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                      "doi" => "10.3171/jns.1983.58.2.0159"
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                        "tituloSerie" => "J&#46; Neurosurg&#46;"
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                        "volumen" => "58"
                        "paginaInicial" => "159"
                        "paginaFinal" => "169"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6294260"
                            "web" => "Medline"
                          ]
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            11 => array:3 [
              "identificador" => "bib12"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Absence of contrast enhancement on CT brain scans of patients with supratentorial malignant gliomas"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46;C&#46; Chamberlain"
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                            2 => "V&#46;A&#46; Levin"
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurology"
                        "fecha" => "1988"
                        "volumen" => "38"
                        "paginaInicial" => "1371"
                        "paginaFinal" => "1374"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2842701"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
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                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Long-term survival in patients with glioblastoma multiforme"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "K&#46;L&#46; Chandler"
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                            2 => "M&#46; Malee"
                            3 => "C&#46;B&#46; Wilson"
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurosurgery"
                        "fecha" => "1993"
                        "volumen" => "32"
                        "paginaInicial" => "716"
                        "paginaFinal" => "720"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8388081"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Olioblastoma multiforme del quiasma &#243;ptico"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Clavel Escribano"
                            1 => "J&#46; Roussos Prindesis"
                            2 => "R&#46; Dinares Sola"
                            3 => "V&#46; Marco Molina"
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
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                        "tituloSerie" => "Rev&#46; Esp&#46; Neurol&#46;"
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                        "volumen" => "4"
                        "paginaInicial" => "516"
                        "paginaFinal" => "518"
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                    ]
                  ]
                ]
              ]
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            14 => array:3 [
              "identificador" => "bib15"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Survival after stereotactic biopsy of malignant gliomas"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "R&#46;J&#46; Coffey"
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                            2 => "F&#46;H&#46; Taylor"
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurosurgery"
                        "fecha" => "1988"
                        "volumen" => "22"
                        "paginaInicial" => "465"
                        "paginaFinal" => "473"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2452376"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Assessment of the long-term effects of primary radiation therapy for brain tumors in children"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "B&#46;F&#46; Danoff"
                            1 => "S&#46; Cowchock"
                            2 => "C&#46; Marquette"
                            3 => "L&#46; Mulgrew"
                            4 => "S&#46; Kramer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer"
                        "fecha" => "1982"
                        "volumen" => "49"
                        "paginaInicial" => "1580"
                        "paginaFinal" => "1586"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7066864"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Reseetion&#44; biopsy&#44; and survival in malignant glial neoplasms&#46; A retrospective study of clinical parameters&#44; therapy&#44; and outcome"
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                        0 => array:2 [
                          "etal" => false
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                            0 => "B&#46;C&#46; Devaux"
                            1 => "J&#46;R&#46; O&#8217;Fallon"
                            2 => "P&#46;J&#46; Kelly"
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                        ]
                      ]
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                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3171/jns.1993.78.5.0767"
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                        "tituloSerie" => "J&#46; Neurosurg&#46;"
                        "fecha" => "1993"
                        "volumen" => "78"
                        "paginaInicial" => "767"
                        "paginaFinal" => "775"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8468607"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Olioblastoma multiforme in children"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "G&#46; Dohrman"
                            1 => "J&#46;R&#46; Farwell"
                            2 => "J&#46;T&#46; Flannery"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3171/jns.1976.44.4.0442"
                      "Revista" => array:6 [
                        "tituloSerie" => "J&#46; Neurosurg&#46;"
                        "fecha" => "1976"
                        "volumen" => "44"
                        "paginaInicial" => "442"
                        "paginaFinal" => "449"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/176331"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Late effects of treatment on the intelligenee of children with posterior fossa tumors"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "P&#46;K&#46; Duffner"
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                            2 => "P&#46; Thomas"
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                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer"
                        "fecha" => "1983"
                        "volumen" => "51"
                        "paginaInicial" => "233"
                        "paginaFinal" => "237"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6821813"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intellectual abilities among survivors of childhood leukemia as a function of CNS irradiation"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "C&#46; Eiser"
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch&#46; Dis&#46; Child&#46;"
                        "fecha" => "1978"
                        "volumen" => "53"
                        "paginaInicial" => "391"
                        "paginaFinal" => "395"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/276312"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Central nervous system tumors in children"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46;R&#46; Farwell"
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                            2 => "J&#46;T&#46; Flannery"
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                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer"
                        "fecha" => "1977"
                        "volumen" => "40"
                        "paginaInicial" => "3123"
                        "paginaFinal" => "3132"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/201364"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Treatment of children with progressive or recurrent brain tumors with carboplatin or iproplatin&#58; a Pediatric Oncology Group randomized phase II study"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "H&#46;S&#46; Friedman"
                            1 => "J&#46;P&#46; Krischer"
                            2 => "P&#46; Burger"
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
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                      "Revista" => array:6 [
                        "tituloSerie" => "J&#46; Clin&#46; Oncol&#46;"
                        "fecha" => "1992"
                        "volumen" => "10"
                        "paginaInicial" => "249"
                        "paginaFinal" => "256"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1732426"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Medulloblastoma in childhood&#46; Survival and functional results"
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                            0 => "J&#46;F&#46; Hirsch"
