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        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Nuestro objetivo fue el estudiar la correlaci&#243;n entre las maniobras anest&#233;sicas y la aparici&#243;n de CSWS en pacientes neuroquir&#250;rgicos&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se estudiaron quinientas veintiuna craniotom&#237;as consecutivas&#44; excluyendo las relacionadas con el hipot&#225;lamo&#44; el tercer ventr&#237;culo o hip&#243;fisis y aquellos con patolog&#237;a renal&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Factores estudiados&#58; ingesta l&#237;quida&#44; diuresis&#44; hipertensi&#243;n intracraneal&#44; corticoides&#44; furosemida&#44; manitol&#44; hipn&#243;ticos&#44; opi&#225;ceos&#44; duraci&#243;n de la cirug&#237;a y tiempo hasta la extubaci&#243;n&#46;</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Se observaron treinta y dos casos &#40;6&#44;14&#37;&#41; de Cerebral salt wasting syndrome &#40;CSWS&#41;&#46; Su aparici&#243;n s&#243;lo se vio relacionada con la administraci&#243;n de opi&#225;ceos&#46; Treinta de estos casos hab&#237;an recibido fentanilo &#62; 0&#44;25<span class="elsevierStyleHsp" style=""></span>mg m&#225;s morfina &#62; 5<span class="elsevierStyleHsp" style=""></span>mg y los otros dos restantes fentanilo 0&#44;20<span class="elsevierStyleHsp" style=""></span>mg m&#225;s morfina 5<span class="elsevierStyleHsp" style=""></span>mg&#46; Ninguno de los 93 pacientes que recibieron fentanilo &#8804; 0&#44;15<span class="elsevierStyleHsp" style=""></span>mg y ninguna morfina desarrollaron CSWS&#46;</p> <span class="elsevierStyleSectionTitle">Conclusi&#243;n</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La administraci&#243;n de dosis medias o altas de opi&#225;ceos &#40;fentanilo &#62;<span class="elsevierStyleHsp" style=""></span>0&#44;25<span class="elsevierStyleHsp" style=""></span>mg y morfina &#62;<span class="elsevierStyleHsp" style=""></span>5<span class="elsevierStyleHsp" style=""></span>mg&#41; en el curso de cirug&#237;a cerebral parece de alg&#250;n modo predisponer a la aparici&#243;n de CSWS&#46;</p>"
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        "resumen" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">We aimed to study the relationship between the anaesthetic manoeuvres and the appearance of Cerebral salt wasting syndrome &#40;CSWS&#41; in neurosurgical patients&#46;</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Five-hundred and twenty-one consecutive craniotomies were studied&#44; excluding those related to the hypothalamus&#44; IIIrd ventricle and pituitary and those with kidney troubles&#46;</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Factors studied&#58; fluid intake&#44; diuresis&#44; intracranial hypertension&#44; corticoids&#44; furosemide&#44; mannitol&#44; hypnotic agents&#44; opioids&#44; anaesthetic gases&#44; duration of surgery&#44; and time to extubation&#46;</p><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Thirty-two cases &#40;6&#44;14&#37;&#41; of CSWS were seen&#46; Its appearance was related only to opioid administration&#46; Thirty of the cases had received fentanyl &#62; 0&#44;25<span class="elsevierStyleHsp" style=""></span>mg plus morphine &#62; 5<span class="elsevierStyleHsp" style=""></span>mg and the other two fentanyl 0&#44;20<span class="elsevierStyleHsp" style=""></span>mg plus morphine 5<span class="elsevierStyleHsp" style=""></span>mg&#46; None of the 93 patients managed with fentanyl &#8804; 0&#44;15<span class="elsevierStyleHsp" style=""></span>mg and no morphine at alla developed CSWS&#46;</p> <span class="elsevierStyleSectionTitle">Conclusi&#243;n</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">The administration of medium&#47;large doses of opioids &#40;fentanyl &#62;<span class="elsevierStyleHsp" style=""></span>0&#44;25<span class="elsevierStyleHsp" style=""></span>mg and morphine &#62;<span class="elsevierStyleHsp" style=""></span>5<span class="elsevierStyleHsp" style=""></span>mg&#41; during brain surgery seems to somehow predispose to CSWS&#46;</p>"
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Cerebral salt wasting syndrome and brain surgery: intraoperative predisposing factors
El síndrome de la pérdida cerebral de sal y la cirugía cerebral: Factores intraoperatorios predisponentes
N. Saiz-Sapena
Servicios de Anestesiología Clínica Universitaria, Universidad de Navarra. Pamplona
V. Vanaclocha*, P. Irimia**, F. Panta*
* Servicios de Neurocirugía Clínica Universitaria, Universidad de Navarra. Pamplona
** Servicios de Neurología Clínica Universitaria, Universidad de Navarra. Pamplona
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      "es" => array:1 [
        "titulo" => "El s&#237;ndrome de la p&#233;rdida cerebral de sal y la cirug&#237;a cerebral&#58; Factores intraoperatorios predisponentes"
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            0 => "S&#237;ndrome pierde-sal"
            1 => "Hiponatremia"
            2 => "Natriuresis"
