Degeneración tumoral en meningocele no intervenido. Descripción de dos casos
Tumoral degeneration occurring over a non-healing meningocele. Report of two cases
D. Rivero-Celada
, L.I. Carcavilla-Loncán, J.M. Cantero-Antón, J. Eiras-Ajuria
Servicio de Neurocirugía. Hospital Universitario Miguel Servet. Zaragoza
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"apellidos" => "Rivero-Celada" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "L.I." "apellidos" => "Carcavilla-Loncán" ] 2 => array:2 [ "nombre" => "J.M." "apellidos" => "Cantero-Antón" ] 3 => array:2 [ "nombre" => "J." "apellidos" => "Eiras-Ajuria" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Neurocirugía. Hospital Universitario Miguel Servet. Zaragoza" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Correspondencia postal: C/ Eugenio Lucas 20, Esc. l<span class="elsevierStyleSup">a</span>, 3° A. 50018 Zaragoza." ] ] ] 1 => array:3 [ "autoresLista" => "M.A. Marín-Cárdenas, J. Alfaro-Torres, F. Duato- Jané" "autores" => array:3 [ 0 => array:3 [ "nombre" => "M.A." "apellidos" => "Marín-Cárdenas" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0010" ] ] ] 1 => array:3 [ "nombre" => "J." "apellidos" => "Alfaro-Torres" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0015" ] ] ] 2 => array:3 [ "nombre" => "F." "apellidos" => "Duato- Jané" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">***</span>" "identificador" => "aff0020" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Unidad de Neurorradiología. Hospital Universitario Miguel Servet. Zaragoza" "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0010" ] 1 => array:3 [ "entidad" => "Servicio de Anatomía Patológica. Hospital Universitario Miguel Servet. Zaragoza" "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0015" ] 2 => array:3 [ "entidad" => "Servicio de Cirugía Plástica. Hospital Universitario Miguel Servet. Zaragoza" "etiqueta" => "<span class="elsevierStyleSup">***</span>" "identificador" => "aff0020" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Tumoral degeneration occurring over a non-healing meningocele. Report of two cases" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2005-06-06" "fechaAceptado" => "2006-01-26" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec159447" "palabras" => array:4 [ 0 => "Meningocele" 1 => "Espina bífida" 2 => "Degeneración carcinomatosa" 3 => "Sarcoma" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec159446" "palabras" => array:4 [ 0 => "Meningocele" 1 => "Spina bifida" 2 => "Carcinomatous degeneration" 3 => "Sarcoma" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Asistir a pacientes que presentan un meningocele gigante y en edad adulta es una rareza clínica, debido en parte a que es una malformación disráfica con una incidencia baja y a que el índice de supervivencia de los recién nacidos con éstas patologías era menor en épocas anteriores, pese a la benignidad de la malformación.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Aportamos a la literatura existente los casos de dos pacientes que nacieron con un disrafismo espinal abierto y que no fueron operados en su momento, llegando a la edad adulta con voluminosos sacos meningocutáneos que tuvieron que ser extirpados, por presentar en el caso de más edad, un absceso con fistulización sin salida de LCR que no mejoró con tratamiento tópico y antibiótico. En el otro caso por sospecha de malignización debido a crecimiento progresivo de la malformación durante el último año, endurecimiento de la piel y dolor.</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">El estudio anatomopatológico de los sacos resecados demostró la existencia de una degeneración carcinomatosa.</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">En nuestros casos y en los pocos casos encontrados en la bibliografía parece que la irritación crónica del LCR y la existencia de células multipotenciales en el saco meningocélico pueden favorecer la malignización de los tejidos que recubren el mismo.</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">La posible malignización descrita en la escasa literatura existente, a la que aportamos nuestros dos casos, sugiere como tratamiento de elección la exéresis quirúrgica de estas lesiones congénitas lo más precozmente posible</p>" ] "en" => array:2 [ "titulo" => "Summary" "resumen" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">A giant meningocelic sac has not been usually described in adult patients, due to the fact that it shows a low incidence and few newborn have survived to date though the malformation is benign.</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">We report two cases of patients born with the described malformation and who were not operated at that time, so they reached adulthood with bigger sacs. They needed surgery to remove the sacs, for a different reason. The older one had a fistulous abcess but the LCR did not come out, and it did not improved by the application of topic and antibiotic treatment. The other patient showed a progressive growth of the malformation during the last year, skin hardening and pain.</p><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">The histological study of the dried sacs proved the existence of a carcinomatous degeneration.</p><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">In the patients we have treated, it seems that a chronic irritation of the LCR and the appearance of multipotent cells in the meningocele may favour the malignancy of the tissues surrounding the sac.