Utilidad de los derivados de la tetraciclina como inhibidores de la angiogénesis tumoral en neoplasias del sistema nervioso. Estudio experimental sobre un tumor neuroectodérmico indiferenciado
Effects of tetracycline derivates as inhibitors of tumor angiogenesis (C.N.S.). Experimental study on an undifferentiated neuroectodermal tumor
J. Vaquero, M. Zurita, S. Coca, S. Oya
Unidad de Investigación en Neurociencias de la Fundación Mapfre-Medicina. Laboratorio de Neuro-oncología experimental del Servicio de Neurocirugía del Hospital Universitario Clínica Puerta de HielTo. Madrid
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Bini" "autores" => array:1 [ 0 => array:2 [ "nombre" => "W." "apellidos" => "Bini" ] ] ] 1 => array:2 [ "autoresLista" => "O. Speck, Th. Thiel, J. Hennig" "autores" => array:3 [ 0 => array:2 [ "nombre" => "O." "apellidos" => "Speck" ] 1 => array:2 [ "nombre" => "Th." "apellidos" => "Thiel" ] 2 => array:2 [ "nombre" => "J." "apellidos" => "Hennig" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147397710273?idApp=UINPBA00004B" "url" => "/11301473/0000000800000003/v1_201305151502/S1130147397710273/v1_201305151502/en/main.assets" ] "es" => array:13 [ "idiomaDefecto" => true "titulo" => "Utilidad de los derivados de la tetraciclina como inhibidores de la angiogénesis tumoral en neoplasias del sistema nervioso. Estudio experimental sobre un tumor neuroectodérmico indiferenciado" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "178" "paginaFinal" => "182" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "J. Vaquero, M. Zurita, S. Coca, S. Oya" "autores" => array:4 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Vaquero" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Zurita" ] 2 => array:2 [ "nombre" => "S." "apellidos" => "Coca" ] 3 => array:2 [ "nombre" => "S." "apellidos" => "Oya" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Unidad de Investigación en Neurociencias de la Fundación Mapfre-Medicina. Laboratorio de Neuro-oncología experimental del Servicio de Neurocirugía del Hospital Universitario Clínica Puerta de HielTo. Madrid" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Effects of tetracycline derivates as inhibitors of tumor angiogenesis (C.N.S.). Experimental study on an undifferentiated neuroectodermal tumor" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec163160" "palabras" => array:4 [ 0 => "Tetraciclina" 1 => "Minociclina" 2 => "Tumor cerebral experimental" 3 => "Angiogénesis tumoral" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec163161" "palabras" => array:4 [ 0 => "Tetracycline" 1 => "Minocycline" 2 => "Experimental brain tumor" 3 => "Tumor angiogenesis" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Se ha realizado un estudio experimental sobre un modelo de tumor neuroectodérmico indiferenciado, con el propósito de conocer el posible efecto antitumoral de un derivado de la tetraciclina (minociclina) con capacidad para inducir una inhibición de la angiogénesis tumoral. La administración intratumoral de minociclina sobre el tumor experimental IL-7, durante 4 semanas, no modificó el crecimiento del tumor ni su patrón de angiogénesis. Estos resultados sugieren la escasa utilidfld de líneas de investigación que traten de controlar el crecimiento de neoplasias indiferenciadas del Sistema Nervioso basándose en una supuesta inhibición de la angiogénesis tumoral inducida por derivados de la tetraciclina.</p>" ] "en" => array:2 [ "titulo" => "Summary" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">An experimental study on a model of undifferentiated neuroectodermal tumor has been accomplished in order to know the possible antitumor effect of a tetracycline derivative (minocycline), with capacity to induce an inhibition of the tumor angiogenesis. The intratumoral administration of minocycline on the experimental tumor IL-7, during 4 weeks, it did not modify the growth of the tumor neither its pattern of angiogenesis. These results suggest the scarce usefulness of research that try of controlling the growth of undifferentiated neoplasias of the Nervous System by means of a supposed inhibition of tumor angiogenesis induced by tetracycline derivatives.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Vaquero, J.; Zurita, M.; Coca, S.; Oya, S.: Utilidad de los derivados de la tetraciclina como inhibidores de la angiogénesis tumoral en neoplasias del sistema nervioso. Estudio experimental sobre un tumor neuroectodérmico indiferenciado. Neurocirugía 1997; 8: 178–182.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:14 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:1 [ 0 => "J. Folkman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Tumor angiogenesis" "paginaInicial" => "153" "paginaFinal" => "170" "serieFecha" => "1993" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "What is the evidence that tumors are angiogenesis dependent?