Consideraciones sobre la citogenética y los factores de proliferación celular en la oncogénesis de los astrocitomas anaplásicos y glioblastoma multiforme
Oncogenesis of anaplastic astrocytoma and glioblastoma. Citogenetics and proliferating cell factors
J.L. Gil-Salú, J.M. González-Darder
Sección de Neurocirugía. Hospital General de Castellón
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Pardo, J. Molet, J.M. Fernández Villa, P. Tresserras, B. Oliver, P. Parés, F. Bartumeus" "autores" => array:7 [ 0 => array:2 [ "nombre" => "S." "apellidos" => "Pardo" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "Molet" ] 2 => array:2 [ "nombre" => "J.M." "apellidos" => "Fernández Villa" ] 3 => array:2 [ "nombre" => "P." "apellidos" => "Tresserras" ] 4 => array:2 [ "nombre" => "B." "apellidos" => "Oliver" ] 5 => array:2 [ "nombre" => "P." "apellidos" => "Parés" ] 6 => array:2 [ "nombre" => "F." "apellidos" => "Bartumeus" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147398709996?idApp=UINPBA00004B" "url" => "/11301473/0000000900000003/v1_201305151511/S1130147398709996/v1_201305151511/es/main.assets" ] "es" => array:13 [ "idiomaDefecto" => true "titulo" => "Consideraciones sobre la citogenética y los factores de proliferación celular en la oncogénesis de los astrocitomas anaplásicos y glioblastoma multiforme" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "199" "paginaFinal" => "208" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "J.L. Gil-Salú, J.M. González-Darder" "autores" => array:2 [ 0 => array:2 [ "nombre" => "J.L." "apellidos" => "Gil-Salú" ] 1 => array:2 [ "nombre" => "J.M." "apellidos" => "González-Darder" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Sección de Neurocirugía. Hospital General de Castellón" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Oncogenesis of anaplastic astrocytoma and glioblastoma. Citogenetics and proliferating cell factors" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec163329" "palabras" => array:3 [ 0 => "Gliomas malignos" 1 => "Citocinética tumoral" 2 => "Control de crecimiento" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec163328" "palabras" => array:3 [ 0 => "Malignant gliomas" 1 => "Tumoral citocinetics" 2 => "Growth control" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Todas las modalidades terapéuticas de que disponemos en la actualidad sobre los astrocitomas anaplásicos y glioblastoma multiforme son paliativas. La finalidad de dichos tratamientos es la de conseguir los más largos períodos de supervivencia con buena calidad de vida, pero incluso la combinación de los distintos tratamientos consigue resultados de supervivencia desalentadores.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">En la actualidad, gracias al auge de los estudios citogenéticos y de biología molecular, nuevas perspectivas en la actividad investigadora nos abren futuras estrategias de tratamiento. Estas técnicas nos muestran cómo la iniciación y progresión de un tumor neuroepitelial es el resultado de la expresión inadecuada y exagerada de proto-oncogenes, a partir de los cuales se ponen en marcha sistemas con actividad biológica que conducen a la desdiferenciación y proliferación celular.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Por otro lado, las técnicas inmunohistológicas empleando anticuerpos monoclonales de alta especificidad, que nos valoran la cinética tumoral, nos permiten evaluar el pronóstico de los pacientes y la eficacia de las diversas opciones terapéuticas.</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La presentación de los mecanismos implicados en la fisiopatología, diagnóstico y técnicas de estudio histológicas de los tumores anaplásicos neuroepiteliales del adulto y cómo dichos mecanismos convergen a nivel molecular repercutiendo en el conocimiento de la biología del ciclo celular, son el objetivo del presente artículo.