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        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">As Magnetic Resonance Spectroscopy is one of the most powerful methods to obtain a non-invasive view of brain metabolism we&#44; as others&#44; judge it a promising tool for tumor grading&#46; We investigated 8 patients harbouring astrocytomas &#40;histologically confirmed via stereotactic serial biopsy&#41; of different malignity with single voxel &#40;PRESS&#41; 1 H MRS techniques&#46; The measurements were also repeated after interstitial radiosurgery using 125 Iodine&#44; when this treatment modality was deemed indicated&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Apart from the decrease of NAA &#40;N-acetyl-L-aspartate&#41;&#44; the tumor spectra show the presence of lactate &#40;Lac&#41; which however does not correlate to the tumor grade&#46; More interesting for this and confirmed in our initial trial is the fact that choline &#40;Cho&#41; varies from almost normal concentrations in low-grade astrocytomas to a fourfould increase in the high-grade lesions with strong correlation to the tumor malignity&#46; After stereotactic radiosurgical treatment&#44; a decrease of the previously increased choline signal is observed&#46; The reduction of choline seems to be dose related&#46;</p>"
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        "resumen" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Considerando que la espectroscopia magn&#233;tica nuclear &#40;MRS&#41; es uno de los m&#233;todos m&#225;s eficaces para obtener una imagen no-invasiva del metabolismo cerebral&#44; juzgamos esta t&#233;cnica muy prometedora para la diferenciaci&#243;n &#40;graduaci&#243;n&#41; tumoral&#46;</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Examinamos ocho pacientes con astrocitomas &#40;his tol&#243;gicamente confirmados por medio de biopsia estereot&#225;ctica seriada&#41; de diferente grado de malignidad con t&#233;cnica single voxel &#40;PRESS&#41; 1 H MRS&#46; Los estudios fueron repetidos despu&#233;s de radiocirug&#237;a intersticial usando I125 en aquellos pacientes en los cuales esta modalidad de tratamiento parec&#237;a indicada&#46; Aparte de la disminuci&#243;n de NAA &#40;N-acetil-L-aspartato&#41;&#44; los espectra de los tumores muestran la presencia de lactato &#40;Lac&#41; lo cual&#44; no obstante&#44; no est&#225; en correlaci&#243;n con la graduaci&#243;n histol&#243;gica de la lesi&#243;n&#46; M&#225;s interesante y confirmado por nuestros estudios iniciales&#44; es el hecho que la cholina &#40;Cho&#41; var&#237;a de una concentraci&#243;n casi normal en astrocitomas de bajo grado a un incremento cuadruple en las lesiones de alto grado con una fuerte correlaci&#243;n con el grado de malignidad del tumor&#46; Despu&#233;s de un tratamiento radioquir&#250;rgico se observa una disminuci&#243;n de la se&#241;al de cholina que previamente hab&#237;a aumentado&#46; La reducci&#243;n de cholina parece ser relacionada a la dosis&#46;</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Pudimos confirmar los valores obtenidos en an&#225;lisis in vitro y consideramos que una graduaci&#243;n tumoral no-invasiva de astrocitomas es posible por medio de la relaci&#243;n &#40;ratio&#41; entre cholina-creatina&#46; No obstante&#44; ser&#225; necesario un colectivo de pacientes m&#225;s grande para verificar nuestros resultados y evaluar la sensitividad de MRS en el monitoring terap&#233;utico a corto y largo plazo&#46;</p>"
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Grading and therapy monitoring of astrocytomas with 1H spectroscopy
Grado de diferenciación y control terapéutico de astrocitomas mediante lH espectroscopía
W. Bini
Dept. of Neurosurgery, Neurozentrum MR Hochfeld, University of Freiburg, Freiburg-Germany
O. Speck*, Th. Thiel*, J. Hennig*
* Dept. of Radiology, MR Hochfeld, University of Freiburg, Freiburg-Germany
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Información del artículo
ISSN: 11301473
Idioma original: Inglés
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