Actualizaciones en la fisiopatología y monitorización de los traumatismos craneoencefálicos graves

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Martínez-Lage, M. Poza" "autores" => array:2 [ 0 => array:2 [ "nombre" => "J.E." "apellidos" => "Martínez-Lage" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Poza" ] ] ] 1 => array:2 [ "autoresLista" => "P. Brown, L. Cervenáková, A. Ruiz Bremón, J. de Pedro" "autores" => array:4 [ 0 => array:2 [ "nombre" => "P." "apellidos" => "Brown" ] 1 => array:2 [ "nombre" => "L." "apellidos" => "Cervenáková" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Ruiz Bremón" ] 3 => array:2 [ "nombre" => "J." "apellidos" => "de Pedro" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147397707292?idApp=UINPBA00004B" "url" => "/11301473/0000000800000004/v1_201305151505/S1130147397707292/v1_201305151505/es/main.assets" ] "es" => array:13 [ "idiomaDefecto" => true "titulo" => "Actualizaciones en la fisiopatología y monitorización de los traumatismos craneoencefálicos graves" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "260" "paginaFinal" => "283" ] ] "autores" => array:2 [ 0 => array:3 [ "autoresLista" => "J. Sahuquillo, M.A. Poca" "autores" => array:2 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Sahuquillo" ] 1 => array:2 [ "nombre" => "M.A." "apellidos" => "Poca" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Neurocirugía Unidad de Neurotraumatología. Hospitales Universitarios Vall d’Hebrón. Barcelona" ] ] ] 1 => array:3 [ "autoresLista" => "S. Pedraza, X. Munar" "autores" => array:2 [ 0 => array:3 [ "nombre" => "S." "apellidos" => "Pedraza" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "identificador" => "aff0010" ] ] ] 1 => array:3 [ "nombre" => "X." "apellidos" => "Munar" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "**" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Unidad de Diagnóstico por la Imagen. Hospitales Universitarios Vall d’Hebrón. Barcelona" "etiqueta" => "*" "identificador" => "aff0010" ] 1 => array:3 [ "entidad" => "Servicio de Anestesiología y Reanimación. Hospitales Universitarios Vall d’Hebrón. Barcelona" "etiqueta" => "**" "identificador" => "aff0015" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Advances in the management of severe head injury patients" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:2 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec163199" "palabras" => array:4 [ 0 => "Traumatismo craneoencefálico" 1 => "Fisiopatología" 2 => "Presión intracraneal" 3 => "Revisión" ] ] 1 => array:4 [ "clase" => "abr" "titulo" => "Abreviaturas" "identificador" => "xpalclavsec163200" "palabras" => array:18 [ 0 => "TCE" 1 => "TCEG" 2 => "TC" 3 => "FSC" 4 => "PIC" 5 => "PPC" 6 => "TAM" 7 => "CMRO2" 8 => "RL" 9 => "RLO" 10 => "BHE" 11 => "TCDB" 12 => "PET" 13 => "SPECT" 14 => "AVDO2" 15 => "CEO2" 16 => "SjO2" 17 => "DTC" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec163198" "palabras" => array:4 [ 0 => "Head injury" 1 => "Physiopathology" 2 => "Intracranial pressure" 3 => "Review" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "Los traumatismos craneoencefálicos (TCE) representan la primera causa de muerte en la población por debajo de los 45 años de edad. En la última década se han producido avances significativos tanto en el conocimiento de los mecanismos básicos de los traumatismos como en su fisiopatología. Aunque una parte considerable de las lesiones se producen de forma inmediata al impacto (lesiones primarias), muchas de ellas aparecen un período variable de tiempo después del traumatismo (lesiones secundarias). La isquemia cerebral, causada por hipertensión intracraneal, por una reducción en la presión de perfusión cerebral o secundaria a insultos sistémicos en la fase prehospitalaria (hipoxia, hipotensión o anemia) es la lesión secundaria de mayor prevalencia en los traumatismos craneoencefálicos graves (TCEG). El hecho de que las lesiones secundarias originan a su vez, importantes cascadas metabólicas, que son la causa más importante de alteraciones celulares y de lesiones estructurales irreversibles, ha sido el avance fisiopatológico más significativo en el conocimiento de los TCE. Este mejor conocimiento de su fisiopatología ha permitido mejorar la monitorización e incrementar de forma significativa la asistencia ofrecida a estos pacientes. En la primera parte de este trabajo, revisamos los conceptos fundamentales en los mecanismos etiopatogénicos implicados en los TCE, en su fisiopatología y en las cascadas metabólicas implicadas. Revisamos también los principios básicos en la monitorización de estos pacientes." ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "Head injury is the leading cause of death amog people under the age of 45. In the last decade significant advances in the understanding of the basic mechanisms of injury and its physiopathology have been made. Although major damage to the brain is often produced inmediately on impact (primary damage), many lesions appear a variable period of time after injury (secondary lesions). Ischemic damage related to high intracranial pressure, low cerebral perfusion pressure or prehospitalary systemic insults (hypoxia, hypotension or anemia), is the most important secondary lesion found after severe head injury. The fact that secondary lesions induce important metabolic cascades which are the leading cause of cellular disorders and structural damage to the brain after severe head injury, has been the main advance in physiopathological knowledge. A better understanding of the pathophysiology of head injury has allowed a better monitoring and an improvement in the standard of care offered to these patients. In the first part of this work, we review the current concepts in basic mechanisms involved in head injury, the pathophysiology of these lesions and the metabolic cascades involved. The accepted standards of monitoring in the management of these patients are also reviewed." ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "Sahuquillo, J.; Poca, M.A.; Pedraza, S.; Munar, X.: Actualizaciones en la fisiopatología y monitorización de los traumatismos craneoencefálicos graves. Neurocirugía 1997; 8: 260–283." ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:145 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Noninvasive transcranial Doppler ultrasound recording of flow velocity in basal cerebral arteries" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1982.57.6.0769" "Revista" => array:6 [ "tituloSerie" => "J. Neurosurg." "fecha" => "1982" "volumen" => "57" "paginaInicial" => "769" "paginaFinal" => "773" "link" => array:1 [ …1] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diffuse axonal injury in head injury: definition, diagnosis and grading" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Histopathology" "fecha" => "1989" "volumen" => "15" "paginaInicial" => "49" "paginaFinal" => "59" "link" => array:1 [ …1] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diffuse axonal injury in head injuries caused by a fall" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1984" "volumen" => "2" "paginaInicial" => "1420" "paginaFinal" => "1422" "link" => array:1 [ …1] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neuropathology of acceleration-induced head injury in the subhuman primate" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Head Injury: Basic and Clinical Aspects" "paginaInicial" => "141" "paginaFinal" => "150" "serieFecha" => "1982" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Head injury in man and experimental animals" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Acta Neurochir" "fecha" => "1983" "numero" => "Suppl. 32" "paginaInicial" => "15" "paginaFinal" => "30" "link" => array:1 [ …1] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diffuse axonal injury due to nonmissile head injury in humans: And analysis of 45 cases" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/ana.410120610" "Revista" => array:6 [ "tituloSerie" => "Ann. Neurol." "fecha" => "1982" "volumen" => "12" "paginaInicial" => "557" "paginaFinal" => "563" "link" => array:1 [ …1] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Brain damage in fatal non-missile head injury" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J. Clin. Pathol." "fecha" => "1980" "volumen" => "33" "paginaInicial" => "1132" "paginaFinal" => "1145" "link" => array:1 [ …1] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diffuse brain damage of inmediate impact type. Its relations hip to “primary brain-stem damage” in head injury" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Brain" "fecha" => "1977" "volumen" => "10" "paginaInicial" => "489" "paginaFinal" => "502" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Thresholds in cerebral ischemia - the ischemic penumbra" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Stroke" "fecha" => "1981" "volumen" => "12" "paginaInicial" => "723" "paginaFinal" => "725" "link" => array:1 [ …1] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Craniocerebral Trauma: Mechanisms, Management, and the Cellular response to Injury. The Upjohn Company" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Kalamazoo, Michigan" "fecha" => "1994" "paginaInicial" => "1" "paginaFinal" => "47" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Biochemical mechanisms of postraumatic neural injury" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Perspectives in Neurological Surgery" "fecha" => "1991" "volumen" => "2" "paginaInicial" => "95" "paginaFinal" => "126" ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cerebral blood flow velocity using Doppler techniques" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:6 [ "editores" => "J.L.Vincent" "paginaInicial" => "522" "paginaFinal" => "529" "serieVolumen" => "14" "serieTitulo" => "Update in intensive care and emergency medicine. Update 1991" "serieFecha" => "1992" ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ultra-early evaluation of regional cerebral blood flow in severely head-injured patients using xenon-enhanced computerized tomography" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J. Neuro surg." "fecha" => "1992" "volumen" => "77" "paginaInicial" => "360" "paginaFinal" => "368" ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Demonstration of early ischemia after severe head injury" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J. Neurosurg." "fecha" => "1991" "volumen" => "74" "paginaInicial" => "364A" "paginaFinal" => "365A" ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Methylprednisolone or naloxone treatment after acute spinal cord injury: 1-year follow-up data. Results of the second national acute spinal cord injury study" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1992.76.1.0023" "Revista" => array:6 [ "tituloSerie" => "J. Neurosurg." "fecha" => "1992" "volumen" => "76" "paginaInicial" => "23" "paginaFinal" => "31" "link" => array:1 [ …1] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal cord injury. Results of the Second National Actue Spinal Cord. Injury Study" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "N. Engl. JMed." "fecha" => "1990" "volumen" => "322" "paginaInicial" => "1405" "paginaFinal" => "1411" ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Guide lines for the Management of Severe Head Injury. The Brain Trauma Foundation, Inc. and American Association of Neurological Surgeons, Park Ridge" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:2 [ "tituloSerie" => "Illinois" "fecha" => "1995" ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Transcranial Doppler ultrasound: present status" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurology" "fecha" => "1990" "volumen" => "40" "paginaInicial" => "696" "paginaFinal" => "700" "link" => array:1 [ …1] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The significance of postraumatic increase in cerebral blood flow velocity: A transcranial doppler ultrasound study" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurosurgery" "fecha" => "1992" "volumen" => "30" "paginaInicial" => "697" "paginaFinal" => "700" "link" => array:1 [ …1] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The role of secondary brain injury in determining outcome from severe head injury" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J. Trauma." "fecha" => "1993" "volumen" => "34" "paginaInicial" => "216" "paginaFinal" => "222" "link" => array:1 [ …1] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Early and late systemic hypotension as a frequent and fundamental source of cerebral is chemia following severe brain injury in the traumatic coma data bank" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Acta Neurochir" "fecha" => "1993" "numero" => "Suppl. 