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        "titulo" => "Abstract"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Lactate dehydrogenase &#40;LDH&#41; enzyme activity has not been analyzed in neonatal nontumoral hydrocephalus&#46; We studied 14 patients with nontumoral hydrocephalus &#40;7 males and 7 females&#41; with ages ranging between 1 and 18 months&#46; All patients were treated by ventriculo-peritoneal shunt&#44; and evaluated clinically and by meassurement of LDH activity in cerebrospinal fluid &#40;CSF&#41; and blood&#44; both&#44; preoperatively and 10 days after the placement of the shunt&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">All patients showed high levels of LDH in the CSF&#44; and high CSF&#47;Blood LDH ratio in the preoperative samples&#46; Although all the patients had clinical improvement&#44; and some of them showed radiological improvement&#44; most retained high levels of LDH activity in the CSF &#40;13 out of 14 patients&#41;&#44; and high CSF&#47;Blood ratio &#40;9 out of 14 patients&#41;&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">In spite of the clinical and radiological improvement due to the control of raised intracranial pressure by shunting&#44; the improvement of metabolic activity of the brain&#44; as measured by LDH activity was not normalized during the investigation periodo Therefore&#44; we feel that the follow-up of such patients using metabolic activity of the brain by monitoring LDH as a marker might be more sensitive than the morphological and clinical parameters&#46;</p>"
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        "resumen" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La actividad enzim&#225;tica de lactato deshidrogenasa &#40;LDH&#41; en las hidrocefalias de origen no tumoral en lactantes es desconocida&#46; Se estudiaron 14 pacientes con hidrocefalia no tumoral&#44; 7 ni&#241;os y 7 ni&#241;as&#44; con edades comprendidas entre 1 y 18 meses&#46; Todos ellos fueron tratados con v&#225;lvulas ventr&#237;culo-peritoneales&#46; Fueron evaluados cl&#237;nicamente&#44; radiol&#243;gicamente&#44; y mediante la detecci&#243;n de LDH en el l&#237;quido cefalorraqu&#237;deo &#40;LCR&#41; antes de la implantaci&#243;n de la v&#225;lvula y 10 d&#237;as despu&#233;s de su implantaci&#243;n&#46;</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Todos los pacientes mostraron niveles elevados de LDH en el LCR y elevaci&#243;n del &#237;ndice LCR&#47;sangre en el per&#237;odo preoperatorio&#46; Diez d&#237;as despu&#233;s de la implantaci&#243;n de v&#225;lvula experimentaron cierta mejor&#237;a cl&#237;nica y radiol&#243;gica&#44; sin embargo los niveles de LDH en el LCR permanecieron elevados en 13 de 14 de los casos&#44; y en 9 de 14 permaneci&#243; elevado el &#237;ndice CSF&#47;sangre&#46;</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A pesar de la mejor&#237;a cl&#237;nica y radiol&#243;gica observada en algunos pacientes debido al alivio de la hipertensi&#243;n intracranial por las v&#225;lvulas&#44; la condici&#243;n metab&#243;lica del enc&#233;falo&#44; estimada a trav&#233;s de la LDH no se normaliz&#243; en este per&#237;odo de tiempo&#46; Por ello creemos que el seguimiento de este tipo de pacientes a trav&#233;s de par&#225;metros metab&#243;licos puede ser m&#225;s sensible para detectar disfunci&#243;n cerebral que los par&#225;metros morfol&#243;gicos o cl&#237;nicos&#46;</p>"
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                      "titulo" => "Anaerobic glycolysis preceding white-matter destruction in experimental neonatal hydrocephalus"
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                          "autores" => array:3 [
                            0 => "P&#46;D&#46; Chumas"
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                            2 => "M&#46;R&#46; Del Bigio"
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                      ]
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                    0 => array:2 [
                      "doi" => "10.3171/jns.1994.80.3.0491"
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                        "tituloSerie" => "J&#46; Neurosurg"
                        "fecha" => "1994"
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                        "paginaFinal" => "494"
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                          0 => array:2 [
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                      "titulo" => "Magnetic Resonance demonstration of intracranial CSF flow in Children"
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                            3 => "M&#46; Campanioni"
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                        "paginaFinal" => "381"
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                          ]
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                      "titulo" => "Computer assisted topography and pneumoencephalography in nontumorous hydrocephalus in infant and children"
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                    ]
                  ]
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                      "Revista" => array:5 [
                        "tituloSerie" => "J&#46; Computo Assist&#46; Tomogr"
                        "fecha" => "1977"
                        "volumen" => "1"
                        "paginaInicial" => "204"
                        "paginaFinal" => "210"
                      ]
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                      "titulo" => "Infantile hydrocephalus epidemiology&#58; An indicator of enhanced survival"
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                          "autores" => array:3 [
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                            2 => "B&#46; Hagberg"
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                    ]
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                        "paginaInicial" => "120"
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                  ]
                ]
              ]
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                      "titulo" => "Changes in cerebrospinal fluid enzyme activity after severe head injury&#46; Diagnostic and prognostic values"
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                          "etal" => false
                          "autores" => array:5 [
                            0 => "P&#46; Hans"
                            1 => "J&#46; Born"
                            2 => "J&#46; Chapelle"
                            3 => "E&#46; Sypropoulos"
                            4 => "L&#46; Bodson"
                          ]
                        ]
                      ]
                    ]
                  ]
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                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Acta&#44; Anesthesiol&#46; Belg&#46;"
                        "fecha" => "1984"
                        "volumen" => "35"
                        "paginaInicial" => "79"
                        "paginaFinal" => "86"
                      ]
                    ]
                  ]
                ]
              ]
            ]
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                      "titulo" => "Cerebrospinal fluid production and histological observations in animals with experimental obstructive hydrocephaluso Exp"
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                          "etal" => false
                          "autores" => array:4 [
                            0 => "G&#46;M&#46; Hochwald"
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                            2 => "A&#46;R&#46; Sadik"
                            3 => "J&#46; Ransohoff"
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                        ]
                      ]
                    ]
                  ]
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                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Neurol"
                        "fecha" => "1969"
                        "volumen" => "25"
                        "paginaInicial" => "190"
                        "paginaFinal" => "199"
                      ]
                    ]
                  ]
                ]
              ]
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                      "titulo" => "Determination of CSF lactate concentration by LDH enzymes for the diagnosis of bacterial and viral meningitis"
