Aspectos inmunológicos en los gliomas: infiltrado celular y características de la célula tumoral
J.A. Gómez-Moreta, F. Morales
Servicio de Neurocirugía. Hospital Virgen de la Vega. Salamanca
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Martín Ferrer, J. Rimbau Muñoz, R. Feliu Tatay" "autores" => array:3 [ 0 => array:2 [ "nombre" => "S." "apellidos" => "Martín Ferrer" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "Rimbau Muñoz" ] 2 => array:2 [ "nombre" => "R." "apellidos" => "Feliu Tatay" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147396707406?idApp=UINPBA00004B" "url" => "/11301473/0000000700000002/v1_201305151451/S1130147396707406/v1_201305151451/es/main.assets" ] "es" => array:12 [ "idiomaDefecto" => true "titulo" => "Aspectos inmunológicos en los gliomas: infiltrado celular y características de la célula tumoral" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "100" "paginaFinal" => "110" ] ] "autores" => array:2 [ 0 => array:3 [ "autoresLista" => "J.A. Gómez-Moreta, F. Morales" "autores" => array:2 [ 0 => array:2 [ "nombre" => "J.A." "apellidos" => "Gómez-Moreta" ] 1 => array:2 [ "nombre" => "F." "apellidos" => "Morales" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Neurocirugía. Hospital Virgen de la Vega. Salamanca" ] ] ] 1 => array:3 [ "autoresLista" => "M.A. Piris, Mª.P. Galindo, J. Broseta" "autores" => array:3 [ 0 => array:3 [ "nombre" => "M.A." "apellidos" => "Piris" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0010" ] ] ] 1 => array:3 [ "nombre" => "Mª.P." "apellidos" => "Galindo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0015" ] ] ] 2 => array:3 [ "nombre" => "J." "apellidos" => "Broseta" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">***</span>" "identificador" => "aff0020" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Servicio de Patología. Sección de Inmunohistoquimia. Hospital Virgen de la Salud. Toledo" "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0010" ] 1 => array:3 [ "entidad" => "Departamento de Estadística y Matemática Aplicadas. Universidad de Salamanca. Salamanca" "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0015" ] 2 => array:3 [ "entidad" => "Cátedra de Neurocirugía. Facultad de Medicina. Universidad de Salamanca. Salamanca" "etiqueta" => "<span class="elsevierStyleSup">***</span>" "identificador" => "aff0020" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec162957" "palabras" => array:5 [ 0 => "Complejos de histocompatibilidad" 1 => "Glioma" 2 => "Inmunidad" 3 => "Célula linfoide" 4 => "Macrófago" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec162958" "palabras" => array:5 [ 0 => "Glioma" 1 => "Histocompatibility complexo" 2 => "Immunity" 3 => "Gliomas, Limphoid cell" 4 => "Macrophage" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Se estudian las características inmunológicas de 32 gliomas clasificados en dos grupos según su histología y siguiendo la escala en grados de Kernohan: los de baja agresividad (grados I y II) Ylos filiados como malignos (grados III y IV). En 21 ocasiones el tumor correspondió al primero de los grupos y en 11 al segundo. La investigación inmunohistoquímica se realizó sobre material congelado a −70 °C utilizando casi siempre técnica FAAFA (fosfatasa alcalina-antifosfatasa alcalina); en algún caso se utilizó técnica PAP (peroxidasa- antiperoxidasa). El estudio abarca la caracterización funcional del infiltrado linfomonocitario y la de la propia célula tumoral en cuanto a la existencia o no de determinantes de histocompatibiliad (CHM) de clase I y II. Se determina también la capacidad proliferativa del tumor utilizando el índice Ki-67. La tipificación del infiltrado permite concluir la presencia de macrófagos (CD68+) en todos los casos, en gran cantidad y difusamente distribuidos entre las células tumorales, siendo más abundantes en tumores con CHM II (28.8% de media) que en los que carecen de estos determinantes antigénicos (19.3% de media). Se identificaron linfocitos T (CD3+) en 30 ocasiones, linfocitos T-facilitadores (CD4+) en 29 y linfocitos T-supresores/citotóxicos (CD8+) en 25, situándose predominantemente en los espacios perivasculares. Otras poblaciones: linfocitos B (CD19+), células plasmáticas (CD38+), células con antígenos de activación (CD25+) y células con actividad killer (CD57+), se identificaron en pocos gliomas y siempre en escasa cantidad. La subpoblación T más abundante fue la T-facilitadora (CD4+) siendo más numerosa en tumores altamente agresivos (7.7% de media) que en los filiados como grados I-II (4.6% de media).