59" "paginaInicial" => "121" "paginaFinal" => "125" "itemHostRev" => array:3 [ …3] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Delayed brain injury: Secondary insults" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Central Nervous System Trauma Status Report. NINCDS," "paginaInicial" => "217" "paginaFinal" => "228" "serieFecha" => "1985" ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparaison of extradural with intraventricular pressure in patients after head injury" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Intracranial Pressure I" "paginaInicial" => "51" "paginaFinal" => "58" "serieFecha" => "1972" ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evaluation of a fiberoptic intracranial pressure monitor" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1990.72.3.0482" "Revista" => array:6 [ "tituloSerie" => "J. Neurosurg." "fecha" => "1990" "volumen" => "72" "paginaInicial" => "482" "paginaFinal" => "487" "link" => array:1 [ …1] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Continuous versus serial global cerebral hemometabolic monitoring: Applications in acute brain trauma" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Acta Neurochir. (Wien)" "fecha" => "1988" "numero" => "Suppl 42" "paginaInicial" => "35" "paginaFinal" => "39" ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Relationship between early patterns of cerebral extraction of oxygen and outcome from severe acute traumatic brain swelling: Cerebral ischemia or cerebral viability?" "fecha" => "1996" "paginaInicial" => "953" "paginaFinal" => "956" ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cerebral extraction of oxygen and related variables in anemic brain-injured patients" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "J. Neurosurg." "fecha" => "1992" "volumen" => "76" "paginaInicial" => "397A" ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Continuous Monitoring of Cerebral Hemodynamic Reserve in Acute Brain Injury: Relationship to Changes in Brain Swelling" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J. Trauma" "fecha" => "1992" "volumen" => "32" "paginaInicial" => "629" "paginaFinal" => "635" "link" => array:1 [ …1] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cerebral lactateoxygen index in acute brain injury with acute anemia: Assessment of false versus true ischemia" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Crit. Care. Med." "fecha" => "1994" "volumen" => "22" "paginaInicial" => "1465" "paginaFinal" => "1470" "link" => array:1 [ …1] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib30" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Modulating cerebral oxygen delivery and extraction in acute traumatic coma" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Neurotrauma 1. Treatment, Reha bilitation and Related Issues" "paginaInicial" => "55" "paginaFinal" => "72" "serieFecha" => "1986" ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib31" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cerebral oxygenation monitoring" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Crit. Care Med" "fecha" => "1993" "volumen" => "21" "paginaInicial" => "1242" "paginaFinal" => "1246" "link" => array:1 [ …1] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib32" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The Microcirculatory Bed of the Brain: Its Structure and Function" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:3 [ "titulo" => "Microcirculation of the Brain. A Synoptic. View by World Experts" "paginaInicial" => "23" "serieFecha" => "1992" ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib33" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nitric oxide and focal cerebral ischemia: Multiplicity of actions and diverse outcome" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cerebrovasc. Brain Metab. Rev." "fecha" => "1994" "volumen" => "6" "paginaInicial" => "299" "paginaFinal" => "324" "link" => array:1 [ …1] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib34" "etiqueta" => "34." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Jugular Bulb Venous Oxygen Saturation and Transcranial Doppler Ultrasonography in Neurosurgical Patients" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Central Nervous System Monitoring in Anesthesia and Intensive Care" "paginaInicial" => "292" "paginaFinal" => "313" "serieFecha" => "1994" ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib35" "etiqueta" => "35." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Benefits and pitfalls of jugular bulb venous oxygen saturation monitoring" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Neurochemical Monitoring in the Intensive Care" "paginaInicial" => "87" "paginaFinal" => "97" "serieFecha" => "1995" ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib36" "etiqueta" => "36." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The free radical pathology and the microcirculation in the mjor central nervous system disorders" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Acta Physiol. Scand" "fecha" => "1970" "volumen" => "492" "numero" => "Suppl. Ill" "paginaInicial" => "91" "paginaFinal" => "119" ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib37" "etiqueta" => "37." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The validity of extradural measurement of the intracranial pressure" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Intracranial Pressure II" "paginaInicial" => "403" "paginaFinal" => "408" "serieFecha" => "1975" ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib38" "etiqueta" => "38." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Exciting your neurons to death: Can we prevent cell loss after brain injury?" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Pediat. Neurosurg." "fecha" => "1994" "volumen" => "21" "paginaInicial" => "117" "paginaFinal" => "122" ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib39" "etiqueta" => "39." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Disturbed Cerebral Autoregulation" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Cerebral Blood Flow and Metabolism" "paginaInicial" => "599" "paginaFinal" => "609" "serieFecha" => "1993" ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib40" "etiqueta" => "40." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Autoregulation. Arterial and Intracranial Pressure" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Cerebral Blood Flow and Metabolism" "paginaInicial" => "553" "paginaFinal" => "580" "serieFecha" => "1993" ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib41" "etiqueta" => "41." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Initial CT findings in 753 patients with severe head injury. A report from the NIH traumatic coma data bank" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1990.73.5.0688" "Revista" => array:6 [ "tituloSerie" => "J. Neurosurg" "fecha" => "1990" "volumen" => "73" "paginaInicial" => "688" "paginaFinal" => "698" "link" => array:1 [ …1] ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib42" "etiqueta" => "42." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dynamic changes in regional, C.B.F., intraventricular pressure. CSF pH and lactate levels during the acute phase of head injury" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1976.44.2.0191" "Revista" => array:6 [ "tituloSerie" => "J. Neurosurg" "fecha" => "1976" "volumen" => "44" "paginaInicial" => "191" "paginaFinal" => "214" "link" => array:1 [ …1] ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bib43" "etiqueta" => "43." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Axonal damage in severe traumatic brain injury: an experimental study in cat" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Acta Neuropathol." "fecha" => "1988" "volumen" => "76" "paginaInicial" => "347" "paginaFinal" => "358" "link" => array:1 [ …1] ] ] ] ] ] ] 43 => array:3 [ "identificador" => "bib44" "etiqueta" => "44." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Simultaneous epidural and intraventricular pressure measurement during the occurrence of supratentorial expanding lesions" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Intracranial Pressure IV" "paginaInicial" => "377" "paginaFinal" => "380" "serieFecha" => "1980" ] ] ] ] ] ] 44 => array:3 [ "identificador" => "bib45" "etiqueta" => "45." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The traumatic coma data bank: design, methods, and baseline characteristics" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J. Neurosurg" "fecha" => "1991" "volumen" => "75" "numero" => "Suppl" "paginaInicial" => "S8" "paginaFinal" => "S13" ] ] ] ] ] ] 45 => array:3 [ "identificador" => "bib46" "etiqueta" => "46." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Anatomy freehand examination techniques" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Transcranial doppler" "paginaInicial" => "9" "paginaFinal" => "32" "serieFecha" => "1992" ] ] ] ] ] ] 46 => array:3 [ "identificador" => "bib47" "etiqueta" => "47." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Head injury in man and experimental animals: Clinical aspects" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00701-008-0166-4" "Revista" => array:6 [ "tituloSerie" => "Acta Neurochirurgica" "fecha" => "1983" "numero" => "(Suppl. 32" "paginaInicial" => "1" "paginaFinal" => "13" "link" => array:1 [ …1] ] ] ] ] ] ] 47 => array:3 [ "identificador" => "bib48" "etiqueta" => "48." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cerebral concussion and diffuse brain injuries" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Head Injury" "paginaInicial" => "137" "paginaFinal" => "158" "serieFecha" => "1993" ] ] ] ] ] ] 48 => array:3 [ "identificador" => "bib49" "etiqueta" => "49." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Biomechanics of acute subdural hematoma" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J. Trauma." "fecha" => "1982" "volumen" => "22" "paginaInicial" => "680" "paginaFinal" => "686" "link" => array:1 [ …1] ] ] ] ] ] ] 49 => array:3 [ "identificador" => "bib50" "etiqueta" => "50." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diffuse axonal injury and traumatic coma in the primate" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/ana.410120611" "Revista" => array:6 [ "tituloSerie" => "Ann. Neurol." "fecha" => "1982" "volumen" => "12" "paginaInicial" => "564" "paginaFinal" => "574" "link" => array:1 [ …1] ] ] ] ] ] ] 50 => array:3 [ "identificador" => "bib51" "etiqueta" => "51." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Survey of critical care management of comatose, head-injured patients in the United States" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Crit. Care. Med." "fecha" => "1995" "volumen" => "23" "paginaInicial" => "560" "paginaFinal" => "567" "link" => array:1 [ …1] ] ] ] ] ] ] 51 => array:3 [ "identificador" => "bib52" "etiqueta" => "52." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Arterial and cerebral venous blood. Arterial-venous differences in man" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J. Biol. Chem" "fecha" => "1942" "volumen" => "144" "paginaInicial" => "325" "paginaFinal" => "332" ] ] ] ] ] ] 52 => array:3 [ "identificador" => "bib53" "etiqueta" => "53." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cardiac arrest, stroke subarachnoid hemorrhage an severe head injury: What do they have in common?" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Nimodipine. Pharmacological and clinical results in cerebral ischemia" "paginaInicial" => "45" "paginaFinal" => "56" "serieFecha" => "1991" ] ] ] ] ] ] 53 => array:3 [ "identificador" => "bib54" "etiqueta" => "54." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Biochemical monitoring in head injury" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Neurotrauma" "paginaInicial" => "577" "paginaFinal" => "591" "serieFecha" => "1996" ] ] ] ] ] ] 54 => array:3 [ "identificador" => "bib55" "etiqueta" => "55." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Jugular venous desaturation and outcome after head injury" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J. Neurol. Neurosurg. Psychiatry" "fecha" => "1994" "volumen" => "57" "paginaInicial" => "717" "paginaFinal" => "723" "link" => array:1 [ …1] ] ] ] ] ] ] 55 => array:3 [ "identificador" => "bib56" "etiqueta" => "56." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Correlación entre tendencias evolutivas de presión intracraneal y patrones de lesión cerebral en el TCE severo" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:2 [ "tituloSerie" => "I Reunión de la Sociedad Española de Neurocirugía" "fecha" => "1996" ] ] ] ] ] ] 56 => array:3 [ "identificador" => "bib57" "etiqueta" => "57." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neuropathology of Head Injury" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Neurotrauma" "paginaInicial" => "43" "paginaFinal" => "59" "serieFecha" => "1996" ] ] ] ] ] ] 57 => array:3 [ "identificador" => "bib58" "etiqueta" => "58." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ischaemic brain damage in fatal non-missile head injuries" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J. Neurol. Sci." "fecha" => "1978" "volumen" => "39" "paginaInicial" => "213" "paginaFinal" => "234" "link" => array:1 [ …1] ] ] ] ] ] ] 58 => array:3 [ "identificador" => "bib59" "etiqueta" => "59." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pathology of Brain Damage" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Head Injury" "paginaInicial" => "91" "paginaFinal" => "113" "serieFecha" => "1993" ] ] ] ] ] ] 59 => array:3 [ "identificador" => "bib60" "etiqueta" => "60." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ischaemic brain damage is still common in fatal non-missile head injury" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J. Neurol. Neurosurg. Psychiatry" "fecha" => "1989" "volumen" => "52" "paginaInicial" => "346" "paginaFinal" => "350" "link" => array:1 [ …1] ] ] ] ] ] ] 60 => array:3 [ "identificador" => "bib61" "etiqueta" => "61." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Anatomy and physiology of glutamate in the CNS" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurology" "fecha" => "1994" "volumen" => "44" "paginaInicial" => "S7" "paginaFinal" => "S13" "link" => array:1 [ …1] ] ] ] ] ] ] 61 => array:3 [ "identificador" => "bib62" "etiqueta" => "62." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The neuroprotective pharmacology of methylprednisolone" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1992.76.1.0013" "Revista" => array:6 [ "tituloSerie" => "J. Neurosurg." "fecha" => "1992" "volumen" => "76" "paginaInicial" => "13" "paginaFinal" => "22" "link" => array:1 [ …1] ] ] ] ] ] ] 62 => array:3 [ "identificador" => "bib63" "etiqueta" => "63." