Journal Information
Vol. 16. Issue 2.
Pages 158-168 (January 2005)
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Vol. 16. Issue 2.
Pages 158-168 (January 2005)
Tratamiento de los gliomas mediante virus oncolíticos: revisión de la literatura
Oncolytic viral terapy of gliomas: review of the literature
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I. Arrese
, P. González, P. Miranda, A. Pérez-Núñez, B. Pascual, R.D. Lobato
Servicio de Neurocirugía, Hospital Universitario 12 de Octubre, Madrid
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Resumen

Los gliomas son los tumores cerebrales primarios más frecuentes. Los tratamientos tradicionales se han basado en la cirugía, la radioterapia y la quimioterapia. Pese al avance en estas terapias, el pronóstico de estos tumores ha permanecido casi constante durante los últimos años. Dada la ausencia de mejoría en el pronóstico, los últimos avances en técnicas de biología molecular han abierto un nuevo campo de investigación para el desarrollo de nuevos tratamientos, y dentro de ellos, se ha evaluado el uso de virus oncolíticos en diferentes ensayos. En esta revisión discutimos los avances ocurridos en el uso de terapias basadas en estos agentes anticancerosos.

Palabras clave:
Virus oncolíticos
Glioma
Biología molecular
Summary

Gliomas are the most frequent primary tumors of the brain. The standard treatment includes surgery, radiotherapy and chemotherapy, but the outcomes of patients with these tumors have remained nearly unchanged for past years. Hopefully, recent advances in molecular biology are rising new clinical expectation for patients with brain tumors. Among the novel techniques in this new fleld of research a new fleld of research, the use of oncolytic viruses has been explored in different trials during last years. In the present review we analyze the advances in the understanding of the oncolytic viral therapy of gliomas.

Key words:
Oncolytic viruses
Glioma
Molecular biology

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