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        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">El Glioblastoma multiforme con agregaci&#243;n familiar es poco frecuente&#44; asoci&#225;ndose la mayor parte de los casos a s&#237;ndromes gen&#233;ticos conocidos &#40;como el s&#237;ndrome de Turcot&#44; el s&#237;ndrome de Li-Fraumeni&#44; la neurofibromatosis&#44; etc&#41;&#46; Sin embargo&#44; existen otros gliomas familiares no asociados a estos cuadros sindr&#243;micos que&#44; aunque menos frecuentes&#44; han mostrado unas caracter&#237;sticas etiol&#243;gicas y cl&#237;nicas diferentes a las de los gliomas espor&#225;dicos&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Por otra parte&#44; hasta un 10&#37; de los gliomas se consideran verdaderamente multic&#233;ntricos&#44; apareciendo de modo s&#237;ncrono o met&#225;crono&#46; Los glioblastomas de aparici&#243;n met&#225;crona han mostrado en algunos estudios un mejor pron&#243;stico&#44; habi&#233;ndose encontrado trastornos gen&#233;ticos diferentes en los tumores de un mismo paciente&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Los gliomas familiares con presentaci&#243;n met&#225;crona son excepcionales&#46; Estos tumores presentan unas implicaciones terap&#233;uticas especiales por la limitaci&#243;n del tratamiento radioter&#225;pico tras el tratamiento inicial&#46; Aunque se han identificado mutaciones variadas en estos pacientes&#44; la identificaci&#243;n precisa de dichos trastornos se basar&#225; en el estudio de su sustrato gen&#233;tico espec&#237;fico&#46; Presentamos un caso cl&#237;nico que combina ambas peculiaridades revisando las caracter&#237;sticas de esta patolog&#237;a&#46;</p>"
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        "titulo" => "Summary"
        "resumen" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Familial glioblastoma multiforme is a rather uncommon entity&#44; being in most cases associated to known genetic disorders &#40;as Turcot syndrome&#44; Li-Fraumeni syndrome&#44; neurofibromatosis&#44; etc&#46;&#41;&#46; However&#44; familial gliomas have also been described&#44; although less frequently&#44; independently of these genetic syndromes showing some special features regarding its etiology and clinical manifestations&#46;</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Less than 10&#37; of gliomas may be considered as true multicentric tumours either synchronous or metachronous in clinical presentation&#46; Metachronous glioblastomas have been associated to better prognosis in some studies&#44; with genetic studies having found clear differences among the tumors within same patients&#46;</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Familial glioblastoma with metachronous presentation is an exceptional disorder&#46; These tumors show special therapeutic implications due to the limitations of radiotherapy once the patient has already irradiated&#46; A variety of non-specific mutations have been found in these patients but true characterization of this disorder remains unclear and will be based on further genetic studies&#46; We present a clinical report on a patient harbouring a familial and metachronous glioblastoma&#46; The main aspects of this entity are reviwed&#46;</p>"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Genetic steps in colorectal cancer"
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                            0 => "W&#46; Bodmer"
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                            2 => "P&#46; Karran"
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                    0 => array:2 [
                      "doi" => "10.1038/ng0394-217"
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                        "tituloSerie" => "Nat Genet"
                        "fecha" => "1994"
                        "volumen" => "6"
                        "paginaInicial" => "217"
                        "paginaFinal" => "219"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8012377"
                            "web" => "Medline"
                          ]
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              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Case of gliosarcomatous tumors of the brain"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "W&#46;L&#46; Bradley"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Proc Conn Med Soc"
                        "fecha" => "1880"
                        "volumen" => "2"
                        "paginaInicial" => "39"
                        "paginaFinal" => "41"
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A case of glioblastoma with m&#250;ltiple centres above and below the tentorium"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "G&#46; Bussone"
                            1 => "M&#46;G&#46; Sinatra"
                            2 => "A&#46; Boiardi"
                            3 => "M&#46; Lazzaroni"
                            4 => "C&#46; Mariani"
                            5 => "A&#46; Allegranza"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurol"
                        "fecha" => "1979"
                        "volumen" => "221"
                        "paginaInicial" => "187"
                        "paginaFinal" => "192"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/91672"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Genetic instability ad Darwinian selection in tumors"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46;P&#46; Cahill"
                            1 => "K&#46;W&#46; Kinzler"
                            2 => "B&#46; Vogelstein"
                            3 => "C&#46; Lengauer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Trends Cell Biol"
                        "fecha" => "1999"
                        "volumen" => "9"
                        "paginaInicial" => "M59"
                        "paginaFinal" => "M60"
                      ]
                    ]
                  ]
                ]
              ]
            ]
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Familial gliomas&#46; Analysis of six families with gliomas and without other inheritable syndromes"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
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                            2 => "P&#46; Peruzzi"
                            3 => "A&#46; Frati"
                            4 => "F&#46; Giangaspero"
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                      ]
                    ]
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                    0 => array:2 [
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                      "Revista" => array:6 [
                        "tituloSerie" => "Neurosurg Rev"
                        "fecha" => "2003"
                        "volumen" => "26"
                        "paginaInicial" => "280"