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Hall, E.D. Free radicals and lipid peroxidation, In Narayan, R.K., Wilberger, J.E., Povlishock, J.T. (eds): Neurotrauma. 1996: 1405–1419." ] ] ] 63 => array:3 [ "identificador" => "bib64" "etiqueta" => "64." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Venous oxygen saturation in the jugular bulb" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Update in Intensive Care and Emergency Medicine" "paginaInicial" => "516" "paginaFinal" => "521" "serieFecha" => "1991" ] ] ] ] ] ] 64 => array:3 [ "identificador" => "bib65" "etiqueta" => "65." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The head-injured child who “talks and dies”" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Child's Nerv. Syst." "fecha" => "1990" "volumen" => "6" "paginaInicial" => "139" "paginaFinal" => "142" ] ] ] ] ] ] 65 => array:3 [ "identificador" => "bib66" "etiqueta" => "66." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Historical Perspective on Head Injury" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Neurotrauma" "paginaInicial" => "3" "paginaFinal" => "11" "serieFecha" => "1996" ] ] ] ] ] ] 66 => array:3 [ "identificador" => "bib67" "etiqueta" => "67." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Current excitement about the glutamate receptors family" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Neuroscientist" "fecha" => "1995" "volumen" => "1" "paginaInicial" => "60" "paginaFinal" => "63" ] ] ] ] ] ] 67 => array:3 [ "identificador" => "bib68" "etiqueta" => "68." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Directly gated transmission at central synapses" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Principles of neural science" "paginaInicial" => "153" "paginaFinal" => "172" "serieFecha" => "1991" ] ] ] ] ] ] 68 => array:3 [ "identificador" => "bib69" "etiqueta" => "69." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mechanisms of ischemic brain damage" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Cerebral sinus thrombosis. Experimental and clinical aspects" "paginaInicial" => "93" "paginaFinal" => "104" "serieFecha" => "1990" ] ] ] ] ] ] 69 => array:3 [ "identificador" => "bib70" "etiqueta" => "70." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neuron-Glial Interaction During Injury and Edema of the CNS" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Acta Neurochir. (Wien)" "fecha" => "1994" "paginaInicial" => "7" "paginaFinal" => "11" ] ] ] ] ] ] 70 => array:3 [ "identificador" => "bib71" "etiqueta" => "71." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The determination of cerebral blood flow in man by the use of nitrous oxide in low concentrations" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Am. J. Physiol." "fecha" => "1945" "volumen" => "143" "paginaInicial" => "53" "paginaFinal" => "66" ] ] ] ] ] ] 71 => array:3 [ "identificador" => "bib72" "etiqueta" => "72." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of indomethacin pretreatment on acute mortality in experimental brain injury" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1989.71.4.0565" "Revista" => array:6 [ "tituloSerie" => "J. Neurosurg." "fecha" => "1989" "volumen" => "71" "paginaInicial" => "565" "paginaFinal" => "572" "link" => array:1 [ …1] ] ] ] ] ] ] 72 => array:3 [ "identificador" => "bib73" "etiqueta" => "73." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Regulation of the cerebral circulation" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Ann. Rev. Physiol." "fecha" => "1981" "volumen" => "43" "paginaInicial" => "397" "paginaFinal" => "407" ] ] ] ] ] ] 73 => array:3 [ "identificador" => "bib74" "etiqueta" => "74." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Assessment of cerebral autoregulation dynamics" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Stroke" "fecha" => "1992" "volumen" => "23" "paginaInicial" => "1031" "link" => array:1 [ …1] ] ] ] ] ] ] 74 => array:3 [ "identificador" => "bib75" "etiqueta" => "75." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Responses to cerebral arterioles to acute hypotension and hypertension" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am. J. Physiol." "fecha" => "1978" "volumen" => "234" "paginaInicial" => "H371" "paginaFinal" => "H383" "link" => array:1 [ …1] ] ] ] ] ] ] 75 => array:3 [ "identificador" => "bib76" "etiqueta" => "76." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dysautoregulation in patients with hypertensive intracerebral hemorrhage" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "A SPECT study, in" "fecha" => "1995" "paginaInicial" => "237" "paginaFinal" => "245" ] ] ] ] ] ] 76 => array:3 [ "identificador" => "bib77" "etiqueta" => "77." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Transmission of Increased Intracranial Pressure. I. Within the Craniospinal Axis" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1964.21.11.0989" "Revista" => array:6 [ "tituloSerie" => "J. Neurosurg." "fecha" => "1964" "volumen" => "21" "paginaInicial" => "989" "paginaFinal" => "997" "link" => array:1 [ …1] ] ] ] ] ] ] 77 => array:3 [ "identificador" => "bib78" "etiqueta" => "78." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cerebral blood flow an oxygen consumption in man" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Physiol. Rev." "fecha" => "1959" "volumen" => "39" "paginaInicial" => "183" "paginaFinal" => "238" "link" => array:1 [ …1] ] ] ] ] ] ] 78 => array:3 [ "identificador" => "bib79" "etiqueta" => "79." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Lassen, N.A. Cerebran and spinal cord blood flow, in Cottrell, J.E., Turndorf, H. (eds): St. Louis, C.V. Mosby; 1986: 1–21." ] ] ] 79 => array:3 [ "identificador" => "bib80" "etiqueta" => "80." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Funcion cerebral y flujo sangufneo" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Investigation y Ciencia" "fecha" => "1990" "paginaInicial" => "18" "paginaFinal" => "28" ] ] ] ] ] ] 80 => array:3 [ "identificador" => "bib81" "etiqueta" => "81." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intracranial Pressure Monitoring. Current Methods" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Problems of Intracranial Pressure in Childhood" "paginaInicial" => "123" "paginaFinal" => "140" "serieFecha" => "1991" ] ] ] ] ] ] 81 => array:3 [ "identificador" => "bib82" "etiqueta" => "82." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The use of a fiber-optic intracranial pressure transducer in clinical practice" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:2 [ "tituloSerie" => "Proceedings of the Annual Meeting of the AANS" "fecha" => "1976" ] ] ] ] ] ] 82 => array:3 [ "identificador" => "bib83" "etiqueta" => "83." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Molecular mechanisms of trauma-induced neuronal degeneration" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Current Opinion in Neurology and Neurosurgery" "fecha" => "1993" "volumen" => "6" "paginaInicial" => "588" "paginaFinal" => "596" "link" => array:1 [ …1] ] ] ] ] ] ] 83 => array:3 [ "identificador" => "bib84" "etiqueta" => "84." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Excitatory amino acids as a final common pathway for neurologic disorders" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "N. Eugl. J. Med." "fecha" => "1994" "volumen" => "330" "paginaInicial" => "613" "paginaFinal" => "622" ] ] ] ] ] ] 84 => array:3 [ "identificador" => "bib85" "etiqueta" => "85." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical experience with a fiber optic brain parenchymal pressure monitor" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Intra cranial Pressure VII" "paginaInicial" => "35" "paginaFinal" => "37" "serieFecha" => "1989" ] ] ] ] ] ] 85 => array:3 [ "identificador" => "bib86" "etiqueta" => "86." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dissociation between cerebral autoregulation and carbon dioxide reactivity during nonpulsatile cardiopulmonary bypass" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Annals of Thoracic Surgery" "fecha" => "1985" "volumen" => "40" "paginaInicial" => "582" "paginaFinal" => "587" "link" => array:1 [ …1] ] ] ] ] ] ] 86 => array:3 [ "identificador" => "bib87" "etiqueta" => "87." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Traumatic Brain Edema: An overview" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Acta Neurochir. (Wien)" "fecha" => "1994" "paginaInicial" => "421" "paginaFinal" => "424" ] ] ] ] ] ] 87 => array:3 [ "identificador" => "bib88" "etiqueta" => "88." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Impact of instability and hypotension on outcome in patients with severe head trauma" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J. Neurosurg" "fecha" => "1991" "volumen" => "75" "numero" => "Suppl" "paginaInicial" => "59" "paginaFinal" => "66" ] ] ] ] ] ] 88 => array:3 [ "identificador" => "bib89" "etiqueta" => "89." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Marshall, R.P. (eds): Advances in Neurotraumatology. Volume 1. Extracerebral collections. Wien, SpringerVerlag; 1986: 209–228." ] ] ] 89 => array:3 [ "identificador" => "bib90" "etiqueta" => "90." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Current head injury research" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Current Opinion in Neurology and Neurosurgery" "fecha" => "1990" "volumen" => "3" "paginaInicial" => "4" "paginaFinal" => "9" ] ] ] ] ] ] 90 => array:3 [ "identificador" => "bib91" "etiqueta" => "91." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A new classification of head injury based on computerized tomography" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J. Neurosurg" "fecha" => "1991" "volumen" => "75" "numero" => "Suppl" "paginaInicial" => "14" "paginaFinal" => "20" ] ] ] ] ] ] 91 => array:3 [ "identificador" => "bib92" "etiqueta" => "92." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Brain swelling caued by trauma and arterial hypertension. Hemodynamic aspects" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch. Neurol." "fecha" => "1969" "volumen" => "21" "paginaInicial" => "545" "paginaFinal" => "553" "link" => array:1 [ …1] ] ] ] ] ] ] 92 => array:3 [ "identificador" => "bib93" "etiqueta" => "93." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Noninvasive cerebral optical spectroscopy for monitoring cerebral oxygen delivery and hemodynamics" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.CCM.0000037960.70104.1E" "Revista" => array:5 [ "tituloSerie" => "Crit. Care. Med." "fecha" => "1991" "paginaInicial" => "89" "paginaFinal" => "97" "link" => array:1 [ …1] ] ] ] ] ] ] 93 => array:3 [ "identificador" => "bib94" "etiqueta" => "94." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intracerebral penetration of infrared light. Technical note" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1992.76.2.0315" "Revista" => array:6 [ "tituloSerie" => "J. Neurosurg." "fecha" => "1992" "volumen" => "76" "paginaInicial" => "315" "paginaFinal" => "318" "link" => array:1 [ …1] ] ] ] ] ] ] 94 => array:3 [ "identificador" => "bib95" "etiqueta" => "95." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The Circulatory System" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Cardiovascular Physiology" "paginaInicial" => "3" "paginaFinal" => "28" "serieFecha" => "1990" ] ] ] ] ] ] 95 => array:3 [ "identificador" => "bib96" "etiqueta" => "96." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Primary focal impact damage to the brainstem in blunt head injuries. Does it exist?" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1973" "volumen" => "2" "paginaInicial" => "215" "paginaFinal" => "218" "link" => array:1 [ …1] ] ] ] ] ] ] 96 => array:3 [ "identificador" => "bib97" "etiqueta" => "97." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cerebral blood flow, cerebral blood volume and cerebral metabolism after severe head injury" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Textbook of Head Injury" "paginaInicial" => "221" "paginaFinal" => "240" "serieFecha" => "1989" ] ] ] ] ] ] 97 => array:3 [ "identificador" => "bib98" "etiqueta" => "98." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Overview of monitoring of cerebral blood flow and metabolism after severe head injury" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Can. J. Neurol. Sci." "fecha" => "1994" "volumen" => "21" "paginaInicial" => "S6" "paginaFinal" => "S11" …1 ] ] ] ] ] ] 98 => array:3 [ "identificador" => "bib99" "etiqueta" => "99." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cerebral blood flow and metabolism in severely head-injured children. Part 2: Autoregulation" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1989.71.1.0072" "Revista" => array:6 [ …6] ] ] ] ] ] 99 => array:3 [ "identificador" => "bib100" "etiqueta" => "100." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Raised intracranial pressure" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:2 [ …2] ] ] ] ] ] 100 => array:3 [ "identificador" => "bib101" "etiqueta" => "101." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cerebral blood flow and metabolism in comatose patients with acute head injury Relationship to intracranial hypertension" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1984.61.2.0241" "Revista" => array:6 [ …6] ] ] ] ] ] 101 => array:3 [ "identificador" => "bib102" "etiqueta" => "102." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Glutamate receptor-mediated neurotoxicity" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ …4] ] ] ] ] ] 102 => array:3 [ "identificador" => "bib103" "etiqueta" => "103." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Restoration of autoregulation of cerebral blood flow by hypocapnia" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ …5] ] ] ] ] ] 103 => array:3 [ "identificador" => "bib104" "etiqueta" => "104." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cerebral circulation under normal and pathologic conditions" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ …5] ] ] ] ] ] 104 => array:3 [ "identificador" => "bib105" "etiqueta" => "106." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hipertensión intracraneal en la fase aguda de los traumatismos craneoencefálicos. Estudio de la incidencia en función del tipo de lesión" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:2 [ …2] ] ] ] ] ] 105 => array:3 [ "identificador" => "bib106" "etiqueta" => "107." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Experimental studies of head injury" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ …4] ] ] ] ] ] 106 => array:3 [ "identificador" => "bib107" "etiqueta" => "108." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ …4] ] ] ] ] ] 107 => array:3 [ "identificador" => "bib108" "etiqueta" => "109." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fate of reactive axonal swellings induced by head injury" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 108 => array:3 [ "identificador" => "bib109" "etiqueta" => "110." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Axonal change in minor head injury" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 109 => array:3 [ "identificador" => "bib110" "etiqueta" => "111." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Failure of autoregulation after closed head injury: An experimental model" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 110 => array:3 [ "identificador" => "bib111" "etiqueta" => "112." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cerebral circulatory monitoring" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:6 [ …6] ] ] ] ] ] 111 => array:3 [ "identificador" => "bib112" "etiqueta" => "113." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Correlation between regional cerebral blood flow and oxidative metabolism. In vivo studies in man" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 112 => array:3 [ "identificador" => "bib113" "etiqueta" => "114." 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Advances in the management of severe head injury patients

J. Sahuquillo, M.A. Poca

Servicio de Neurocirugía Unidad de Neurotraumatología. Hospitales Universitarios Vall d’Hebrón. Barcelona

S. Pedraza*, X. Munar**

* Unidad de Diagnóstico por la Imagen. Hospitales Universitarios Vall d’Hebrón. Barcelona

** Servicio de Anestesiología y Reanimación. Hospitales Universitarios Vall d’Hebrón. Barcelona

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            1 => "Physiopathology"
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        "titulo" => "Resumen"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Los traumatismos craneoencef&#225;licos &#40;TCE&#41; representan la primera causa de muerte en la poblaci&#243;n por debajo de los 45 a&#241;os de edad&#46; En la &#250;ltima d&#233;cada se han producido avances significativos tanto en el conocimiento de los mecanismos b&#225;sicos de los traumatismos como en su fisiopatolog&#237;a&#46; Aunque una parte considerable de las lesiones se producen de forma inmediata al impacto &#40;lesiones primarias&#41;&#44; muchas de ellas aparecen un per&#237;odo variable de tiempo despu&#233;s del traumatismo &#40;lesiones secundarias&#41;&#46; La isquemia cerebral&#44; causada por hipertensi&#243;n intracraneal&#44; por una reducci&#243;n en la presi&#243;n de perfusi&#243;n cerebral o secundaria a insultos sist&#233;micos en la fase prehospitalaria &#40;hipoxia&#44; hipotensi&#243;n o anemia&#41; es la lesi&#243;n secundaria de mayor prevalencia en los traumatismos craneoencef&#225;licos graves &#40;TCEG&#41;&#46; El hecho de que las lesiones secundarias originan a su vez&#44; importantes cascadas metab&#243;licas&#44; que son la causa m&#225;s importante de alteraciones celulares y de lesiones estructurales irreversibles&#44; ha sido el avance fisiopatol&#243;gico m&#225;s significativo en el conocimiento de los TCE&#46; Este mejor conocimiento de su fisiopatolog&#237;a ha permitido mejorar la monitorizaci&#243;n e incrementar de forma significativa la asistencia ofrecida a estos pacientes&#46; En la primera parte de este trabajo&#44; revisamos los conceptos fundamentales en los mecanismos etiopatog&#233;nicos implicados en los TCE&#44; en su fisiopatolog&#237;a y en las cascadas metab&#243;licas implicadas&#46; Revisamos tambi&#233;n los principios b&#225;sicos en la monitorizaci&#243;n de estos pacientes&#46;</p>"
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        "titulo" => "Abstract"
        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Head injury is the leading cause of death amog people under the age of 45&#46; In the last decade significant advances in the understanding of the basic mechanisms of injury and its physiopathology have been made&#46; Although major damage to the brain is often produced inmediately on impact &#40;primary damage&#41;&#44; many lesions appear a variable period of time after injury &#40;secondary lesions&#41;&#46; Ischemic damage related to high intracranial pressure&#44; low cerebral perfusion pressure or prehospitalary systemic insults &#40;hypoxia&#44; hypotension or anemia&#41;&#44; is the most important secondary lesion found after severe head injury&#46; The fact that secondary lesions induce important metabolic cascades which are the leading cause of cellular disorders and structural damage to the brain after severe head injury&#44; has been the main advance in physiopathological knowledge&#46; A better understanding of the pathophysiology of head injury has allowed a better monitoring and an improvement in the standard of care offered to these patients&#46; In the first part of this work&#44; we review the current concepts in basic mechanisms involved in head injury&#44; the pathophysiology of these lesions and the metabolic cascades involved&#46; The accepted standards of monitoring in the management of these patients are also reviewed&#46;</p>"
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      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara">Sahuquillo&#44; J&#46;&#59; Poca&#44; M&#46;A&#46;&#59; Pedraza&#44; S&#46;&#59; Munar&#44; X&#46;&#58; Actualizaciones en la fisiopatolog&#237;a y monitorizaci&#243;n de los traumatismos craneoencef&#225;licos graves&#46; Neurocirug&#237;a 1997&#59; 8&#58; 260&#8211;283&#46;</p>"
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                    0 => array:2 [
                      "titulo" => "Noninvasive transcranial Doppler ultrasound recording of flow velocity in basal cerebral arteries"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
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                    0 => array:2 [
                      "doi" => "10.3171/jns.1982.57.6.0769"
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                        "tituloSerie" => "J&#46; Neurosurg&#46;"
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                        "paginaFinal" => "773"
                        "link" => array:1 [ …1]
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                    0 => array:2 [
                      "titulo" => "Diffuse axonal injury in head injury&#58; definition&#44; diagnosis and grading"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
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                        "tituloSerie" => "Histopathology"
                        "fecha" => "1989"
                        "volumen" => "15"
                        "paginaInicial" => "49"
                        "paginaFinal" => "59"
                        "link" => array:1 [ …1]
                      ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diffuse axonal injury in head injuries caused by a fall"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1984"
                        "volumen" => "2"
                        "paginaInicial" => "1420"
                        "paginaFinal" => "1422"
                        "link" => array:1 [ …1]
                      ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Neuropathology of acceleration-induced head injury in the subhuman primate"
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                        0 => array:2 [ …2]
                      ]
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                  ]
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                    0 => array:1 [
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                        "titulo" => "Head Injury&#58; Basic and Clinical Aspects"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Head injury in man and experimental animals"
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                        0 => array:2 [ …2]
                      ]
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                  ]
                  "host" => array:1 [
                    0 => array:1 [
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                        "tituloSerie" => "Acta Neurochir"
                        "fecha" => "1983"
                        "numero" => "Suppl&#46; 32"
                        "paginaInicial" => "15"
                        "paginaFinal" => "30"
                        "link" => array:1 [ …1]
                      ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diffuse axonal injury due to nonmissile head injury in humans&#58; And analysis of 45 cases"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/ana.410120610"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann&#46; Neurol&#46;"
                        "fecha" => "1982"
                        "volumen" => "12"
                        "paginaInicial" => "557"
                        "paginaFinal" => "563"
                        "link" => array:1 [ …1]
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                    0 => array:2 [
                      "titulo" => "Brain damage in fatal non-missile head injury"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J&#46; Clin&#46; Pathol&#46;"
                        "fecha" => "1980"
                        "volumen" => "33"
                        "paginaInicial" => "1132"
                        "paginaFinal" => "1145"
                        "link" => array:1 [ …1]
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                    0 => array:2 [
                      "titulo" => "Diffuse brain damage of inmediate impact type&#46; Its relations hip to &#8220;primary brain-stem damage&#8221; in head injury"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
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                    ]
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                      "Revista" => array:5 [
                        "tituloSerie" => "Brain"
                        "fecha" => "1977"
                        "volumen" => "10"
                        "paginaInicial" => "489"
                        "paginaFinal" => "502"
                      ]
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                  ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Thresholds in cerebral ischemia - the ischemic penumbra"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Stroke"
                        "fecha" => "1981"
                        "volumen" => "12"
                        "paginaInicial" => "723"
                        "paginaFinal" => "725"
                        "link" => array:1 [ …1]
                      ]
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                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Craniocerebral Trauma&#58; Mechanisms&#44; Management&#44; and the Cellular response to Injury&#46; The Upjohn Company"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Kalamazoo&#44; Michigan"
                        "fecha" => "1994"
                        "paginaInicial" => "1"
                        "paginaFinal" => "47"
                      ]
                    ]
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              ]
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                    0 => array:2 [
                      "titulo" => "Biochemical mechanisms of postraumatic neural injury"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
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                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Perspectives in Neurological Surgery"
                        "fecha" => "1991"
                        "volumen" => "2"
                        "paginaInicial" => "95"
                        "paginaFinal" => "126"
                      ]
                    ]
                  ]
                ]
              ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cerebral blood flow velocity using Doppler techniques"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
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                        "serieTitulo" => "Update in intensive care and emergency medicine&#46; Update 1991"
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                  ]
                ]
              ]
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                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ultra-early evaluation of regional cerebral blood flow in severely head-injured patients using xenon-enhanced computerized tomography"
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J&#46; Neuro surg&#46;"
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                        "volumen" => "77"
                        "paginaInicial" => "360"
