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                        "paginaFinal" => "402"
                        "link" => array:1 [
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                        "paginaFinal" => "1557"
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                    0 => array:2 [
                      "titulo" => "Hipertermia en Oncolog&#237;a"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46; Guix"
                            1 => "J&#46;R&#46; Guix"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Revista cient&#237;fica del Centro M&#233;dico Delfos"
                        "fecha" => "1997"
                        "volumen" => "1"
                        "paginaInicial" => "20"
                        "paginaFinal" => "23"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10&#46;"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "In vitro exposure to 0&#44;6 MHz currents affects differently cell growth and cell viability in human cancer lines and primary lymphocytes Twenty-Fourth Annual Meeting of Bioelectro magnetics Society"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "M&#46;L&#46; Hern&#225;ndez-Bule"
                            1 => "M&#46;A&#46; Trillo"
                            2 => "J&#46; Matilla"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "BEMS"
                        "fecha" => "2002"
                        "paginaInicial" => "222"
                        "paginaFinal" => "223"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Capacitative pulsed electric stimulation of bone cells induction of cyclic-AMP changes and DNA synthesis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "R&#46; Korestein"
                            1 => "D&#46; Somjen"
                            2 => "H&#46; Fischler"
                            3 => "I&#46; Bindennan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Biochemica et Biophysica Acta"
                        "fecha" => "1984"
                        "volumen" => "803"
                        "paginaInicial" => "302"
                        "paginaFinal" => "307"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Morphological and Electrophysiological Changes Produced by Electrical Stimulation in Cultured Neuroblastoma Cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "V&#46; Krauthamer"
                            1 => "M&#46; Bekken"
                            2 => "J&#46;L&#46; Horowitz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Bio electromagnetics"
                        "fecha" => "1991"
                        "volumen" => "12"
                        "paginaInicial" => "299"
                        "paginaFinal" => "314"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Actin polymerization induced by pulsed stimulation of bone cells in vitro"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "F&#46; Laub"
                            1 => "R&#46; Korestein"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Biochemica et Biophysica Acta"
                        "fecha" => "1984"
                        "volumen" => "803"
                        "paginaInicial" => "308"
                        "paginaFinal" => "313"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Transferencia el&#233;ctrica capacitiva &#40;TEC&#41; T&#233;cnica no invasiva de hipertermia profunda en el tratamiento de los gliomas cerebrales&#46; Resulta dos preliminares"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A&#46; Ley"
                            1 => "J&#46;M&#46; Cladellas"
                            2 => "S&#46; Colet"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Neurocirug&#237;a"
                        "fecha" => "1992"
                        "volumen" => "3"
                        "paginaInicial" => "118"
                        "paginaFinal" => "123"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hipertermia craneal no invasiva mediante la t&#233;cnica de Transferencia El&#233;ctrica Capacitiva-TEC Resultados de la termometr&#237;a cerebral e intratumoral"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "Ley-Valle"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurocirug&#237;a"
                        "fecha" => "2003"
                        "volumen" => "14"
                        "paginaInicial" => "41"
                        "paginaFinal" => "45"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12655383"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of Pulsed Electric Fields on DNA Synthesis in an Osteoblast-Like Cell Line UMR-106"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "Y&#46; Long"
                            1 => "H&#46; Liu"
                            2 => "Z&#46; Guan"
                            3 => "X&#46; He"
                            4 => "G&#46; Cai"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Tsinghua Science and Technology"
                        "fecha" => "2000"
                        "volumen" => "5"
                        "paginaInicial" => "439"
                        "paginaFinal" => "442"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Protein measurement with the Folin reagent"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "O&#46;H&#46; Lowry"
                            1 => "N&#46;J&#46; Rosebrough"
                            2 => "A&#46;L&#46; Farr"
                            3 => "R&#46;J&#46; Randall"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Biol Chem"
                        "fecha" => "1951"
                        "volumen" => "193"
                        "paginaInicial" => "265"
                        "paginaFinal" => "275"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14907713"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Electric Field-directed Cell Shapes Changes Displacement&#44; and Cytoskeletal Reorganization are Calcium Dependent"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "E&#46;K&#46; Onuma"
                            1 => "S-W&#46; Hui"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "J Cell Biol&#46;"
                        "fecha" => "1988"
                        "volumen" => "106"
                        "paginaInicial" => "2067"
                        "paginaFinal" => "2075"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3133378"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0001731008747094"
                          "estado" => "S300"
                          "issn" => "00017310"
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                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Electric Fields Stimulate DNA Synthesis of Mouse Osteoblast-Like Cells &#40;MC3T3-E1&#41; by a Mechanism Involving Calcium Ion"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "H&#46; Ozawa"
                            1 => "E&#46; Abe"
                            2 => "Y&#46; Shibasaki"
                            3 => "T&#46; Fukuhara"
                            4 => "T&#46; Suda"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/jcp.1041380306"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Cell Physiol"
                        "fecha" => "1989"
