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        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Para un gran n&#250;mero de tumores pituitarios la cirug&#237;a es el tratamiento de primera l&#237;nea y el abordaje transesfenoidal microquir&#250;rgico el m&#225;s utilizado&#46; En estos momentos&#44; el mismo se ejecuta tanto por la v&#237;a sublabial como por la transnasal&#46; Recientemente&#44; el abordaje transnasal endosc&#243;pico ha irrumpido como una opci&#243;n en desarrollo&#44; que pudiera llegar a predominar en un futuro pr&#243;ximo&#46;</p> <span class="elsevierStyleSectionTitle">Objetivos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Evaluar mediante el an&#225;lisis de los resultados si es posible realizar en nuestro medio el abordaje transnasal transesfenoidal endosc&#243;pico para las lesiones de la regi&#243;n selar con resultados quir&#250;rgicos&#44; al menos&#44; similares a los obtenidos con el m&#233;todo transesfenoidal tradicional&#46;</p> <span class="elsevierStyleSectionTitle">Material y m&#233;todo</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Como fase I de un ensayo en 3 etapas se realiza una investigaci&#243;n limitada tipo cohorte&#44; estrictamente controlada y prospectiva de 10 pacientes seleccionados seg&#250;n criterios de inclusi&#243;n y a los cuales se les practic&#243; el abordaje transnasal endosc&#243;pico como m&#233;todo de tratamiento quir&#250;rgico entre Agosto del 2002 y Agosto del 2003 en el servicio de Neurocirug&#237;a del Hospital &#8220;Hermanos Ameijeiras&#8221;&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Se operaron seis casos que ten&#237;an macroadenomas hipoflsarios&#44; tres productores de GH&#44; uno secretor de PRL y otros dos no productores&#46; A los otros cuatro se les hab&#237;a diagnosticado f&#237;stula de LCR a trav&#233;s del piso selar&#46; De los seis macroadenomas&#44; en cinco se logr&#243; ex&#233;resis total del tumor&#44; mientras que en el otro se obtuvo ex&#233;resis subtotal&#46; La rinorrea desapareci&#243; en 2 pacientes con f&#237;stula de LCR y se mantuvo en los otros 2&#46; De las complicaciones observadas en el 30&#37; de los casos&#44; solo en 1 &#40;10&#37;&#41; transcendieron m&#225;s all&#225; del transoperatorio&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Los resultados obtenidos en la fase 1 con la utilizaci&#243;n del m&#233;todo transnasal endosc&#243;pico&#44; hacen que el procedimiento en nuestro medi&#243; sea lo suficientemente seguro como para justificar el pase a la fase II del ensayo &#40;aleatorizada y controlada&#41;&#44; en busca de informaci&#243;n m&#225;s consistente&#44; en relaci&#243;n al valor real de la t&#233;cnica a estas alturas del desarrollo de la cirug&#237;a hipofisaria&#46;</p>"
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        "resumen" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Transnasal transsphenoidal endoscopic approach to the sella turcica has recently become an option to the pituitary surgery which could predom&#237;nate in a near future&#46;</p> <span class="elsevierStyleSectionTitle">Objectives</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">To eval&#250;ate through the analysis of our results whether it is possible to perform in our Hospital the endoscopic transnasal transsphenoidal approach to the sella with results at least as good as those we obtain with the microscopic sublabial transseptal transsphenoidal approach&#46;</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">As the first stage of a three stage randomized trial&#44; this is a prospective study of 10 patients operated on&#44; using transnasal transsphenoidal endoscopic aproach between august 2002 and August 2003 at the department of neurosurgery of &#8220;Hermanos Ameijeiras Hospital&#8221;&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Six patients had pituitary macroadenomas and four had cerebrospinal fluid leak through the sellar floor&#46; In five of six macroadenomas total tumor resection was obtained and in the other one a subtotal resection was performed&#46; Two of four patients with cerebrospinal fluid leak could be cured while the other two patients do not&#46; Complications were present in 30&#37; of cases&#44; but in only 1 &#40;10&#37;&#41; it reached the postoperatory period&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Transnasal transsphenoidal endoscopic approach to the sella can be done save enough in our Hospital to justify the start of the second stage of one randomized trial to determine if the endoscopic techni-que is better than the usual transsphenoidal approach&#46;</p>"
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