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Vol. 7. Issue 3.
Pages 189-192 (January 1996)
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Vol. 7. Issue 3.
Pages 189-192 (January 1996)
Efectos de la administración de dexametasona sobre un modelo experimental de tumor neuroectodérmico primitivo
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M. Zurita, S. Oya, S. Coca, J. Vaquero
Laboratorio de Neuro-oncología experimental, Servicio de Neurocirugía, Hospital Universitario Clínica Puerta de Hierro; Departamentos de Biología Celular y Anatomía Patológica, Facultad de Medicina, Universidad Complutense, Madrid
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Resumen

Se ha realizado un estudio experimental sobre el tumor IL-7, implantado subcutáneamente en ratas Wistar, al objeto de verificar si la administración sistémica o intralesional de dexametasona puede ejercer un efecto antitumoral. Los resultados obtenidos muestran que, tras cuatro semanas de tratamiento, la administración de este fármaco, ya sea por vía sistémica o mediante inyección directa intratumoral, no modifica significativamente el volumen del tumor ni el índice de proliferación celular. Teniendo en cuenta el carácter neuroectodérmico primitivo del tumor IL-7, los presentes resultados sugieren la ineficacia de la dexametasona, como agente citolítico, sobre neoplasias cerebrales humanas que muestren características histológicas de tumor neuroectodérmico primitivo.

Palabras Clave:
Tumor neuroectodérmico primitivo
Dexametasona
Tumor cerebral experimental
Summary

An experimental study has been performed on the IL-7 tumor growing in the subcutaneous tissue of Wistar rats. The possibility of an antitumor effect of dexamethasone, after systemic or intralesional administration was evaluated. After four weeks of dexamethasone administration, a reduction in the tumor volume or proliferation cell index was not reached. Due to the fact that IL-7 may be considered as a primitive neuroectodermal tumor, our present results suggest that dexamethasone is inefficacious as a cytolytic agent for the control of human primitive neuroectodermal tumors.

Key Words:
Primitive neuroectodermal tumor
Dexamethasone
Experimental brain tumor

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