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                          "autores" => array:3 [
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                            2 => "G&#46; Secmmer"
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                        ]
                      ]
                    ]
                  ]
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                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Mikrobiol&#46; Bul"
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                        "volumen" => "23"
                        "paginaInicial" => "105"
                        "paginaFinal" => "110"
                      ]
                    ]
                  ]
                ]
              ]
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                    0 => array:2 [
                      "titulo" => "LDH enzymes in cerebrospinal fluid in various brain tumors"
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                        0 => array:2 [
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                          "autores" => array:4 [
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                            2 => "Y&#46; Eshel"
                            3 => "I&#46; Sarova-Pinhas"
                          ]
                        ]
                      ]
                    ]
                  ]
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                      "Revista" => array:7 [
                        "tituloSerie" => "J&#46; Neurol&#46; Neurosurg&#46; Psychiatry"
                        "fecha" => "1989"
                        "volumen" => "53"
                        "paginaInicial" => "697"
                        "paginaFinal" => "699"
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                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2213048"
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                        "tituloSerie" => "Neurosurg&#46; Norh Am"
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                        "paginaFinal" => "93"
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                      "titulo" => "Cerebrospinal fluid and extracellular fluid&#58; Their relationship to pressure and duration of canine hydrocephalus"
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                          "autores" => array:1 [
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Child&#39;s Nerv Syst"
                        "fecha" => "1985"
                        "volumen" => "1"
                        "paginaInicial" => "12"
                        "paginaFinal" => "15"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Enzymatic changes in the cerebrospinal fluid as indices of pathological changes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46; Pasaoglu"
                            1 => "H&#46; Pasaglu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Acta&#46; Neurochir&#46; &#40;Wien&#41;"
                        "fecha" => "1989"
                        "volumen" => "97"
                        "paginaInicial" => "71"
                        "paginaFinal" => "76"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The brain as sponge&#58; A Computed tomographic look at Hakim Hypothesis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46;A&#46; Pen"
                            1 => "J&#46;W&#46; Bacus"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Neurosurgery"
                        "fecha" => "1984"
                        "volumen" => "14"
                        "paginaInicial" => "670"
                        "paginaFinal" => "675"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6462401"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S1699258X06730157"
                          "estado" => "S300"
                          "issn" => "1699258X"
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                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The surgical treatment of Hydrocephalus&#46; An historical review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "R&#46;H&#46; Pudenz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Surg&#46; Neurol"
                        "fecha" => "1981"
                        "volumen" => "15"
                        "paginaInicial" => "15"
                        "paginaFinal" => "26"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7256520"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "En Pediatric Neurosurgery"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "A&#46;J&#46; Raimondi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Theoretical principIes&#46; Art of surgical technique"
                        "paginaInicial" => "454"
                        "paginaFinal" => "464"
                        "serieFecha" => "1987"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Study of serum and cerebrospinal enzyme in diagnosis of cerebrovascular disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "B&#46; Ruzak-Skocir"
                            1 => "M&#46; Trbojevic-Cepe"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurologija"
                        "fecha" => "1990"
                        "volumen" => "39"
                        "paginaInicial" => "239"
                        "paginaFinal" => "250"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2290471"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Changes in Glucose metabolism with time in hydrocephalus rats"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "T&#46; Songabe"
                            1 => "M&#46; Matsumae"
                            2 => "O&#46; Sato"
                            3 => "I&#46; Miura"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Biochem&#46; lnt"
                        "fecha" => "1989"
                        "volumen" => "19"
                        "paginaInicial" => "513"
                        "paginaFinal" => "518"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Long term outcome in aqueduct stenosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "R&#46; Villani"
                            1 => "G&#46; Tomei"
                            2 => "S&#46;M&#46; Gaini"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Child&#39;s Nerv&#46; Syst"
                        "fecha" => "1995"
                        "volumen" => "11"
                        "paginaInicial" => "180"
                        "itemHostRev" => array:3 [
                          "pii" => "S1699258X05727443"
                          "estado" => "S300"
                          "issn" => "1699258X"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cerebrospinal edema and its sequel in hydrocephalus"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46;O&#46; Weller"
                            1 => "J&#46; Mitchell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:6 [
                        "editores" => "Jj&#46;Cervos-NavarroR&#46;Fersz"
                        "paginaInicial" => "pp111"
                        "paginaFinal" => "pp123"
                        "serieVolumen" => "28"
                        "serieTitulo" => "Advances in Neurology&#58; Brain Edema"
                        "serieFecha" => "1980"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "II&#58; Gliosis and ganglion cell death in the developing cat retina during hydrocephalus and after decopression"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "E&#46;C&#46; Williamson"
                            1 => "R&#46;E&#46; Pearson"
                            2 => "J&#46;P&#46; McAllister"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Dev&#46; Brain Res"
                        "fecha" => "1992"
                        "volumen" => "70"
                        "paginaInicial" => "47"
                        "paginaFinal" => "49"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
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Vol. 11. Núm. 1.
Páginas 59-62 (enero 1999)
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Vol. 11. Núm. 1.
Páginas 59-62 (enero 1999)
Lactate dehydrogenase enzyme as a metabolic marker for the evaluation of shunting in infants with non-tumoral hydrocephalus
Lactato deshidrogenasa como marcador metabólico en la evaluación de válvulas en lactantes con hidrocefalia no tumoral
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1664
A. Faleh Tamimi, M. Al Khatib, W. Almmani, A. Qudah
Section of Neurosurgery, and Section of Clinical Laboratories. Hospital of Jordan University. Arnman. Jordania
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Abstract