                        "paginaFinal" => "282"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12827520"
                            "web" => "Medline"
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                    0 => array:2 [
                      "titulo" => "Multicentric glioma as a cause of multiple cerebral lesions"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "W&#46;M&#46; Chadduch"
                            1 => "D&#46; Roycroft"
                            2 => "M&#46;W&#46; Brown"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Neurosurg"
                        "fecha" => "1983"
                        "volumen" => "13"
                        "paginaInicial" => "170"
                        "paginaFinal" => "175"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
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                    0 => array:2 [
                      "titulo" => "Radiographic incidence of multicentric malignant gliomas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "H&#46;R&#46; Djalilian"
                            1 => "W&#46;V&#46; Shah"
                            2 => "W&#46;A&#46; Hall"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Surg Neurol"
                        "fecha" => "1995"
                        "volumen" => "51"
                        "paginaInicial" => "554"
                        "paginaFinal" => "558"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10321888"
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                      "titulo" => "Central nervous system cancers in first-degree relatives and spouses"
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                          "autores" => array:4 [
                            0 => "S&#46;A&#46; Grossman"
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                            2 => "R&#46; Hrubam"
                            3 => "S&#46; Piantadosi"
                          ]
                        ]
                      ]
                    ]
                  ]
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                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Cancer Inv"
                        "fecha" => "1999"
                        "volumen" => "17"
                        "paginaInicial" => "299"
                        "paginaFinal" => "308"
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                  ]
                ]
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                      "titulo" => "Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences"
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                          "autores" => array:4 [
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                            2 => "B&#46; Voglestein"
                            3 => "S&#46;R&#46; Hamilton"
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                        ]
                      ]
                    ]
                  ]
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                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Ann J Pathol"
                        "fecha" => "1994"
                        "volumen" => "145"
                        "paginaInicial" => "148"
                        "paginaFinal" => "156"
                      ]
                    ]
                  ]
                ]
              ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cerebral and cerebellar glial tumors in the same individual"
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                          "etal" => false
                          "autores" => array:2 [
                            0 => "Z&#46; Kotwica"
                            1 => "W&#46; Papierz"
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                        ]
                      ]
                    ]
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                  "host" => array:1 [
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                      "Revista" => array:5 [
                        "tituloSerie" => "Neurosurg"
                        "fecha" => "1992"
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                        "paginaFinal" => "442"
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                          "autores" => array:5 [
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                            3 => "C&#46;A&#46; Griffin"
                            4 => "S&#46; Piantadosi"
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurooncol"
                        "fecha" => "1990"
                        "volumen" => "9"
                        "paginaInicial" => "139"
                        "paginaFinal" => "145"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2175769"
                            "web" => "Medline"
                          ]
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "A molecular genetic model of astrocytoma histopathology"
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                          "autores" => array:1 [
                            0 => "D&#46;N&#46; Louis"
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                  "host" => array:1 [
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                      "Revista" => array:6 [
                        "tituloSerie" => "Brain Pathol"
                        "fecha" => "1997"
                        "volumen" => "7"
                        "paginaInicial" => "755"
                        "paginaFinal" => "764"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9161727"
                            "web" => "Medline"
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                ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Independent molecular development of metachronous glioblastomas whit extended intervening recurrence-free interval"
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                          "etal" => false
                          "autores" => array:6 [
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                            1 => "H&#46;-K&#46; Schackert"
                            2 => "S&#46; Von Kannern"
                            3 => "P&#46; Lichter"
                            4 => "S&#46; Joos"
                            5 => "G&#46; Schackert"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Brain Pathol"
                        "fecha" => "2003"
                        "volumen" => "13"
                        "paginaInicial" => "598"
                        "paginaFinal" => "607"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14655763"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Betrachtungen zur Genetik der Familiaren Gliome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "E&#46; Metzel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Genet Med Gemellol"
                        "fecha" => "1964"
