Revisión del traumatismo craneoencefálico
Overview of nead injury
A. Bárcena-Orbe
, J.M. Cañizal-García, C. Mestre-Moreiro, J.C. Calvo- Pérez, A.F. Molina-Foncea, J. Casado-Gómez
Servicio de Neurocirugía. Hospital Universitario Central de la Defensa. Madrid
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Madrid" "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0015" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Overview of nead injury" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2006-03-20" "fechaAceptado" => "2006-04-28" "PalabrasClave" => array:2 [ "es" => array:2 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec159427" "palabras" => array:5 [ 0 => "Traumatismo craneoencefálico" 1 => "Daño axonal difuso" 2 => "Metabolismo cerebral" 3 => "Guías de práctica clínica" 4 => "Infarto cerebral" ] ] 1 => array:4 [ "clase" => "abr" "titulo" => "Abreviaturas" "identificador" => "xpalclavsec159429" "palabras" => array:17 [ 0 => "AVDL" 1 => "AVDO<span class="elsevierStyleInf">2</span>" 2 => "BR" 3 => "CEO<span class="elsevierStyleInf">2</span>" 4 => "cNOS" 5 => "CSW" 6 => "CTE" 7 => "DAI" 8 => "EVP" 9 => "FSC" 10 => "GPDH" 11 => "HIC" 12 => "iNOS" 13 => "LOI" 14 => "PAM" 15 => "PtiO<span class="elsevierStyleInf">2</span>" 16 => "RLO" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec159428" "palabras" => array:5 [ 0 => "Head injury" 1 => "Diffuse axonal injury" 2 => "Brain metabolism" 3 => "Guidelines" 4 => "Brain infarction" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">En este artículo se ha realizado una revisión sistemática de los aspectos prácticos más destacables del manejo del traumatismo craneoencefálico en base a la literatura médica que hemos considerado relevante. El trabajo se ha desarrollado en diferentes apartados que comprenden la epidemiología, pronóstico y clasificación, anatomía patológica y fisiopatología, evaluación clínica y tratamiento. Se han tratado con especial énfasis las conexiones entre los rasgos fisiopatológicos con mayor grado de evidencia, de acuerdo con las guías de práctica clínica, y los esquemas de manejo terapéutico.</p>" ] "en" => array:2 [ "titulo" => "Summary" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A systematic revision of the main practical aspects related with the head injury management has been made in this article on the basis of relevant literature. The paper has been developed in different sections consisting of epidemiological factors, prognosis and classification, neuropathology and pathophysiology, clinical evaluation and treatment. According to clinical guidelines, the connections between the pathophysiological features with higher evidence degree and the schemes of therapeutic approahes have been emphasized.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Bárcena-Orbe, A.; Rodríguez-Arias, C.A.; Rivero-Martín, B.; Cañizal-García, J.M.; Mestre-Moreiro, C.; Calvo- Pérez, J.C.; Molina-Foncea, A.F.; Casado-Gómez, J.: Revisión del traumatismo craneoencefálico. Neurocirugía 2006; 17: 495–518.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:52 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Resources for Optimal Care of the Injuried Patients" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "American College of Surgeons. Committe on trauma" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:3 [ "fecha" => "1990" "editorial" => "ACS" "editorialLocalizacion" => "Chicago" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tratamiento del edema cerebral postraumático con especial referencia al protocolo de Lund" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "B. Asgeirsson" 1 => "P.O. Grände" 2 => "C.H. Nordström" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Traumatismo Craneoencefálico Grave" "paginaInicial" => "260" "paginaFinal" => "275" "serieFecha" => "1996" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cerebrospinal fluid pressure and intracranial volume-pressure relationships" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C.J.J. Avezaat" 1 => "J.H.M. van Eijndhoven" 2 => "D.J. Wyper" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Neurol Neurosurg Psychiatry" "fecha" => "1979" "volumen" => "42" "paginaInicial" => "687" "paginaFinal" => "700" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/490174" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Promising strategies to minimize secondary brain damage after head trauma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "H. Bayr" 1 => "R.S.B. Clark" 2 => "P. Kochaneck" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Crit Care Med" "fecha" => "2003" "volumen" => "1" "numero" => "Suppl" "paginaInicial" => "S112" "paginaFinal" => "S117" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Guidelines for the management of severe head injury. Brain Trauma Foundation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:10 [ 0 => "R. Bullock" 1 => "R.M. Chesnut" 2 => "G. Clifton" 3 => "J. Ghajar" 4 => "D.W. Marion" 5 => "R.K. Narayan" 6 => "D.W. Newell" 7 => "L.H. Pitts" 8 => "M.J. Rosner" 9 => "J.W. Wilberger" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur J Emerg Med" "fecha" => "1996" "volumen" => "3" "paginaInicial" => "109" "paginaFinal" => "127" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9028756" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Systems analysis of intracranial pressure. Comparison with volume-pressure test and CSFpulse amplitude analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "H. Chopp" 1 => "H.D. Portnoy" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1980.53.4.0516" "Revista" => array:6 [ "tituloSerie" => "J Neurosurg" "fecha" => "1980" "volumen" => "53" "paginaInicial" => "516" "paginaFinal" => "527" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7420174" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Validation study of a central venous pressure-based protocol for the management of neurosurgical patients with hyponatremia and natriuresis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S.C. Damaraju" 1 => "V. Rajshekhar" 2 => "M.J. Chandy" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurosurgery" "fecha" => "1997" "volumen" => "40" "paginaInicial" => "312" "paginaFinal" => "317" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9007863" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Benefits and pitfalls of jugular bulbvenous oxygen saturation monitoring" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "N.M. Dearden" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Neurochemical Monitoring in the Intensive Care" "paginaInicial" => "87" "paginaFinal" => "97" "serieFecha" => "1995" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Paleoencéfalo y neoencéfalo" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Delmas" 1 => "A. Delmas" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Vías y Centros Nerviosos: Introducción a la Neurología" "paginaInicial" => "123" "paginaFinal" => "159" "serieFecha" => "1965" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "High-dose barbiturate control of elevated intracranial pressure in patients with severe head injury" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "H.M. Eisenberg" 1 => "R.F. Frankowski" 2 => "C.F. Contant" 3 => "L.F. Marshall" 4 => "M.D. Walker" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1988.69.1.0015" "Revista" => array:6 [ "tituloSerie" => "J Neurosurg" "fecha" => "1988" "volumen" => "69" "paginaInicial" => "15" "paginaFinal" => "23" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3288723" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The traumatic coma data bank: design, methods, and baseline characteristics" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M.A. Foulkes" 1 => "H.M. Eisenberg" 2 => "J.A. Jane" 3 => "A. Marmarou" 4 => "L.F. Marshall" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Neurosurg (Suppl)" "fecha" => "1991" "volumen" => "M75" "paginaInicial" => "S8" "paginaFinal" => "S13" ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cerebral concussion and diffuse brain injuries" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "T.A. Gennarelli" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Head Injury" "paginaInicial" => "148" "paginaFinal" => "153" "serieFecha" => "1993" ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neuropathology of head injury" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "D.I. Graham" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Neurotrauma" "paginaInicial" => "43" "paginaFinal" => "59" "serieFecha" => "1996" ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pathology of brain damage" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D.I. Graham" 1 => "J.H. Adams" 2 => "T.A. Gennarelli" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Head Injury" "paginaInicial" => "91" "paginaFinal" => "113" "serieFecha" => "1993" ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Free radicals and lipid peroxidation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "E.D. Hall" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Neurotrauma" "paginaInicial" => "1405" "paginaFinal" => "1419" "serieFecha" => "1996" ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diffuse axonal injuries_Pathophysiology and imaging" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "D.A. Hammond" 1 => "B.A. Wasserman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neuroimaging Clin N Am" "fecha" => "2002" "volumen" => "12" "paginaInicial" => "205" "paginaFinal" => "216" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12391632" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cerebral salt wasting syndrome: a review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M.R. Harrigan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurosurgery" "fecha" => "1996" "volumen" => "38" "paginaInicial" => "152" "paginaFinal" => "160" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8747964" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidural pulse waveform as an indicator of intracranial pressure dynamics" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "O. Hirai" 1 => "H. Handa" 2 => "M. Ishikawa" 3 => "S.H. Kim" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Surg Neurol" "fecha" => "1984" "volumen" => "21" "paginaInicial" => "67" "paginaFinal" => "74" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6689813" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Biological Plasticity_The future of science in neurosurgery" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "C. Hodge" 1 => "M. Boakye" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurosurgery" "fecha" => "2001" "volumen" => "48" "paginaInicial" => "2" "paginaFinal" => "16" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11152347" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidemiology of head injury" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "B. Jennett" 1 => "R. MacMillan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Br Med J" "fecha" => "1981" "volumen" => "282" "paginaInicial" => "101" "paginaFinal" => "104" ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Aspects of coma after severe head