IV. Angiogénesis en oligodendrogliomas
IV. Angiogenesis in oligodendrogliomas
J. Vaquero, M. Zurita, S. Coca
Unidad de Investigación en Neurociencias de la Fundación Mapfre-Medicina, Laboratorio Neuro-oncología experimental, Servicio de Neurocirugía, Clínica Puerta de Hierro, Madrid
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Peculiaridades clínicas de los oligodendrogliomas" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "394" "paginaFinal" => "396" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "V. Clinical peculiarities of the oligodendrogliomas" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J.L. Gil Salú" "autores" => array:1 [ 0 => array:2 [ "nombre" => "J.L." "apellidos" => "Gil Salú" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147399707852?idApp=UINPBA00004B" "url" => "/11301473/0000001000000005/v1_201305151016/S1130147399707852/v1_201305151016/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1130147399707839" "issn" => "11301473" "doi" => "10.1016/S1130-1473(99)70783-9" "estado" => "S300" "fechaPublicacion" => "1999-01-01" "aid" => "70783" "copyright" => "Sociedad Española de Neurocirugía" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Neurocirugia. 1999;10:381-6" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1727 "formatos" => array:3 [ "EPUB" => 20 "HTML" => 938 "PDF" => 769 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "III. Oligodendrogliomas: Biología molecular" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "381" "paginaFinal" => "386" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "III. Oligodendrogliomas: Molecular biology" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M.J. Bello, J.A. Rey" "autores" => array:2 [ 0 => array:2 [ "nombre" => "M.J." "apellidos" => "Bello" ] 1 => array:2 [ "nombre" => "J.A." "apellidos" => "Rey" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147399707839?idApp=UINPBA00004B" "url" => "/11301473/0000001000000005/v1_201305151016/S1130147399707839/v1_201305151016/es/main.assets" ] "es" => array:13 [ "idiomaDefecto" => true "titulo" => "IV. Angiogénesis en oligodendrogliomas" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "388" "paginaFinal" => "392" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "J. Vaquero, M. Zurita, S. Coca" "autores" => array:3 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Vaquero" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Zurita" ] 2 => array:2 [ "nombre" => "S." "apellidos" => "Coca" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Unidad de Investigación en Neurociencias de la Fundación Mapfre-Medicina, Laboratorio Neuro-oncología experimental, Servicio de Neurocirugía, Clínica Puerta de Hierro, Madrid" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "IV. Angiogenesis in oligodendrogliomas" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec156790" "palabras" => array:3 [ 0 => "Oligodendroglioma" 1 => "Factores pronósticos" 2 => "Angiogénesis" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec156791" "palabras" => array:3 [ 0 => "Oligodendroglioma" 1 => "Prognostic factors" 2 => "Angiogenesis" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">En la presente revisión se muestra la experiencia de los autores en el estudio de los patrones de angiogénesis en oligodendrogliomas. Marcando inmunohistoquímicamente el endotelio vascular (CD-34) se aprecia que los oligodendrogliomas malignos muestran un típico patrón glomeruloide de los capilares intratumorales, que contrasta con el aspecto lineal de los capilares correspondientes a los oligodendrogliomas de bajo grado. Cuando se realizan estudios cuantitativos se observa que, al contrario de observaciones descritas en astrocitomas, en oligodendrogliomas de bajo grado (al menos cuado se cumplen las condiciones de haber presentado un índice de Ki-67 inferior a 1% Y haber sido tratados con cirugía y radioterapia) el simple análisis de la densidad vascular no parece constituir un factor pronóstico significativo. Sin embargo, sí se obtiene significación pronóstica cuando se analiza morfométricamente el área endotelial en relación al número de células. Pacientes con tumores que presentaron un índice de superficie vascular (ISV) superior a 15<span class="elsevierStyleHsp" style=""></span>μm<span class="elsevierStyleSup">2</span> tuvieron una supervivencia a 5 y 10 años del 50 y 0% respectivamente, frente a una supervivencia del 100 y 71% para pacientes cuyos tumores mostraron un ISV inferior a 15<span class="elsevierStyleHsp" style=""></span>μm<span class="elsevierStyleSup">2</span>.