array:23 [
  "pii" => "S1130147396710783"
  "issn" => "11301473"
  "doi" => "10.1016/S1130-1473(96)71078-3"
  "estado" => "S300"
  "fechaPublicacion" => "1996-01-01"
  "aid" => "71078"
  "copyright" => "Sociedad Española de Neurocirugía"
  "copyrightAnyo" => "1996"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "fla"
  "cita" => "Neurocirugia. 1996;7:189-92"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 3127
    "formatos" => array:3 [
      "EPUB" => 22
      "HTML" => 1023
      "PDF" => 2082
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S1130147396710795"
    "issn" => "11301473"
    "doi" => "10.1016/S1130-1473(96)71079-5"
    "estado" => "S300"
    "fechaPublicacion" => "1996-01-01"
    "aid" => "71079"
    "copyright" => "Sociedad Española de Neurocirugía"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Neurocirugia. 1996;7:193-8"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 2411
      "formatos" => array:3 [
        "EPUB" => 18
        "HTML" => 906
        "PDF" => 1487
      ]
    ]
    "es" => array:9 [
      "idiomaDefecto" => true
      "titulo" => "Síndrome de túnel carpiano experiencia en 124 pacientes"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "193"
          "paginaFinal" => "198"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:2 [
        0 => array:2 [
          "autoresLista" => "A. Rodríguez de Lope, J.M. Castilla, A. Gómez, N. López-Ariztegui, V. Martín, M.J. Ramiro, E. González, R. Carrillo"
          "autores" => array:8 [
            0 => array:2 [
              "nombre" => "A."
              "apellidos" => "Rodríguez de Lope"
            ]
            1 => array:2 [
              "nombre" => "J.M."
              "apellidos" => "Castilla"
            ]
            2 => array:2 [
              "nombre" => "A."
              "apellidos" => "Gómez"
            ]
            3 => array:2 [
              "nombre" => "N."
              "apellidos" => "López-Ariztegui"
            ]
            4 => array:2 [
              "nombre" => "V."
              "apellidos" => "Martín"
            ]
            5 => array:2 [
              "nombre" => "M.J."
              "apellidos" => "Ramiro"
            ]
            6 => array:2 [
              "nombre" => "E."
              "apellidos" => "González"
            ]
            7 => array:2 [
              "nombre" => "R."
              "apellidos" => "Carrillo"
            ]
          ]
        ]
        1 => array:2 [
          "autoresLista" => "I. Jiménez"
          "autores" => array:1 [
            0 => array:2 [
              "nombre" => "I."
              "apellidos" => "Jiménez"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147396710795?idApp=UINPBA00004B"
    "url" => "/11301473/0000000700000003/v1_201305151453/S1130147396710795/v1_201305151453/es/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S1130147396710771"
    "issn" => "11301473"
    "doi" => "10.1016/S1130-1473(96)71077-1"
    "estado" => "S300"
    "fechaPublicacion" => "1996-01-01"
    "aid" => "71077"
    "copyright" => "Sociedad Española de Neurocirugía"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Neurocirugia. 1996;7:181-8"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 1635
      "formatos" => array:3 [
        "EPUB" => 14
        "HTML" => 808
        "PDF" => 813
      ]
    ]
    "es" => array:9 [
      "idiomaDefecto" => true
      "titulo" => "Traumatismos medulares experimentales: Revisión de la literatura y descripción de un modelo mediante compresión mantenida en la rata"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "181"
          "paginaFinal" => "188"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:2 [
        0 => array:2 [
          "autoresLista" => "M.A. Pérez-Espejo, M. Poza y Poza"
          "autores" => array:2 [
            0 => array:2 [
              "nombre" => "M.A."
              "apellidos" => "Pérez-Espejo"
            ]
            1 => array:2 [
              "nombre" => "M."
              "apellidos" => "Poza y Poza"
            ]
          ]
        ]
        1 => array:2 [
          "autoresLista" => "S.S. Haghighi, J.J. Oró"
          "autores" => array:2 [
            0 => array:2 [
              "nombre" => "S.S."
              "apellidos" => "Haghighi"
            ]
            1 => array:2 [
              "nombre" => "J.J."
              "apellidos" => "Oró"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147396710771?idApp=UINPBA00004B"
    "url" => "/11301473/0000000700000003/v1_201305151453/S1130147396710771/v1_201305151453/es/main.assets"
  ]
  "es" => array:12 [
    "idiomaDefecto" => true
    "titulo" => "Efectos de la administración de dexametasona sobre un modelo experimental de tumor neuroectodérmico primitivo"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "189"
        "paginaFinal" => "192"
      ]
    ]
    "autores" => array:1 [
      0 => array:3 [
        "autoresLista" => "M. Zurita, S. Oya, S. Coca, J. Vaquero"
        "autores" => array:4 [
          0 => array:2 [
            "nombre" => "M."
            "apellidos" => "Zurita"
          ]
          1 => array:2 [
            "nombre" => "S."
            "apellidos" => "Oya"
          ]
          2 => array:2 [
            "nombre" => "S."
            "apellidos" => "Coca"
          ]
          3 => array:2 [
            "nombre" => "J."
            "apellidos" => "Vaquero"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:1 [
            "entidad" => "Laboratorio de Neuro-oncología experimental, Servicio de Neurocirugía, Hospital Universitario Clínica Puerta de Hierro&#59; Departamentos de Biología Celular y Anatomía Patológica, Facultad de Medicina, Universidad Complutense, Madrid"
          ]
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "PalabrasClave" => array:2 [
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras Clave"
          "identificador" => "xpalclavsec162990"
          "palabras" => array:3 [
            0 => "Tumor neuroectodérmico primitivo"
            1 => "Dexametasona"
            2 => "Tumor cerebral experimental"
          ]
        ]
      ]
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Key Words"
          "identificador" => "xpalclavsec162989"
          "palabras" => array:3 [
            0 => "Primitive neuroectodermal tumor"
            1 => "Dexamethasone"
            2 => "Experimental brain tumor"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Se ha realizado un estudio experimental sobre el tumor IL-7&#44; implantado subcut&#225;neamente en ratas Wistar&#44; al objeto de verificar si la administraci&#243;n sist&#233;mica o intralesional de dexametasona puede ejercer un efecto antitumoral&#46; Los resultados obtenidos muestran que&#44; tras cuatro semanas de tratamiento&#44; la administraci&#243;n de este f&#225;rmaco&#44; ya sea por v&#237;a sist&#233;mica o mediante inyecci&#243;n directa intratumoral&#44; no modifica significativamente el volumen del tumor ni el &#237;ndice de proliferaci&#243;n celular&#46; Teniendo en cuenta el car&#225;cter neuroectod&#233;rmico primitivo del tumor IL-7&#44; los presentes resultados sugieren la ineficacia de la dexametasona&#44; como agente citol&#237;tico&#44; sobre neoplasias cerebrales humanas que muestren caracter&#237;sticas histol&#243;gicas de tumor neuroectod&#233;rmico primitivo&#46;</p>"