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                            2 => "P&#46; Czernichow"
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Acta Neuroehir&#46;"
                        "fecha" => "1979"
                        "volumen" => "48"
                        "paginaInicial" => "1"
                        "paginaFinal" => "15"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Optic glioma of childhood&#46; Natural history and rationale for conservative management"
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                            0 => "W&#46;F&#46; Hoyt"
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
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                        "fecha" => "1969"
                        "volumen" => "53"
                        "paginaInicial" => "793"
                        "paginaFinal" => "798"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5386369"
                            "web" => "Medline"
                          ]
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                ]
              ]
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            24 => array:3 [
              "identificador" => "bib25"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Malignant optic glioma of adulthood"
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                            4 => "R&#46;D&#46; Suckling"
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Brain"
                        "fecha" => "1973"
                        "volumen" => "96"
                        "paginaInicial" => "121"
                        "paginaFinal" => "132"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4695718"
                            "web" => "Medline"
                          ]
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                ]
              ]
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            25 => array:3 [
              "identificador" => "bib26"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Imaging-based stereotaxic serial biopsies in untreated intracranial glial neoplasms"
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                          "etal" => false
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                            3 => "B&#46;A&#46; Kall"
                            4 => "B&#46;W&#46; Scheithauer"
                            5 => "J&#46;J&#46; Illig"
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                        ]
                      ]
                    ]
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                    0 => array:2 [
                      "doi" => "10.3171/jns.1987.66.6.0865"
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                        "tituloSerie" => "J&#46; Neurosurg&#46;"
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                        "paginaFinal" => "874"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3033172"
                            "web" => "Medline"
                          ]
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            26 => array:3 [
              "identificador" => "bib27"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Surgical resection and radiation therapy versus biopsy and radiation therapy in the treatment of glioblastoma multiforme"
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                    0 => array:2 [
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                        "paginaFinal" => "766"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8385709"
                            "web" => "Medline"
                          ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tumors of the cerebral hemispheres in children"
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                        "paginaInicial" => "547"
                        "paginaFinal" => "554"
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              ]
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            28 => array:3 [
              "identificador" => "bib29"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
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                ]
              ]
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Carboplatin treatment of progressive optic pathway gliomas to delay radiotherapy"
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                    0 => array:2 [
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8331404"
                            "web" => "Medline"
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                    ]
                  ]
                ]
              ]
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            30 => array:3 [
              "identificador" => "bib31"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Positron emission tomography with 11 C-methionine and computed tomography of intracranial tumours compared with histopathologic examination of multiple biopsies"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "M&#46; Mosskin"
                            1 => "H&#46; von Holst"
                            2 => "M&#46; Bergstr&#246;m"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Radiol&#46;"
                        "fecha" => "1987"
                        "volumen" => "28"
                        "paginaInicial" => "673"
                        "paginaFinal" => "681"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2962599"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib32"
              "etiqueta" => "32&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The role of surgery in the management of supratentorial intermediate and high-grade astrocytomas in adults"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;M&#46; Nazzaro"
                            1 => "E&#46;A&#46; Neuwelt"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3171/jns.1990.73.3.0331"
                      "Revista" => array:6 [
                        "tituloSerie" => "J&#46; Neurosurg&#46;"
                        "fecha" => "1990"
                        "volumen" => "73"
                        "paginaInicial" => "331"
                        "paginaFinal" => "344"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2166779"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib33"
              "etiqueta" => "33&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Survival and prognosis of patients with astrocytoma with atypical or anaplastic features"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "D&#46;F&#46; Nelson"
                            1 => "J&#46;S&#46; Nelson"
                            2 => "D&#46;R&#46; Davis"
                            3 => "C&#46;H&#46; Chang"
                            4 => "T&#46;W&#46; Griffin"
                            5 => "T&#46;F&#46; Pajak"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J&#46; Neurooneol&#46;"
                        "fecha" => "1985"
                        "volumen" => "3"
                        "paginaInicial" => "99"
                        "paginaFinal" => "103"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib34"
              "etiqueta" => "34&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The dilemma of childhood optic gliomas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46;C&#46; Oxenhandler"
                            1 => "M&#46;P&#46; Sayers"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3171/jns.1978.48.1.0034"
                      "Revista" => array:6 [
                        "tituloSerie" => "J&#46; Neurosurg&#46;"
                        "fecha" => "1978"
                        "volumen" => "48"
                        "paginaInicial" => "34"
                        "paginaFinal" => "41"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/412924"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib35"
              "etiqueta" => "35&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A prospective study of cognitive function in ehildren receiving whole-brain radiotherapy and chemotherapy&#58; 2-year results"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "R&#46;J&#46; Pacher"
                            1 => "L&#46;N&#46; Sutton"
                            2 => "T&#46;E&#46; Atkins"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3171/jns.1989.70.5.0707"
                      "Revista" => array:6 [
                        "tituloSerie" => "J&#46; Neurosurg&#46;"
                        "fecha" => "1989"
                        "volumen" => "70"
                        "paginaInicial" => "707"
                        "paginaFinal" => "713"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2709111"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib36"
              "etiqueta" => "36&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Management of chiasmal and hypothalamic gliomas of infancy and childhood with chemotherapy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "J&#46; Petronio"
                            1 => "M&#46;S&#46;B&#46; Edwards"