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J. Folkman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J. Natl. Cancer Inst." "fecha" => "1990" "volumen" => "82" "paginaInicial" => "4" "paginaFinal" => "6" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1688381" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Angiogenic factors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Folkman" 1 => "M. Klagsbrun" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Science" "fecha" => "1987" "volumen" => "235" "paginaInicial" => "442" "paginaFinal" => "447" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2432664" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Antiangiogenesis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M.J. Folkman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Biologic Therapy of Cancer" "paginaInicial" => "743" "paginaFinal" => "753" "serieFecha" => "1991" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Brain tumor angiogenesis: Drug delivery kand new inhibitors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "C. Guerin" 1 => "R.J. Tamargo" 2 => "A. Olivi" 3 => "H. Brem" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Angiogenesis in Health and Disease" "paginaInicial" => "265" "paginaFinal" => "273" "serieFecha" => "1992" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The therapy of human tumors in athymic (nude) mice" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D.P. Houchens" 1 => "A.A. Ovejera" 2 => "A.D. Bauker" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Proceedings of the Symposium on the use of athymic (nude) mice in Cancer Research" "paginaInicial" => "267" "paginaFinal" => "280" "serieFecha" => "1978" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Antiangiogenic action of heparin plus cortisone is associated with decreased collagenous protein synthesis in the chick chorioallantoic membrane system" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M. Maragoudakis" 1 => "M. Sarmonika" 2 => "M. Panoutsacopoulou" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J. Pharmacol. Exp. Ther." "fecha" => "1989" "volumen" => "251" "paginaInicial" => "679" "paginaFinal" => "682" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2478695" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Inhibition of basement membrane biosynthesis prevents angiogenesis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.E. Maragoudakis" 1 => "M. Sarmonika" 2 => "M. Panoutsacopoulou" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J. Pharmacol. Exp. Ther." "fecha" => "1988" "volumen" => "244" "paginaInicial" => "729" "paginaFinal" => "733" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2450202" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Angiogenesis inhibition by minocycline" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R.J. Tamargo" 1 => "R.A. Bok" 2 => "H. Brem" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Res" "fecha" => "1991" "volumen" => "51" "paginaInicial" => "672" "paginaFinal" => "675" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1702361" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Antiangiogenic agents potentiate cytotoxic cancer therapies against primary and metastatic disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "B.A. Teicher" 1 => "E.A. Sotomayor" 2 => "Z.D. Huang" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Res" "fecha" => "1992" "volumen" => "52" "paginaInicial" => "6702" "paginaFinal" => "6704" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1384969" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Arrest of in vivo growth of a solid Leydig-celI tumor by prolonged inhibition of mitochondrial protein synthesis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C. Van den Bogert" 1 => "B.H.J. Dontje" 2 => "A.M. Kroon" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Res" "fecha" => "1983" "volumen" => "43" "paginaInicial" => "2247" "paginaFinal" => "2251" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6831447" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Experimental induction of primitive neuroectodermal tumours in rats: A reappraissement of the ENU-model of neurocarcinogenesis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J. Vaquero" 1 => "S. Oya" 2 => "S. Coca" 3 => "M. Zurita" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Acta Neurochir (Wien)" "fecha" => "1994" "volumen" => "131" "paginaInicial" => "294" "paginaFinal" => "301" ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Minocycline, an angiogenesis inhibitor, when delivered interstitialIy acts synergistically with carmustine (BCNU) to prolong survival in an intracranial 9L gliosarcoma model" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Weingart" 1 => "H. Brem" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Proc. Am. Assoc. Cancer. Res." "fecha" => "1993" "volumen" => "34" "paginaInicial" => "303" "itemHostRev" => array:3 [ "pii" => "S0168827809000592" "estado" => "S300" "issn" => "01688278" ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The role of minocycline in the treatment of intracranial 9L glioma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.D. Weingart" 1 => "E.P. Sipos" 2 => "H. Brem" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1995.82.4.0635" "Revista" => array:6 [ "tituloSerie" => "J. Neurosurg." "fecha" => "1995" "volumen" => "82" "paginaInicial" => "635" "paginaFinal" => "640" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7897527" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/11301473/0000000800000003/v1_201305151502/S1130147397710285/v1_201305151502/es/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/11301473/0000000800000003/v1_201305151502/S1130147397710285/v1_201305151502/es/main.pdf?idApp=UINPBA00004B&text.app=https://revistaneurocirugia.com/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147397710285?idApp=UINPBA00004B" ]
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