      ]
      "en" => array:2 [
        "titulo" => "Summary"
        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">An experimental study has been performed on the IL-7 tumor growing in the subcutaneous tissue of Wistar rats&#46; The possibility of an antitumor effect of dexamethasone&#44; after systemic or intralesional administration was evaluated&#46; After four weeks of dexamethasone administration&#44; a reduction in the tumor volume or proliferation cell index was not reached&#46; Due to the fact that IL-7 may be considered as a primitive neuroectodermal tumor&#44; our present results suggest that dexamethasone is inefficacious as a cytolytic agent for the control of human primitive neuroectodermal tumors&#46;</p>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara">Zurita&#44; M&#46;&#59; Oya&#44; S&#46;&#59; Coca&#44; S&#46;&#59; Vaquero&#44; J&#46;&#58; Efectos de la administraci&#243;n de dexametasona sobre un modelo experimental de tumor neuroectod&#233;rrnico primitivo&#46; Neurocirug&#237;a 1996&#59; 7&#58; 189&#8211;192&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Bibliograf&#237;a"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:19 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Steroid-induced CT changes in patients with recurrent malignant glioma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46;G&#46; Cairncross"
                            1 => "D&#46;R&#46; MacDonald"
                            2 => "W&#46; Pexman"
                            3 => "F&#46;J&#46; Ives"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurology"
                        "fecha" => "1988"
                        "volumen" => "38"
                        "paginaInicial" => "724"
                        "paginaFinal" => "726"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3362369"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The use of steroids for control of cerebral edema"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "L&#46;A&#46; French"
                            1 => "J&#46;H&#46; Galicich"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Neurosurg"
                        "fecha" => "1964"
                        "volumen" => "10"
                        "paginaInicial" => "212"
                        "paginaFinal" => "223"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14095874"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of glucocorticoids on glioma cells in culture&#46; Minireview on cancer research"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "R&#46;I&#46; Freshney"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Exp Cell Biol"
                        "fecha" => "1984"
                        "volumen" => "52"
                        "paginaInicial" => "286"
                        "paginaFinal" => "292"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6541165"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Use of dexamethasone in the treatment of cerebral edema associated with brain tumors"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46;H&#46; Galicich"
                            1 => "L&#46;A&#46; French"
                            2 => "J&#46;C&#46; Melby"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1961"
                        "volumen" => "81"
                        "paginaInicial" => "46"
                        "paginaFinal" => "53"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Use of dexamethasone in the treatment of cerebral edema resulting from brain tumors and brain surgery"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;H&#46; Galicich"
                            1 => "L&#46;A&#46; French"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Am Practitioner Dig Treat"
                        "fecha" => "1961"
                        "volumen" => "12"
                        "paginaInicial" => "169"
                        "paginaFinal" => "174"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Influence of preoperative dexamethasone therapy on proliferating cell nuclear antigen &#40;PCNA&#41; expression in comparison to other parameters in meningiomas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "J&#46; Gottschal"
                            1 => "S&#46; Goebel"
                            2 => "G&#46; Jauzke"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Histol Histopath"
                        "fecha" => "1992"
                        "volumen" => "7"
                        "paginaInicial" => "653"
                        "paginaFinal" => "661"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The therapy of human tumors in athymic &#40;nude&#41; mice"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "D&#46;P&#46; Houchens"
                            1 => "A&#46;A&#46; Ovejera"
                            2 => "A&#46;D&#46; Bauker"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Proceedings of the Symposium on the use of athymic &#40;nude&#41; mice in Cancer Research"
                        "paginaInicial" => "267"
                        "paginaFinal" => "280"
                        "serieFecha" => "1978"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Therapeutic effects of local delivery of dexamethasone on experimental brain tumors and peritumoral brain edema"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "Y&#46; Ikeda"
                            1 => "B&#46; Carson"
                            2 => "J&#46;A&#46; Lauer"
                            3 => "D&#46;M&#46; Long"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3171/jns.1993.79.5.0716"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurosurg"
                        "fecha" => "1993"
                        "volumen" => "79"
                        "paginaInicial" => "716"
                        "paginaFinal" => "721"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8410250"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of hydrocortisone on Ehrlich ascites tumor"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "M&#46; Kodama"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer Res"
                        "fecha" => "1962"
                        "volumen" => "22"
                        "paginaInicial" => "1212"
                        "paginaFinal" => "1219"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14034077"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of steroid hormones on the in vivo incorporation of glycine-2-14C into solid Ehrlich tumor&#44; kidney and liver"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46; Kodama"
                            1 => "T&#46; Kodama"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer Res"
                        "fecha" => "1970"