injury" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "B. Jennett" 1 => "G. Teasdale" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1977" "volumen" => "1" "paginaInicial" => "878" "paginaFinal" => "881" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2895379" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The association between neuronal nitric synthase and neuronal sensitivity in the brain after brain injury" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "P.R. Liu" 1 => "C.S. Robertson" 2 => "A. Valadka" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann NY Acad Sci" "fecha" => "2002" "volumen" => "962" "paginaInicial" => "226" "paginaFinal" => "241" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12076978" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Outcome from severe head injury related to the type of intracranial lesion. A computerized tomography study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:9 [ 0 => "R.D. Lobato" 1 => "F. Cordobés" 2 => "J.J. Rivas" 3 => "M. de la Fuente" 4 => "A. Montero" 5 => "A. Bárcena" 6 => "C. Pérez" 7 => "A. Cabrera" 8 => "E. Lamas" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1983.59.5.0762" "Revista" => array:6 [ "tituloSerie" => "J Neurosurg" "fecha" => "1983" "volumen" => "59" "paginaInicial" => "762" "paginaFinal" => "774" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6619928" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genomics of the periinfarction cortex after focal ischemia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A. Lu" 1 => "Y. Tang" 2 => "R. Ran" 3 => "J.F. Clark" 4 => "B.J. Aronow" 5 => "F.R. Sharp" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.WCB.0000062340.80057.06" "Revista" => array:6 [ "tituloSerie" => "J Cereb Blood Flow Metab" "fecha" => "2003" "volumen" => "23" "paginaInicial" => "786" "paginaFinal" => "810" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12843783" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The diagnosis of head injury requires a classification based on computerized axial tomography" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:9 [ 0 => "L.F. Marshall" 1 => "S.B. Marshall" 2 => "M.R. Klauber" 3 => "M. Van Berkum Clark" 4 => "H. Eisenberg" 5 => "J.A. Jane" 6 => "Tg. Luerssen" 7 => "A. Marmarou" 8 => "M.A. Foulkes" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "J Neurotrauma" "fecha" => "1992" "volumen" => "9" "numero" => "Suppl" "paginaInicial" => "S287" "paginaFinal" => "S292" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1588618" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pressure-volume index in head injury" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:10 [ 0 => "A.L. Maset" 1 => "A. Marmarou" 2 => "J.D. Ward" 3 => "S. Choi" 4 => "H.A. Lutz" 5 => "D. Brooks" 6 => "R.J. Moulton" 7 => "A. DeSalles" 8 => "J.P. Muizelaar" 9 => "H. Turner" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1987.67.6.0832" "Revista" => array:6 [ "tituloSerie" => "J Neurosurg" "fecha" => "1987" "volumen" => "67" "paginaInicial" => "832" "paginaFinal" => "840" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3681422" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Levels of nitric oxide are markedly increased in cerebrospinal fluid from patients with severe head injury" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J.A. Navarro-Gonzalvez" 1 => "J. Arenas" 2 => "R.D. Lobato" 3 => "P. Gómez" 4 => "C.A. Rodríguez-Arias" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Chim Acta" "fecha" => "2000" "volumen" => "290" "paginaInicial" => "221" "paginaFinal" => "222" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10660812" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Raised intracranial pressure. -A clinical guide" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "B. North" 1 => "P. Reilly" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:2 [ "tituloSerie" => "Oxford, Heinemann Medical Books" "fecha" => "1990" ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Efficacy of hyperventilation, blood pressure elevation, and metabolic supression therapy in controlling intracranial pressure after head injury" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:9 [ 0 => "M. Oertel" 1 => "D.F. Kelly" 2 => "J.H. Lee" 3 => "D.L. McArthur" 4 => "T.C. Glenn" 5 => "P. Vespa" 6 => "W.J. Boscardin" 7 => "D.A. Hovda" 8 => "N.A. Martin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.2002.97.5.1045" "Revista" => array:6 [ "tituloSerie" => "J Neurosurg" "fecha" => "2002" "volumen" => "97" "paginaInicial" => "1045" "paginaFinal" => "1053" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12450025" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib30" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Oxidative damage after severe head injury and its relationship to neurological outcome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "A. Paolin" 1 => "L. Nardin" 2 => "P. Gaetani" 3 => "Rodriguez" 4 => "R. Baena" 5 => "O. Pansarasa" 6 => "F. Marzatico" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurosurgery" "fecha" => "2002" "volumen" => "51" "paginaInicial" => "949" "paginaFinal" => "955" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12234402" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib31" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Actualizaciones en los métodos de monitorización cerebral regional en los pacientes neurocríticos: presión tisular de oxígeno, microdiálisis cerebral y técnicas de espectroscopía por infrarrojos" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M.A. Poca" 1 => "J. Sahuquillo" 2 => "M.P. Mena" 