                        "volumen" => "138"
                        "paginaInicial" => "477"
                        "paginaFinal" => "483"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2538484"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "DNA Syn thesis in Cartilage Cells is Stimulated by Oscillating Electric Fields"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "G&#46;A&#46; Rodan"
                            1 => "L&#46;A&#46; Bourret"
                            2 => "L&#46;A&#46; Norton"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Science"
                        "fecha" => "1978"
                        "volumen" => "199"
                        "paginaInicial" => "690"
                        "paginaFinal" => "692"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/625660"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Improvement of tumor oxygenation status by mild temperature hyperthermia alone or in combination with carbogen"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "C&#46;W&#46;M&#46; Song"
                            1 => "A&#46; Shakil"
                            2 => "R&#46;J&#46; Griffin"
                            3 => "K&#46; Okajima"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "SeminOncol"
                        "fecha" => "1997"
                        "volumen" => "24"
                        "paginaInicial" => "626"
                        "paginaFinal" => "632"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Response of cytosolic Calcium&#44; cyclic AMP&#44; and cyclic GMP in dimethylsulfoxide-differentiated HL-60 cells to modulated low frecuency electric currents"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "W&#46; Sontag"
                            1 => "H&#46; Dertinger"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Bioelectromagnetics"
                        "fecha" => "1998"
                        "volumen" => "19"
                        "paginaInicial" => "452"
                        "paginaFinal" => "458"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9849914"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Molecular and Cellular mechanism of Hypertermia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "C&#46; Streffer"
                          ]
                        ]
                      ]
                    ]
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                    0 => array:1 [
                      "LibroEditado" => array:6 [
                        "editores" => "M&#46;H&#46;SeegenschmiedtP&#46;FessendenC&#46;C&#46;Vernon"
                        "paginaInicial" => "47"
                        "paginaFinal" => "74"
                        "serieVolumen" => "1"
                        "serieTitulo" => "Thermoradiotherapy and Thermochemotherapy"
                        "serieFecha" => "1995"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Experimental Low-Level Direct Current Therapy in Liver Metastases&#58; Influence of Polarity and Current Dose"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; Turley"
                            1 => "H&#46; Schaefer"
                            2 => "N&#46; Schaefer"
                            3 => "M&#46; Wagner"
                            4 => "D&#46; Maintz"
                            5 => "J&#46;C&#46; Qiao"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Bioelectromagnetics"
                        "fecha" => "2000"
                        "volumen" => "21"
                        "paginaInicial" => "395"
                        "paginaFinal" => "401"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10899775"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Heating the patient&#58; apromising approach&#63; Review Arricie"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "J&#46; Van der Zee"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Oncol"
                        "fecha" => "2002"
                        "volumen" => "13"
                        "paginaInicial" => "1173"
                        "paginaFinal" => "1184"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12181239"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
              "etiqueta" => "26&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Physiological electric fields control the Gl&#47;S phase cell eyele checkpoint to inhibit endothelial cell proliferation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "E&#46; Wang"
                            1 => "Y&#46; Yin"
                            2 => "M&#46; Zhao"
                            3 => "J&#46; Forrester"
                            4 => "C&#46; McCaig"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1096/fj.02-0510fje"
                      "Revista" => array:6 [
                        "tituloSerie" => "FASEB J"
                        "fecha" => "2003"
                        "volumen" => "17"
                        "paginaInicial" => "458"
                        "paginaFinal" => "460"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12551844"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib27"
              "etiqueta" => "27&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Advances in the treatment of Malignant Tumours by Electrochemistry Therapy &#40;ECT&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "Xin Yu-Ling"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Surg Suppl"
                        "fecha" => "1994"
                        "volumen" => "574"
                        "paginaInicial" => "31"
                        "paginaFinal" => "36"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7531017"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib28"
              "etiqueta" => "28&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Electrochemistry Treatment of KB cells in Vitro"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "Yu Ye"
                            1 => "Jian-Ren Li"
                            2 => "Zhou B-S"
                            3 => "F&#46; Rojas"
                            4 => "J&#46; Yu"
                            5 => "C&#46;K&#46; Chou"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Bio electromagnetics"
                        "fecha" => "1999"
                        "volumen" => "20"
                        "paginaInicial" => "3"
                        "paginaFinal" => "41"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
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Vol. 15. Núm. 4.
Páginas 366-371 (enero 2004)
Niveles atérmicos de corrientes eléctricas usadas en terapia por transferencia eléctrica capacitiva inducen efectos citotóxicos parciales en cultivos de neuroblastoma humano
Nonthermal levéis of electric currents applied in capaci-tive electric transfer therapy provokes partial cytotoxic effects in human neuroblastoma cultures
Visitas
1973
M.L. Hernández-Bule, M.A. Trillo, M.A. Martínez-Pascual, J. Leal, A. Úbeda
Servicios de Investigación-BioElectroMagnetismo. Hospital Ramón y Cajal. Madrid
E. Bazán*
* Servicios de Investigación-Neurobiología. Hospital Ramón y Cajal. 28034 Madrid.
Este artículo ha recibido
Información del artículo
Resumen

