Tratamiento con radiocirugía estereotáxica del glioma cerebral primario de alto grado
Stereotactic radiosurgery in primary high grade malignat glioma
D. Ortiz de Urbina, M. Santos, J. Samblás, J.M. Delgado, J.C. Bustos, J.A. Gutiérrez-Díaz, I. García-Berrocal, S. Rodríguez, M.C. Rubio, G. Donckaster, F. Sansivirini, F.A. Calvo
Sanatorio San Francisco de Asís. Madrid
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"apellidos" => "Samblás" ] 3 => array:2 [ "nombre" => "J.M." "apellidos" => "Delgado" ] 4 => array:2 [ "nombre" => "J.C." "apellidos" => "Bustos" ] 5 => array:2 [ "nombre" => "J.A." "apellidos" => "Gutiérrez-Díaz" ] 6 => array:2 [ "nombre" => "I." "apellidos" => "García-Berrocal" ] 7 => array:2 [ "nombre" => "S." "apellidos" => "Rodríguez" ] 8 => array:2 [ "nombre" => "M.C." "apellidos" => "Rubio" ] 9 => array:2 [ "nombre" => "G." "apellidos" => "Donckaster" ] 10 => array:2 [ "nombre" => "F." "apellidos" => "Sansivirini" ] 11 => array:2 [ "nombre" => "F.A." "apellidos" => "Calvo" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Sanatorio San Francisco de Asís. Madrid" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Stereotactic radiosurgery in primary high grade malignat glioma" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec156767" "palabras" => array:2 [ 0 => "Radiocirugía estereotáxica" 1 => "Glioma cerebral de alto grado" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec156766" "palabras" => array:2 [ 0 => "Stereotactic Radiosurgety" 1 => "High grade glioma" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Analizar en un estudio fase II el control local, tiempo a progresión y supervivencia (SPV) de pacientes con glioma cerebral primario de alto grado tratados con radiocirugía estereotáxica (RC), como tratamiento de intensificación local.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Dieciocho pacientes, 8 astrocitomas anaplásicos y 10 glioblastomas multiformes de diámetro máximo menor o igual a 5<span class="elsevierStyleHsp" style=""></span>cm, han sido tratados con RC, administrándose una dosis margen que incluye el volumen tumoral de 10–20 Gy (mediana: 15 Gy), alcanzando una dosis máxima intratumoral de 12.5–40 Gy (mediana 17 Gy). Catorce pacientes (78%) recibieron radioterapia externa fraccionada (mediana de dosis: 60 Gy).</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La mediana de SPV ha sido 11.5 meses y la SPV actuarial a 1 y 2 años de 42.5% y 10.6% respectivamente. Diez de 18 pacientes (55%) presentaron progresión tumoral con una mediana de tiempo a progresión de 10 meses (límites: 1–14 meses). Sólo 1 paciente (5.5%) desarrolló toxicidad severa.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La RC es una atractiva modalidad de tratamiento de intensificación local en glioma maligno cerebral de tamaño menor o igual a 5<span class="elsevierStyleHsp" style=""></span>cm, tolerable y factible.</p>" ] "en" => array:2 [ "titulo" => "Summary" "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To analyze in a phase II clinical trial the local control, time to progression and survival of patients with primary malignant glioma treated with stereotactic radiosurgery (SRS) as a treatment boost.