                        "volumen" => "13"
                        "paginaInicial" => "124"
                        "paginaFinal" => "131"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14169789"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Multiple primaty malignant neoplasm&#46; III&#46; Tumors of multicentric origin"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "C&#46;G&#46; Moertel"
                            1 => "M&#46;B&#46; Dockerty"
                            2 => "A&#46;H&#46; Baggenstoss"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Cancer"
                        "fecha" => "1961"
                        "volumen" => "14"
                        "paginaInicial" => "238"
                        "paginaFinal" => "248"
                      ]
                    ]
                  ]
                ]
              ]
            ]
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                      "titulo" => "Mutation of a multiL homolog in hereditary colon cancer"
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                            0 => "N&#46; Papadopoulus"
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                            2 => "Y&#46;F&#46; Wei"
                          ]
                        ]
                      ]
                    ]
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                      "Revista" => array:6 [
                        "tituloSerie" => "Science"
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                        "paginaInicial" => "1625"
                        "paginaFinal" => "1629"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8128251"
                            "web" => "Medline"
                          ]
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                ]
              ]
            ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Analysis of p53 tumor suppresor gene in families with multiple glioma patients"
                      "autores" => array:1 [
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                          "etal" => true
                          "autores" => array:3 [
                            0 => "N&#46; Paunu"
                            1 => "K&#46; Syrjakosji"
                            2 => "R&#46; Sankila"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurooncol"
                        "fecha" => "2002"
                        "volumen" => "55"
                        "paginaInicial" => "159"
                        "paginaFinal" => "165"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11859970"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Second Primary glioblastoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "R&#46;M&#46; Reis"
                            1 => "R&#46; Herva"
                            2 => "S&#46; Brandners"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neuropathol Exp Neurol"
                        "fecha" => "2001"
                        "volumen" => "60"
                        "paginaInicial" => "208"
                        "paginaFinal" => "215"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11273008"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "autores" => array:1 [
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                            0 => "D&#46;S&#46; Russel"
                            1 => "L&#46;J&#46; Rubenstein"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Pathology of tumors of the nervous system"
                        "paginaInicial" => "124"
                        "paginaFinal" => "126"
                        "serieFecha" => "1989"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The forms of growth in glioma and their practical significance"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "H&#46;J&#46; Sherer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Brain"
                        "fecha" => "1940"
                        "volumen" => "63"
                        "paginaInicial" => "1"
                        "paginaFinal" => "35"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Multicentric gliomas of the cerebral and cerebellar hemispheres&#46; Case report"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46; Solomon"
                            1 => "G&#46;E&#46; Perret"
                            2 => "W&#46;F&#46; McCormich"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Neurosurg"
                        "fecha" => "1969"
                        "volumen" => "31"
                        "paginaInicial" => "887"
                        "paginaFinal" => "893"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Which glioblastoma multiforme patient will become a longterm survivor&#63; A population based study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "J&#46;N&#46; Scott"
                            1 => "N&#46;B&#46; Rewcastle"
                            2 => "P&#46;M&#46;A&#46; Brasher"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Neurol"
                        "fecha" => "1999"
                        "volumen" => "46"
                        "paginaInicial" => "183"
                        "paginaFinal" => "188"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10443883"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Synchronous and metrachronous malignant gliomas&#46; CT findings"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "T&#46; Van Tassel"
                            1 => "Y&#46; Lee"
                            2 => "J&#46;M&#46; Burner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "AJNR"
                        "fecha" => "1988"
                        "volumen" => "9"
                        "paginaInicial" => "725"
                        "paginaFinal" => "732"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2840813"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inheritance of glioma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "H&#46;J&#46; Van de Weil"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:3 [
                        "fecha" => "1960"
                        "editorial" => "Elsevier"
                        "editorialLocalizacion" => "New York"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Molecular pathways in the formation of gliomas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46; Von Deimling"
                            1 => "D&#46;N&#46; Louis"
                            2 => "O&#46;D&#46; Wiestler"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/glia.440150312"
                      "Revista" => array:6 [
                        "tituloSerie" => "Glia"
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                        "volumen" => "15"
                        "paginaInicial" => "328"
                        "paginaFinal" => "338"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8586467"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pathology of tumors"
