Factores pronósticos en la evolución de los ependimomas intracraneales
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Gelabert González, A. Prieto González, R. Martínez Rumbo, A. Bollar Zabala, A. García Allut" "autores" => array:5 [ 0 => array:2 [ "nombre" => "M." "apellidos" => "Gelabert González" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Prieto González" ] 2 => array:2 [ "nombre" => "R." "apellidos" => "Martínez Rumbo" ] 3 => array:2 [ "nombre" => "A." "apellidos" => "Bollar Zabala" ] 4 => array:2 [ "nombre" => "A." "apellidos" => "García Allut" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147393708611?idApp=UINPBA00004B" "url" => "/11301473/0000000400000002/v1_201305151425/S1130147393708611/v1_201305151425/es/main.assets" ] "es" => array:12 [ "idiomaDefecto" => true "titulo" => "Factores pronósticos en la evolución de los ependimomas intracraneales" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "125" "paginaFinal" => "131" ] ] "autores" => array:2 [ 0 => array:3 [ "autoresLista" => "J. Piquer, J. Cabanes, P. Riesgo, C. Botella, J. Navarro, M. Orozco, J. Alvarez Garijo" "autores" => array:7 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Piquer" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "Cabanes" ] 2 => array:2 [ "nombre" => "P." "apellidos" => "Riesgo" ] 3 => array:2 [ "nombre" => "C." "apellidos" => "Botella" ] 4 => array:2 [ "nombre" => "J." "apellidos" => "Navarro" ] 5 => array:2 [ "nombre" => "M." "apellidos" => "Orozco" ] 6 => array:2 [ "nombre" => "J." "apellidos" => "Alvarez Garijo" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Hospital Universitario La Fe. Valencia" ] ] ] 1 => array:3 [ "autoresLista" => "M. Hemández, J.A. Ramos" "autores" => array:2 [ 0 => array:3 [ "nombre" => "M." "apellidos" => "Hemández" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0010" ] ] ] 1 => array:3 [ "nombre" => "J.A." "apellidos" => "Ramos" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Servicio de Neurocirugía; Servicio de Anatomía Patológica" "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0010" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec162450" "palabras" => array:4 [ 0 => "Ependimoma" 1 => "pronóstico" 2 => "supervivencia postoperatoria" 3 => "neoplasia cerebral" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec162451" "palabras" => array:4 [ 0 => "Ependymoma" 1 => "prognosis" 2 => "postoperative survival" 3 => "brain neoplasm" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Se analizan los factores pronósticos y supervivencia de 38 pacientes afectados de ependimomas intracraneales, que fueron intervenidos quirúrgicamente en el Hospital La Fe de Valencia durante el período 1969–1990. La edad media fue de 12 años (rango, 1–59 años). Se practicó resección total de la lesión en 17 pacientes, subtotal en 20 y parcial en uno. La histología tumoral fue revisada en cada caso y se agrupó en ependimomas de bajo (58%) y alto grado de malignidad (42%). En 16 pacientes se administró radioterapia complementaria (dosis media 4900 cGy). El tiempo medio de seguimiento se aproximó a los 49 meses, siendo la probabilidad de supervivencia a los 5 años del 58% tras excluir la mortalidad operatoria. Los factores que se asociaron con una supervivencia más favorable fueron: extirpación radical, histología de bajo grado, radioterapia complementaria y ausencia de signos de invasión de tronco o pares craneales. Por el contrario, la supervivencia fue menor en aquellos casos con signos de invasión de tronco o pares craneales, extirpación subtotal o parcial, histología de alto grado y desestimación de radioterapia complementaria. El grado histológico de la neoplasia fue la única variable con valor pronóstico estadísticamente significativo (p<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0,05).