                        "paginaFinal" => "368"
                      ]
                    ]
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                    0 => array:2 [
                      "titulo" => "Demonstration of early ischemia after severe head injury"
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                  "host" => array:1 [
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                        "tituloSerie" => "J&#46; Neurosurg&#46;"
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                        "paginaFinal" => "365A"
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                    0 => array:2 [
                      "titulo" => "Methylprednisolone or naloxone treatment after acute spinal cord injury&#58; 1-year follow-up data&#46; Results of the second national acute spinal cord injury study"
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                        0 => array:2 [ …2]
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                      "doi" => "10.3171/jns.1992.76.1.0023"
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                        "tituloSerie" => "J&#46; Neurosurg&#46;"
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                        "paginaFinal" => "31"
                        "link" => array:1 [ …1]
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                    0 => array:2 [
                      "titulo" => "A randomized&#44; controlled trial of methylprednisolone or naloxone in the treatment of acute spinal cord injury&#46; Results of the Second National Actue Spinal Cord&#46; Injury Study"
                      "autores" => array:1 [
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                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "N&#46; Engl&#46; JMed&#46;"
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                        "volumen" => "322"
                        "paginaInicial" => "1405"
                        "paginaFinal" => "1411"
                      ]
                    ]
                  ]
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                    0 => array:2 [
                      "titulo" => "Guide lines for the Management of Severe Head Injury&#46; The Brain Trauma Foundation&#44; Inc&#46; and American Association of Neurological Surgeons&#44; Park Ridge"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:2 [
                        "tituloSerie" => "Illinois"
                        "fecha" => "1995"
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              "identificador" => "bib18"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Transcranial Doppler ultrasound&#58; present status"
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                  "host" => array:1 [
                    0 => array:1 [
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                        "tituloSerie" => "Neurology"
                        "fecha" => "1990"
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                        "paginaFinal" => "700"
                        "link" => array:1 [ …1]
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "The significance of postraumatic increase in cerebral blood flow velocity&#58; A transcranial doppler ultrasound study"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
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                  "host" => array:1 [
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                        "tituloSerie" => "Neurosurgery"
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                        "volumen" => "30"
                        "paginaInicial" => "697"
                        "paginaFinal" => "700"
                        "link" => array:1 [ …1]
                      ]
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              "etiqueta" => "20&#46;"
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                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The role of secondary brain injury in determining outcome from severe head injury"
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                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J&#46; Trauma&#46;"
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                        "volumen" => "34"
                        "paginaInicial" => "216"
                        "paginaFinal" => "222"
                        "link" => array:1 [ …1]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Early and late systemic hypotension as a frequent and fundamental source of cerebral is chemia following severe brain injury in the traumatic coma data bank"
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                        0 => array:2 [ …2]
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                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Neurochir"
                        "fecha" => "1993"
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                        "paginaFinal" => "125"
                        "itemHostRev" => array:3 [ …3]
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                    0 => array:2 [
                      "titulo" => "Delayed brain injury&#58; Secondary insults"
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                        "titulo" => "Central Nervous System Trauma Status Report&#46; NINCDS&#44;"
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                        "paginaFinal" => "228"
                        "serieFecha" => "1985"
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              "referencia" => array:1 [
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                    0 => array:2 [
                      "titulo" => "Comparaison of extradural with intraventricular pressure in patients after head injury"
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                        "titulo" => "Intracranial Pressure I"
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                        "paginaFinal" => "58"
                        "serieFecha" => "1972"
                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib24"
              "etiqueta" => "24&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evaluation of a fiberoptic intracranial pressure monitor"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
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                        "tituloSerie" => "J&#46; Neurosurg&#46;"
                        "fecha" => "1990"
                        "volumen" => "72"
                        "paginaInicial" => "482"
                        "paginaFinal" => "487"
                        "link" => array:1 [ …1]
                      ]
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              "etiqueta" => "25&#46;"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Continuous versus serial global cerebral hemometabolic monitoring&#58; Applications in acute brain trauma"
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                        0 => array:2 [ …2]
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                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Acta Neurochir&#46; &#40;Wien&#41;"
                        "fecha" => "1988"
                        "numero" => "Suppl 42"
                        "paginaInicial" => "35"
                        "paginaFinal" => "39"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
              "etiqueta" => "26&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Relationship between early patterns of cerebral extraction of oxygen and outcome from severe acute traumatic brain swelling&#58; Cerebral ischemia or cerebral viability&#63;"
                        "fecha" => "1996"
                        "paginaInicial" => "953"
                        "paginaFinal" => "956"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib27"
              "etiqueta" => "27&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cerebral extraction of oxygen and related variables in anemic brain-injured patients"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "J&#46; Neurosurg&#46;"
                        "fecha" => "1992"
                        "volumen" => "76"
                        "paginaInicial" => "397A"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib28"
              "etiqueta" => "28&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Continuous Monitoring of Cerebral Hemodynamic Reserve in Acute Brain Injury&#58; Relationship to Changes in Brain Swelling"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J&#46; Trauma"
                        "fecha" => "1992"
                        "volumen" => "32"
                        "paginaInicial" => "629"
                        "paginaFinal" => "635"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib29"
              "etiqueta" => "29&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cerebral lactateoxygen index in acute brain injury with acute anemia&#58; Assessment of false versus true ischemia"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Crit&#46; Care&#46; Med&#46;"
                        "fecha" => "1994"
                        "volumen" => "22"
                        "paginaInicial" => "1465"
                        "paginaFinal" => "1470"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib30"
              "etiqueta" => "30&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Modulating cerebral oxygen delivery and extraction in acute traumatic coma"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Neurotrauma 1&#46; Treatment&#44; Reha bilitation and Related Issues"
                        "paginaInicial" => "55"
                        "paginaFinal" => "72"
                        "serieFecha" => "1986"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib31"
              "etiqueta" => "31&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cerebral oxygenation monitoring"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Crit&#46; Care Med"
                        "fecha" => "1993"
                        "volumen" => "21"
                        "paginaInicial" => "1242"
                        "paginaFinal" => "1246"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib32"
              "etiqueta" => "32&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The Microcirculatory Bed of the Brain&#58; Its Structure and Function"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:3 [
                        "titulo" => "Microcirculation of the Brain&#46; A Synoptic&#46; View by World Experts"
                        "paginaInicial" => "23"
                        "serieFecha" => "1992"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib33"
              "etiqueta" => "33&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Nitric oxide and focal cerebral ischemia&#58; Multiplicity of actions and diverse outcome"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cerebrovasc&#46; Brain Metab&#46; Rev&#46;"
                        "fecha" => "1994"
                        "volumen" => "6"
                        "paginaInicial" => "299"
                        "paginaFinal" => "324"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib34"
              "etiqueta" => "34&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Jugular Bulb Venous Oxygen Saturation and Transcranial Doppler Ultrasonography in Neurosurgical Patients"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Central Nervous System Monitoring in Anesthesia and Intensive Care"
                        "paginaInicial" => "292"
                        "paginaFinal" => "313"
                        "serieFecha" => "1994"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib35"
              "etiqueta" => "35&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Benefits and pitfalls of jugular bulb venous oxygen saturation monitoring"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Neurochemical Monitoring in the Intensive Care"
                        "paginaInicial" => "87"
                        "paginaFinal" => "97"
                        "serieFecha" => "1995"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib36"
              "etiqueta" => "36&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The free radical pathology and the microcirculation in the mjor central nervous system disorders"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Physiol&#46; Scand"
                        "fecha" => "1970"
                        "volumen" => "492"
                        "numero" => "Suppl&#46; Ill"
                        "paginaInicial" => "91"
                        "paginaFinal" => "119"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib37"
              "etiqueta" => "37&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The validity of extradural measurement of the intracranial pressure"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Intracranial Pressure II"
                        "paginaInicial" => "403"
                        "paginaFinal" => "408"
                        "serieFecha" => "1975"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib38"
              "etiqueta" => "38&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Exciting your neurons to death&#58; Can we prevent cell loss after brain injury&#63;"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Pediat&#46; Neurosurg&#46;"
                        "fecha" => "1994"
                        "volumen" => "21"
                        "paginaInicial" => "117"
                        "paginaFinal" => "122"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib39"
