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Vol. 11. Issue 5.
Pages 373-376 (January 2000)
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Vol. 11. Issue 5.
Pages 373-376 (January 2000)
Inhibición farmacológica del Factor de Crecimiento Fibroblástico básico (FCFb) en un modelo experimental de tumor neuroectodérmico
Pharmacologic inhibition of basic Jibroblastic growth factor in an experimental model of neuroectodermal tumor
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C. Morales, M. Zurita, C. Olivares, I. Zurita, J. Vaquero
Laboratorio de Neuro-oncología Experimental de la Unidad de Investigación en Neurociencias de la Fundación Mapfre-Medicina. Servicio de Neurocirugía del Hospital Umversitario Clínica Puerta de Hierro, Madrid
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Resumen

Teniendo en cuenta que el Factor de Crecimiento Fibroblástico básico (FCFb) ha sido relacionado con la angiogénesis tumor-dependiente en gliomas malignos, se ha realizado un estudio experimental para evaluar el posible efecto de una inhibición del FCFb sobre el crecimiento de tumores neuroectodérmicos indiferenciados. En nuestro estudio se ha utilizado el polisulfato de pentosan (PSP), fármaco con efecto inhibidor del FCFb, administrado intralesionalmente sobre un tumor neuroectodérmico maligno de origen murino, que se desarrolla a un ritmo conocido tras su implantación subcutánea en ratas singénicas recién nacidas. La administración intratumoral diaria de 25mg/kg de PSP, durante tres semanas, no modificó el ritmo de crecimiento tumoral ni modificó el patrón de angiogénesis en la neoplasia. Aunque es dificil extrapolar estos resultados al campo de la neuro-oncología humana, dichos hallazgos sugieren la ineficacia de una terapia antiangiogénica en gliomas malignos humanos, que tuviera como objetivo un bloqueo farmacológico del FCFb.

Palabras clave:
Tumor cerebral
Angiogénesis
Factor de Crecimiento Fibroblástico
Polisulfato de pentosán
Terapia antiangiogénica
Summary

Keeping in mind that the basic Fibroblastic Growth Factor (bFGF) has been related with the angiogenesis in malignant gliomas, an experimental study to evaluate the possible effect of an inhibition of the bFGF on the growth of malignant neuroectodermal tumors has been carried out. In our study, the pentosan polisulfato (PSP) has been used as inhibitor of the bFGF.1t has been locally administered on a murin malignant neuroectodermal tumors with well known rhythm of growth. The administration daily intratumoral of 25mg/kg of PSP, during three weeks, did not modify the rhythm oftumor growth neither the pattern of angiogenesis. Although it is difficult to extrapolate these results to the field of the human neuro-oncology, these findings suggest the inefficiency of an antiangiogenic therapy that has as objective to block the bFGF in human malignant brain tumors.

Key words:
Brain tumor
Angiogenesis
Fibroblastic Growth Factor
Pentosan polysulfate
Antiangiogenic therapy

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