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Vol. 7. Issue 1.
Pages 19-26 (January 1996)
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Vol. 7. Issue 1.
Pages 19-26 (January 1996)
Tumor neuroepitelial disembrioplásico: una causa de epilepsia curable quirúrgicamente
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J. Vaquero, M. Zurita, S. Coca, S. Oya, F. de Prado
Servicio de Neurocirugía, Hospital Universitario Clínica Puerta de Hierro, Universidad Autónoma
Departamento de Biología Celular, Facultad de Medicina de la Universidad Complutense y Servicio de Anatomía Patológica, Hospital Universitario del Ejército del Aire. Madrid
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Resumen

Los llamados «Tumores neuroepiteliales disembrioplásicos » (TND) fueron individualizados en 1988 por Daumas-Duport y cols. Clínicamente se manifiestan por una historia de larga evolución consistente en crisis epilépticas rebeldes al tratamiento médico. Anatomopatológicamente sus células predominantes son de pequeño tamaño, con aspecto similar, desde el punto de vista de la microscopía óptica, al de las células de oligodendroglía, y se asocian a alteraciones neuronales, con desorganización de la corteza cerebral. En la presente publicación se aportan 2 nuevos casos de TND y se revisan los aspectos anatomoclínicos de esta entidad. Nuestros hallazgos confirman observaciones previas en el sentido de que estas neoplasias son biológicamente benignas y constituyen básicamente lesiones epileptogénicas susceptibles de ser tratadas quirúrgicamente con magníficos resultados. Por otra parte, el estudio anatomopatológico realizado en nuestros casos demuestra la naturaleza neuronal de estos tumores, lo que unido a observaciones recogidas en la literatura, nos lleva a sugerir que los llamados «tumores neuroepiteliales disembrioplásicos» deberían ser reclasificados como «neurocitomas disembrioplásicos».

Palabras Clave:
Tumor neuroepitelial disembrioplásico
Neurocitoma
Epilepsia
Tumor cerebral
Summary

The so-called dysembryoplastic neuroepithelial tumors (DNT) were described by Daumas-Duport el al. in 1988, as a clinico-pathological entity. These tumors cause chronic medically intractable seizures, and the main constituent cells show features of oligodendrocytes when they were studied by optical microscopy. The association with neuronal atypias and cortical dysplasia is a frequent finding. In the present report we describe two cases of DNT and the clinical and pathological features of this entity are revised. Our present results agree with previous reports showing the benignity of DNT and their character of epileptogenic lesioils surgically curable. On the other hand, our pathological study suggests the neuronal nature of DNT and their reclassification as «dysembryoplastic neurocytomas » is proposed.

Key Words:
Dysembryoplastic neuroepithelial tumor
Neurocytoma
Epilepsy
Brain tumor

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