                            2 => "M&#46; Prados"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3171/jns.1991.74.5.0701"
                      "Revista" => array:6 [
                        "tituloSerie" => "J&#46; Neurosurg&#46;"
                        "fecha" => "1991"
                        "volumen" => "74"
                        "paginaInicial" => "701"
                        "paginaFinal" => "708"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1901597"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib37"
              "etiqueta" => "37&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Supratentorial malignant gliomas of childhood&#46; Results of treatment with radiation therapy and chemotherapy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "S&#46; Phuphanich"
                            1 => "M&#46;S&#46;B&#46; Edwards"
                            2 => "V&#46;A&#46; Levin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Neurosurg&#46;"
                        "fecha" => "1984"
                        "volumen" => "60"
                        "paginaInicial" => "465"
                        "paginaFinal" => "499"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib38"
              "etiqueta" => "38&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Optic glioma&#46; Long-term folow-up of 85 histopathologically verified cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "J&#46;A&#46; Rush"
                            1 => "B&#46;R&#46; Younge"
                            2 => "R&#46;J&#46; Campbell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ophthalmology"
                        "fecha" => "1982"
                        "volumen" => "89"
                        "paginaInicial" => "1213"
                        "paginaFinal" => "1219"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6818504"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib39"
              "etiqueta" => "39&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidemiology and faetors affeeting survival"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "M&#46; Saloman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:6 [
                        "editores" => "M&#46;L&#46;J&#46;Apuzzo"
                        "paginaInicial" => "95"
                        "paginaFinal" => "111"
                        "serieVolumen" => "95"
                        "serieTitulo" => "Malignant cerebral glioma&#46; Neurosurgieal Topies"
                        "serieFecha" => "1990"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            39 => array:3 [
              "identificador" => "bib40"
              "etiqueta" => "40&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Long-term survival in patients with malignant astrocytoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Saloman"
                            1 => "H&#46; Scholtz"
                            2 => "R&#46;S&#46; Kaplan"
                            3 => "S&#46; Kulik"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Naurosurgery"
                        "fecha" => "1994"
                        "volumen" => "34"
                        "paginaInicial" => "213"
                        "paginaFinal" => "220"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            40 => array:3 [
              "identificador" => "bib41"
              "etiqueta" => "41&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Radiotherapy of intracranial astrocytomas&#58; analysis of 417 cases treated from 1960 through 1969"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "P&#46;W&#46; Scanlon"
                            1 => "W&#46;F&#46; Taylor"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurosurgery"
                        "fecha" => "1979"
                        "volumen" => "5"
                        "paginaInicial" => "301"
                        "paginaFinal" => "308"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/228216"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            41 => array:3 [
              "identificador" => "bib42"
              "etiqueta" => "42&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Treatment of neuroectodermal brain tumors"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "W&#46;R&#46; Shapiro"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/ana.410120302"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann&#46; Neurol&#46;"
                        "fecha" => "1982"
                        "volumen" => "12"
                        "paginaInicial" => "231"
                        "paginaFinal" => "237"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6753729"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            42 => array:3 [
              "identificador" => "bib43"
              "etiqueta" => "43&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Postoperative regression of optochiasma astrocytoma&#58; a case for expectant therapy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46;L&#46; Venes"
                            1 => "J&#46; Latack"
                            2 => "R&#46;S&#46; Kandt"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurosurgery"
                        "fecha" => "1984"
                        "volumen" => "15"
                        "paginaInicial" => "421"
                        "paginaFinal" => "423"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6435008"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            43 => array:3 [
              "identificador" => "bib44"
              "etiqueta" => "44&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Randomized comparisons of radiotherapy and nitrosoureas for&#44; the treatment of malignant glioma after surgery"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "M&#46;D&#46; Walker"
                            1 => "S&#46;B&#46; Green"
                            2 => "D&#46;P&#46; Byar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM198012043032303"
                      "Revista" => array:6 [
                        "tituloSerie" => "N&#46; Engl&#46; J&#46; Med&#46;"
                        "fecha" => "1980"
                        "volumen" => "303"
                        "paginaInicial" => "1323"
                        "paginaFinal" => "1329"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7001230"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            44 => array:3 [
              "identificador" => "bib45"
              "etiqueta" => "45&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Malignant evolution of childhood chiasmal pilocytic astrocytoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "W&#46;B&#46; Wilson"
                            1 => "M&#46; Feinsod"
                            2 => "W&#46;F&#46; Hoyt"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurology"
                        "fecha" => "1976"
                        "volumen" => "26"
                        "paginaInicial" => "322"
                        "paginaFinal" => "325"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/944389"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            45 => array:3 [
              "identificador" => "bib46"
              "etiqueta" => "46&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The prognostic importance of tumor size in malignant gliomas&#58; a computed tomographic scan study by the Brain Tumor Cooperative Group"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46;R&#46; Wood"
                            1 => "S&#46;B&#46; Green"
                            2 => "W&#46;R&#46; Shapiro"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1200/jco.1988.6.2.338"
                      "Revista" => array:6 [
                        "tituloSerie" => "J&#46; Clin&#46; Oncol&#46;"
                        "fecha" => "1988"
                        "volumen" => "6"
                        "paginaInicial" => "338"
                        "paginaFinal" => "343"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3339397"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            46 => array:3 [
              "identificador" => "bib47"
              "etiqueta" => "47&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Brain Tumors&#46; Their biology and pathology"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "K&#46;J&#46; Z&#252;lch"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:4 [
                        "edicion" => "2&#170;"
                        "fecha" => "1965"
                        "editorial" => "Springer"
                        "editorialLocalizacion" => "New York"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
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Vol. 7. Núm. 1.
Páginas 49-54 (enero 1996)
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Vol. 7. Núm. 1.
Páginas 49-54 (enero 1996)
Evolución benigna de un glioblastoma multiforme hipotalámico. Caso clínico
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2893
M. Clavel Escribano, B. López Ibor, P. Clavel Laria
Servicios de Neurocirugía y Oncología Pediátrica del Hospital General de Cataluña. Barcelona
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Resumen