              "etiqueta" => "39&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Disturbed Cerebral Autoregulation"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Cerebral Blood Flow and Metabolism"
                        "paginaInicial" => "599"
                        "paginaFinal" => "609"
                        "serieFecha" => "1993"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            39 => array:3 [
              "identificador" => "bib40"
              "etiqueta" => "40&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Autoregulation&#46; Arterial and Intracranial Pressure"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Cerebral Blood Flow and Metabolism"
                        "paginaInicial" => "553"
                        "paginaFinal" => "580"
                        "serieFecha" => "1993"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            40 => array:3 [
              "identificador" => "bib41"
              "etiqueta" => "41&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Initial CT findings in 753 patients with severe head injury&#46; A report from the NIH traumatic coma data bank"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3171/jns.1990.73.5.0688"
                      "Revista" => array:6 [
                        "tituloSerie" => "J&#46; Neurosurg"
                        "fecha" => "1990"
                        "volumen" => "73"
                        "paginaInicial" => "688"
                        "paginaFinal" => "698"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            41 => array:3 [
              "identificador" => "bib42"
              "etiqueta" => "42&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dynamic changes in regional&#44; C&#46;B&#46;F&#46;&#44; intraventricular pressure&#46; CSF pH and lactate levels during the acute phase of head injury"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3171/jns.1976.44.2.0191"
                      "Revista" => array:6 [
                        "tituloSerie" => "J&#46; Neurosurg"
                        "fecha" => "1976"
                        "volumen" => "44"
                        "paginaInicial" => "191"
                        "paginaFinal" => "214"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            42 => array:3 [
              "identificador" => "bib43"
              "etiqueta" => "43&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Axonal damage in severe traumatic brain injury&#58; an experimental study in cat"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Neuropathol&#46;"
                        "fecha" => "1988"
                        "volumen" => "76"
                        "paginaInicial" => "347"
                        "paginaFinal" => "358"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            43 => array:3 [
              "identificador" => "bib44"
              "etiqueta" => "44&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Simultaneous epidural and intraventricular pressure measurement during the occurrence of supratentorial expanding lesions"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Intracranial Pressure IV"
                        "paginaInicial" => "377"
                        "paginaFinal" => "380"
                        "serieFecha" => "1980"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            44 => array:3 [
              "identificador" => "bib45"
              "etiqueta" => "45&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The traumatic coma data bank&#58; design&#44; methods&#44; and baseline characteristics"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J&#46; Neurosurg"
                        "fecha" => "1991"
                        "volumen" => "75"
                        "numero" => "Suppl"
                        "paginaInicial" => "S8"
                        "paginaFinal" => "S13"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            45 => array:3 [
              "identificador" => "bib46"
              "etiqueta" => "46&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Anatomy freehand examination techniques"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Transcranial doppler"
                        "paginaInicial" => "9"
                        "paginaFinal" => "32"
                        "serieFecha" => "1992"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            46 => array:3 [
              "identificador" => "bib47"
              "etiqueta" => "47&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Head injury in man and experimental animals&#58; Clinical aspects"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00701-008-0166-4"
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Neurochirurgica"
                        "fecha" => "1983"
                        "numero" => "&#40;Suppl&#46; 32"
                        "paginaInicial" => "1"
                        "paginaFinal" => "13"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            47 => array:3 [
              "identificador" => "bib48"
              "etiqueta" => "48&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cerebral concussion and diffuse brain injuries"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Head Injury"
                        "paginaInicial" => "137"
                        "paginaFinal" => "158"
                        "serieFecha" => "1993"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            48 => array:3 [
              "identificador" => "bib49"
              "etiqueta" => "49&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Biomechanics of acute subdural hematoma"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J&#46; Trauma&#46;"
                        "fecha" => "1982"
                        "volumen" => "22"
                        "paginaInicial" => "680"
                        "paginaFinal" => "686"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            49 => array:3 [
              "identificador" => "bib50"
              "etiqueta" => "50&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diffuse axonal injury and traumatic coma in the primate"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/ana.410120611"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann&#46; Neurol&#46;"
                        "fecha" => "1982"
                        "volumen" => "12"
                        "paginaInicial" => "564"
                        "paginaFinal" => "574"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            50 => array:3 [
              "identificador" => "bib51"
              "etiqueta" => "51&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Survey of critical care management of comatose&#44; head-injured patients in the United States"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Crit&#46; Care&#46; Med&#46;"
                        "fecha" => "1995"
                        "volumen" => "23"
                        "paginaInicial" => "560"
                        "paginaFinal" => "567"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            51 => array:3 [
              "identificador" => "bib52"
              "etiqueta" => "52&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Arterial and cerebral venous blood&#46; Arterial-venous differences in man"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J&#46; Biol&#46; Chem"
                        "fecha" => "1942"
                        "volumen" => "144"
                        "paginaInicial" => "325"
                        "paginaFinal" => "332"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            52 => array:3 [
              "identificador" => "bib53"
              "etiqueta" => "53&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cardiac arrest&#44; stroke subarachnoid hemorrhage an severe head injury&#58; What do they have in common&#63;"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Nimodipine&#46; Pharmacological and clinical results in cerebral ischemia"
                        "paginaInicial" => "45"
                        "paginaFinal" => "56"
                        "serieFecha" => "1991"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            53 => array:3 [
              "identificador" => "bib54"
              "etiqueta" => "54&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Biochemical monitoring in head injury"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Neurotrauma"
                        "paginaInicial" => "577"
                        "paginaFinal" => "591"
                        "serieFecha" => "1996"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            54 => array:3 [
              "identificador" => "bib55"
              "etiqueta" => "55&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Jugular venous desaturation and outcome after head injury"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J&#46; Neurol&#46; Neurosurg&#46; Psychiatry"
                        "fecha" => "1994"
                        "volumen" => "57"
                        "paginaInicial" => "717"
                        "paginaFinal" => "723"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            55 => array:3 [
              "identificador" => "bib56"
              "etiqueta" => "56&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Correlaci&#243;n entre tendencias evolutivas de presi&#243;n intracraneal y patrones de lesi&#243;n cerebral en el TCE severo"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:2 [
                        "tituloSerie" => "I Reuni&#243;n de la Sociedad Espa&#241;ola de Neurocirug&#237;a"
                        "fecha" => "1996"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            56 => array:3 [
              "identificador" => "bib57"
              "etiqueta" => "57&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Neuropathology of Head Injury"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Neurotrauma"
                        "paginaInicial" => "43"
                        "paginaFinal" => "59"
                        "serieFecha" => "1996"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            57 => array:3 [
              "identificador" => "bib58"
              "etiqueta" => "58&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ischaemic brain damage in fatal non-missile head injuries"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J&#46; Neurol&#46; Sci&#46;"
                        "fecha" => "1978"
                        "volumen" => "39"
                        "paginaInicial" => "213"
                        "paginaFinal" => "234"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            58 => array:3 [
              "identificador" => "bib59"
              "etiqueta" => "59&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pathology of Brain Damage"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Head Injury"
                        "paginaInicial" => "91"
                        "paginaFinal" => "113"
                        "serieFecha" => "1993"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            59 => array:3 [
              "identificador" => "bib60"
              "etiqueta" => "60&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ischaemic brain damage is still common in fatal non-missile head injury"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J&#46; Neurol&#46; Neurosurg&#46; Psychiatry"
                        "fecha" => "1989"
                        "volumen" => "52"
                        "paginaInicial" => "346"
                        "paginaFinal" => "350"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            60 => array:3 [
              "identificador" => "bib61"
              "etiqueta" => "61&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Anatomy and physiology of glutamate in the CNS"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurology"
                        "fecha" => "1994"
                        "volumen" => "44"
                        "paginaInicial" => "S7"
                        "paginaFinal" => "S13"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            61 => array:3 [
              "identificador" => "bib62"
              "etiqueta" => "62&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The neuroprotective pharmacology of methylprednisolone"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3171/jns.1992.76.1.0013"
                      "Revista" => array:6 [
                        "tituloSerie" => "J&#46; Neurosurg&#46;"
                        "fecha" => "1992"
                        "volumen" => "76"
                        "paginaInicial" => "13"
                        "paginaFinal" => "22"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            62 => array:3 [
              "identificador" => "bib63"
              "etiqueta" => "63&#46;"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Hall&#44; E&#46;D&#46; Free radicals and lipid peroxidation&#44; In Narayan&#44; R&#46;K&#46;&#44; Wilberger&#44; J&#46;E&#46;&#44; Povlishock&#44; J&#46;T&#46; &#40;eds&#41;&#58; Neurotrauma&#46; 1996&#58; 1405&#8211;1419&#46;"
                ]
              ]
            ]
            63 => array:3 [
              "identificador" => "bib64"
              "etiqueta" => "64&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Venous oxygen saturation in the jugular bulb"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Update in Intensive Care and Emergency Medicine"
                        "paginaInicial" => "516"
                        "paginaFinal" => "521"
                        "serieFecha" => "1991"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            64 => array:3 [
