Efectos de la administración de dexametasona sobre un modelo experimental de tumor neuroectodérmico primitivo
M. Zurita, S. Oya, S. Coca, J. Vaquero
Laboratorio de Neuro-oncología experimental, Servicio de Neurocirugía, Hospital Universitario Clínica Puerta de Hierro; Departamentos de Biología Celular y Anatomía Patológica, Facultad de Medicina, Universidad Complutense, Madrid
Leído
3107
Vecesse ha leído el artículo
2084
Total PDF
1023
Total HTML
Compartir estadísticas
array:23 [ "pii" => "S1130147396710783" "issn" => "11301473" "doi" => "10.1016/S1130-1473(96)71078-3" "estado" => "S300" "fechaPublicacion" => "1996-01-01" "aid" => "71078" "copyright" => "Sociedad Española de Neurocirugía" "copyrightAnyo" => "1996" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Neurocirugia. 1996;7:189-92" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 3127 "formatos" => array:3 [ "EPUB" => 22 "HTML" => 1023 "PDF" => 2082 ] ] "itemSiguiente" => array:18 [ "pii" => "S1130147396710795" "issn" => "11301473" "doi" => "10.1016/S1130-1473(96)71079-5" "estado" => "S300" "fechaPublicacion" => "1996-01-01" "aid" => "71079" "copyright" => "Sociedad Española de Neurocirugía" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Neurocirugia. 1996;7:193-8" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2411 "formatos" => array:3 [ "EPUB" => 18 "HTML" => 906 "PDF" => 1487 ] ] "es" => array:9 [ "idiomaDefecto" => true "titulo" => "Síndrome de túnel carpiano experiencia en 124 pacientes" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "193" "paginaFinal" => "198" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:2 [ 0 => array:2 [ "autoresLista" => "A. Rodríguez de Lope, J.M. Castilla, A. Gómez, N. López-Ariztegui, V. Martín, M.J. Ramiro, E. González, R. Carrillo" "autores" => array:8 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Rodríguez de Lope" ] 1 => array:2 [ "nombre" => "J.M." "apellidos" => "Castilla" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Gómez" ] 3 => array:2 [ "nombre" => "N." "apellidos" => "López-Ariztegui" ] 4 => array:2 [ "nombre" => "V." "apellidos" => "Martín" ] 5 => array:2 [ "nombre" => "M.J." "apellidos" => "Ramiro" ] 6 => array:2 [ "nombre" => "E." "apellidos" => "González" ] 7 => array:2 [ "nombre" => "R." "apellidos" => "Carrillo" ] ] ] 1 => array:2 [ "autoresLista" => "I. Jiménez" "autores" => array:1 [ 0 => array:2 [ "nombre" => "I." "apellidos" => "Jiménez" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147396710795?idApp=UINPBA00004B" "url" => "/11301473/0000000700000003/v1_201305151453/S1130147396710795/v1_201305151453/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1130147396710771" "issn" => "11301473" "doi" => "10.1016/S1130-1473(96)71077-1" "estado" => "S300" "fechaPublicacion" => "1996-01-01" "aid" => "71077" "copyright" => "Sociedad Española de Neurocirugía" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Neurocirugia. 1996;7:181-8" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1635 "formatos" => array:3 [ "EPUB" => 14 "HTML" => 808 "PDF" => 813 ] ] "es" => array:9 [ "idiomaDefecto" => true "titulo" => "Traumatismos medulares experimentales: Revisión de la literatura y descripción de un modelo mediante compresión mantenida en la rata" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "181" "paginaFinal" => "188" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:2 [ 0 => array:2 [ "autoresLista" => "M.A. Pérez-Espejo, M. Poza y Poza" "autores" => array:2 [ 0 => array:2 [ "nombre" => "M.A." "apellidos" => "Pérez-Espejo" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Poza y Poza" ] ] ] 1 => array:2 [ "autoresLista" => "S.S. Haghighi, J.J. Oró" "autores" => array:2 [ 0 => array:2 [ "nombre" => "S.S." "apellidos" => "Haghighi" ] 1 => array:2 [ "nombre" => "J.J." "apellidos" => "Oró" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147396710771?idApp=UINPBA00004B" "url" => "/11301473/0000000700000003/v1_201305151453/S1130147396710771/v1_201305151453/es/main.assets" ] "es" => array:12 [ "idiomaDefecto" => true "titulo" => "Efectos de la administración de dexametasona sobre un modelo experimental de tumor neuroectodérmico primitivo" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "189" "paginaFinal" => "192" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "M. Zurita, S. Oya, S. Coca, J. Vaquero" "autores" => array:4 [ 0 => array:2 [ "nombre" => "M." "apellidos" => "Zurita" ] 1 => array:2 [ "nombre" => "S." "apellidos" => "Oya" ] 2 => array:2 [ "nombre" => "S." "apellidos" => "Coca" ] 3 => array:2 [ "nombre" => "J." "apellidos" => "Vaquero" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Laboratorio de Neuro-oncología experimental, Servicio de Neurocirugía, Hospital Universitario Clínica Puerta de Hierro; Departamentos de Biología Celular y Anatomía Patológica, Facultad de Medicina, Universidad Complutense, Madrid" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras Clave" "identificador" => "xpalclavsec162990" "palabras" => array:3 [ 0 => "Tumor neuroectodérmico primitivo" 1 => "Dexametasona" 2 => "Tumor cerebral experimental" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key Words" "identificador" => "xpalclavsec162989" "palabras" => array:3 [ 0 => "Primitive neuroectodermal tumor" 1 => "Dexamethasone" 2 => "Experimental brain tumor" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Se ha realizado un estudio experimental sobre el tumor IL-7, implantado subcutáneamente en ratas Wistar, al objeto de verificar si la administración sistémica o intralesional de dexametasona puede ejercer un efecto antitumoral. Los resultados obtenidos muestran que, tras cuatro semanas de tratamiento, la administración de este fármaco, ya sea por vía sistémica o mediante inyección directa intratumoral, no modifica significativamente el volumen del tumor ni el índice de proliferación celular. Teniendo en cuenta el carácter neuroectodérmico primitivo del tumor IL-7, los presentes resultados sugieren la ineficacia de la dexametasona, como agente citolítico, sobre neoplasias cerebrales humanas que muestren características histológicas de tumor neuroectodérmico primitivo.</p>" ] "en" => array:2 [ "titulo" => "Summary" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">An experimental study has been performed on the IL-7 tumor growing in the subcutaneous tissue of Wistar rats. The possibility of an antitumor effect of dexamethasone, after systemic or intralesional administration was evaluated. After four weeks of dexamethasone administration, a reduction in the tumor volume or proliferation cell index was not reached. Due to the fact that IL-7 may be considered as a primitive neuroectodermal tumor, our present results suggest that dexamethasone is inefficacious as a cytolytic agent for the control of human primitive neuroectodermal tumors.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Zurita, M.; Oya, S.; Coca, S.; Vaquero, J.: Efectos de la administración de dexametasona sobre un modelo experimental de tumor neuroectodérrnico primitivo. Neurocirugía 1996; 7: 189–192.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:19 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Steroid-induced CT changes in patients with recurrent malignant glioma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J.G. Cairncross" 1 => "D.R. MacDonald" 2 => "W. Pexman" 3 => "F.J. Ives" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurology" "fecha" => "1988" "volumen" => "38" "paginaInicial" => "724" "paginaFinal" => "726" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3362369" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The use of steroids for control of cerebral edema" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "L.A. French" 1 => "J.H. Galicich" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Neurosurg" "fecha" => "1964" "volumen" => "10" "paginaInicial" => "212" "paginaFinal" => "223" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14095874" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of glucocorticoids on glioma cells in culture. Minireview on cancer research" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R.I. Freshney" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Exp Cell Biol" "fecha" => "1984" "volumen" => "52" "paginaInicial" => "286" "paginaFinal" => "292" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6541165" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Use of dexamethasone in the treatment of cerebral edema associated with brain tumors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.H. Galicich" 1 => "L.A. French" 2 => "J.C. Melby" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Lancet" "fecha" => "1961" "volumen" => "81" "paginaInicial" => "46" "paginaFinal" => "53" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Use of dexamethasone in the treatment of cerebral edema resulting from brain tumors