Lactate dehydrogenase (LDH) enzyme activity has not been analyzed in neonatal nontumoral hydrocephalus. We studied 14 patients with nontumoral hydrocephalus (7 males and 7 females) with ages ranging between 1 and 18 months. All patients were treated by ventriculo-peritoneal shunt, and evaluated clinically and by meassurement of LDH activity in cerebrospinal fluid (CSF) and blood, both, preoperatively and 10 days after the placement of the shunt.

All patients showed high levels of LDH in the CSF, and high CSF/Blood LDH ratio in the preoperative samples. Although all the patients had clinical improvement, and some of them showed radiological improvement, most retained high levels of LDH activity in the CSF (13 out of 14 patients), and high CSF/Blood ratio (9 out of 14 patients).

In spite of the clinical and radiological improvement due to the control of raised intracranial pressure by shunting, the improvement of metabolic activity of the brain, as measured by LDH activity was not normalized during the investigation periodo Therefore, we feel that the follow-up of such patients using metabolic activity of the brain by monitoring LDH as a marker might be more sensitive than the morphological and clinical parameters.

Key words:
Hydrocephalus
Infants
Lactate dehydrogenase
Resumen

La actividad enzimática de lactato deshidrogenasa (LDH) en las hidrocefalias de origen no tumoral en lactantes es desconocida. Se estudiaron 14 pacientes con hidrocefalia no tumoral, 7 niños y 7 niñas, con edades comprendidas entre 1 y 18 meses. Todos ellos fueron tratados con válvulas ventrículo-peritoneales. Fueron evaluados clínicamente, radiológicamente, y mediante la detección de LDH en el líquido cefalorraquídeo (LCR) antes de la implantación de la válvula y 10 días después de su implantación.

Todos los pacientes mostraron niveles elevados de LDH en el LCR y elevación del índice LCR/sangre en el período preoperatorio. Diez días después de la implantación de válvula experimentaron cierta mejoría clínica y radiológica, sin embargo los niveles de LDH en el LCR permanecieron elevados en 13 de 14 de los casos, y en 9 de 14 permaneció elevado el índice CSF/sangre.

A pesar de la mejoría clínica y radiológica observada en algunos pacientes debido al alivio de la hipertensión intracranial por las válvulas, la condición metabólica del encéfalo, estimada a través de la LDH no se normalizó en este período de tiempo. Por ello creemos que el seguimiento de este tipo de pacientes a través de parámetros metabólicos puede ser más sensible para detectar disfunción cerebral que los parámetros morfológicos o clínicos.

Palabras clave:
Lactato deshidrogenasa
Lactantes
Hidrocefalia

Artículo

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