              "identificador" => "bib65"
              "etiqueta" => "65&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The head-injured child who &#8220;talks and dies&#8221;"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Child&#39;s Nerv&#46; Syst&#46;"
                        "fecha" => "1990"
                        "volumen" => "6"
                        "paginaInicial" => "139"
                        "paginaFinal" => "142"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            65 => array:3 [
              "identificador" => "bib66"
              "etiqueta" => "66&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Historical Perspective on Head Injury"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Neurotrauma"
                        "paginaInicial" => "3"
                        "paginaFinal" => "11"
                        "serieFecha" => "1996"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            66 => array:3 [
              "identificador" => "bib67"
              "etiqueta" => "67&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Current excitement about the glutamate receptors family"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Neuroscientist"
                        "fecha" => "1995"
                        "volumen" => "1"
                        "paginaInicial" => "60"
                        "paginaFinal" => "63"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            67 => array:3 [
              "identificador" => "bib68"
              "etiqueta" => "68&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Directly gated transmission at central synapses"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Principles of neural science"
                        "paginaInicial" => "153"
                        "paginaFinal" => "172"
                        "serieFecha" => "1991"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            68 => array:3 [
              "identificador" => "bib69"
              "etiqueta" => "69&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mechanisms of ischemic brain damage"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Cerebral sinus thrombosis&#46; Experimental and clinical aspects"
                        "paginaInicial" => "93"
                        "paginaFinal" => "104"
                        "serieFecha" => "1990"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            69 => array:3 [
              "identificador" => "bib70"
              "etiqueta" => "70&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Neuron-Glial Interaction During Injury and Edema of the CNS"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Acta Neurochir&#46; &#40;Wien&#41;"
                        "fecha" => "1994"
                        "paginaInicial" => "7"
                        "paginaFinal" => "11"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            70 => array:3 [
              "identificador" => "bib71"
              "etiqueta" => "71&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The determination of cerebral blood flow in man by the use of nitrous oxide in low concentrations"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Am&#46; J&#46; Physiol&#46;"
                        "fecha" => "1945"
                        "volumen" => "143"
                        "paginaInicial" => "53"
                        "paginaFinal" => "66"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            71 => array:3 [
              "identificador" => "bib72"
              "etiqueta" => "72&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of indomethacin pretreatment on acute mortality in experimental brain injury"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3171/jns.1989.71.4.0565"
                      "Revista" => array:6 [
                        "tituloSerie" => "J&#46; Neurosurg&#46;"
                        "fecha" => "1989"
                        "volumen" => "71"
                        "paginaInicial" => "565"
                        "paginaFinal" => "572"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            72 => array:3 [
              "identificador" => "bib73"
              "etiqueta" => "73&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Regulation of the cerebral circulation"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Ann&#46; Rev&#46; Physiol&#46;"
                        "fecha" => "1981"
                        "volumen" => "43"
                        "paginaInicial" => "397"
                        "paginaFinal" => "407"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            73 => array:3 [
              "identificador" => "bib74"
              "etiqueta" => "74&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Assessment of cerebral autoregulation dynamics"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Stroke"
                        "fecha" => "1992"
                        "volumen" => "23"
                        "paginaInicial" => "1031"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            74 => array:3 [
              "identificador" => "bib75"
              "etiqueta" => "75&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Responses to cerebral arterioles to acute hypotension and hypertension"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am&#46; J&#46; Physiol&#46;"
                        "fecha" => "1978"
                        "volumen" => "234"
                        "paginaInicial" => "H371"
                        "paginaFinal" => "H383"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            75 => array:3 [
              "identificador" => "bib76"
              "etiqueta" => "76&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dysautoregulation in patients with hypertensive intracerebral hemorrhage"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "A SPECT study&#44; in"
                        "fecha" => "1995"
                        "paginaInicial" => "237"
                        "paginaFinal" => "245"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            76 => array:3 [
              "identificador" => "bib77"
              "etiqueta" => "77&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Transmission of Increased Intracranial Pressure&#46; I&#46; Within the Craniospinal Axis"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3171/jns.1964.21.11.0989"
                      "Revista" => array:6 [
                        "tituloSerie" => "J&#46; Neurosurg&#46;"
                        "fecha" => "1964"
                        "volumen" => "21"
                        "paginaInicial" => "989"
                        "paginaFinal" => "997"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            77 => array:3 [
              "identificador" => "bib78"
              "etiqueta" => "78&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cerebral blood flow an oxygen consumption in man"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Physiol&#46; Rev&#46;"
                        "fecha" => "1959"
                        "volumen" => "39"
                        "paginaInicial" => "183"
                        "paginaFinal" => "238"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            78 => array:3 [
              "identificador" => "bib79"
              "etiqueta" => "79&#46;"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Lassen&#44; N&#46;A&#46; Cerebran and spinal cord blood flow&#44; in Cottrell&#44; J&#46;E&#46;&#44; Turndorf&#44; H&#46; &#40;eds&#41;&#58; St&#46; Louis&#44; C&#46;V&#46; Mosby&#59; 1986&#58; 1&#8211;21&#46;"
                ]
              ]
            ]
            79 => array:3 [
              "identificador" => "bib80"
              "etiqueta" => "80&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Funcion cerebral y flujo sangufneo"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Investigation y Ciencia"
                        "fecha" => "1990"
                        "paginaInicial" => "18"
                        "paginaFinal" => "28"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            80 => array:3 [
              "identificador" => "bib81"
              "etiqueta" => "81&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intracranial Pressure Monitoring&#46; Current Methods"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Problems of Intracranial Pressure in Childhood"
                        "paginaInicial" => "123"
                        "paginaFinal" => "140"
                        "serieFecha" => "1991"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            81 => array:3 [
              "identificador" => "bib82"
              "etiqueta" => "82&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The use of a fiber-optic intracranial pressure transducer in clinical practice"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:2 [
                        "tituloSerie" => "Proceedings of the Annual Meeting of the AANS"
                        "fecha" => "1976"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            82 => array:3 [
              "identificador" => "bib83"
              "etiqueta" => "83&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Molecular mechanisms of trauma-induced neuronal degeneration"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Current Opinion in Neurology and Neurosurgery"
                        "fecha" => "1993"
                        "volumen" => "6"
                        "paginaInicial" => "588"
                        "paginaFinal" => "596"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            83 => array:3 [
              "identificador" => "bib84"
              "etiqueta" => "84&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Excitatory amino acids as a final common pathway for neurologic disorders"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "N&#46; Eugl&#46; J&#46; Med&#46;"
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                        "volumen" => "330"
                        "paginaInicial" => "613"
                        "paginaFinal" => "622"
                      ]
                    ]
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                ]
              ]
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            84 => array:3 [
              "identificador" => "bib85"
              "etiqueta" => "85&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical experience with a fiber optic brain parenchymal pressure monitor"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Intra cranial Pressure VII"
                        "paginaInicial" => "35"
                        "paginaFinal" => "37"
                        "serieFecha" => "1989"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            85 => array:3 [
              "identificador" => "bib86"
              "etiqueta" => "86&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dissociation between cerebral autoregulation and carbon dioxide reactivity during nonpulsatile cardiopulmonary bypass"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Annals of Thoracic Surgery"
                        "fecha" => "1985"
                        "volumen" => "40"
                        "paginaInicial" => "582"
                        "paginaFinal" => "587"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
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            86 => array:3 [
              "identificador" => "bib87"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Traumatic Brain Edema&#58; An overview"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
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                    0 => array:1 [
                      "Revista" => array:4 [
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                        "paginaInicial" => "421"
                        "paginaFinal" => "424"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Impact of instability and hypotension on outcome in patients with severe head trauma"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J&#46; Neurosurg"
                        "fecha" => "1991"
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                        "numero" => "Suppl"
                        "paginaInicial" => "59"
                        "paginaFinal" => "66"
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                  "referenciaCompleta" => "Marshall&#44; R&#46;P&#46; &#40;eds&#41;&#58; Advances in Neurotraumatology&#46; Volume 1&#46; Extracerebral collections&#46; Wien&#44; SpringerVerlag&#59; 1986&#58; 209&#8211;228&#46;"
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            89 => array:3 [
              "identificador" => "bib90"
              "etiqueta" => "90&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Current head injury research"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Current Opinion in Neurology and Neurosurgery"
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                        "volumen" => "3"
                        "paginaInicial" => "4"
                        "paginaFinal" => "9"
                      ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A new classification of head injury based on computerized tomography"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
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                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J&#46; Neurosurg"
                        "fecha" => "1991"
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                        "numero" => "Suppl"
                        "paginaInicial" => "14"
                        "paginaFinal" => "20"
