Diagnóstico diferencial de tumores cerebrales “in vitro” por espectroscopía de resonancia magnética de protón. Método de los cocientes espectrales
Differential diagnosis of brain tumors by proton magnetic resonance spectroscopy “in vitro”. The method of spectroscopic ratios
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array:22 [ "pii" => "S1130147398707146" "issn" => "11301473" "doi" => "10.1016/S1130-1473(98)70714-6" "estado" => "S300" "fechaPublicacion" => "1998-01-01" "aid" => "70714" "copyright" => "Sociedad Española de Neurocirugía" "copyrightAnyo" => "1998" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Neurocirugia. 1998;9:4-10" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 5200 "formatos" => array:3 [ "EPUB" => 16 "HTML" => 1321 "PDF" => 3863 ] ] "itemSiguiente" => array:18 [ "pii" => "S1130147398707158" "issn" => "11301473" "doi" => "10.1016/S1130-1473(98)70715-8" "estado" => "S300" "fechaPublicacion" => "1998-01-01" "aid" => "70715" "copyright" => "Sociedad Española de Neurocirugía" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Neurocirugia. 1998;9:11-20" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 3286 "formatos" => array:3 [ "EPUB" => 13 "HTML" => 951 "PDF" => 2322 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Ependimomas del filum terminal" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "11" "paginaFinal" => "20" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Ependymomas of the filum terminale" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M. López-Escobar Fernández, E. Gómez Cárdenas, A. Contreras Jiménez, C. Ramos Guillén" "autores" => array:4 [ 0 => array:2 [ "nombre" => "M." "apellidos" => "López-Escobar Fernández" ] 1 => array:2 [ "nombre" => "E." "apellidos" => "Gómez Cárdenas" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Contreras Jiménez" ] 3 => array:2 [ "nombre" => "C." "apellidos" => "Ramos Guillén" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147398707158?idApp=UINPBA00004B" "url" => "/11301473/0000000900000001/v1_201305151507/S1130147398707158/v1_201305151507/es/main.assets" ] "es" => array:13 [ "idiomaDefecto" => true "titulo" => "Diagnóstico diferencial de tumores cerebrales “in vitro” por espectroscopía de resonancia magnética de protón. Método de los cocientes espectrales" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "4" "paginaFinal" => "10" ] ] "autores" => array:2 [ 0 => array:3 [ "autoresLista" => "J.Mª. Pascual, F. Carceller, J.M. Roda" "autores" => array:3 [ 0 => array:2 [ "nombre" => "J.Mª." "apellidos" => "Pascual" ] 1 => array:2 [ "nombre" => "F." "apellidos" => "Carceller" ] 2 => array:2 [ "nombre" => "J.M." "apellidos" => "Roda" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Neurocirugía. Hospital Universitario La Paz. 28046 Madrid" ] ] ] 1 => array:3 [ "autoresLista" => "S. Cerdán" "autores" => array:1 [ 0 => array:3 [ "nombre" => "S." "apellidos" => "Cerdán" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Instituto de Investigaciones Biomédicas del C.S.I.C. Madrid" "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0010" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Differential diagnosis of brain tumors by proton magnetic resonance spectroscopy “in vitro”. The method of spectroscopic ratios" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:2 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Abreviaturas" "identificador" => "xpalclavsec163231" "palabras" => array:13 [ 0 => "Ala" 1 => "Cho" 2 => "Cr" 3 => "Glu" 4 => "Gln" 5 => "Gly" 6 => "Ino" 7 => "Lac" 8 => "NAA" 9 => "RMN" 10 => "SNC" 11 => "Tau" 12 => "TSP" ] ] 1 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec163233" "palabras" => array:1 [ 0 => "Espectroscopía <span class="elsevierStyleSup">1</span>H RMN, tumores cerebrales, diagnóstico in vitro:" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec163232" "palabras" => array:1 [ 0 => "<span class="elsevierStyleSup">1</span>H NMR spectroscopy, brain tumors, in vitro diagnosis" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Se han estudiado por espectroscopía de <span class="elsevierStyleSup">1</span>H RMN de alta resolución extractos de biopsias de cerebro humano normal (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>5), de astrocitomas de bajo grado (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>7), de astrocitomas de alto grado y glioblastomas (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>16), de meningiomas (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>18), de oligodendrogliomas (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>4) y de meduloblastomas (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>3). Los espectros obtenidos se compararon entre sí utilizando ocho cocientes de intensidad de resonancias específicas: colina/creatina, colina/N-acetilaspártico, creatina/N-acetilaspártico, colina/inositol, glutamina/glutamato, taurina/N-acetilaspártico, alanina/creatina y alanina/N-acetilaspártico. Estos