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">All currently available therapies on anaplastic astrocytomas and glioblastoma multiforme are palliative. The goal of treatment is to provide the longest period of good quality life but the setup treatment achieve discouraging results.</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Now, by the neurogenetics and the molecular biology of human brain tumors studies new approaches of research activity shows future treatment strategies. So, the initiation and progression of a neuroepithelial tumor is the result of inappropiate expresion of protooncogen, which encoding systems with biological activities that influence cell differentiation and proliferation.</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">With the production of monoclonal antibodies with high specific binding characteristics, inmunohistology, tumoral cytocinetics studies became the preferable method by which to evaluate the prognosis and treatment options. In this article, the pathogenesis and diagnosis technics are reviewed and we can appreciate Iike in cell cycle, all oncogenic influences must converge.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Gil-Salú, J.; González-Darder, J.: Consideraciones sobre la citogenética y los factores de proliferación celular en la oncogénesis de los astrocitomas anaplásicos y glioblastoma multiforme. Neurocirugía 1998; 9: 199–208.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:73 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Oncogenes: cause or consequence in the development of glial tumours" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A. Akbasak" 1 => "B. 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2023 Marzo | 0 | 2 | 2 |
| 2021 Octubre | 0 | 1 | 1 |
| 2018 Febrero | 11 | 8 | 19 |
| 2018 Enero | 15 | 8 | 23 |
| 2017 Diciembre | 15 | 12 | 27 |
| 2017 Noviembre | 46 | 44 | 90 |
| 2017 Octubre | 12 | 6 | 18 |
| 2017 Septiembre | 16 | 14 | 30 |
| 2017 Agosto | 11 | 5 | 16 |
| 2017 Julio | 10 | 7 | 17 |
| 2017 Junio | 17 | 9 | 26 |
| 2017 Mayo | 18 | 15 | 33 |
| 2017 Abril | 10 | 14 | 24 |
| 2017 Marzo | 32 | 7 | 39 |
| 2017 Febrero | 7 | 8 | 15 |
| 2017 Enero | 9 | 6 | 15 |
| 2016 Diciembre | 33 | 12 | 45 |
| 2016 Noviembre | 36 | 15 | 51 |
| 2016 Octubre | 33 | 16 | 49 |
| 2016 Septiembre | 33 | 9 | 42 |
| 2016 Agosto | 31 | 8 | 39 |
| 2016 Julio | 27 | 17 | 44 |
| 2015 Diciembre | 3 | 0 | 3 |
| 2015 Septiembre | 1 | 0 | 1 |
| 2015 Agosto | 1 | 0 | 1 |
| 2015 Julio | 0 | 10 | 10 |
| 2015 Junio | 10 | 11 | 21 |
| 2015 Mayo | 19 | 21 | 40 |
| 2015 Abril | 14 | 17 | 31 |
| 2015 Marzo | 20 | 31 | 51 |
| 2015 Febrero | 13 | 15 | 28 |
| 2015 Enero | 16 | 13 | 29 |
| 2014 Diciembre | 17 | 14 | 31 |
| 2014 Noviembre | 15 | 15 | 30 |
| 2014 Octubre | 17 | 24 | 41 |
| 2014 Septiembre | 22 | 25 | 47 |
| 2014 Agosto | 20 | 27 | 47 |
| 2014 Julio | 15 | 18 | 33 |
| 2014 Junio | 19 | 31 | 50 |
| 2014 Mayo | 24 | 17 | 41 |
| 2014 Abril | 15 | 17 | 32 |
| 2014 Marzo | 13 | 22 | 35 |
| 2014 Febrero | 14 | 19 | 33 |
| 2014 Enero | 15 | 19 | 34 |
| 2013 Diciembre | 14 | 22 | 36 |
| 2013 Noviembre | 13 | 10 | 23 |
| 2013 Octubre | 25 | 20 | 45 |
| 2013 Septiembre | 14 | 19 | 33 |
| 2013 Agosto | 30 | 24 | 54 |
| 2013 Julio | 20 | 33 | 53 |
| 2013 Junio | 19 | 32 | 51 |
| 2013 Mayo | 18 | 17 | 35 |
| 2013 Abril | 16 | 16 | 32 |
| 2013 Marzo | 16 | 26 | 42 |
| 2013 Febrero | 8 | 15 | 23 |
| 2013 Enero | 17 | 9 | 26 |
| 2012 Diciembre | 20 | 10 | 30 |
| 2012 Noviembre | 0 | 8 | 8 |
| 2012 Octubre | 0 | 1 | 1 |
| 2012 Septiembre | 0 | 1 | 1 |
| 2012 Enero | 10 | 0 | 10 |
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