                      ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Brain swelling caued by trauma and arterial hypertension&#46; Hemodynamic aspects"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
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                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch&#46; Neurol&#46;"
                        "fecha" => "1969"
                        "volumen" => "21"
                        "paginaInicial" => "545"
                        "paginaFinal" => "553"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
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              ]
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              "identificador" => "bib93"
              "etiqueta" => "93&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Noninvasive cerebral optical spectroscopy for monitoring cerebral oxygen delivery and hemodynamics"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/01.CCM.0000037960.70104.1E"
                      "Revista" => array:5 [
                        "tituloSerie" => "Crit&#46; Care&#46; Med&#46;"
                        "fecha" => "1991"
                        "paginaInicial" => "89"
                        "paginaFinal" => "97"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
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              ]
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              "identificador" => "bib94"
              "etiqueta" => "94&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intracerebral penetration of infrared light&#46; Technical note"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3171/jns.1992.76.2.0315"
                      "Revista" => array:6 [
                        "tituloSerie" => "J&#46; Neurosurg&#46;"
                        "fecha" => "1992"
                        "volumen" => "76"
                        "paginaInicial" => "315"
                        "paginaFinal" => "318"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib95"
              "etiqueta" => "95&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The Circulatory System"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Cardiovascular Physiology"
                        "paginaInicial" => "3"
                        "paginaFinal" => "28"
                        "serieFecha" => "1990"
                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib96"
              "etiqueta" => "96&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Primary focal impact damage to the brainstem in blunt head injuries&#46; Does it exist&#63;"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1973"
                        "volumen" => "2"
                        "paginaInicial" => "215"
                        "paginaFinal" => "218"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib97"
              "etiqueta" => "97&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cerebral blood flow&#44; cerebral blood volume and cerebral metabolism after severe head injury"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
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                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Textbook of Head Injury"
                        "paginaInicial" => "221"
                        "paginaFinal" => "240"
                        "serieFecha" => "1989"
                      ]
                    ]
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              ]
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              "identificador" => "bib98"
              "etiqueta" => "98&#46;"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Overview of monitoring of cerebral blood flow and metabolism after severe head injury"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Can&#46; J&#46; Neurol&#46; Sci&#46;"
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                        "volumen" => "21"
                        "paginaInicial" => "S6"
                        "paginaFinal" => "S11"
                         …1
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                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib99"
              "etiqueta" => "99&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cerebral blood flow and metabolism in severely head-injured children&#46; Part 2&#58; Autoregulation"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3171/jns.1989.71.1.0072"
                      "Revista" => array:6 [ …6]
                    ]
                  ]
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              ]
            ]
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              "identificador" => "bib100"
              "etiqueta" => "100&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Raised intracranial pressure"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:2 [ …2]
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              "identificador" => "bib101"
              "etiqueta" => "101&#46;"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cerebral blood flow and metabolism in comatose patients with acute head injury Relationship to intracranial hypertension"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3171/jns.1984.61.2.0241"
                      "Revista" => array:6 [ …6]
                    ]
                  ]
                ]
              ]
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            101 => array:3 [
              "identificador" => "bib102"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Glutamate receptor-mediated neurotoxicity"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [ …4]
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                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Restoration of autoregulation of cerebral blood flow by hypocapnia"
                      "autores" => array:1 [ …1]
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                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [ …5]
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                    0 => array:2 [
                      "titulo" => "Cerebral circulation under normal and pathologic conditions"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [ …5]
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              "identificador" => "bib105"
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                      "titulo" => "Hipertensi&#243;n intracraneal en la fase aguda de los traumatismos craneoencef&#225;licos&#46; Estudio de la incidencia en funci&#243;n del tipo de lesi&#243;n"
                      "autores" => array:1 [ …1]
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                    0 => array:1 [
                      "Revista" => array:2 [ …2]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Experimental studies of head injury"
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                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [ …4]
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                    0 => array:1 [
                      "autores" => array:1 [ …1]
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                    0 => array:1 [
                      "Revista" => array:4 [ …4]
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                      "titulo" => "Fate of reactive axonal swellings induced by head injury"
                      "autores" => array:1 [ …1]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [ …6]
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                      "titulo" => "Axonal change in minor head injury"
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [ …6]
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                      "titulo" => "Failure of autoregulation after closed head injury&#58; An experimental model"
                      "autores" => array:1 [ …1]
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                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [ …6]
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              "etiqueta" => "112&#46;"
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                      "titulo" => "Cerebral circulatory monitoring"
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                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:6 [ …6]
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                      "titulo" => "Correlation between regional cerebral blood flow and oxidative metabolism&#46; In vivo studies in man"
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                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [ …6]
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                      "doi" => "10.1038/jcbfm.1981.34"
                      "Revista" => array:6 [ …6]
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                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Anaerobic metabolism within the brain&#58; Its relationship to brain failure in head-injured patients"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:6 [ …6]
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              "etiqueta" => "116&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The predictive value of cerebral anaerobic metabolism with cerebral infarction after head injury"
                      "autores" => array:1 [ …1]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3171/jns.1987.67.3.0361"
                      "Revista" => array:6 [ …6]
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            115 => array:3 [
              "identificador" => "bib116"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cerebral arteriovenous oxygen difference as an estimate of cerebral blood flow in comatose patients"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [ …5]
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            116 => array:3 [
              "identificador" => "bib117"
              "etiqueta" => "118&#46;"
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                  "contribucion" => array:1 [
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                      "titulo" => "Intracranial presure monitoring in patients with cerebral hemorrhage &#40;letter&#41;"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [ …5]
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            117 => array:3 [
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              "referencia" => array:1 [
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                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The vasodilatory cascade and intracranial pressure"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [ …4]
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Cerebral perfusion pressure&#58; Link between intracranial pressure and systemic circulatio"
                      "autores" => array:1 [ …1]
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                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:6 [ …6]
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            119 => array:3 [
              "identificador" => "bib120"
              "etiqueta" => "121&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pathophysiology and management of increased intracraial pressure"
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                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [ …4]
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              "etiqueta" => "122&#46;"
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                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "CPP management I&#46;&#58; Results"
                      "autores" => array:1 [ …1]
                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [ …4]
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            121 => array:3 [
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                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Re-examining the issue of intracranial pressure gradients in head injury Its relevance in optimizin patient management"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [ …4]
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            122 => array:3 [
              "identificador" => "bib123"
              "etiqueta" => "124&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Reactividad vascular al CO2 en la fase aguda de los traumatis mos craneoencef&#225;licos severos&#46; Estudio preliminar de 20 casos"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [ …5]
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            123 => array:3 [
              "identificador" => "bib124"
              "etiqueta" => "125&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Acute subdural hematoma an diffuse axonal injury after severe head trauma&#46; Clinico-pathological study"
                      "autores" => array:1 [ …1]
                    ]
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                    0 => array:2 [
                      "doi" => "10.3171/jns.1988.68.6.0894"
                      "Revista" => array:6 [ …6]
                    ]
                  ]
                ]
              ]
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            124 => array:3 [
              "identificador" => "bib125"
              "etiqueta" => "126&#46;"
              "referencia" => array:1 [
                0 => array:2 [
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Información del artículo

ISSN: 11301473
Idioma original: Español

DOI:10.1016/S1130-1473(97)70728-0

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