and brain surgery" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.H. Galicich" 1 => "L.A. French" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Am Practitioner Dig Treat" "fecha" => "1961" "volumen" => "12" "paginaInicial" => "169" "paginaFinal" => "174" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Influence of preoperative dexamethasone therapy on proliferating cell nuclear antigen (PCNA) expression in comparison to other parameters in meningiomas" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "J. Gottschal" 1 => "S. Goebel" 2 => "G. Jauzke" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Histol Histopath" "fecha" => "1992" "volumen" => "7" "paginaInicial" => "653" "paginaFinal" => "661" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The therapy of human tumors in athymic (nude) mice" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D.P. Houchens" 1 => "A.A. Ovejera" 2 => "A.D. Bauker" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Proceedings of the Symposium on the use of athymic (nude) mice in Cancer Research" "paginaInicial" => "267" "paginaFinal" => "280" "serieFecha" => "1978" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Therapeutic effects of local delivery of dexamethasone on experimental brain tumors and peritumoral brain edema" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "Y. Ikeda" 1 => "B. Carson" 2 => "J.A. Lauer" 3 => "D.M. Long" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1993.79.5.0716" "Revista" => array:6 [ "tituloSerie" => "J Neurosurg" "fecha" => "1993" "volumen" => "79" "paginaInicial" => "716" "paginaFinal" => "721" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8410250" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of hydrocortisone on Ehrlich ascites tumor" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M. Kodama" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Res" "fecha" => "1962" "volumen" => "22" "paginaInicial" => "1212" "paginaFinal" => "1219" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14034077" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of steroid hormones on the in vivo incorporation of glycine-2-14C into solid Ehrlich tumor, kidney and liver" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M. Kodama" 1 => "T. Kodama" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Res" "fecha" => "1970" "volumen" => "30" "paginaInicial" => "228" "paginaFinal" => "235" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5458961" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of dexamethasone and metylprednisolone on cell cultures of human glioblastomas" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J. Mealey Jr." 1 => "T.T. Chen" 2 => "G.P. Schanz" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1971.34.3.0324" "Revista" => array:6 [ "tituloSerie" => "J Neurosurg" "fecha" => "1971" "volumen" => "34" "paginaInicial" => "324" "paginaFinal" => "334" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4323143" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Does dexamethasone inhibit the growth of human gliomas?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "G. Sherbert" 1 => "M.S. Lakshmi" 2 => "S.K. Haddad" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1977.47.6.0864" "Revista" => array:6 [ "tituloSerie" => "J Neurosurg" "fecha" => "1977" "volumen" => "47" "paginaInicial" => "864" "paginaFinal" => "870" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/925742" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Growth inhibition of the 9L glioma using polymers to release heparin and cortisone acetato" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R.J. Tamargo" 1 => "K.W. Leong" 2 => "H. Brem" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Neuro-Oncol" "fecha" => "1990" "volumen" => "9" "paginaInicial" => "131" "paginaFinal" => "138" ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Interstitial delivery of dexamethasone in the brain for the reduction of peritumoral edema" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "R.J. Tamargo" 1 => "A.K. Sills Jr." 2 => "C.S. Reinhard" 3 => "M.L. Pinn" 4 => "D.M. Long" 5 => "H. Brem" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1991.74.6.0956" "Revista" => array:6 [ "tituloSerie" => "J Neurosurg" "fecha" => "1991" "volumen" => "74" "paginaInicial" => "956" "paginaFinal" => "961" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2033457" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Interstitial