Cirugia transeptoesfenoidal en adenomas hipofisarios productores de prolactina
Transsphenoidal approach to prolactinomas
O. López-Arbolay
, O. Morales-Sabina, J.L. González-González, N. Valdés-Lorenzo
Servicio de Neurocirugía. Hospital Clínico Quirúrgico “Hermanos Ameijeiras”. Ciudad de la Habana. Cuba
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Valdés-Lorenzo" "autores" => array:4 [ 0 => array:3 [ "nombre" => "O." "apellidos" => "López-Arbolay" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "O." "apellidos" => "Morales-Sabina" ] 2 => array:2 [ "nombre" => "J.L." "apellidos" => "González-González" ] 3 => array:2 [ "nombre" => "N." "apellidos" => "Valdés-Lorenzo" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Neurocirugía. Hospital Clínico Quirúrgico “Hermanos Ameijeiras”. Ciudad de la Habana. Cuba" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Correspondencia postal: San Lázaro 701. 10300 Centro Habana. Ciudad de la Habana. Cuba." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Transsphenoidal approach to prolactinomas" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2005-04-08" "fechaAceptado" => "2005-05-19" "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Para un gran número de tumores pituitarios, la cirugía es el tratamiento de primera línea y el abordaje transesfenoidal microquirúrgico el proceder más utilizado. El tratamiento actual de los prolactinomas es bastante controversial, por los buenos resultados alcanzados con los nuevos agonistas dopaminérgicos; no obstante la adenomectomía selectiva se incluye entre las modalidades de tratamiento para aquellos prolactinomas que no respondan a dicho tratamiento dopaminérgico.</p> <span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Evaluar los resultados del tratamiento microquirúrgico por vía transeptoesfenoidal de los adenomas productores de prolactina en el Servicio de Neurocirugía del Hospital “Hermanos Ameijeiras”.</p> <span class="elsevierStyleSectionTitle">Material y método</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Presentamos un estudio retrospectivo y descriptivo de 63 pacientes intervenidos por vía sublabial transeptoesfenoidal microquirúrgica, portadores de este tipo de adenomas, y tratados en nuestro servicio desde 1996 hasta el 2003. Se analizan edad, sexo, cuadro clínico, tamaño de las lesiones, niveles hormonales, complicaciones y evolución postoperatoria.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Se encontró un franco predominio del sexo femenino, 86% (54 pacientes). Se operaron 31 pacientes con macroadenomas y 32 con microadenomas. La complicación más común en el postoperatorio fue la diabetes insípida transitoria (11 enfermos), siendo de poca trascendencia. Se logró reducir las cifras iniciales de prolactina a valores no tumorales en el 90.6% de lo microadenomas (29 casos) y en el 67.7% de los macroadenomas (21 casos). Los síntomas más frecuentes que aquejaban a nuestros pacientes mejoraron, sobre todo la cefalea en el 82% (36 casos) y los trastornos visuales en el 69% (18 casos).</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Se concluye que la adenomectomía transeptoesfenoidal es un proceder seguro y eficaz como opción de tratamiento para pacientes con adenomas secretores de prolactina que tengan indicación quirúrgica.</p>" ] "en" => array:2 [ "titulo" => "Summary" "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Transeptal transsphenoidal surgery for pituitary tumors is a well established surgical technique. In particular the use of medical treatment in patient with prolactinomas has induced the control of hiperprolactinemia and the shrinkage of the tumor in the great majority of the patients, for that reason the treatment of the prolactinomas is controversial.</p> <span class="elsevierStyleSectionTitle">Objective</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">We evaluate the results of trassphenoidal microsurgical treatment of prolactin secreting adenomas at our Unit.</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">We made a retrospective analysis of 63 patients operated on via transsphenoidal microsurgical technique for prolactin secreting adenomas between 1996 and 2003. Age, sex, symptoms, tumor size, hormonal levels, complications and postsurgical outcome werw considered.