</p><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">This possible malignancy, already described in the bibliography, suggests a prompt elective surgical treatment of the patients with these congenital lesions as soon as possible.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Rivero-Celada, D.; Carcavilla-Loncán, L.I.; Marín-Cárdenas, M.A.; Cantero-Antón, J.M.; Alfaro-Torres J.; Duato-Jané, F.; Eiras-Ajuria, J.: Degeneración tumoral en meningocele no intervenido. Descripción de dos casos. Neurocirugía 2006; 17: 532–537.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:21 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nonhealing myelomeningecele in an adult" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "T. Banerjee" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "South Med J." "fecha" => "1977" "volumen" => "70" "paginaInicial" => "367" "paginaFinal" => "368" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/322304" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Triad of anorectal, sacral and presacral anormalies" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "G. Currarino" 1 => "D. Coln" 2 => "T. Votteler" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "A. JR." "fecha" => "1981" "volumen" => "137" "paginaInicial" => "395" "paginaFinal" => "398" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Normal and abnormal early development of the Nervous System" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M.S. Dias" 1 => "D.G. McLone" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "En Pediatric Neurosurgery. Surgery of the developing nervous System" "paginaInicial" => "31" "paginaFinal" => "71" "serieFecha" => "2001" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Anterior sacral meningocele with Currarino's syndrome: report of two cases" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "J. Dios Seoane" 1 => "S. Amaro" 2 => "M.G. Fantini" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurocirugía" "fecha" => "2002" "volumen" => "13" "paginaInicial" => "455" "paginaFinal" => "462" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12529774" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Is meningocele really an isolated lesion?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "Y. Ersahin" 1 => "E. Barcin" 2 => "S. Mutluer" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Childs Nery Syst" "fecha" => "2001" "volumen" => "17" "paginaInicial" => "487" "paginaFinal" => "490" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Midline Fusion Defects and Defects of Formation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "B.N. French" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "En Youmans J. R. Neurological Surgery; W. B. Saunders Company." "fecha" => "1982" "paginaInicial" => "1236" "paginaFinal" => "1372" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intracranial teratocarcinoma in a child with anterior sacral and intrasacral meningocele" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "R.O. Holness" 1 => "H.J. Hoffman" 2 => "K. Mancer" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurosurgery" "fecha" => "1978" "volumen" => "2" "paginaInicial" => "143" "paginaFinal" => "147" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/732963" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Presacral tumor associated with the Currarino triad in an adolescent" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "T. Horii" 1 => "H. Tsuchiya" 2 => "K. Tomita" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Orthop Trauma Surg." "fecha" => "2001" "volumen" => "121" "paginaInicial" => "114" "paginaFinal" => "116" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11195108" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Spina Bifida — A Vanishig Nightmare?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Lober" 1 => "A.M. Ward" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Arch Dis Chile." "fecha" => "1979" "volumen" => "60" "paginaInicial" => "413" "paginaFinal" => "419" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Delayed malignant development of a congenital teratoma with spina bifida: Case report" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.G. Love" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J. Neurosurg." "fecha" => "1968" "volumen" => "29" "paginaInicial" => "532" "paginaFinal" => "534" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Carcinoma associated with lipomeningocele. Case report" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "G. Marini" 1 => "A. Bollati" 2 => "G. Galli" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurosurgery" "fecha" => "1979" "volumen" => "5" "paginaInicial" => "268" "paginaFinal" => "269" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/481734" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidermoid cyst occurring within a lumbosacral myelomeningocele" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "J.F. Martinez-Lage" 1 => "J. Masegosa" 2 => "J. Sola" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Case report. J Neurosurg" "fecha" => "1983" "volumen" => "59" "paginaInicial" => "1095" "paginaFinal" => "1097" ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cervical meningocele and meningomyelocystocele. Apropos of 4 cases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D. May" 1 => "B. Rilliet" 2 => "J. Berney" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurochirurgie" "fecha" => "1992" "volumen" => "38" "paginaInicial" => "347" "paginaFinal" => "352" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1306889" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association of wilms tumor with spinal dysraphism" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "K. Mehes" 1 => "J. Weisenbach" 2 => "P. Kajtar" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pediatr Hematol Oncol." "fecha" => "2003" "volumen" => "20" "paginaInicial" => "261" "paginaFinal" => "264" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12637224" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Malignant teratoma arising within a lipomeningocele. Case report" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.P. Mickle" 1 => "J.E. McLennan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Neurosurg" "fecha" => "1975" "volumen" => "3" "paginaInicial" => "761" "paginaFinal" => "763" ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevention of folic acid-preventable spina bifida and anencephaly" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "G.P. Oakley Jr." 1 => "J.D. Erickson" 2 => "L.M. James" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Ciba Found Symp" "fecha" => "1994" "paginaInicial" => "212" "paginaFinal" => "223" ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M. Poza" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Cirugía del sistema nervioso y del raquis (fundamentos); Universidad de Murcia" "fecha" => "1993" "paginaInicial" => "252" "paginaFinal" => "259" ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Langman. Embriología médica" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "T.W. Sadler" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:2 [ "paginaInicial" => "345" "serieFecha" => "1991" ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical epidemiological study of neural tube defects classified according to the five sites of closure" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A. Sanchis Calvo" 1 => "M. Martinez-Frias" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "An Esp Pediatr." "fecha" => "2001" "volumen" => "54" "paginaInicial" => "165" "paginaFinal" => "173" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11181213" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Anterior sacral meningocele completely occupied by an epidermoid tumor" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "H. Shamoto" 1 => "Y. Yoshida" 2 => "R. Shirane" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Childs Nery Syst" "fecha" => "1999" "volumen" => "15" "paginaInicial" => "209" "paginaFinal" => "211" ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Carcinoma associated with myelomeningocele: Case report" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R.H. Thorp" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1967.27.5.0446" "Revista" => array:6 [ "tituloSerie" => "J. Neurosurg." "fecha" => "1967" "volumen" => "27" "paginaInicial" => "446" "paginaFinal" => "448" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4862501" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/11301473/0000001700000006/v1_201305151259/S1130147306703177/v1_201305151259/es/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/11301473/0000001700000006/v1_201305151259/S1130147306703177/v1_201305151259/es/main.pdf?idApp=UINPBA00004B&text.app=https://revistaneurocirugia.com/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147306703177?idApp=UINPBA00004B" ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2023 Marzo | 1 | 6 | 7 |
| 2018 Septiembre | 5 | 2 | 7 |
| 2018 Marzo | 2 | 1 | 3 |
| 2018 Febrero | 13 | 5 | 18 |
| 2018 Enero | 14 | 32 | 46 |
| 2017 Diciembre | 14 | 7 | 21 |
| 2017 Noviembre | 57 | 12 | 69 |
| 2017 Octubre | 6 | 12 | 18 |
| 2017 Septiembre | 11 | 7 | 18 |
| 2017 Agosto | 14 | 8 | 22 |
| 2017 Julio | 14 | 6 | 20 |
| 2017 Junio | 19 | 11 | 30 |
| 2017 Mayo | 15 | 5 | 20 |
| 2017 Abril | 19 | 7 | 26 |
| 2017 Marzo | 16 | 8 | 24 |
| 2017 Febrero | 5 | 7 | 12 |
| 2017 Enero | 7 | 13 | 20 |
| 2016 Diciembre | 27 | 10 | 37 |
| 2016 Noviembre | 15 | 7 | 22 |
| 2016 Octubre | 19 | 21 | 40 |
| 2016 Septiembre | 25 | 9 | 34 |
| 2016 Agosto | 35 | 11 | 46 |
| 2016 Julio | 23 | 18 | 41 |
| 2016 Mayo | 1 | 0 | 1 |
| 2016 Febrero | 1 | 0 | 1 |
| 2015 Diciembre | 2 | 0 | 2 |
| 2015 Junio | 9 | 5 | 14 |
| 2015 Mayo | 21 | 10 | 31 |
| 2015 Abril | 14 | 9 | 23 |
| 2015 Marzo | 16 | 9 | 25 |
| 2015 Febrero | 17 | 12 | 29 |
| 2015 Enero | 17 | 13 | 30 |
| 2014 Diciembre | 18 | 13 | 31 |
| 2014 Noviembre | 14 | 9 | 23 |
| 2014 Octubre | 15 | 15 | 30 |
| 2014 Septiembre | 21 | 15 | 36 |
| 2014 Agosto | 24 | 13 | 37 |
| 2014 Julio | 16 | 10 | 26 |
| 2014 Junio | 21 | 23 | 44 |
| 2014 Mayo | 22 | 23 | 45 |
| 2014 Abril | 12 | 10 | 22 |
| 2014 Marzo | 17 | 16 | 33 |
| 2014 Febrero | 23 | 22 | 45 |
| 2014 Enero | 14 | 14 | 28 |
| 2013 Diciembre | 12 | 23 | 35 |
| 2013 Noviembre | 20 | 11 | 31 |
| 2013 Octubre | 19 | 16 | 35 |
| 2013 Septiembre | 22 | 16 | 38 |
| 2013 Agosto | 29 | 21 | 50 |
| 2013 Julio | 29 | 10 | 39 |
| 2013 Junio | 21 | 10 | 31 |
| 2013 Mayo | 17 | 11 | 28 |
| 2013 Abril | 21 | 10 | 31 |
| 2013 Marzo | 12 | 13 | 25 |
| 2013 Febrero | 6 | 6 | 12 |
| 2013 Enero | 16 | 3 | 19 |
| 2012 Diciembre | 13 | 13 | 26 |
| 2012 Noviembre | 1 | 4 | 5 |
| 2012 Octubre | 0 | 1 | 1 |
| 2012 Septiembre | 0 | 2 | 2 |
| 2012 Enero | 6 | 0 | 6 |
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