                        "volumen" => "30"
                        "paginaInicial" => "228"
                        "paginaFinal" => "235"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5458961"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of dexamethasone and metylprednisolone on cell cultures of human glioblastomas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46; Mealey Jr&#46;"
                            1 => "T&#46;T&#46; Chen"
                            2 => "G&#46;P&#46; Schanz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3171/jns.1971.34.3.0324"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurosurg"
                        "fecha" => "1971"
                        "volumen" => "34"
                        "paginaInicial" => "324"
                        "paginaFinal" => "334"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4323143"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Does dexamethasone inhibit the growth of human gliomas&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "G&#46; Sherbert"
                            1 => "M&#46;S&#46; Lakshmi"
                            2 => "S&#46;K&#46; Haddad"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3171/jns.1977.47.6.0864"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurosurg"
                        "fecha" => "1977"
                        "volumen" => "47"
                        "paginaInicial" => "864"
                        "paginaFinal" => "870"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/925742"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Growth inhibition of the 9L glioma using polymers to release heparin and cortisone acetato"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "R&#46;J&#46; Tamargo"
                            1 => "K&#46;W&#46; Leong"
                            2 => "H&#46; Brem"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Neuro-Oncol"
                        "fecha" => "1990"
                        "volumen" => "9"
                        "paginaInicial" => "131"
                        "paginaFinal" => "138"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Interstitial delivery of dexamethasone in the brain for the reduction of peritumoral edema"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "R&#46;J&#46; Tamargo"
                            1 => "A&#46;K&#46; Sills Jr&#46;"
                            2 => "C&#46;S&#46; Reinhard"
                            3 => "M&#46;L&#46; Pinn"
                            4 => "D&#46;M&#46; Long"
                            5 => "H&#46; Brem"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3171/jns.1991.74.6.0956"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurosurg"
                        "fecha" => "1991"
                        "volumen" => "74"
                        "paginaInicial" => "956"
                        "paginaFinal" => "961"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2033457"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Interstitial chemotherapy for brain tumors&#58; review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "T&#46; Tomita"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Neuro-Oncol"
                        "fecha" => "1991"
                        "volumen" => "10"
                        "paginaInicial" => "57"
                        "paginaFinal" => "74"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Growth of human tumors in cortisone-treated laboratory animals&#58; The possibility of obtaining permanently transplantable human tumors"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "H&#46;V&#46; Toolan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer Res"
                        "fecha" => "1953"
                        "volumen" => "13"
                        "paginaInicial" => "389"
                        "paginaFinal" => "394"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/13042839"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Experimental induction of primitive neuroectodermal tumours in rats&#58; A reappraisement of the ENU-induced model of neurocarcinogenesis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46; Vaquero"
                            1 => "S&#46; Oya"
                            2 => "S&#46; Coca"
                            3 => "M&#46; Zurita"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Acta Neurochir &#40;Wien&#41;"
                        "fecha" => "1994"
                        "volumen" => "131"
                        "paginaInicial" => "294"
                        "paginaFinal" => "301"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Steroid-induced inhibition of growth in glial tumors&#58; A kinetic analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "C&#46;B&#46; Wilson"
                            1 => "M&#46; Barker"
                            2 => "T&#46; Hoshino"
                            3 => "A&#46; Oliver"
                            4 => "R&#46; Downie"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Steroids and Brain Edema"
                        "paginaInicial" => "95"
                        "paginaFinal" => "100"
                        "serieFecha" => "1972"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The effect of glucocorticosteroids on growth and metabolism of experimental glial tumors"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "R&#46;L&#46; Wright"
                            1 => "B&#46; Shaumba"
                            2 => "J&#46; Keller"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3171/jns.1969.30.2.0140"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurosurg"
                        "fecha" => "1969"
                        "volumen" => "30"
                        "paginaInicial" => "140"
                        "paginaFinal" => "145"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5780882"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "es"
  "url" => "/11301473/0000000700000003/v1_201305151453/S1130147396710783/v1_201305151453/es/main.assets"
  "Apartado" => null
  "PDF" => "https://static.elsevier.es/multimedia/11301473/0000000700000003/v1_201305151453/S1130147396710783/v1_201305151453/es/main.pdf?idApp=UINPBA00004B&text.app=https://revistaneurocirugia.com/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147396710783?idApp=UINPBA00004B"
]
Compartir
Información de la revista
Vol. 7. Núm. 3.
Páginas 189-192 (enero 1996)
Compartir
Compartir
Descargar PDF
Más opciones de artículo
Vol. 7. Núm. 3.
Páginas 189-192 (enero 1996)
Efectos de la administración de dexametasona sobre un modelo experimental de tumor neuroectodérmico primitivo
Visitas
3107
M. Zurita, S. Oya, S. Coca, J. Vaquero
Laboratorio de Neuro-oncología experimental, Servicio de Neurocirugía, Hospital Universitario Clínica Puerta de Hierro; Departamentos de Biología Celular y Anatomía Patológica, Facultad de Medicina, Universidad Complutense, Madrid
Este artículo ha recibido
Información del artículo
Resumen

