Influencia de la actinomicina D sobre el flujo sanguíneo cerebral en un modelo de isquemia experimental
G. Posadas Narro, J. de Raro del Moral, J. Vaquero Crespo, C. San Juan Robles, G. Bravo Zabalgoitia, J. Ortiz Berrocal
Servicios de Neurocirugía y Medina Nuclear. Clínica Puerta de Hierro. Universidad Autónoma de Madrid-España
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Posadas Narro, J. de Raro del Moral, J. Vaquero Crespo, C. San Juan Robles, G. Bravo Zabalgoitia, J. Ortiz Berrocal" "autores" => array:6 [ 0 => array:2 [ "nombre" => "G." "apellidos" => "Posadas Narro" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "de Raro del Moral" ] 2 => array:2 [ "nombre" => "J." "apellidos" => "Vaquero Crespo" ] 3 => array:2 [ "nombre" => "C." "apellidos" => "San Juan Robles" ] 4 => array:2 [ "nombre" => "G." "apellidos" => "Bravo Zabalgoitia" ] 5 => array:2 [ "nombre" => "J." "apellidos" => "Ortiz Berrocal" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicios de Neurocirugía y Medina Nuclear. Clínica Puerta de Hierro. Universidad Autónoma de Madrid-España" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec162591" "palabras" => array:3 [ 0 => "Isquemia" 1 => "Actinomicina D" 2 => "Flujo sanguíneo cerebral" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec162590" "palabras" => array:3 [ 0 => "Ischemia" 1 => "Actinomycin D" 2 => "Cerebral blood flow" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Existen estudios experimentales sobre el mejoramiento del vasoespasmo que sigue a la hemorragia subaracnoidea por la Actinomicina D, pero no existe ningún estudio acerca de su efecto en la isquemia cerebral.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Hemos realizado el presente estudio experimental en 18 ratas; produciéndoles isquemia cerebral parcial (mediante ligadura permanente de la arteria carótida común derecha, y clipaje transitorio de la carótida común izquierda), que fueron tratadas con Actinomicina D (vía intraperitoneal) por 5 días. Se administró dicha sustancia a las 6 y 12 horas postisquemia, en los grupos A (6 ratas) y B (6 ratas) respectivamente. El grupo C (control) constituído también por 6 ratas, no recibió tratamiento alguno. El análisis estadístico antes y después del tratamiento se realizó observando las modificaciones del flujo sanguíneo cerebral utilizando HMPAO marcado con Tc-99m (marcador radioactivo).</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se encontró ausencia de modificación del flujo sanguíneo cerebral, y por lo tanto ausencia de mejoría de la isquemia cerebral.</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Se concluye que la Actinomicina D no modifica el flujo sanguíneo ni mejora la isquemia cerebral experimental en ratas.</p>" ] "en" => array:2 [ "titulo" => "Summary" "resumen" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Though there are some studies reporting a favourable effect of Actinomycin D posthemorrhagic cerebral vasospasm, the effect of this drug on brain ischemia has not been analyzed.</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">We have performed an experimental study in 18 rats. Ischemia was produced by permanent and transitory ligature of the right and left common carotid artery respectively.</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The animals were divided into three groups. Actinomycin was injected intraperitoneally 6 and 12 hours after ischemia in groups A and B. Animals in group C did not receive any treatment.</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Cerebral blood flow (CBF) was measured using HMPAO labeled with Tc 99m.</p><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">There was no modification of CBF. The conclusion is that Actinomycin D does not improve cerebral ischemia in this experimental model.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Posadas Narro, G.; Haro del Moral, J. de; Vaquero Crespo, J.; San Juan Robles, C.; Bravo Zabalgoitia, G. y Ortiz Berrocal, J.: Influencia de la actinomicina D sobre el flujo sanguíneo cerebral en un modelo de isquemia experimental. Neurocirugía 1994; 5: 10–15.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:47 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Strong attenuations of ischemic and postischemic brain edema in rats by a novel free radical scavenger" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "K. 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| 2017 Septiembre | 11 | 14 | 25 |
| 2017 Agosto | 10 | 5 | 15 |
| 2017 Julio | 13 | 4 | 17 |
| 2017 Junio | 16 | 6 | 22 |
| 2017 Mayo | 17 | 13 | 30 |
| 2017 Abril | 14 | 6 | 20 |
| 2017 Marzo | 12 | 4 | 16 |
| 2017 Febrero | 3 | 1 | 4 |
| 2017 Enero | 7 | 4 | 11 |
| 2016 Diciembre | 26 | 20 | 46 |
| 2016 Noviembre | 15 | 21 | 36 |
| 2016 Octubre | 29 | 22 | 51 |
| 2016 Septiembre | 44 | 21 | 65 |
| 2016 Agosto | 52 | 15 | 67 |
| 2016 Julio | 33 | 9 | 42 |
| 2015 Diciembre | 2 | 0 | 2 |
| 2015 Julio | 1 | 0 | 1 |
| 2015 Junio | 12 | 8 | 20 |
| 2015 Mayo | 24 | 20 | 44 |
| 2015 Abril | 13 | 21 | 34 |
| 2015 Marzo | 13 | 28 | 41 |
| 2015 Febrero | 11 | 18 | 29 |
| 2015 Enero | 22 | 14 | 36 |
| 2014 Diciembre | 13 | 14 | 27 |
| 2014 Noviembre | 14 | 16 | 30 |
| 2014 Octubre | 18 | 19 | 37 |
| 2014 Septiembre | 11 | 17 | 28 |
| 2014 Agosto | 15 | 21 | 36 |
| 2014 Julio | 10 | 10 | 20 |
| 2014 Junio | 22 | 32 | 54 |
| 2014 Mayo | 23 | 18 | 41 |
| 2014 Abril | 20 | 18 | 38 |
| 2014 Marzo | 12 | 17 | 29 |
| 2014 Febrero | 12 | 20 | 32 |
| 2014 Enero | 11 | 12 | 23 |
| 2013 Diciembre | 13 | 10 | 23 |
| 2013 Noviembre | 15 | 22 | 37 |
| 2013 Octubre | 23 | 17 | 40 |
| 2013 Septiembre | 25 | 19 | 44 |
| 2013 Agosto | 16 | 10 | 26 |
| 2013 Julio | 18 | 21 | 39 |
| 2013 Junio | 9 | 19 | 28 |
| 2013 Mayo | 15 | 14 | 29 |
| 2013 Abril | 11 | 13 | 24 |
| 2013 Marzo | 13 | 17 | 30 |
| 2013 Febrero | 13 | 6 | 19 |
| 2013 Enero | 8 | 7 | 15 |
| 2012 Diciembre | 9 | 13 | 22 |
| 2012 Noviembre | 1 | 8 | 9 |
| 2012 Octubre | 0 | 2 | 2 |
| 2012 Septiembre | 0 | 2 | 2 |
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