</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Methods and material A total of 18 patients, with anaplastic astrocytomas (8 cases) and glioblastoma multiformes (10 cases) (maximum diameter=<span class="elsevierStyleHsp" style=""></span>5<span class="elsevierStyleHsp" style=""></span>cm) have been treated with SRS, receiving a single marginal tumor dose of 10–20 Gy (median: 15 Gy), at 90% isodose line, and achieving a maximun tumor dose of 12.5–40 Gy (median: 17 Gy). Fourteen patients (78%) were treated with external beam radiotherapy (median dose: 60 Gy).</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The median survival time was 11.5 months, and the 1 -and 2-year actuarial survival were 42.5% and 10.6% respectively. Ten out of 18 patients (55%) had tumor progression and the median time to tumor progression was 10 months (range: 1–14 months). One patient (5.5%) developed severe toxicity.</p> <span class="elsevierStyleSectionTitle">Conclusion</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">SRS is an attractive, feasible and tolerable treatment modality for local intensification in malignant glioma, lesser o equal than 5<span class="elsevierStyleHsp" style=""></span>cm in size.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Ortiz de Urbina, D.; Santos, M.; Samblas, J.; Delgado, J.M.; Bustos, J.C.; Gutiérrez-Díaz, J.A., García-Berrocal, I.; Rodríguez, S.; Rubio, M.C.; Donckaster, G.; Sansivirini, F.; Calvo, F.A.: Tratamiento con radiocirugía estereotáxica del glioma cerebral primario de alto grado. 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2023 Marzo | 2 | 0 | 2 |
| 2019 Septiembre | 1 | 0 | 1 |
| 2018 Febrero | 19 | 5 | 24 |
| 2018 Enero | 18 | 10 | 28 |
| 2017 Diciembre | 26 | 24 | 50 |
| 2017 Noviembre | 20 | 35 | 55 |
| 2017 Octubre | 18 | 28 | 46 |
| 2017 Septiembre | 11 | 26 | 37 |
| 2017 Agosto | 13 | 24 | 37 |
| 2017 Julio | 19 | 20 | 39 |
| 2017 Junio | 30 | 38 | 68 |
| 2017 Mayo | 23 | 29 | 52 |
| 2017 Abril | 26 | 44 | 70 |
| 2017 Marzo | 12 | 42 | 54 |
| 2017 Febrero | 7 | 47 | 54 |
| 2017 Enero | 15 | 20 | 35 |
| 2016 Diciembre | 41 | 27 | 68 |
| 2016 Noviembre | 19 | 29 | 48 |
| 2016 Octubre | 31 | 42 | 73 |
| 2016 Septiembre | 57 | 75 | 132 |
| 2016 Agosto | 70 | 49 | 119 |
| 2016 Julio | 38 | 30 | 68 |
| 2016 Mayo | 1 | 0 | 1 |
| 2016 Abril | 1 | 0 | 1 |
| 2016 Febrero | 3 | 0 | 3 |
| 2015 Diciembre | 2 | 0 | 2 |
| 2015 Julio | 5 | 10 | 15 |
| 2015 Junio | 15 | 21 | 36 |
| 2015 Mayo | 14 | 23 | 37 |
| 2015 Abril | 14 | 20 | 34 |
| 2015 Marzo | 11 | 32 | 43 |
| 2015 Febrero | 16 | 37 | 53 |
| 2015 Enero | 17 | 30 | 47 |
| 2014 Diciembre | 14 | 33 | 47 |
| 2014 Noviembre | 23 | 31 | 54 |
| 2014 Octubre | 14 | 27 | 41 |
| 2014 Septiembre | 17 | 33 | 50 |
| 2014 Agosto | 12 | 37 | 49 |
| 2014 Julio | 14 | 39 | 53 |
| 2014 Junio | 17 | 31 | 48 |
| 2014 Mayo | 21 | 37 | 58 |
| 2014 Abril | 18 | 25 | 43 |
| 2014 Marzo | 19 | 34 | 53 |
| 2014 Febrero | 24 | 32 | 56 |
| 2014 Enero | 27 | 36 | 63 |
| 2013 Diciembre | 21 | 27 | 48 |
| 2013 Noviembre | 22 | 33 | 55 |
| 2013 Octubre | 25 | 29 | 54 |
| 2013 Septiembre | 20 | 34 | 54 |
| 2013 Agosto | 24 | 35 | 59 |
| 2013 Julio | 31 | 29 | 60 |
| 2013 Junio | 22 | 82 | 104 |
| 2013 Mayo | 25 | 44 | 69 |
| 2013 Abril | 10 | 31 | 41 |
| 2013 Marzo | 14 | 37 | 51 |
| 2013 Febrero | 12 | 27 | 39 |
| 2013 Enero | 19 | 22 | 41 |
| 2012 Diciembre | 10 | 27 | 37 |
| 2012 Noviembre | 0 | 16 | 16 |
| 2012 Octubre | 0 | 2 | 2 |
| 2012 Septiembre | 0 | 2 | 2 |
| 2012 Enero | 11 | 0 | 11 |
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