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                        "paginaFinal" => "474"
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                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pituitary metastasis&#58; Incidence in cancer patients and clinical differentiation from pituitary adenoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46;B&#46; Max"
                            1 => "M&#46;D&#46;F&#46; Deck"
                            2 => "D&#46;A&#46; Rottenberg"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurology"
                        "fecha" => "1981"
                        "volumen" => "31"
                        "paginaInicial" => "998"
                        "paginaFinal" => "1002"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7196526"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pituitary metastasis&#58; MR findings"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:8 [
                            0 => "N&#46;A&#46; Mayr"
                            1 => "W&#46;T&#46;C&#46; Yuh"
                            2 => "M&#46;G&#46; Muhonen"
                            3 => "T&#46;M&#46; Koci"
                            4 => "E&#46;T&#46; Tali"
                            5 => "H&#46;D&#46; Hguyen"
                            6 => "R&#46;A&#46; Bergman"
                            7 => "J&#46;R&#46; Jinkins"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J&#46; Computo Assist&#46; Tomogr"
                        "fecha" => "1993"
                        "volumen" => "17"
                        "paginaInicial" => "432"
                        "paginaFinal" => "437"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
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              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Metastatic carcinoma to the pituitary gland"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "P&#46;C&#46; Mc Cormick"
                            1 => "K&#46;D&#46; Post"
                            2 => "A&#46;D&#46; Kandji"
                            3 => "A&#46;P&#46; Hays"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Br&#46; J&#46; Neurosurg&#46;"
                        "fecha" => "1989"
                        "volumen" => "3"
                        "paginaInicial" => "71"
                        "paginaFinal" => "79"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2789715"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Metastatic lesions in the sella turcica and pituitary gland"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "V&#46; Roessmann"
                            1 => "F&#46; Kaufman"
                            2 => "R&#46;L&#46; Friede"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer"
                        "fecha" => "1970"
                        "volumen" => "25"
                        "paginaInicial" => "478"
                        "paginaFinal" => "480"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5413515"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prominent &#171;tail sign&#187; in patients with a metastatic tumor"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "M&#46; Senegor"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurosurgery"
                        "fecha" => "1991"
                        "volumen" => "29"
                        "paginaInicial" => "294"
                        "paginaFinal" => "296"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1886674"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Magnetic resonance imaging of tuberculum sllae meningiomas&#58; Preventing preoperative misdiagnosis of pituitary macroadenoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46;L&#46; Taylor"
                            1 => "J&#46;A&#46; Barakos"
                            2 => "G&#46;R&#46; Harsh"
                            3 => "C&#46;B&#46; Wilson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurosurgery"
                        "fecha" => "1992"
                        "volumen" => "31"
                        "paginaInicial" => "621"
                        "paginaFinal" => "627"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1407446"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Surgical revrsal of a subacute complete unilateral visual loss from an ovarian mtastasis to the pituitary gland"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46;K&#46; Wu"
                            1 => "T&#46;R&#46; Hedges"
                            2 => "M&#46;L&#46; Anderson"
                            3 => "R&#46;D&#46; Folkerth"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Neurosurgery"
                        "fecha" => "1992"
                        "volumen" => "31"
                        "paginaInicial" => "354"
                        "paginaFinal" => "392"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
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Vol. 8. Issue 4.
Pages 316-320 (January 1997)
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Vol. 8. Issue 4.
Pages 316-320 (January 1997)
Metástasis hipofisarias como primera manifestación de cáncer orgánico. Dificultades diagnósticas
Pituitary metastases as first manifestation of systemic cancer
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A. Maíllo, P. Díaz, J. Hernández, I. Onzain, F. Morales
Servicio de Neurocirugía. Hospital Universitario de Salamanca
I. Subhi-Issa Ahmad*
* Servicio de Anatomía Patológica. Hospital Universitario de Salamanca
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Resumen

Las metástasis hipofisarias constituyen una entidad poco frecuente en la patología neuroquirúrgica. Cuando se diagnostican suele ser en el entorno de un proceso de diseminación generalizado a partir de un cáncer primitivo fuera del sistema nervioso. Por el contrario suele ser más raro que se presenten como metástasis aislada. Esta rareza, unido al hecho de que el diagnóstico por imagen suele presentar dificultades, hace que se diagnostiquen en la gran mayoría de forma retrospectiva.

Se describen tres pacientes con metástasis hipofisarias, en dos de los cuales este proceso fue la primera manifestación de la enfermedad, y se hacen algunas consideraciones etiopatogénicas, clínicas, diagnósticas y terapéuticas.

Palabras Clave:
Tumores hipofisarios
Metástasis hipofisarias
Cirugía transesfenoidal
Summary

Pituitary metastases is a rare clinical diagnosis usually made in the setting of known primary systemic cancer with widespread metastasis to other organs. Pituitary metastases as the first manifestation of a still undiagnosed systemic cancer is much less frequent.

The cases of three patients harboring pituitary metastases are described. In two of them the pituitary tumor was the first manifestation of the systemic cancer and loss of visual acuity was the most common initial clinical sign.

Key words:
Pituitary tumors
Hypophyseal metastatic tumor
Transsphenoidal surgery

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