</p>" ] "en" => array:2 [ "titulo" => "Summary" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">The authors show the different patterns of angiogenesis in oligodendrogliomas after inmunohistochemical demonstration of the endothelial marker CD-34. High-grade oligodendrogliomas show a glomeruloid morphology of intratumor vessels. Nevertheless low-grade oligodendrogliomas show a lineal pattern of intratumor vessels. Furthermore, in contrast with previous observations in astrocytomas, the present study suggests that tumor angiogenesis, expressed as number of microvessels in tumor specimens, has no influence on behavior of low-grade oligodendrogliomas. In low-grade oligodendrogliomas treated by surgery and radiotherapy, and showing a Ki-67 index lesser to 1%, a tumor vascular surface index (VSI) was determined as the CD-34 immunostained endothelial surface in μm<span class="elsevierStyleSup">2</span> per 1000 tumor cells. Patients with a VSI of less than 15 showed a survival at 5 and 10 years of 100% and 71%, respectively, versus a survival of 50% and 0% for patients presenting a VSI greater than 15 (P<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.05).</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">These observations suggest the usefulness of the VSI as a long-term prognostic factor in low-grade oligodendroglioma.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Vaquero, J.; Zurita, M.; Coca, S.: Oligodendrogliomas: Estado actual. IV. Angiogénesis en oligodendrogliomas. Neurocirugía 1999; 10: 388–392.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:22 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2023 Marzo | 2 | 1 | 3 |
| 2020 Marzo | 1 | 0 | 1 |
| 2018 Febrero | 7 | 6 | 13 |
| 2018 Enero | 15 | 10 | 25 |
| 2017 Diciembre | 14 | 14 | 28 |
| 2017 Noviembre | 21 | 27 | 48 |
| 2017 Octubre | 11 | 8 | 19 |
| 2017 Septiembre | 11 | 13 | 24 |
| 2017 Agosto | 8 | 8 | 16 |
| 2017 Julio | 12 | 8 | 20 |
| 2017 Junio | 19 | 9 | 28 |
| 2017 Mayo | 10 | 10 | 20 |
| 2017 Abril | 17 | 10 | 27 |
| 2017 Marzo | 10 | 3 | 13 |
| 2017 Febrero | 4 | 4 | 8 |
| 2017 Enero | 6 | 2 | 8 |
| 2016 Diciembre | 25 | 9 | 34 |
| 2016 Noviembre | 14 | 10 | 24 |
| 2016 Octubre | 21 | 16 | 37 |
| 2016 Septiembre | 21 | 12 | 33 |
| 2016 Agosto | 37 | 14 | 51 |
| 2016 Julio | 29 | 17 | 46 |
| 2015 Diciembre | 2 | 0 | 2 |
| 2015 Julio | 2 | 0 | 2 |
| 2015 Junio | 12 | 10 | 22 |
| 2015 Mayo | 14 | 10 | 24 |
| 2015 Abril | 12 | 8 | 20 |
| 2015 Marzo | 12 | 11 | 23 |
| 2015 Febrero | 14 | 14 | 28 |
| 2015 Enero | 9 | 12 | 21 |
| 2014 Diciembre | 13 | 14 | 27 |
| 2014 Noviembre | 10 | 19 | 29 |
| 2014 Octubre | 19 | 22 | 41 |
| 2014 Septiembre | 14 | 23 | 37 |
| 2014 Agosto | 11 | 18 | 29 |
| 2014 Julio | 8 | 15 | 23 |
| 2014 Junio | 15 | 14 | 29 |
| 2014 Mayo | 12 | 17 | 29 |
| 2014 Abril | 6 | 10 | 16 |
| 2014 Marzo | 13 | 13 | 26 |
| 2014 Febrero | 12 | 18 | 30 |
| 2014 Enero | 11 | 10 | 21 |
| 2013 Diciembre | 14 | 12 | 26 |
| 2013 Noviembre | 17 | 13 | 30 |
| 2013 Octubre | 13 | 11 | 24 |
| 2013 Septiembre | 19 | 13 | 32 |
| 2013 Agosto | 20 | 29 | 49 |
| 2013 Julio | 18 | 8 | 26 |
| 2013 Junio | 8 | 13 | 21 |
| 2013 Mayo | 10 | 11 | 21 |
| 2013 Abril | 8 | 8 | 16 |
| 2013 Marzo | 9 | 13 | 22 |
| 2013 Febrero | 10 | 6 | 16 |
| 2013 Enero | 13 | 7 | 20 |
| 2012 Diciembre | 8 | 11 | 19 |
| 2012 Noviembre | 0 | 13 | 13 |
| 2012 Octubre | 0 | 2 | 2 |
| 2012 Septiembre | 0 | 2 | 2 |
| 2012 Enero | 7 | 0 | 7 |
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