            3 => "S&#237;ndrome de secreci&#243;n inadecuada de hormona antidiur&#233;tica"
            4 => "Tratamiento&#58; hiponatremia&#46; Balance hidroelectrol&#237;tico&#58; fisiolog&#237;a"
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            0 => "Cerebral salt wasting"
            1 => "Hyponatremia"
            2 => "Natriuresis"
            3 => "Syndrome of inappropriate antidiuretic hormone secretion"
            4 => "Hyponatremia therapy"
            5 => "Water Electrolyte Balance physiology"
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      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Nuestro objetivo fue el estudiar la correlaci&#243;n entre las maniobras anest&#233;sicas y la aparici&#243;n de CSWS en pacientes neuroquir&#250;rgicos&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se estudiaron quinientas veintiuna craniotom&#237;as consecutivas&#44; excluyendo las relacionadas con el hipot&#225;lamo&#44; el tercer ventr&#237;culo o hip&#243;fisis y aquellos con patolog&#237;a renal&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Factores estudiados&#58; ingesta l&#237;quida&#44; diuresis&#44; hipertensi&#243;n intracraneal&#44; corticoides&#44; furosemida&#44; manitol&#44; hipn&#243;ticos&#44; opi&#225;ceos&#44; duraci&#243;n de la cirug&#237;a y tiempo hasta la extubaci&#243;n&#46;</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Se observaron treinta y dos casos &#40;6&#44;14&#37;&#41; de Cerebral salt wasting syndrome &#40;CSWS&#41;&#46; Su aparici&#243;n s&#243;lo se vio relacionada con la administraci&#243;n de opi&#225;ceos&#46; Treinta de estos casos hab&#237;an recibido fentanilo &#62; 0&#44;25<span class="elsevierStyleHsp" style=""></span>mg m&#225;s morfina &#62; 5<span class="elsevierStyleHsp" style=""></span>mg y los otros dos restantes fentanilo 0&#44;20<span class="elsevierStyleHsp" style=""></span>mg m&#225;s morfina 5<span class="elsevierStyleHsp" style=""></span>mg&#46; Ninguno de los 93 pacientes que recibieron fentanilo &#8804; 0&#44;15<span class="elsevierStyleHsp" style=""></span>mg y ninguna morfina desarrollaron CSWS&#46;</p> <span class="elsevierStyleSectionTitle">Conclusi&#243;n</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La administraci&#243;n de dosis medias o altas de opi&#225;ceos &#40;fentanilo &#62;<span class="elsevierStyleHsp" style=""></span>0&#44;25<span class="elsevierStyleHsp" style=""></span>mg y morfina &#62;<span class="elsevierStyleHsp" style=""></span>5<span class="elsevierStyleHsp" style=""></span>mg&#41; en el curso de cirug&#237;a cerebral parece de alg&#250;n modo predisponer a la aparici&#243;n de CSWS&#46;</p>"
      ]
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        "titulo" => "Summary"
        "resumen" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">We aimed to study the relationship between the anaesthetic manoeuvres and the appearance of Cerebral salt wasting syndrome &#40;CSWS&#41; in neurosurgical patients&#46;</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Five-hundred and twenty-one consecutive craniotomies were studied&#44; excluding those related to the hypothalamus&#44; IIIrd ventricle and pituitary and those with kidney troubles&#46;</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Factors studied&#58; fluid intake&#44; diuresis&#44; intracranial hypertension&#44; corticoids&#44; furosemide&#44; mannitol&#44; hypnotic agents&#44; opioids&#44; anaesthetic gases&#44; duration of surgery&#44; and time to extubation&#46;</p><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Thirty-two cases &#40;6&#44;14&#37;&#41; of CSWS were seen&#46; Its appearance was related only to opioid administration&#46; Thirty of the cases had received fentanyl &#62; 0&#44;25<span class="elsevierStyleHsp" style=""></span>mg plus morphine &#62; 5<span class="elsevierStyleHsp" style=""></span>mg and the other two fentanyl 0&#44;20<span class="elsevierStyleHsp" style=""></span>mg plus morphine 5<span class="elsevierStyleHsp" style=""></span>mg&#46; None of the 93 patients managed with fentanyl &#8804; 0&#44;15<span class="elsevierStyleHsp" style=""></span>mg and no morphine at alla developed CSWS&#46;</p> <span class="elsevierStyleSectionTitle">Conclusi&#243;n</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">The administration of medium&#47;large doses of opioids &#40;fentanyl &#62;<span class="elsevierStyleHsp" style=""></span>0&#44;25<span class="elsevierStyleHsp" style=""></span>mg and morphine &#62;<span class="elsevierStyleHsp" style=""></span>5<span class="elsevierStyleHsp" style=""></span>mg&#41; during brain surgery seems to somehow predispose to CSWS&#46;</p>"
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      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara">Saiz-Sapena&#44; N&#46;&#59; Vanaclocha&#44; V&#46;&#59; Irimia&#44; P&#46;&#59; Panta&#44; F&#46;&#58; Cerebral salt wasting syndrome and brain surgery intraoperative predisposing factors&#46; Neurocirug&#237;a 1999&#59; 10&#58; 61&#8211;66&#46;</p>"
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