Se presenta una niña de dos años de edad con inicio de un cuadro agudo de hipertensión craneal de pocas horas de evolución. En los estudios de neuroimagen se apreció una gran tumoración hipotalámica (glioblastoma multiforme) extendida al tercer ventrículo y suelo de ambos ventrículos laterales, provocando una hidrocefalia por obstrucción de ambos agujeros de Monro. La tumoración fue resecada de forma subtotal con un abordaje microquirúrgico subfrontal bilateral.

Posteriormente fue tratada con ciclos de quimioterapia, desapareciendo en la última RM la imagen del único resto tumoral que infiltraba el quiasma óptico. Casi tres años tras la intervención, la niña se encuentra asintomática y libre de tumor.

Palabras Clave:
Glioblastoma multiforme hipotalámico
Resección quirúrgica
Quimioterapia
Summary

We are reporting the case of a two years old girl with a clinical history of sudden onset of increased intracranial pressure. The neuroimaging studies disclosed a large hypothalamic mass (glioblastoma multiforme) extending to the third ventricle and the floor of the lateral ventricles, causing hydrocephalus by the obstruction of Monro foramina. The tumor was subtotalIy resected through a subfrontal bilateral microsurgical approach.

After surgery she was treated with several cycles of chemotherapy. The only rest of the tumor, left at the level of the optic chiasm, disappeared in the last MRI control. Three years after surgery the patient is asymptomatic and tumor-free.

Key Words:
Hypothalamic glioblastoma multiforme
Surgical resection
Chemotherapy

Artículo

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