Se ha realizado un estudio experimental sobre el tumor IL-7, implantado subcutáneamente en ratas Wistar, al objeto de verificar si la administración sistémica o intralesional de dexametasona puede ejercer un efecto antitumoral. Los resultados obtenidos muestran que, tras cuatro semanas de tratamiento, la administración de este fármaco, ya sea por vía sistémica o mediante inyección directa intratumoral, no modifica significativamente el volumen del tumor ni el índice de proliferación celular. Teniendo en cuenta el carácter neuroectodérmico primitivo del tumor IL-7, los presentes resultados sugieren la ineficacia de la dexametasona, como agente citolítico, sobre neoplasias cerebrales humanas que muestren características histológicas de tumor neuroectodérmico primitivo.

Palabras Clave:
Tumor neuroectodérmico primitivo
Dexametasona
Tumor cerebral experimental
Summary

An experimental study has been performed on the IL-7 tumor growing in the subcutaneous tissue of Wistar rats. The possibility of an antitumor effect of dexamethasone, after systemic or intralesional administration was evaluated. After four weeks of dexamethasone administration, a reduction in the tumor volume or proliferation cell index was not reached. Due to the fact that IL-7 may be considered as a primitive neuroectodermal tumor, our present results suggest that dexamethasone is inefficacious as a cytolytic agent for the control of human primitive neuroectodermal tumors.

