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        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Se estudian las caracter&#237;sticas inmunol&#243;gicas de 32 gliomas clasificados en dos grupos seg&#250;n su histolog&#237;a y siguiendo la escala en grados de Kernohan&#58; los de baja agresividad &#40;grados I y II&#41; Ylos filiados como malignos &#40;grados III y IV&#41;&#46; En 21 ocasiones el tumor correspondi&#243; al primero de los grupos y en 11 al segundo&#46; La investigaci&#243;n inmunohistoqu&#237;mica se realiz&#243; sobre material congelado a &#8722;70 &#176;C utilizando casi siempre t&#233;cnica FAAFA &#40;fosfatasa alcalina-antifosfatasa alcalina&#41;&#59; en alg&#250;n caso se utiliz&#243; t&#233;cnica PAP &#40;peroxidasa- antiperoxidasa&#41;&#46; El estudio abarca la caracterizaci&#243;n funcional del infiltrado linfomonocitario y la de la propia c&#233;lula tumoral en cuanto a la existencia o no de determinantes de histocompatibiliad &#40;CHM&#41; de clase I y II&#46; Se determina tambi&#233;n la capacidad proliferativa del tumor utilizando el &#237;ndice Ki-67&#46; La tipificaci&#243;n del infiltrado permite concluir la presencia de macr&#243;fagos &#40;CD68&#43;&#41; en todos los casos&#44; en gran cantidad y difusamente distribuidos entre las c&#233;lulas tumorales&#44; siendo m&#225;s abundantes en tumores con CHM II &#40;28&#46;8&#37; de media&#41; que en los que carecen de estos determinantes antig&#233;nicos &#40;19&#46;3&#37; de media&#41;&#46; Se identificaron linfocitos T &#40;CD3&#43;&#41; en 30 ocasiones&#44; linfocitos T-facilitadores &#40;CD4&#43;&#41; en 29 y linfocitos T-supresores&#47;citot&#243;xicos &#40;CD8&#43;&#41; en 25&#44; situ&#225;ndose predominantemente en los espacios perivasculares&#46; Otras poblaciones&#58; linfocitos B &#40;CD19&#43;&#41;&#44; c&#233;lulas plasm&#225;ticas &#40;CD38&#43;&#41;&#44; c&#233;lulas con ant&#237;genos de activaci&#243;n &#40;CD25&#43;&#41; y c&#233;lulas con actividad killer &#40;CD57&#43;&#41;&#44; se identificaron en pocos gliomas y siempre en escasa cantidad&#46; La subpoblaci&#243;n T m&#225;s abundante fue la T-facilitadora &#40;CD4&#43;&#41; siendo m&#225;s numerosa en tumores altamente agresivos &#40;7&#46;7&#37; de media&#41; que en los filiados como grados I-II &#40;4&#46;6&#37; de media&#41;&#46;</p>"
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        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A study is made of the immunological characteristics of 32 gliomas classified into two groups according to their histology and following the grading scale of Kernohan&#46;&#59; those of low aggressiveness &#40;grades I and II&#41; and those deemed malignant &#40;grades III and IV&#41;&#46; 21 cases&#44; corresponded to the first group and 11 to the second&#46; Immunohistochemical study was performed on material frozen at &#8722;70 &#176;C&#44; almost always using APAAP &#40;alkaline phosphatase-antialkaline phosphatase&#41; technique&#44; although in sorne cases the PAP &#40;peroxidase- antiperoxidase&#41; technique was employed&#46; The study addressed the functional characterization of lymphomonocyte infiltration and of tumor cellularity itself in regard to the existence or not of classes I and II histocompatibility determinants &#40;MHC&#41;&#46; The proliferative capacity of the tumors&#44; was also determined using the Ki-67 indexo Infiltrate typing showed that in all the cases macrophages &#40;CD68&#43;&#41; were distributed diffusely in large amounts among the tumor cells&#46; They were more abundant in tumors with MHC II &#40;mean&#44; 28&#46;8&#37;&#41; than in those lacking these antigen determinants &#40;mean&#44; 19&#46;3&#37;&#41;&#46; T lymphocytes &#40;CD3&#43;&#41; were identified in thirty cases&#44; helper&#47;inducer T lymphocytes in 29 and suppressor&#47;cytotoxic T limphocytes &#40;CD8&#43;&#41; in 25&#59; these cells were predominantly located in the perivascular space&#46; Other populations&#44; including B cells &#40;CD19&#43;&#41;&#44; plasma cells &#40;CD38&#43;&#41;&#44; cells displaying activation antigens &#40;CD25&#43;&#41; and cells with killer activity &#40;CD57&#43;&#41; were only identified in a few gliomas and always at low levels&#46; The most abundant T subset wasT-helper&#47;inducer &#40;CD4&#43;&#41;&#44; this being more numerous in the strongly aggressive tumors &#40;mean&#44; 7&#46;7&#37;&#41; than in those belonging to grade I-II &#40;mean&#44; 4&#46;6&#37;&#41;&#46;</p>"
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Vol. 7. Núm. 2.
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Vol. 7. Núm. 2.
Páginas 100-110 (enero 1996)
Aspectos inmunológicos en los gliomas: infiltrado celular y características de la célula tumoral
Visitas
1940
J.A. Gómez-Moreta, F. Morales
Servicio de Neurocirugía. Hospital Virgen de la Vega. Salamanca
M.A. Piris*, Mª.P. Galindo**, J. Broseta***
* Servicio de Patología. Sección de Inmunohistoquimia. Hospital Virgen de la Salud. Toledo
** Departamento de Estadística y Matemática Aplicadas. Universidad de Salamanca. Salamanca
*** Cátedra de Neurocirugía. Facultad de Medicina. Universidad de Salamanca. Salamanca
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Resumen