</p>" ] "en" => array:2 [ "titulo" => "Summary" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">The prognostic factors and survival data were analyzed for 38 patients with intracranial ependymoma treated surgically at the Hospital La Fe in Valencia during the years 1969 to 1990. The median age was 12 years (range, 1–59 yr). Gross total resection was performed in 17 patients, subtotal in 20 and partial in only 1 case. Tumor histology was reviewed individually and grouped into low grade (58%) and high grade (42%). Sixteen patients underwent radiotherapy (median dose 4900 cGy). With a median follow-up of 49 monts, the actuarial survival rates at 5 years were 58% after the exclusion of perioperative mortality. Factors associated with an improved 5-year survival rate were: total tumor removal, low grade histology, radiation therapy and absent brain-stem o cranial nerve signs in infratentorial cases. The 5-year survival rate was lower when associated with presence of physical signs of parenchymal invasion or lower cranial nerve involvement in infratentorial tumors, subtotal tumor removal, high grade histology and no radiotherapy treatment. The tumor's histological grade was the onIy prognostic variable with significant difference (p<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0,05).</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Piquer, J.; Cabanes, J.; Hemández, M.; Riesgo, P.; Ramos, J.A.; Botella, C.; Navarro, J.; Orozco, M.; Alvarez Garijo, J.: Factores pronósticos en la evolución de los ependimomas intracraneales. Neurocirugía 1993; 4: 125–131.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:43 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intracranial tumors: Response and resistance to therapeutic endeavors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "H.J.G. Bloom" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Int J Radiot Oncol Biol Phys" "fecha" => "1992" "volumen" => "8" "paginaInicial" => "1083" "paginaFinal" => "1113" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." 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|---|---|---|---|
| 2023 Marzo | 2 | 2 | 4 |
| 2021 Marzo | 1 | 0 | 1 |
| 2021 Febrero | 1 | 0 | 1 |
| 2020 Diciembre | 1 | 0 | 1 |
| 2020 Octubre | 1 | 0 | 1 |
| 2020 Agosto | 1 | 0 | 1 |
| 2020 Julio | 1 | 0 | 1 |
| 2020 Abril | 1 | 0 | 1 |
| 2020 Marzo | 2 | 0 | 2 |
| 2020 Febrero | 2 | 0 | 2 |
| 2019 Mayo | 2 | 0 | 2 |
| 2019 Febrero | 2 | 0 | 2 |
| 2018 Noviembre | 2 | 0 | 2 |
| 2018 Octubre | 2 | 0 | 2 |
| 2018 Septiembre | 1 | 0 | 1 |
| 2018 Abril | 2 | 0 | 2 |
| 2018 Marzo | 11 | 38 | 49 |
| 2018 Febrero | 12 | 69 | 81 |
| 2018 Enero | 14 | 53 | 67 |
| 2017 Diciembre | 17 | 92 | 109 |
| 2017 Noviembre | 46 | 122 | 168 |
| 2017 Octubre | 16 | 68 | 84 |
| 2017 Septiembre | 15 | 81 | 96 |
| 2017 Agosto | 8 | 86 | 94 |
| 2017 Julio | 3 | 111 | 114 |
| 2017 Junio | 13 | 137 | 150 |
| 2017 Mayo | 8 | 66 | 74 |
| 2017 Abril | 13 | 71 | 84 |
| 2017 Marzo | 5 | 126 | 131 |
| 2017 Febrero | 3 | 110 | 113 |
| 2017 Enero | 15 | 58 | 73 |
| 2016 Diciembre | 21 | 60 | 81 |
| 2016 Noviembre | 24 | 89 | 113 |
| 2016 Octubre | 38 | 100 | 138 |
| 2016 Septiembre | 90 | 206 | 296 |
| 2016 Agosto | 212 | 237 | 449 |
| 2016 Julio | 76 | 131 | 207 |
| 2015 Diciembre | 2 | 0 | 2 |
| 2015 Noviembre | 1 | 0 | 1 |
| 2015 Septiembre | 1 | 0 | 1 |
| 2015 Agosto | 2 | 0 | 2 |
| 2015 Julio | 1 | 5 | 6 |
| 2015 Junio | 11 | 29 | 40 |
| 2015 Mayo | 30 | 39 | 69 |
| 2015 Abril | 19 | 28 | 47 |
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| 2014 Mayo | 34 | 37 | 71 |
| 2014 Abril | 25 | 47 | 72 |
| 2014 Marzo | 25 | 37 | 62 |
| 2014 Febrero | 18 | 24 | 42 |
| 2014 Enero | 23 | 31 | 54 |
| 2013 Diciembre | 13 | 24 | 37 |
| 2013 Noviembre | 16 | 18 | 34 |
| 2013 Octubre | 32 | 28 | 60 |
| 2013 Septiembre | 34 | 26 | 60 |
| 2013 Agosto | 25 | 29 | 54 |
| 2013 Julio | 23 | 25 | 48 |
| 2013 Junio | 27 | 35 | 62 |
| 2013 Mayo | 21 | 32 | 53 |
| 2013 Abril | 27 | 34 | 61 |
| 2013 Marzo | 22 | 25 | 47 |
| 2013 Febrero | 16 | 21 | 37 |
| 2013 Enero | 15 | 9 | 24 |
| 2012 Diciembre | 13 | 22 | 35 |
| 2012 Noviembre | 0 | 6 | 6 |
| 2012 Octubre | 0 | 1 | 1 |
| 2012 Septiembre | 0 | 3 | 3 |
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