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        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Se presentan 8 casos de met&#225;stasis intracraneales de neuroblastomas en ni&#241;os&#46; Una vez diagnosticado el tumor primitivo&#44; el intervalo de tiempo transcurrido hasta la aparici&#243;n de la manifestaci&#243;n neurol&#243;gica&#44; por metastasis intracraneales&#44; vari&#243; entre 2 meses y 30 meses con una media de 12&#44;3 meses&#46; La TAC se utiliz&#243; en todos los casos como medio diagn&#243;stico&#44; observ&#225;ndose met&#225;stasis m&#250;ltiples en 6 casos y &#250;nicas en 2 casos&#46; El tratamiento realizado nna vez diagnosticada la afectaci&#243;n intracraneal fue de quimioterapia en 2 casos&#44; quimioterapia y radioterapia en 5 casos y cirug&#237;a&#44; quimioterapia y radioterapia en un paciente con una met&#225;stasis &#250;nica localizada en el cerebelo&#46; La supervivencia despu&#233;s de la afectaci&#243;n neurol&#243;gica fue corta varian&#183; do entre 1 mes y 22 meses con una media de 9 meses&#46; Las met&#225;stasis cerebrales por neurobastomas&#44; en ni&#241;os&#44; se pueden considerar como un signo de mal pron&#243;stico en la evoluci&#243;n de los pacientes&#46;</p>"
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        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Eight cases of intracranial metastatic neuroblastoma in children&#183; are reported&#46; The interval between diagnosis of primitive neuroblastoma and the development of neurological symptoms ranged from 2 to 30 months &#40;mean &#61; 12&#44;3 months&#41;&#46; Cerebral CT scans were performed in all patients&#46; Multiple intracranial metastases were observed in 6 cases and a single metatases in only 2 cases&#46; Treatment regimes were&#58; chemotherapy in 2 cases&#44; chemotherapy and radiotherapy in 5 cases&#44; and surgery&#44; chemotherapy and radiotherapy in one case with a single metastases&#44; which was located in the cerebellum&#46; Survival after neurological manifestation was short&#44; ranging between 1 and 22 months&#44; &#40;average 9 months&#41;&#46; According to our experience cerebral involvement can ben considered a sign of a bad prognosis in the evolution of patients with neuroblastoma&#46;</p>"
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Metástasis intracraneales de neuroblastoma en el niño
A. Isla, F. Alvarez, M.ªC. González, A. Pérez-Higueras, M. García-Blázquez
Servicios de Neurocirugía y de Oncología Pediátrica. Hospital «La Paz». Madrid. España
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