chemotherapy for brain tumors: review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "T. Tomita" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Neuro-Oncol" "fecha" => "1991" "volumen" => "10" "paginaInicial" => "57" "paginaFinal" => "74" ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Growth of human tumors in cortisone-treated laboratory animals: The possibility of obtaining permanently transplantable human tumors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "H.V. Toolan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Res" "fecha" => "1953" "volumen" => "13" "paginaInicial" => "389" "paginaFinal" => "394" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/13042839" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Experimental induction of primitive neuroectodermal tumours in rats: A reappraisement of the ENU-induced model of neurocarcinogenesis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J. Vaquero" 1 => "S. Oya" 2 => "S. Coca" 3 => "M. Zurita" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Acta Neurochir (Wien)" "fecha" => "1994" "volumen" => "131" "paginaInicial" => "294" "paginaFinal" => "301" ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Steroid-induced inhibition of growth in glial tumors: A kinetic analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "C.B. Wilson" 1 => "M. Barker" 2 => "T. Hoshino" 3 => "A. Oliver" 4 => "R. Downie" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Steroids and Brain Edema" "paginaInicial" => "95" "paginaFinal" => "100" "serieFecha" => "1972" ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The effect of glucocorticosteroids on growth and metabolism of experimental glial tumors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R.L. Wright" 1 => "B. Shaumba" 2 => "J. Keller" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1969.30.2.0140" "Revista" => array:6 [ "tituloSerie" => "J Neurosurg" "fecha" => "1969" "volumen" => "30" "paginaInicial" => "140" "paginaFinal" => "145" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5780882" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/11301473/0000000700000003/v1_201305151453/S1130147396710783/v1_201305151453/es/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/11301473/0000000700000003/v1_201305151453/S1130147396710783/v1_201305151453/es/main.pdf?idApp=UINPBA00004B&text.app=https://revistaneurocirugia.com/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147396710783?idApp=UINPBA00004B" ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2023 Marzo | 0 | 2 | 2 |
| 2018 Febrero | 16 | 15 | 31 |
| 2018 Enero | 18 | 22 | 40 |
| 2017 Diciembre | 17 | 31 | 48 |
| 2017 Noviembre | 24 | 61 | 85 |
| 2017 Octubre | 21 | 30 | 51 |
| 2017 Septiembre | 14 | 35 | 49 |
| 2017 Agosto | 25 | 36 | 61 |
| 2017 Julio | 16 | 25 | 41 |
| 2017 Junio | 36 | 33 | 69 |
| 2017 Mayo | 32 | 33 | 65 |
| 2017 Abril | 26 | 23 | 49 |
| 2017 Marzo | 16 | 30 | 46 |
| 2017 Febrero | 10 | 18 | 28 |
| 2017 Enero | 15 | 25 | 40 |
| 2016 Diciembre | 18 | 21 | 39 |
| 2016 Noviembre | 12 | 34 | 46 |
| 2016 Octubre | 10 | 67 | 77 |
| 2016 Septiembre | 52 | 91 | 143 |
| 2016 Agosto | 64 | 56 | 120 |
| 2016 Julio | 41 | 69 | 110 |
| 2015 Diciembre | 2 | 0 | 2 |
| 2015 Agosto | 2 | 0 | 2 |
| 2015 Julio | 1 | 8 | 9 |
| 2015 Junio | 18 | 48 | 66 |
| 2015 Mayo | 12 | 67 | 79 |
| 2015 Abril | 13 | 50 | 63 |
| 2015 Marzo | 14 | 45 | 59 |
| 2015 Febrero | 13 | 47 | 60 |
| 2015 Enero | 14 | 32 | 46 |
| 2014 Diciembre | 16 | 44 | 60 |
| 2014 Noviembre | 12 | 47 | 59 |
| 2014 Octubre | 16 | 58 | 74 |
| 2014 Septiembre | 18 | 63 | 81 |
| 2014 Agosto | 10 | 70 | 80 |
| 2014 Julio | 14 | 48 | 62 |
| 2014 Junio | 16 | 61 | 77 |
| 2014 Mayo | 19 | 62 | 81 |
| 2014 Abril | 19 | 64 | 83 |
| 2014 Marzo | 18 | 41 | 59 |
| 2014 Febrero | 20 | 25 | 45 |
| 2014 Enero | 14 | 55 | 69 |
| 2013 Diciembre | 21 | 42 | 63 |
| 2013 Noviembre | 21 | 34 | 55 |
| 2013 Octubre | 21 | 31 | 52 |
| 2013 Septiembre | 24 | 41 | 65 |
| 2013 Agosto | 34 | 40 | 74 |
| 2013 Julio | 28 | 24 | 52 |
| 2013 Junio | 18 | 37 | 55 |
| 2013 Mayo | 17 | 21 | 38 |
| 2013 Abril | 19 | 28 | 47 |
| 2013 Marzo | 14 | 26 | 40 |
| 2013 Febrero | 10 | 12 | 22 |
| 2013 Enero | 18 | 14 | 32 |
| 2012 Diciembre | 8 | 23 | 31 |
| 2012 Noviembre | 0 | 13 | 13 |
| 2012 Octubre | 0 | 5 | 5 |
| 2012 Septiembre | 0 | 1 | 1 |
| 2012 Enero | 6 | 0 | 6 |
Mostrar todo
