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        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Existen estudios experimentales sobre el mejoramiento del vasoespasmo que sigue a la hemorragia subaracnoidea por la Actinomicina D&#44; pero no existe ning&#250;n estudio acerca de su efecto en la isquemia cerebral&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Hemos realizado el presente estudio experimental en 18 ratas&#59; produci&#233;ndoles isquemia cerebral parcial &#40;mediante ligadura permanente de la arteria car&#243;tida com&#250;n derecha&#44; y clipaje transitorio de la car&#243;tida com&#250;n izquierda&#41;&#44; que fueron tratadas con Actinomicina D &#40;v&#237;a intraperitoneal&#41; por 5 d&#237;as&#46; Se administr&#243; dicha sustancia a las 6 y 12 horas postisquemia&#44; en los grupos A &#40;6 ratas&#41; y B &#40;6 ratas&#41; respectivamente&#46; El grupo C &#40;control&#41; constitu&#237;do tambi&#233;n por 6 ratas&#44; no recibi&#243; tratamiento alguno&#46; El an&#225;lisis estad&#237;stico antes y despu&#233;s del tratamiento se realiz&#243; observando las modificaciones del flujo sangu&#237;neo cerebral utilizando HMPAO marcado con Tc-99m &#40;marcador radioactivo&#41;&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se encontr&#243; ausencia de modificaci&#243;n del flujo sangu&#237;neo cerebral&#44; y por lo tanto ausencia de mejor&#237;a de la isquemia cerebral&#46;</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Se concluye que la Actinomicina D no modifica el flujo sangu&#237;neo ni mejora la isquemia cerebral experimental en ratas&#46;</p>"
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        "resumen" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Though there are some studies reporting a favourable effect of Actinomycin D posthemorrhagic cerebral vasospasm&#44; the effect of this drug on brain ischemia has not been analyzed&#46;</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">We have performed an experimental study in 18 rats&#46; Ischemia was produced by permanent and transitory ligature of the right and left common carotid artery respectively&#46;</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The animals were divided into three groups&#46; Actinomycin was injected intraperitoneally 6 and 12 hours after ischemia in groups A and B&#46; Animals in group C did not receive any treatment&#46;</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Cerebral blood flow &#40;CBF&#41; was measured using HMPAO labeled with Tc 99m&#46;</p><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">There was no modification of CBF&#46; The conclusion is that Actinomycin D does not improve cerebral ischemia in this experimental model&#46;</p>"
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        "nota" => "<p class="elsevierStyleNotepara">Posadas Narro&#44; G&#46;&#59; Haro del Moral&#44; J&#46; de&#59; Vaquero Crespo&#44; J&#46;&#59; San Juan Robles&#44; C&#46;&#59; Bravo Zabalgoitia&#44; G&#46; y Ortiz Berrocal&#44; J&#46;&#58; Influencia de la actinomicina D sobre el flujo sangu&#237;neo cerebral en un modelo de isquemia experimental&#46; Neurocirug&#237;a 1994&#59; 5&#58; 10&#8211;15&#46;</p>"
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Influencia de la actinomicina D sobre el flujo sanguíneo cerebral en un modelo de isquemia experimental
G. Posadas Narro, J. de Raro del Moral, J. Vaquero Crespo, C. San Juan Robles, G. Bravo Zabalgoitia, J. Ortiz Berrocal
Servicios de Neurocirugía y Medina Nuclear. Clínica Puerta de Hierro. Universidad Autónoma de Madrid-España
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    "titulo" => "Influencia de la actinomicina D sobre el flujo sangu&#237;neo cerebral en un modelo de isquemia experimental"
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            "entidad" => "Servicios de Neurocirug&#237;a y Medina Nuclear&#46; Cl&#237;nica Puerta de Hierro&#46; Universidad Aut&#243;noma de Madrid-Espa&#241;a"
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        "titulo" => "Resumen"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Existen estudios experimentales sobre el mejoramiento del vasoespasmo que sigue a la hemorragia subaracnoidea por la Actinomicina D&#44; pero no existe ning&#250;n estudio acerca de su efecto en la isquemia cerebral&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Hemos realizado el presente estudio experimental en 18 ratas&#59; produci&#233;ndoles isquemia cerebral parcial &#40;mediante ligadura permanente de la arteria car&#243;tida com&#250;n derecha&#44; y clipaje transitorio de la car&#243;tida com&#250;n izquierda&#41;&#44; que fueron tratadas con Actinomicina D &#40;v&#237;a intraperitoneal&#41; por 5 d&#237;as&#46; Se administr&#243; dicha sustancia a las 6 y 12 horas postisquemia&#44; en los grupos A &#40;6 ratas&#41; y B &#40;6 ratas&#41; respectivamente&#46; El grupo C &#40;control&#41; constitu&#237;do tambi&#233;n por 6 ratas&#44; no recibi&#243; tratamiento alguno&#46; El an&#225;lisis estad&#237;stico antes y despu&#233;s del tratamiento se realiz&#243; observando las modificaciones del flujo sangu&#237;neo cerebral utilizando HMPAO marcado con Tc-99m &#40;marcador radioactivo&#41;&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se encontr&#243; ausencia de modificaci&#243;n del flujo sangu&#237;neo cerebral&#44; y por lo tanto ausencia de mejor&#237;a de la isquemia cerebral&#46;</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Se concluye que la Actinomicina D no modifica el flujo sangu&#237;neo ni mejora la isquemia cerebral experimental en ratas&#46;</p>"
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        "titulo" => "Summary"
        "resumen" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Though there are some studies reporting a favourable effect of Actinomycin D posthemorrhagic cerebral vasospasm&#44; the effect of this drug on brain ischemia has not been analyzed&#46;</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">We have performed an experimental study in 18 rats&#46; Ischemia was produced by permanent and transitory ligature of the right and left common carotid artery respectively&#46;</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The animals were divided into three groups&#46; Actinomycin was injected intraperitoneally 6 and 12 hours after ischemia in groups A and B&#46; Animals in group C did not receive any treatment&#46;</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Cerebral blood flow &#40;CBF&#41; was measured using HMPAO labeled with Tc 99m&#46;</p><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">There was no modification of CBF&#46; The conclusion is that Actinomycin D does not improve cerebral ischemia in this experimental model&#46;</p>"
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        "nota" => "<p class="elsevierStyleNotepara">Posadas Narro&#44; G&#46;&#59; Haro del Moral&#44; J&#46; de&#59; Vaquero Crespo&#44; J&#46;&#59; San Juan Robles&#44; C&#46;&#59; Bravo Zabalgoitia&#44; G&#46; y Ortiz Berrocal&#44; J&#46;&#58; Influencia de la actinomicina D sobre el flujo sangu&#237;neo cerebral en un modelo de isquemia experimental&#46; Neurocirug&#237;a 1994&#59; 5&#58; 10&#8211;15&#46;</p>"
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