El presente estudio investiga la respuesta celular a corrientes eléctricas débiles, de señal sinusoidal y 0,5 MHz. La aplicación experimental de corrientes con idéntica señal, pero de intensidad suficientemente elevada como para incrementar significativamente la temperatura de los tejidos blanco, ha proporcionado respuestas satisfactorias en el tratamiento clínico de tumores cerebrales mediante terapia térmica por transferencia eléctrica capacitiva (TEC). Los resultados del presente trabajo muestran que la exposición in vitro a niveles atérmicos de señal TEC provoca efectos citotoxicos en células de neuroblastoma humano. Tal respuesta parece estar mediada por alteraciones en el ciclo celular. En su conjunto, los resultados sugieren que la potencial eficacia terapéutica de la técnica TEC podría obedecer a una acción sinérgica entre una respuesta tisular a los efectos térmicos del paso de la corriente más, una respuesta celular atérmica a la propia señal eléctrica.

Palabras clave:
Electroterapia
Transferencia eléctrica capacitiva
Neuroblastoma
Hipertermia
Ciclo celular
Abreviaturas:
AMPc
CET
DMEM
FBS
NB69
TEC
μA/mm2
MHz
mM
W
Summary

The present study investigates the cellular res-ponse to weak, sine wave, 0.5-MHz electric currents. The experimental exposure to identical signals at an intensity high enough as to significantly increase the temperature in target tissues, has provided positive res-ponses in clinical treatments of tumors with capacitive electric transfer (CET) thermal therapy. The present results show that the in vitro exposure to CET signals at athermal doses causes cytotoxic effects in human neuroblastoma cells. Such a response seems to be due to signal-induced alterations in the cell cycle. As a whole, the results suggest that the potential therapeutic effects of the CET strategy could be due to the thermal response of the tissues to the currents, added to an athermal response of the cells to the electric current itself.

Key words:
Electrotherapy
Capacitive electric transfer
Neuroblastoma
Hyperthermia
Cell cycle

Artículo

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