barbiturates on lipid peroxidation in brain tissue in vitro: comparison with the effects of promethazine and chlorpromazine" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D.S. Smith" 1 => "S. Rehncrona" 2 => "B.K. Siesjo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Anesthesiology" "fecha" => "1980" "volumen" => "53" "paginaInicial" => "186" "paginaFinal" => "194" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7425331" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cerebral protection with barbiturates: relationto anesthetic effect" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "P.A. Steen" 1 => "J.D. Michenfelder" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Stroke" "fecha" => "1978" "volumen" => "9" "paginaInicial" => "140" "paginaFinal" => "142" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/644607" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mechanisms of barbi turate protection" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "P.A. Steen" 1 => "J.D. Michenfelder" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Anesthesiology" "fecha" => "1980" "volumen" => "53" "paginaInicial" => "183" "paginaFinal" => "185" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7425330" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/11301473/0000001600000001/v1_201305151233/S1130147305704267/v1_201305151233/es/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/11301473/0000001600000001/v1_201305151233/S1130147305704267/v1_201305151233/es/main.pdf?idApp=UINPBA00004B&text.app=https://revistaneurocirugia.com/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147305704267?idApp=UINPBA00004B" ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2023 Marzo | 4 | 3 | 7 |
| 2018 Febrero | 9 | 4 | 13 |
| 2018 Enero | 15 | 13 | 28 |
| 2017 Diciembre | 10 | 17 | 27 |
| 2017 Noviembre | 21 | 20 | 41 |
| 2017 Octubre | 9 | 17 | 26 |
| 2017 Septiembre | 7 | 31 | 38 |
| 2017 Agosto | 12 | 21 | 33 |
| 2017 Julio | 9 | 23 | 32 |
| 2017 Junio | 20 | 23 | 43 |
| 2017 Mayo | 14 | 31 | 45 |
| 2017 Abril | 20 | 32 | 52 |
| 2017 Marzo | 20 | 28 | 48 |
| 2017 Febrero | 8 | 29 | 37 |
| 2017 Enero | 12 | 26 | 38 |
| 2016 Diciembre | 26 | 19 | 45 |
| 2016 Noviembre | 17 | 27 | 44 |
| 2016 Octubre | 31 | 41 | 72 |
| 2016 Septiembre | 45 | 68 | 113 |
| 2016 Agosto | 73 | 53 | 126 |
| 2016 Julio | 32 | 30 | 62 |
| 2016 Junio | 4 | 0 | 4 |
| 2016 Mayo | 2 | 0 | 2 |
| 2016 Abril | 1 | 0 | 1 |
| 2016 Marzo | 1 | 0 | 1 |
| 2016 Febrero | 4 | 0 | 4 |
| 2016 Enero | 1 | 0 | 1 |
| 2015 Diciembre | 1 | 0 | 1 |
| 2015 Septiembre | 1 | 0 | 1 |
| 2015 Julio | 0 | 7 | 7 |
| 2015 Junio | 24 | 12 | 36 |
| 2015 Mayo | 31 | 25 | 56 |
| 2015 Abril | 19 | 29 | 48 |
| 2015 Marzo | 20 | 22 | 42 |
| 2015 Febrero | 17 | 35 | 52 |
| 2015 Enero | 27 | 27 | 54 |
| 2014 Diciembre | 19 | 25 | 44 |
| 2014 Noviembre | 16 | 34 | 50 |
| 2014 Octubre | 17 | 43 | 60 |
| 2014 Septiembre | 17 | 48 | 65 |
| 2014 Agosto | 19 | 52 | 71 |
| 2014 Julio | 15 | 29 | 44 |
| 2014 Junio | 30 | 35 | 65 |
| 2014 Mayo | 48 | 41 | 89 |
| 2014 Abril | 28 | 28 | 56 |
| 2014 Marzo | 16 | 47 | 63 |
| 2014 Febrero | 16 | 33 | 49 |
| 2014 Enero | 13 | 45 | 58 |
| 2013 Diciembre | 15 | 22 | 37 |
| 2013 Noviembre | 20 | 36 | 56 |
| 2013 Octubre | 22 | 36 | 58 |
| 2013 Septiembre | 28 | 50 | 78 |
| 2013 Agosto | 24 | 47 | 71 |
| 2013 Julio | 27 | 25 | 52 |
| 2013 Junio | 19 | 46 | 65 |
| 2013 Mayo | 22 | 42 | 64 |
| 2013 Abril | 18 | 36 | 54 |
| 2013 Marzo | 15 | 44 | 59 |
| 2013 Febrero | 10 | 42 | 52 |
| 2013 Enero | 11 | 17 | 28 |
| 2012 Diciembre | 7 | 23 | 30 |
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| 2012 Octubre | 0 | 1 | 1 |
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| 2012 Enero | 19 | 0 | 19 |
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