Metástasis en el sistema nervioso central: biología molecular
Metástasis tumors of the central nervous system: molecular biology
M. Josefa Bello
, P. González-Gómez, J.A. Rey
Laboratorio de Oncogenetica Molecular y Epigenetica del Cáncer, Unidad de Investigación, Departamento de Cirugía Experimental, Hospital Universitario “La Paz”. Madrid
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Correlación anatomo-angiográfica y su implicancia en la cirugía de aneurismas intracraneanos. (Arterias: ácigos cerebral anterior, mediana del cuerpo calloso y cerebral media accesoria)</span> de Martínez y cols" "tienePdf" => "es" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "588" "paginaFinal" => "589" ] ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "F. González-Llanos, J.M. Pascual, J.M. Roda" "autores" => array:3 [ 0 => array:2 [ "nombre" => "F." "apellidos" => "González-Llanos" ] 1 => array:2 [ "nombre" => "J.M." "apellidos" => "Pascual" ] 2 => array:2 [ "nombre" => "J.M." 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"apellidos" => "Rey" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Laboratorio de Oncogenetica Molecular y Epigenetica del Cáncer, Unidad de Investigación, Departamento de Cirugía Experimental, Hospital Universitario “La Paz”. Madrid" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Correspondencia postal: Laboratorio de Oncogenética Molecular y Epigenética del Cáncer. Unidad de Investigación. Departamento de Cirugía Experimental, Hospital Universitario “La Paz”. Paseo de la Castellana, 261. 28046. Madrid, España." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Metástasis tumors of the central nervous system: molecular biology" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2004-06-09" "fechaAceptado" => "2004-06-18" "PalabrasClave" => array:2 [ "es" => array:2 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec158649" "palabras" => array:5 [ 0 => "Metástasis en el sistema nervioso" 1 => "Biología molecular" 2 => "GST" 3 => "Oncogen" 4 => "Metilación" ] ] 1 => array:4 [ "clase" => "abr" "titulo" => "Abreviaturas" "identificador" => "xpalclavsec158650" "palabras" => array:13 [ 0 => "DAP-Kinasa" 1 => "DCC" 2 => "EGFR" 3 => "GSTP-1" 4 => "HCG" 5 => "MDR-1" 6 => "MGMT" 7 => "MMP-2" 8 => "PTEN" 9 => "RB 1" 10 => "THBS1" 11 => "TIMP-3" 12 => "VEGF" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec158651" "palabras" => array:5 [ 0 => "Metastatic tumours of the nervous system" 1 => "Molecular biology" 2 => "TSG" 3 => "Oncogene" 4 => "Methylation" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Las metástasis en el sistema nervioso representan un importante y creciente problema en la práctica clínica, siendo causa de gran mortalidad en los países desarrollados. En este artículo revisamos los escasos datos existentes hasta el momento acerca de los mecanismos moleculares implicados en la patogénesis de las metástasis en el sistema nervioso, que incluyen diversas alteraciones genéticas, en genes supresores de tumores y oncogenes, así como la alteración del equilibrio epigenético de la célula. Concluimos que en un futuro un mayor conocimiento de dichos mecanismos moleculares contribuirán a un mejor diagnóstico, tratamiento y evolución clínica de estos pacientes.</p>" ] "en" => array:2 [ "titulo" => "Summary" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Metastases in the nervous system represent an important and growing problem in the clinical practice, being the cause of a great mortality in the developed countries. This article reviews the few data available on the molecular mechanisms involved in the pathogenesis of these tumours, leading to oncogene activation, inactivation of tumour suppresor genes, not only by the clasical mechanisms, but also by the tumour cell epigenetic balance alteration. We conclude that all this knowledge will lead in the future to a better diagnosis, treatment and clinic evolution of these patients.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Bello, M.J.; González-Gómez, P.; Rey, J.A.: Metástasis en el sistema nervioso central: biología molecular. Neurocirugía 2004; 15: 590–595.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:33 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2023 Marzo | 1 | 2 | 3 |
| 2018 Marzo | 0 | 1 | 1 |
| 2018 Febrero | 21 | 7 | 28 |
| 2018 Enero | 26 | 11 | 37 |
| 2017 Diciembre | 15 | 22 | 37 |
| 2017 Noviembre | 34 | 43 | 77 |
| 2017 Octubre | 23 | 22 | 45 |
| 2017 Septiembre | 37 | 40 | 77 |
| 2017 Agosto | 36 | 26 | 62 |
| 2017 Julio | 38 | 38 | 76 |
| 2017 Junio | 33 | 19 | 52 |
| 2017 Mayo | 41 | 32 | 73 |
| 2017 Abril | 25 | 39 | 64 |
| 2017 Marzo | 33 | 25 | 58 |
| 2017 Febrero | 28 | 29 | 57 |
| 2017 Enero | 25 | 20 | 45 |
| 2016 Diciembre | 31 | 25 | 56 |
| 2016 Noviembre | 29 | 33 | 62 |
| 2016 Octubre | 34 | 28 | 62 |
| 2016 Septiembre | 58 | 67 | 125 |
| 2016 Agosto | 77 | 48 | 125 |
| 2016 Julio | 53 | 43 | 96 |
| 2015 Diciembre | 6 | 0 | 6 |
| 2015 Agosto | 3 | 0 | 3 |
| 2015 Julio | 0 | 11 | 11 |
| 2015 Junio | 16 | 38 | 54 |
| 2015 Mayo | 16 | 51 | 67 |
| 2015 Abril | 25 | 41 | 66 |
| 2015 Marzo | 20 | 41 | 61 |
| 2015 Febrero | 18 | 49 | 67 |
| 2015 Enero | 13 | 37 | 50 |
| 2014 Diciembre | 15 | 32 | 47 |
| 2014 Noviembre | 11 | 38 | 49 |
| 2014 Octubre | 24 | 40 | 64 |
| 2014 Septiembre | 24 | 38 | 62 |
| 2014 Agosto | 15 | 37 | 52 |
| 2014 Julio | 14 | 40 | 54 |
| 2014 Junio | 24 | 56 | 80 |
| 2014 Mayo | 26 | 43 | 69 |
| 2014 Abril | 21 | 45 | 66 |
| 2014 Marzo | 19 | 41 | 60 |
| 2014 Febrero | 17 | 37 | 54 |
| 2014 Enero | 16 | 14 | 30 |
| 2013 Diciembre | 15 | 31 | 46 |
| 2013 Noviembre | 24 | 23 | 47 |
| 2013 Octubre | 20 | 22 | 42 |
| 2013 Septiembre | 24 | 39 | 63 |
| 2013 Agosto | 27 | 22 | 49 |
| 2013 Julio | 24 | 32 | 56 |
| 2013 Junio | 14 | 28 | 42 |
| 2013 Mayo | 11 | 29 | 40 |
| 2013 Abril | 13 | 34 | 47 |
| 2013 Marzo | 16 | 39 | 55 |
| 2013 Febrero | 13 | 25 | 38 |
| 2013 Enero | 15 | 17 | 32 |
| 2012 Diciembre | 14 | 19 | 33 |
| 2012 Noviembre | 2 | 13 | 15 |
| 2012 Octubre | 0 | 2 | 2 |
| 2012 Septiembre | 0 | 2 | 2 |
| 2012 Enero | 9 | 0 | 9 |
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