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                          "etal" => false
                          "autores" => array:1 [
                            0 => "R&#46;A&#46; Willis"
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
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                        "editorialLocalizacion" => "London"
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                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib27"
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                    ]
                  ]
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                    ]
                  ]
                ]
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Glioblastoma familiar múltiple de aparición metácrona: implicaciones etiopatogénicas y pronósticas
Familiar glioblastoma presentig as a true multicentric tumor: etiopathogenic and pronostic features
B. Iza
, O. Mateo-Sierra, F. Ruiz-Juretszke, J. Garbizu, R. Carrillo
Servicio de Neurocirugía, Hospital General Universitario Gregorio Marañón. Madrid
J. Guzmán de Villoria*
* Servicio de Neurorradiología, Hospital General Universitario Gregorio Marañón. Madrid
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        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">El Glioblastoma multiforme con agregaci&#243;n familiar es poco frecuente&#44; asoci&#225;ndose la mayor parte de los casos a s&#237;ndromes gen&#233;ticos conocidos &#40;como el s&#237;ndrome de Turcot&#44; el s&#237;ndrome de Li-Fraumeni&#44; la neurofibromatosis&#44; etc&#41;&#46; Sin embargo&#44; existen otros gliomas familiares no asociados a estos cuadros sindr&#243;micos que&#44; aunque menos frecuentes&#44; han mostrado unas caracter&#237;sticas etiol&#243;gicas y cl&#237;nicas diferentes a las de los gliomas espor&#225;dicos&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Por otra parte&#44; hasta un 10&#37; de los gliomas se consideran verdaderamente multic&#233;ntricos&#44; apareciendo de modo s&#237;ncrono o met&#225;crono&#46; Los glioblastomas de aparici&#243;n met&#225;crona han mostrado en algunos estudios un mejor pron&#243;stico&#44; habi&#233;ndose encontrado trastornos gen&#233;ticos diferentes en los tumores de un mismo paciente&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Los gliomas familiares con presentaci&#243;n met&#225;crona son excepcionales&#46; Estos tumores presentan unas implicaciones terap&#233;uticas especiales por la limitaci&#243;n del tratamiento radioter&#225;pico tras el tratamiento inicial&#46; Aunque se han identificado mutaciones variadas en estos pacientes&#44; la identificaci&#243;n precisa de dichos trastornos se basar&#225; en el estudio de su sustrato gen&#233;tico espec&#237;fico&#46; Presentamos un caso cl&#237;nico que combina ambas peculiaridades revisando las caracter&#237;sticas de esta patolog&#237;a&#46;</p>"
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        "titulo" => "Summary"
        "resumen" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Familial glioblastoma multiforme is a rather uncommon entity&#44; being in most cases associated to known genetic disorders &#40;as Turcot syndrome&#44; Li-Fraumeni syndrome&#44; neurofibromatosis&#44; etc&#46;&#41;&#46; However&#44; familial gliomas have also been described&#44; although less frequently&#44; independently of these genetic syndromes showing some special features regarding its etiology and clinical manifestations&#46;</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Less than 10&#37; of gliomas may be considered as true multicentric tumours either synchronous or metachronous in clinical presentation&#46; Metachronous glioblastomas have been associated to better prognosis in some studies&#44; with genetic studies having found clear differences among the tumors within same patients&#46;</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Familial glioblastoma with metachronous presentation is an exceptional disorder&#46; These tumors show special therapeutic implications due to the limitations of radiotherapy once the patient has already irradiated&#46; A variety of non-specific mutations have been found in these patients but true characterization of this disorder remains unclear and will be based on further genetic studies&#46; We present a clinical report on a patient harbouring a familial and metachronous glioblastoma&#46; The main aspects of this entity are reviwed&#46;</p>"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Genetic steps in colorectal cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "W&#46; Bodmer"
                            1 => "T&#46; Bishop"
                            2 => "P&#46; Karran"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/ng0394-217"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nat Genet"
                        "fecha" => "1994"
                        "volumen" => "6"
                        "paginaInicial" => "217"
                        "paginaFinal" => "219"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8012377"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Case of gliosarcomatous tumors of the brain"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "W&#46;L&#46; Bradley"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Proc Conn Med Soc"
                        "fecha" => "1880"
                        "volumen" => "2"
                        "paginaInicial" => "39"
                        "paginaFinal" => "41"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A case of glioblastoma with m&#250;ltiple centres above and below the tentorium"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "G&#46; Bussone"
                            1 => "M&#46;G&#46; Sinatra"
                            2 => "A&#46; Boiardi"
                            3 => "M&#46; Lazzaroni"
                            4 => "C&#46; Mariani"
                            5 => "A&#46; Allegranza"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurol"
                        "fecha" => "1979"
                        "volumen" => "221"
                        "paginaInicial" => "187"
                        "paginaFinal" => "192"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/91672"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib4"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Genetic instability ad Darwinian selection in tumors"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46;P&#46; Cahill"
                            1 => "K&#46;W&#46; Kinzler"
                            2 => "B&#46; Vogelstein"
                            3 => "C&#46; Lengauer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Trends Cell Biol"
                        "fecha" => "1999"
                        "volumen" => "9"
                        "paginaInicial" => "M59"
                        "paginaFinal" => "M60"