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">There was a female predominance of 86% of the cases and middle aged patients were more commonly seen 31 patients had tumors more than 10mm in diameter on the CT scan. The most frecuent complication was transient diabetes insipidus (11 cases). Prolactin levels were reduced to non tumoral values in 90.6% of microadenomas (29 cases) and in 67.7% of macroadenomas (21 cases). Headache was the most frecuent complain in our patients with amelioration after surgery in 82% (36 cases). Campimetric visual defects werw reduced in 69% (18 cases).</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Transsphenoidal adenomectomy is a safe treatment option for patients with prolactin secreting adenomas with surgical indication.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">López-Arbolay, O.; Morales-Sabina, O.; González-González, J.L.; Valdés-Lorenzo, N.: Cirugía transeptoesfenoidal en adenomas hipofisarios productores de prolactina. Neurocirugía 2006; 17: 226–231.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:25 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Gonadotropic pituitary carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "P. Beauchesne" 1 => "J. Trouillas" 2 => "F. Barcal" 3 => "J. Brunon" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Case report. Neurosurgery" "fecha" => "1995" "volumen" => "37" "paginaInicial" => "810" "paginaFinal" => "816" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prolactinoma in 53 men: clinical characteristics and modes of treatment (male prolactinomas)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M. Beresin" 1 => "I. Shimon" 2 => "M. Madani" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/BF03349742" "Revista" => array:6 [ "tituloSerie" => "J Endocrinol Invest" "fecha" => "1995" "volumen" => "18" "paginaInicial" => "436" "paginaFinal" => "441" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7594238" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Transsphenoidal surgery: operative techniques" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "C. Cawley" 1 => "G. Tindall" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Pituitary disorders: comprehensive management" "paginaInicial" => "349" "paginaFinal" => "359" "serieFecha" => "1999" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Medical treatment of pituitary adenoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "P. Chanson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rev Prat" "fecha" => "1996" "volumen" => "46" "paginaInicial" => "1509" "paginaFinal" => "1513" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8881166" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Transsphenoidal pituitary resection for preoperative diagnosis of prolactin secreting pituitary adenoma in women: Long term follow-up" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S.L. Feigenbaum" 1 => "D.E. Downey" 2 => "C.B. Wilson" 3 => "R.B. Jaffe" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1210/jcem.81.5.8626821" "Revista" => array:6 [ "tituloSerie" => "J Clin Endocrinol Metab" "fecha" => "1996" "volumen" => "81" "paginaInicial" => "1711" "paginaFinal" => "1719" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8626821" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tumor. Handbook of Neurosurgery" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M.S. Greenberg" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:3 [ "paginaInicial" => "386" "paginaFinal" => "495" "serieFecha" => "2001" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Surgical therapy of pituitary adenomas" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M. Giovanelli" 1 => "M. Losa" 2 => "P. Mortini" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Metabolism" "fecha" => "1996" "volumen" => "45" "numero" => "8 Suppl 1" "paginaInicial" => "115" "paginaFinal" => "116" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8769402" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Hung, S.: Estudios en pacientes con tumores hipofisarios y silla turca vacía primaria. Instituto Superior de Ciencias Médicas. Ciudad de la Habana. 1993. Tesis Doctoral." ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The surgical management of pituitary adenomas in a series of 3093 cases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.A. Jane" 1 => "E.R. Laws" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Coll Surg" "fecha" => "2001" "volumen" => "193" "paginaInicial" => "651" "paginaFinal" => "659" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11768682" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Normal growth and pubertal development during bromocriptine therapy in two patients with prolactinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "N. Kamel" 1 => "A.R. Vysal" 2 => "V. Cesur" 3 => "G. Erdogan" 4 => "N. Baskal" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Endocr" "fecha" => "1995" "volumen" => "42" "paginaInicial" => "581" "paginaFinal" => "586" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Carcinomas of the pituitary: Definition and Review of the literature" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "D. Lubke" 1 => "W. Saeger" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Gen Diagn Pathol" "fecha" => "1995" "volumen" => "14" "paginaInicial" => "81" "paginaFinal" => "92" ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Maiquez, A.: Cirugía transeptoesfenoidal para afecciones de la región selar. Instituto Superior de Ciencias Médicas. Ciudad de la Habana. 1995. Tesis." ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Transsphenoidal adenomectomy for microprolactinoma: 10 to 20 years of follow-up" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "F. Massoud" 1 => "O. Serri" 2 => "J. Hardy" 3 => "M. Somma" 4 => "H. Beauregard" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Surg Neurol" "fecha" => "1996" "volumen" => "450" "paginaInicial" => "341" "paginaFinal" => "346" ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Stereotactic radiosurgery of pituitary adenomas" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "E.D. Motti" 1 => "M. Losa" 2 => "S. Pieralli" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Metabolism" "fecha" => "1996" "volumen" => "45" "numero" => "8 Suppl 1" "paginaInicial" => "111" "paginaFinal" => "114" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8769401" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pituitary adenoma secreting prolactin. Results of their surgical treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "P. Often" 1 => "B. Rilliet" 2 => "A. Reverdin" 3 => "B. Demierre" 4 => "J. Berney" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurochirurgie" "fecha" => "1996" "volumen" => "42" "paginaInicial" => "44" "paginaFinal" => "52" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8763764" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Técnicas Quirúrgicas. In: Cirugía de la hipófisis y la región selar" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "E. Pardal" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:4 [ "edicion" => "1°" "fecha" => "1984" "editorial" => "López Libreros Editores" "editorialLocalizacion" => "Buenos Aires" ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prolacting producing hypophyseal carcinoma. Case report of an extremely rare metastatic tumor" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "W. Saeger" 1 => "V. Bosse" 2 => "E. Pfingst" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pathologe" "fecha" => "1995" "volumen" => "16" "paginaInicial" => "354" "paginaFinal" => "358" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7479609" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Endoscopic management of lessions of the sella turcica" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "D.S. Sethi" 1 => "P.K. Pillay" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Laryngol Otol" "fecha" => "1995" "volumen" => "109" "paginaInicial" => "956" "paginaFinal" => "962" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7499948" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Radiation therapy of pituitary tumors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "G.E. Sheline" 1 => "V.M. Wara" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:5 [ "titulo" => "Neurological Surgery" "paginaInicial" => "3499" "paginaFinal" => "3503" "edicion" => "3°" "serieFecha" => "1990" ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The outcome of hypophysectomy for prolactinomas in the era of dopamine agonist therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S.G. Soule" 1 => "J. Farhi" 2 => "G.S. Conway" 3 => "H.S. Jacobs" 4 => "M. Powell" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Clin Endocrinol