cocientes permitieron realizar un, diagnóstico diferencial entre todos los tejidos estudiados con excepción de la comparación entre oligodendrogliomas y astrocitomas. Los tumores cerebrales pudieron diferenciarse del tejido cerebral normal por su menor contenido en N-acetilaspártico. Los meningiomas se caracterizaron por su alto contenido en alanina y los medulobiastomas por sus elevados contenidos en colina y taurina. En el caso de los astrocitomas fue posible discriminar entre los grados de malignidad bajo y alto en base al mayor valor del cociente colina/inositol y menor valor del cociente glutamina/glutamato en los astrocitomas de alto grado. Estos resultados indican que la aplicación de cocientes en la comparación de espectros de biopsias cerebrales constituye una herramienta útil en el diagnóstico diferencial de tumores por espectroscopía de’ <span class="elsevierStyleSup">1</span>H RMN.</p>" ] "en" => array:2 [ "titulo" => "Summary" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We have studied high resolution 1H NMR spectra of extracts from biopsies of normal brain (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>5), low grade astrocytomas (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>7), high grade astrocytomas and glioblastomas (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>16), meningiomas (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>18), oligodendrogliomas (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>4) and medulloblastomas (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>3). The spectra were compared using eight different intensity ratios. of specific resonances: choline/creatine, choline/N-acetyl-aspartic, creatine/N-acetilaspartic, choline/inositol; glutamine/glutamate, turine/N-acetylaspartic, alanine/creatine and alanine/N-acetylaspartic. These ratios allowed a differential diagnosis for each of the tissue samples studied, with the exception of the comparison between oligodendrogliomas and astrocytomas. Brain tumors contained always less N-acetylaspartic than the normal brain. Meningiomas were characterized by their high content in alanine and medulloblastomas by their high content in choline and taurineo High grade astrocytomas and glioblastomas could be distinguished from low grade astrocytomas by their higher choline/inositol ratio and lower glutamine/glutamate ratio. These results indicate that comparisons between intensity ratios in spectra of cerebral biopsies provide a useful tool for the differential diagnosis of brain tumors by high resolution <span class="elsevierStyleSup">1</span>H NMR.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Pascual, J.Mª.; Carceller, F.; Cerdán, S.; Roda, J.M.: Diagnóstico diferencial de tumores cerebrales “in vitro” por espectroscopía de resonancia magnética de protón. Método de cocientes espectrales. Neurocirugía 1998; 9: 4–10.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:17 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2023 Marzo | 2 | 3 | 5 |
| 2018 Noviembre | 1 | 2 | 3 |
| 2018 Marzo | 1 | 0 | 1 |
| 2018 Febrero | 21 | 7 | 28 |
| 2018 Enero | 29 | 18 | 47 |
| 2017 Diciembre | 34 | 27 | 61 |
| 2017 Noviembre | 54 | 50 | 104 |
| 2017 Octubre | 46 | 42 | 88 |
| 2017 Septiembre | 25 | 53 | 78 |
| 2017 Agosto | 24 | 62 | 86 |
| 2017 Julio | 30 | 54 | 84 |
| 2017 Junio | 31 | 72 | 103 |
| 2017 Mayo | 35 | 84 | 119 |
| 2017 Abril | 20 | 106 | 126 |
| 2017 Marzo | 15 | 96 | 111 |
| 2017 Febrero | 18 | 106 | 124 |
| 2017 Enero | 13 | 53 | 66 |
| 2016 Diciembre | 36 | 52 | 88 |
| 2016 Noviembre | 33 | 84 | 117 |
| 2016 Octubre | 52 | 82 | 134 |
| 2016 Septiembre | 95 | 134 | 229 |
| 2016 Agosto | 149 | 143 | 292 |
| 2016 Julio | 66 | 135 | 201 |
| 2015 Diciembre | 4 | 0 | 4 |
| 2015 Septiembre | 1 | 0 | 1 |
| 2015 Julio | 4 | 8 | 12 |
| 2015 Junio | 14 | 86 | 100 |
| 2015 Mayo | 22 | 112 | 134 |
| 2015 Abril | 10 | 114 | 124 |
| 2015 Marzo | 17 | 105 | 122 |
| 2015 Febrero | 15 | 110 | 125 |
| 2015 Enero | 13 | 101 | 114 |
| 2014 Diciembre | 15 | 73 | 88 |
| 2014 Noviembre | 14 | 101 | 115 |
| 2014 Octubre | 21 | 97 | 118 |
| 2014 Septiembre | 19 | 127 | 146 |
| 2014 Agosto | 15 | 120 | 135 |
| 2014 Julio | 21 | 77 | 98 |
| 2014 Junio | 25 | 80 | 105 |
| 2014 Mayo | 25 | 90 | 115 |
| 2014 Abril | 12 | 69 | 81 |
| 2014 Marzo | 18 | 51 | 69 |
| 2014 Febrero | 19 | 64 | 83 |
| 2014 Enero | 12 | 68 | 80 |
| 2013 Diciembre | 9 | 51 | 60 |
| 2013 Noviembre | 14 | 53 | 67 |
| 2013 Octubre | 16 | 76 | 92 |
| 2013 Septiembre | 16 | 98 | 114 |
| 2013 Agosto | 15 | 58 | 73 |
| 2013 Julio | 18 | 75 | 93 |
| 2013 Junio | 15 | 68 | 83 |
| 2013 Mayo | 9 | 70 | 79 |
| 2013 Abril | 13 | 54 | 67 |
| 2013 Marzo | 10 | 40 | 50 |
| 2013 Febrero | 8 | 29 | 37 |
| 2013 Enero | 14 | 25 | 39 |
| 2012 Diciembre | 11 | 27 | 38 |
| 2012 Noviembre | 1 | 21 | 22 |
| 2012 Octubre | 0 | 1 | 1 |
| 2012 Septiembre | 0 | 2 | 2 |
| 2012 Enero | 8 | 0 | 8 |
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