</p>" ] "en" => array:2 [ "titulo" => "Summary" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A study is made of the immunological characteristics of 32 gliomas classified into two groups according to their histology and following the grading scale of Kernohan.; those of low aggressiveness (grades I and II) and those deemed malignant (grades III and IV). 21 cases, corresponded to the first group and 11 to the second. Immunohistochemical study was performed on material frozen at −70 °C, almost always using APAAP (alkaline phosphatase-antialkaline phosphatase) technique, although in sorne cases the PAP (peroxidase- antiperoxidase) technique was employed. The study addressed the functional characterization of lymphomonocyte infiltration and of tumor cellularity itself in regard to the existence or not of classes I and II histocompatibility determinants (MHC). The proliferative capacity of the tumors, was also determined using the Ki-67 indexo Infiltrate typing showed that in all the cases macrophages (CD68+) were distributed diffusely in large amounts among the tumor cells. They were more abundant in tumors with MHC II (mean, 28.8%) than in those lacking these antigen determinants (mean, 19.3%). T lymphocytes (CD3+) were identified in thirty cases, helper/inducer T lymphocytes in 29 and suppressor/cytotoxic T limphocytes (CD8+) in 25; these cells were predominantly located in the perivascular space. Other populations, including B cells (CD19+), plasma cells (CD38+), cells displaying activation antigens (CD25+) and cells with killer activity (CD57+) were only identified in a few gliomas and always at low levels. The most abundant T subset wasT-helper/inducer (CD4+), this being more numerous in the strongly aggressive tumors (mean, 7.7%) than in those belonging to grade I-II (mean, 4.6%).</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Gómez-Moreta, J.A.; Piris, M.A.; Galindo, Mª. P.; Broseta, J.; Morales, F.: Aspectos inmunológicos en los gliomas: infiltrado celular y características de la célula tumoral. Neurocirugía 1996; 7: 100–110.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:65 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2023 Marzo | 2 | 2 | 4 |
| 2022 Enero | 0 | 1 | 1 |
| 2018 Febrero | 8 | 13 | 21 |
| 2018 Enero | 15 | 8 | 23 |
| 2017 Diciembre | 13 | 12 | 25 |
| 2017 Noviembre | 24 | 20 | 44 |
| 2017 Octubre | 7 | 13 | 20 |
| 2017 Septiembre | 14 | 16 | 30 |
| 2017 Agosto | 9 | 16 | 25 |
| 2017 Julio | 10 | 7 | 17 |
| 2017 Junio | 17 | 11 | 28 |
| 2017 Mayo | 20 | 13 | 33 |
| 2017 Abril | 8 | 5 | 13 |
| 2017 Marzo | 19 | 32 | 51 |
| 2017 Febrero | 6 | 17 | 23 |
| 2017 Enero | 10 | 15 | 25 |
| 2016 Diciembre | 27 | 19 | 46 |
| 2016 Noviembre | 24 | 25 | 49 |
| 2016 Octubre | 30 | 25 | 55 |
| 2016 Septiembre | 33 | 30 | 63 |
| 2016 Agosto | 41 | 19 | 60 |
| 2016 Julio | 25 | 16 | 41 |
| 2016 Junio | 1 | 0 | 1 |
| 2016 Febrero | 1 | 0 | 1 |
| 2016 Enero | 1 | 0 | 1 |
| 2015 Diciembre | 3 | 0 | 3 |
| 2015 Julio | 2 | 6 | 8 |
| 2015 Junio | 12 | 28 | 40 |
| 2015 Mayo | 10 | 22 | 32 |
| 2015 Abril | 14 | 27 | 41 |
| 2015 Marzo | 17 | 19 | 36 |
| 2015 Febrero | 14 | 22 | 36 |
| 2015 Enero | 16 | 22 | 38 |
| 2014 Diciembre | 12 | 27 | 39 |
| 2014 Noviembre | 12 | 19 | 31 |
| 2014 Octubre | 22 | 33 | 55 |
| 2014 Septiembre | 13 | 27 | 40 |
| 2014 Agosto | 12 | 23 | 35 |
| 2014 Julio | 12 | 25 | 37 |
| 2014 Junio | 23 | 26 | 49 |
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| 2014 Marzo | 15 | 29 | 44 |
| 2014 Febrero | 14 | 27 | 41 |
| 2014 Enero | 10 | 22 | 32 |
| 2013 Diciembre | 15 | 19 | 34 |
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| 2013 Octubre | 20 | 25 | 45 |
| 2013 Septiembre | 16 | 40 | 56 |
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