Se estudian las características inmunológicas de 32 gliomas clasificados en dos grupos según su histología y siguiendo la escala en grados de Kernohan: los de baja agresividad (grados I y II) Ylos filiados como malignos (grados III y IV). En 21 ocasiones el tumor correspondió al primero de los grupos y en 11 al segundo. La investigación inmunohistoquímica se realizó sobre material congelado a −70 °C utilizando casi siempre técnica FAAFA (fosfatasa alcalina-antifosfatasa alcalina); en algún caso se utilizó técnica PAP (peroxidasa- antiperoxidasa). El estudio abarca la caracterización funcional del infiltrado linfomonocitario y la de la propia célula tumoral en cuanto a la existencia o no de determinantes de histocompatibiliad (CHM) de clase I y II. Se determina también la capacidad proliferativa del tumor utilizando el índice Ki-67. La tipificación del infiltrado permite concluir la presencia de macrófagos (CD68+) en todos los casos, en gran cantidad y difusamente distribuidos entre las células tumorales, siendo más abundantes en tumores con CHM II (28.8% de media) que en los que carecen de estos determinantes antigénicos (19.3% de media). Se identificaron linfocitos T (CD3+) en 30 ocasiones, linfocitos T-facilitadores (CD4+) en 29 y linfocitos T-supresores/citotóxicos (CD8+) en 25, situándose predominantemente en los espacios perivasculares. Otras poblaciones: linfocitos B (CD19+), células plasmáticas (CD38+), células con antígenos de activación (CD25+) y células con actividad killer (CD57+), se identificaron en pocos gliomas y siempre en escasa cantidad. La subpoblación T más abundante fue la T-facilitadora (CD4+) siendo más numerosa en tumores altamente agresivos (7.7% de media) que en los filiados como grados I-II (4.6% de media).

Palabras clave:
Complejos de histocompatibilidad
Glioma
Inmunidad
Célula linfoide
Macrófago
Summary

A study is made of the immunological characteristics of 32 gliomas classified into two groups according to their histology and following the grading scale of Kernohan.; those of low aggressiveness (grades I and II) and those deemed malignant (grades III and IV). 21 cases, corresponded to the first group and 11 to the second. Immunohistochemical study was performed on material frozen at −70 °C, almost always using APAAP (alkaline phosphatase-antialkaline phosphatase) technique, although in sorne cases the PAP (peroxidase- antiperoxidase) technique was employed. The study addressed the functional characterization of lymphomonocyte infiltration and of tumor cellularity itself in regard to the existence or not of classes I and II histocompatibility determinants (MHC). The proliferative capacity of the tumors, was also determined using the Ki-67 indexo Infiltrate typing showed that in all the cases macrophages (CD68+) were distributed diffusely in large amounts among the tumor cells. They were more abundant in tumors with MHC II (mean, 28.8%) than in those lacking these antigen determinants (mean, 19.3%). T lymphocytes (CD3+) were identified in thirty cases, helper/inducer T lymphocytes in 29 and suppressor/cytotoxic T limphocytes (CD8+) in 25; these cells were predominantly located in the perivascular space. Other populations, including B cells (CD19+), plasma cells (CD38+), cells displaying activation antigens (CD25+) and cells with killer activity (CD57+) were only identified in a few gliomas and always at low levels. The most abundant T subset wasT-helper/inducer (CD4+), this being more numerous in the strongly aggressive tumors (mean, 7.7%) than in those belonging to grade I-II (mean, 4.6%).

Key words:
Glioma
Histocompatibility complexo
Immunity
Gliomas, Limphoid cell
Macrophage

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