Key Words:
Primitive neuroectodermal tumor
Dexamethasone
Experimental brain tumor

Artículo

Opciones para acceder a los textos completos de la publicación Neurocirugía
Socio
Socio de la Sociedad Española de Neurocirugía

Si es la primera vez que accede a la web puede obtener sus claves de acceso poniéndose en contacto con Elsevier España en suscripciones@elsevier.com o a través de su teléfono de Atención al Cliente 902 88 87 40 si llama desde territorio español o del +34 932 418 800 (de 9 a 18h., GMT + 1) si lo hace desde el extranjero.

Si ya tiene sus datos de acceso, clique aquí.

Si olvidó su clave de acceso puede recuperarla clicando aquí y seleccionando la opción "He olvidado mi contraseña".

Suscriptor
Suscriptor de la revista

Si ya tiene sus datos de acceso, clique aquí.

Si olvidó su clave de acceso puede recuperarla clicando aquí y seleccionando la opción "He olvidado mi contraseña".
Suscribirse
Suscribirse a:

Neurocirugía

Comprar
Comprar acceso al artículo

Comprando el artículo el PDF del mismo podrá ser descargado

Precio 19,34 €

Comprar ahora
Contactar
Teléfono para suscripciones e incidencias
De lunes a viernes de 9h a 18h (GMT+1) excepto los meses de julio y agosto que será de 9 a 15h
Llamadas desde España
932 415 960
Llamadas desde fuera de España
+34 932 415 960
Email
Idiomas
Neurocirugía
Opciones de artículo
Herramientas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?