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Familial gliomas&#46; Analysis of six families with gliomas and without other inheritable syndromes"
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                          "autores" => array:5 [
                            0 => "E&#46; Caroli"
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                            2 => "P&#46; Peruzzi"
                            3 => "A&#46; Frati"
                            4 => "F&#46; Giangaspero"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s10143-003-0281-x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurosurg Rev"
                        "fecha" => "2003"
                        "volumen" => "26"
                        "paginaInicial" => "280"
                        "paginaFinal" => "282"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12827520"
                            "web" => "Medline"
                          ]
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                    0 => array:2 [
                      "titulo" => "Multicentric glioma as a cause of multiple cerebral lesions"
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                          "autores" => array:3 [
                            0 => "W&#46;M&#46; Chadduch"
                            1 => "D&#46; Roycroft"
                            2 => "M&#46;W&#46; Brown"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Neurosurg"
                        "fecha" => "1983"
                        "volumen" => "13"
                        "paginaInicial" => "170"
                        "paginaFinal" => "175"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Radiographic incidence of multicentric malignant gliomas"
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                        0 => array:2 [
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                          "autores" => array:3 [
                            0 => "H&#46;R&#46; Djalilian"
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                            2 => "W&#46;A&#46; Hall"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Surg Neurol"
                        "fecha" => "1995"
                        "volumen" => "51"
                        "paginaInicial" => "554"
                        "paginaFinal" => "558"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10321888"
                            "web" => "Medline"
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                  ]
                ]
              ]
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Central nervous system cancers in first-degree relatives and spouses"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46;A&#46; Grossman"
                            1 => "M&#46; Osman"
                            2 => "R&#46; Hrubam"
                            3 => "S&#46; Piantadosi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Cancer Inv"
                        "fecha" => "1999"
                        "volumen" => "17"
                        "paginaInicial" => "299"
                        "paginaFinal" => "308"
                      ]
                    ]
                  ]
                ]
              ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "H&#46; Kim"
                            1 => "J&#46; Jen"
                            2 => "B&#46; Voglestein"
                            3 => "S&#46;R&#46; Hamilton"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Ann J Pathol"
                        "fecha" => "1994"
                        "volumen" => "145"
                        "paginaInicial" => "148"
                        "paginaFinal" => "156"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cerebral and cerebellar glial tumors in the same individual"
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                          "etal" => false
                          "autores" => array:2 [
                            0 => "Z&#46; Kotwica"
                            1 => "W&#46; Papierz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Neurosurg"
                        "fecha" => "1992"
                        "volumen" => "30"
                        "paginaInicial" => "439"
                        "paginaFinal" => "442"
                      ]
                    ]
                  ]
                ]
              ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Familiar clustering of malignant astrocytomas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "D&#46; Lossignol"
                            1 => "S&#46;A&#46; Grossman"
                            2 => "V&#46;R&#46; Sheider"
                            3 => "C&#46;A&#46; Griffin"
                            4 => "S&#46; Piantadosi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurooncol"
                        "fecha" => "1990"
                        "volumen" => "9"
                        "paginaInicial" => "139"
                        "paginaFinal" => "145"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2175769"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A molecular genetic model of astrocytoma histopathology"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "D&#46;N&#46; Louis"
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                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Brain Pathol"
                        "fecha" => "1997"
                        "volumen" => "7"
                        "paginaInicial" => "755"
                        "paginaFinal" => "764"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9161727"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Independent molecular development of metachronous glioblastomas whit extended intervening recurrence-free interval"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "R&#46; Mart&#237;nez"
                            1 => "H&#46;-K&#46; Schackert"
                            2 => "S&#46; Von Kannern"
                            3 => "P&#46; Lichter"
                            4 => "S&#46; Joos"
                            5 => "G&#46; Schackert"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Brain Pathol"
                        "fecha" => "2003"
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                        "paginaInicial" => "598"
                        "paginaFinal" => "607"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14655763"
                            "web" => "Medline"
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              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Betrachtungen zur Genetik der Familiaren Gliome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "E&#46; Metzel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Genet Med Gemellol"
                        "fecha" => "1964"
                        "volumen" => "13"
                        "paginaInicial" => "124"