Oxf" "fecha" => "1996" "volumen" => "440" "paginaInicial" => "711" "paginaFinal" => "716" ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tumors of the sellar and parasellar area in adults" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "G.T. Tindall" 1 => "D.L. Barrow" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:5 [ "titulo" => "Neurological Surgery" "paginaInicial" => "3447" "paginaFinal" => "3493" "edicion" => "3°" "serieFecha" => "1990" ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pituitary adenomas and granular cell tumors: incidence, cell type, and location of tumor in 100 pituitary glands at autopsy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "T. Tomita" 1 => "E. Gates" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Clin Pathol" "fecha" => "1999" "volumen" => "111" "paginaInicial" => "817" "paginaFinal" => "825" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10361519" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tratamiento de los estados hiperprolactinémicos con lisurida en un estudio simple abierto" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.E. Vázquez" 1 => "E. Vázquez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ginec Obstet Méx" "fecha" => "1991" "volumen" => "59" "paginaInicial" => "202" "paginaFinal" => "205" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1937125" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Surgical management of TSH-secreting pituitary adenomas" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "C.J. Wang" 1 => "S.L. Howng" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Kao Hsiung I Hsueh Ko Hsueh Tsa Chih" "fecha" => "1996" "volumen" => "12" "paginaInicial" => "590" "paginaFinal" => "594" ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Transcranial surgery for large pituitary adenomas. In: Microneurosurgery of CNS Tumors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M.G. Yasargil" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:3 [ "paginaInicial" => "200" "paginaFinal" => "204" "serieFecha" => "1996" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/11301473/0000001700000003/v1_201305151254/S1130147306703438/v1_201305151254/es/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/11301473/0000001700000003/v1_201305151254/S1130147306703438/v1_201305151254/es/main.pdf?idApp=UINPBA00004B&text.app=https://revistaneurocirugia.com/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147306703438?idApp=UINPBA00004B" ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2023 Marzo | 3 | 4 | 7 |
| 2018 Febrero | 11 | 6 | 17 |
| 2018 Enero | 16 | 6 | 22 |
| 2017 Diciembre | 16 | 8 | 24 |
| 2017 Noviembre | 41 | 26 | 67 |
| 2017 Octubre | 11 | 5 | 16 |
| 2017 Septiembre | 17 | 19 | 36 |
| 2017 Agosto | 14 | 6 | 20 |
| 2017 Julio | 12 | 5 | 17 |
| 2017 Junio | 25 | 6 | 31 |
| 2017 Mayo | 19 | 10 | 29 |
| 2017 Abril | 18 | 9 | 27 |
| 2017 Marzo | 6 | 9 | 15 |
| 2017 Febrero | 5 | 7 | 12 |
| 2017 Enero | 17 | 4 | 21 |
| 2016 Diciembre | 38 | 3 | 41 |
| 2016 Noviembre | 46 | 9 | 55 |
| 2016 Octubre | 50 | 10 | 60 |
| 2016 Septiembre | 46 | 14 | 60 |
| 2016 Agosto | 60 | 22 | 82 |
| 2016 Julio | 39 | 20 | 59 |
| 2015 Diciembre | 3 | 0 | 3 |
| 2015 Julio | 2 | 8 | 10 |
| 2015 Junio | 18 | 7 | 25 |
| 2015 Mayo | 18 | 10 | 28 |
| 2015 Abril | 17 | 12 | 29 |
| 2015 Marzo | 17 | 11 | 28 |
| 2015 Febrero | 15 | 9 | 24 |
| 2015 Enero | 28 | 16 | 44 |
| 2014 Diciembre | 19 | 16 | 35 |
| 2014 Noviembre | 14 | 10 | 24 |
| 2014 Octubre | 19 | 15 | 34 |
| 2014 Septiembre | 16 | 10 | 26 |
| 2014 Agosto | 15 | 10 | 25 |
| 2014 Julio | 19 | 12 | 31 |
| 2014 Junio | 25 | 21 | 46 |
| 2014 Mayo | 33 | 17 | 50 |
| 2014 Abril | 23 | 12 | 35 |
| 2014 Marzo | 26 | 17 | 43 |
| 2014 Febrero | 26 | 16 | 42 |
| 2014 Enero | 24 | 14 | 38 |
| 2013 Diciembre | 19 | 21 | 40 |
| 2013 Noviembre | 21 | 22 | 43 |
| 2013 Octubre | 19 | 23 | 42 |
| 2013 Septiembre | 22 | 33 | 55 |
| 2013 Agosto | 24 | 27 | 51 |
| 2013 Julio | 26 | 31 | 57 |
| 2013 Junio | 17 | 29 | 46 |
| 2013 Mayo | 19 | 15 | 34 |
| 2013 Abril | 9 | 9 | 18 |
| 2013 Marzo | 12 | 26 | 38 |
| 2013 Febrero | 12 | 14 | 26 |
| 2013 Enero | 15 | 9 | 24 |
| 2012 Diciembre | 15 | 22 | 37 |
| 2012 Noviembre | 0 | 6 | 6 |
| 2012 Octubre | 0 | 1 | 1 |
| 2012 Septiembre | 0 | 2 | 2 |
| 2012 Enero | 9 | 0 | 9 |
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