Revisión de algunos conceptos básicos de neuro-onco-biología. Oncogenes y gliomas
M. Pérez-Espejo, M. Poza y Poza
Servicio Regional de Neurocirugía. Hospital Universitario «Virgen de la Arrixaca». Murcia
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Albert, J.M. Izquierdo" "autores" => array:2 [ 0 => array:2 [ "nombre" => "P." "apellidos" => "Albert" ] 1 => array:2 [ "nombre" => "J.M." "apellidos" => "Izquierdo" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S113014739370843X?idApp=UINPBA00004B" "url" => "/11301473/0000000400000003/v1_201305151427/S113014739370843X/v1_201305151427/es/main.assets" ] "es" => array:12 [ "idiomaDefecto" => true "titulo" => "Revisión de algunos conceptos básicos de neuro-onco-biología. Oncogenes y gliomas" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "177" "paginaFinal" => "182" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "M. Pérez-Espejo, M. Poza y Poza" "autores" => array:2 [ 0 => array:2 [ "nombre" => "M." "apellidos" => "Pérez-Espejo" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Poza y Poza" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio Regional de Neurocirugía. Hospital Universitario «Virgen de la Arrixaca». Murcia" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:1 [ "en" => array:2 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key Words" "identificador" => "xpalclavsec162476" "palabras" => array:4 [ 0 => "Oncogene" 1 => "Growth Factor" 2 => "Gliomas" 3 => "Cytogenetics" ] ] 1 => array:4 [ "clase" => "keyword" "titulo" => "Palabras Clave" "identificador" => "xpalclavsec162477" "palabras" => array:4 [ 0 => "Oncogen" 1 => "Factores de crecimiento" 2 => "Gliomas" 3 => "Citogenética" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">El trabajo que presentamos, dirigido esencialmente al lector clínico, constituye una revisión sucinta de los conceptos de oncogen, protooncogen, antioncogen y gen modulador, así como de sus relaciones con los factores de crecimiento y de transformación celular (EGF, TGF, FGF, PDGF) y sus receptores. Asimismo se apuntan los mecanismos de secreción protéica intracelular -autocrinia- y las «señales» que desencadenan las reacciones biocinéticas que conducirán a la creación de poblaciones celulares autónomas en relación con el tejido circundante; todo ello con especial referencia a los gliomas cerebrales. Finalmente se exponen algunas de las alteraciones cromosómicas o reagrupamientos de material genético más frecuentemente halladas en este tipo de tumores.</p>" ] "en" => array:2 [ "titulo" => "Summary" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">This article is a brief review, fundamentally adressed to the clinicians readers, on the moderns concepts of oncogenes, protooncogenes, antioncogenes, modulator genes and their relationships with the cell growth and transforming factors (EGF, TGF, FGF, PDGF) and their receptors. The mechanisms of protein secretion into the cell -autocrinia- and the biological «signals » which promote biocynetics reactions and subsequent rise of autonomous celular populations are also remarked, focusing all of these events in the particular field of brain gliomas. Finally some of the most usual chromosomal alterations or genetic material gains or deletions in these tumors are exposed.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Pérez-Espejo, M.; Poza y Poza, M.: Revisión de algunos conceptos básicos de neuro-onco-biología. Oncogenes y gliomas. Neurocirugía 1993; 4: 177–182.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:50 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2023 Marzo | 2 | 0 | 2 |
| 2021 Marzo | 1 | 0 | 1 |
| 2021 Febrero | 1 | 0 | 1 |
| 2020 Noviembre | 2 | 0 | 2 |
| 2020 Julio | 1 | 0 | 1 |
| 2020 Junio | 1 | 0 | 1 |
| 2020 Abril | 2 | 0 | 2 |
| 2020 Marzo | 2 | 0 | 2 |
| 2020 Febrero | 2 | 0 | 2 |
| 2019 Mayo | 2 | 0 | 2 |
| 2019 Febrero | 2 | 0 | 2 |
| 2018 Noviembre | 2 | 0 | 2 |
| 2018 Octubre | 2 | 0 | 2 |
| 2018 Septiembre | 1 | 0 | 1 |
| 2018 Abril | 2 | 0 | 2 |
| 2018 Marzo | 4 | 0 | 4 |
| 2018 Febrero | 14 | 6 | 20 |
| 2018 Enero | 19 | 5 | 24 |
| 2017 Diciembre | 15 | 15 | 30 |
| 2017 Noviembre | 45 | 39 | 84 |
| 2017 Octubre | 11 | 7 | 18 |
| 2017 Septiembre | 17 | 9 | 26 |
| 2017 Agosto | 14 | 6 | 20 |
| 2017 Julio | 13 | 8 | 21 |
| 2017 Junio | 21 | 20 | 41 |
| 2017 Mayo | 18 | 6 | 24 |
| 2017 Abril | 12 | 6 | 18 |
| 2017 Marzo | 13 | 16 | 29 |
| 2017 Febrero | 9 | 4 | 13 |
| 2017 Enero | 6 | 2 | 8 |
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| 2016 Noviembre | 25 | 15 | 40 |
| 2016 Octubre | 21 | 15 | 36 |
| 2016 Septiembre | 25 | 15 | 40 |
| 2016 Agosto | 38 | 16 | 54 |
| 2016 Julio | 30 | 19 | 49 |
| 2015 Diciembre | 2 | 0 | 2 |
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| 2015 Junio | 14 | 10 | 24 |
| 2015 Mayo | 24 | 28 | 52 |
| 2015 Abril | 13 | 22 | 35 |
| 2015 Marzo | 17 | 45 | 62 |
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