                        "paginaFinal" => "131"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14169789"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Multiple primaty malignant neoplasm&#46; III&#46; Tumors of multicentric origin"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "C&#46;G&#46; Moertel"
                            1 => "M&#46;B&#46; Dockerty"
                            2 => "A&#46;H&#46; Baggenstoss"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Cancer"
                        "fecha" => "1961"
                        "volumen" => "14"
                        "paginaInicial" => "238"
                        "paginaFinal" => "248"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mutation of a multiL homolog in hereditary colon cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "N&#46; Papadopoulus"
                            1 => "N&#46;C&#46; Nicolaides"
                            2 => "Y&#46;F&#46; Wei"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Science"
                        "fecha" => "1994"
                        "volumen" => "263"
                        "paginaInicial" => "1625"
                        "paginaFinal" => "1629"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8128251"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Analysis of p53 tumor suppresor gene in families with multiple glioma patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "N&#46; Paunu"
                            1 => "K&#46; Syrjakosji"
                            2 => "R&#46; Sankila"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurooncol"
                        "fecha" => "2002"
                        "volumen" => "55"
                        "paginaInicial" => "159"
                        "paginaFinal" => "165"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11859970"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Second Primary glioblastoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "R&#46;M&#46; Reis"
                            1 => "R&#46; Herva"
                            2 => "S&#46; Brandners"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neuropathol Exp Neurol"
                        "fecha" => "2001"
                        "volumen" => "60"
                        "paginaInicial" => "208"
                        "paginaFinal" => "215"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11273008"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46;S&#46; Russel"
                            1 => "L&#46;J&#46; Rubenstein"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Pathology of tumors of the nervous system"
                        "paginaInicial" => "124"
                        "paginaFinal" => "126"
                        "serieFecha" => "1989"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The forms of growth in glioma and their practical significance"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "H&#46;J&#46; Sherer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Brain"
                        "fecha" => "1940"
                        "volumen" => "63"
                        "paginaInicial" => "1"
                        "paginaFinal" => "35"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Multicentric gliomas of the cerebral and cerebellar hemispheres&#46; Case report"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46; Solomon"
                            1 => "G&#46;E&#46; Perret"
                            2 => "W&#46;F&#46; McCormich"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Neurosurg"
                        "fecha" => "1969"
                        "volumen" => "31"
                        "paginaInicial" => "887"
                        "paginaFinal" => "893"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Which glioblastoma multiforme patient will become a longterm survivor&#63; A population based study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "J&#46;N&#46; Scott"
                            1 => "N&#46;B&#46; Rewcastle"
                            2 => "P&#46;M&#46;A&#46; Brasher"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Neurol"
                        "fecha" => "1999"
                        "volumen" => "46"
                        "paginaInicial" => "183"
                        "paginaFinal" => "188"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10443883"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Synchronous and metrachronous malignant gliomas&#46; CT findings"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "T&#46; Van Tassel"
                            1 => "Y&#46; Lee"
                            2 => "J&#46;M&#46; Burner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "AJNR"
                        "fecha" => "1988"
                        "volumen" => "9"
                        "paginaInicial" => "725"
                        "paginaFinal" => "732"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2840813"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inheritance of glioma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "H&#46;J&#46; Van de Weil"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:3 [
                        "fecha" => "1960"
                        "editorial" => "Elsevier"
                        "editorialLocalizacion" => "New York"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Molecular pathways in the formation of gliomas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46; Von Deimling"
                            1 => "D&#46;N&#46; Louis"
                            2 => "O&#46;D&#46; Wiestler"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/glia.440150312"
                      "Revista" => array:6 [
                        "tituloSerie" => "Glia"
                        "fecha" => "1995"
                        "volumen" => "15"
                        "paginaInicial" => "328"
                        "paginaFinal" => "338"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8586467"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
              "etiqueta" => "26&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pathology of tumors"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "R&#46;A&#46; Willis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:3 [
                        "fecha" => "1960"
                        "editorial" => "Butterworths"
                        "editorialLocalizacion" => "London"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib27"
              "etiqueta" => "27&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "K&#46;J&#46; Z&#252;lch"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Brain tumors&#46; Their biology and pathology"
                        "paginaInicial" => "74"
                        "paginaFinal" => "76"
                        "serieFecha" => "1957"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
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ISSN: 11301473
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