3 => "A. Vilalta" 4 => "M. Riveiro" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurocirugía" "fecha" => "2005" "volumen" => "16" "paginaInicial" => "385" "paginaFinal" => "410" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16276448" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib32" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Plasma vitamin C levels are decreased and correlates with brain damage in patients with intracranial hemorrhage or head trauma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.C. Polidori" 1 => "P. Mecocci" 2 => "B. Frei" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Stroke" "fecha" => "2001" "volumen" => "32" "paginaInicial" => "898" "paginaFinal" => "905" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11283389" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib33" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Outcome analysis of patients with severe head injuries and prolonged intracranial hypertension" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D.K. Resnick" 1 => "D.W. Marion" 2 => "P. Carlier" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Trauma" "fecha" => "1997" "volumen" => "42" "paginaInicial" => "1108" "paginaFinal" => "1111" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9210550" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib34" "etiqueta" => "34." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Anaerobic metabolism within the brain failure in head-injuried patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "C.S. Robertson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:6 [ "editores" => "J.L.VincentD.BilhariJ.W.Holaday" "paginaInicial" => "85" "paginaFinal" => "102" "serieVolumen" => "4" "serieTitulo" => "Update in Intensive Care and Emergency Medicine, Brain Failure" "serieFecha" => "1989" ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib35" "etiqueta" => "35." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Posterior pituitary" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "G.L. Robertson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Endocrinology and Metabolism" "paginaInicial" => "338" "paginaFinal" => "388" "serieFecha" => "1987" ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib36" "etiqueta" => "36." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Implicación de la cadena respiratoria en la isquemia-revascularización y su relación con los radicales libres. Variaciones de los complejos I y IV en un modelo experimental de colgajo libre cutáneo" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "C.A. Rodríguez Arias" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:2 [ "tituloSerie" => "Tesis Doctoral. Universidad de Salamanca" "fecha" => "1997" ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib37" "etiqueta" => "37." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "CPP management I: Results" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M.J. Rosner" 1 => "S.D. Rosner" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Intracranial Pressure IX" "paginaInicial" => "218" "paginaFinal" => "221" "serieFecha" => "1994" ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib38" "etiqueta" => "38." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "CPP management II: Optimization of CPP or vasoparalysis does not exist in the living brain?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M.J. Rosner" 1 => "S.D. Rosner" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Intracranial Pressure IX" "paginaInicial" => "221" "paginaFinal" => "223" "serieFecha" => "1994" ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib39" "etiqueta" => "39." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Does an increase in cerebral perfussion pressure always mean a better oxygenated brain?. A study in head-injuried patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "J. Sahuquillo" 1 => "S. Amorós" 2 => "A. Santos" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Acta Neurochir (Suppl)" "fecha" => "2000" "volumen" => "76" "paginaInicial" => "457" "paginaFinal" => "462" ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib40" "etiqueta" => "40." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Autorregulación cerebral: conceptos fisiopatológicos y metodología para su valoración en el paciente neurotraumatizado" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J. Sahuquillo" 1 => "A. Rodríguez-Baeza" 2 => "M. Báguena" 3 => "F. Reina" 4 => "L. Campos" 5 => "E. Rubio" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Medicina Intensiva" "fecha" => "1996" "volumen" => "20" "paginaInicial" => "69" "paginaFinal" => "78" ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib41" "etiqueta" => "41." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Trapping of oxygen free radicals during brain ischemia and reperfusion" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A. Sakamoto" 1 => "R. Ogawa" 2 => "T. Ohnishi" 3 => "S.T. Ohnishi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Central Nervous System Trauma. Research Techniques. Boca Raton," "paginaInicial" => "445" "paginaFinal" => "453" "serieFecha" => "1995" ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib42" "etiqueta" => "42." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pharmacologic therapy for traumatic brain injury: experimental approaches" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D.H. Smith" 1 => "K. Casey" 2 => "T.K. McIntosh" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "New Horizons" "fecha" => "1995" "volumen" => "3" "paginaInicial" => "562" "paginaFinal" => "572" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7496768" "web" => "Medline" ] ] ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bib43" "etiqueta" => "43." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pathological regulation in cerebral ischemia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "L. Symon" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Cerebral Blood Flow. Physiological and Clinical Aspects" "paginaInicial" => "423" "paginaFinal" => "424" "serieFecha" => "1987" ] ] ] ] ] ] 43 => array:3 [ "identificador" => "bib44" "etiqueta" => "44." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Optimal temperature for the management of severe traumatic brain injury_ Effect of hypothermia on intracranial pressure, systemic and intracranial dynamics, and metabolism" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "T. Takashi" 1 => "M. Kazuya" 2 => "M. Tomoya" 3 => "Y. Shintaro" 4 => "I. Kazufumi" 5 => "S. Minoru" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurosurgery" "fecha" => "2003" "volumen" => "52" "paginaInicial" => "102" "paginaFinal" => "112" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12493106" "web" => "Medline" ] ] ] ] ] ] ] ] 44 => array:3 [ "identificador" => "bib45" "etiqueta" => "45." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Craniocerebral trauma: protection and retrieval of the neuronal population after injury" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "G.M. Teasdale" 1 => "D.I. Graham" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Neurosurgery" "fecha" => "1998" "volumen" => "4" "paginaInicial" => "723" "paginaFinal" => "738" ] ] ] ] ] ] 45 => array:3 [ "identificador" => "bib46" "etiqueta" => "46." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intracranial pressure: its measurement and treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J. Ward" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Yearbook of Intensive Care and Emergency Medicine" "paginaInicial" => "631" "paginaFinal" => "637" "serieFecha" => "1994" ] ] ] ] ] ] 46 => array:3 [ "identificador" => "bib47" "etiqueta" => "47." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Free radicals, antioxidants, and neurological injury_ Possible relationship to cerebral protection by anesthetics" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.X. Wilson" 1 => "A.W. Gelb" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Neurosurg Anesthesiol" "fecha" => "2002" "volumen" => "14" "paginaInicial" => "66" "paginaFinal" => "79" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11773828" "web" => "Medline" ] ] ] ] ] ] ] ] 47 => array:3 [ "identificador" => "bib48" "etiqueta" => "48." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Traumatic axonal injury induces calcium influx modulated by tetrodotoxin-sensitive sodium channels" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J.A. Wolf" 1 => "P.K. Stys" 2 => "T. Lusardi" 3 => "D. Meaney" 4 => "D.H. Smith" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Neurosc" "fecha" => "2001" "volumen" => "21" "paginaInicial" => "1923" "paginaFinal" => "1930" ] ] ] ] ] ] 48 => array:3 [ "identificador" => "bib49" "etiqueta" => "49." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pontine and extrapontine myelinosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D.G. Wright" 1 => "R. Laureano" 2 => "M. Victor" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Brain" "fecha" => "1979" "volumen" => "102" "paginaInicial" => "361" "paginaFinal" => "385" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/455045" "web" => "Medline" ] ] ] ] ] ] ] ] 49 => array:3 [ "identificador" => "bib50" "etiqueta" => "50." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Postraumatic seizures" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "S.A. Yablon" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Phys Med Rehabil" "fecha" => "1993" "volumen" => "74" "paginaInicial" => "983" "paginaFinal" => "1001" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8379848" "web" => "Medline" ] ] ] ] ] ] ] ] 50 => array:3 [ "identificador" => "bib51" "etiqueta" => "51." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Brain oxygenation and energy metabolism_Part I_ Biological function and pathophysiology" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A. Zauner" 1 => "W. Daugherty" 2 => "R. Bullock" 3 => "D. Warner" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurosurgery" "fecha" => "2002" "volumen" => "51" "paginaInicial" => "289" "paginaFinal" => "302" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12182767" "web" => "Medline" ] ] ] ] ] ] ] ] 51 => array:3 [ "identificador" => "bib52" "etiqueta" => "52." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Transport of water and glycerol in aquaporin 3 is gated by H+" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "T. Zeuthen" 1 => "D.A. Klaerke" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Biol Chem" "fecha" => "1999" "volumen" => "274" "paginaInicial" => "21631" "paginaFinal" => "21636" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10419471" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/11301473/0000001700000006/v1_201305151259/S1130147306703141/v1_201305151259/es/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/11301473/0000001700000006/v1_201305151259/S1130147306703141/v1_201305151259/es/main.pdf?idApp=UINPBA00004B&text.app=https://revistaneurocirugia.com/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147306703141?idApp=UINPBA00004B" ]
| año/Mes | Html | Total | |
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