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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Analizar en un estudio fase II el control local&#44; tiempo a progresi&#243;n y supervivencia &#40;SPV&#41; de pacientes con glioma cerebral primario de alto grado tratados con radiocirug&#237;a estereot&#225;xica &#40;RC&#41;&#44; como tratamiento de intensificaci&#243;n local&#46;</p> <span class="elsevierStyleSectionTitle">Material y m&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Dieciocho pacientes&#44; 8 astrocitomas anapl&#225;sicos y 10 glioblastomas multiformes de di&#225;metro m&#225;ximo menor o igual a 5<span class="elsevierStyleHsp" style=""></span>cm&#44; han sido tratados con RC&#44; administr&#225;ndose una dosis margen que incluye el volumen tumoral de 10&#8211;20 Gy &#40;mediana&#58; 15 Gy&#41;&#44; alcanzando una dosis m&#225;xima intratumoral de 12&#46;5&#8211;40 Gy &#40;mediana 17 Gy&#41;&#46; Catorce pacientes &#40;78&#37;&#41; recibieron radioterapia externa fraccionada &#40;mediana de dosis&#58; 60 Gy&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La mediana de SPV ha sido 11&#46;5 meses y la SPV actuarial a 1 y 2 a&#241;os de 42&#46;5&#37; y 10&#46;6&#37; respectivamente&#46; Diez de 18 pacientes &#40;55&#37;&#41; presentaron progresi&#243;n tumoral con una mediana de tiempo a progresi&#243;n de 10 meses &#40;l&#237;mites&#58; 1&#8211;14 meses&#41;&#46; S&#243;lo 1 paciente &#40;5&#46;5&#37;&#41; desarroll&#243; toxicidad severa&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La RC es una atractiva modalidad de tratamiento de intensificaci&#243;n local en glioma maligno cerebral de tama&#241;o menor o igual a 5<span class="elsevierStyleHsp" style=""></span>cm&#44; tolerable y factible&#46;</p>"
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        "titulo" => "Summary"
        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To analyze in a phase II clinical trial the local control&#44; time to progression and survival of patients with primary malignant glioma treated with stereotactic radiosurgery &#40;SRS&#41; as a treatment boost&#46;</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Methods and material A total of 18 patients&#44; with anaplastic astrocytomas &#40;8 cases&#41; and glioblastoma multiformes &#40;10 cases&#41; &#40;maximum diameter&#61;<span class="elsevierStyleHsp" style=""></span>5<span class="elsevierStyleHsp" style=""></span>cm&#41; have been treated with SRS&#44; receiving a single marginal tumor dose of 10&#8211;20 Gy &#40;median&#58; 15 Gy&#41;&#44; at 90&#37; isodose line&#44; and achieving a maximun tumor dose of 12&#46;5&#8211;40 Gy &#40;median&#58; 17 Gy&#41;&#46; Fourteen patients &#40;78&#37;&#41; were treated with external beam radiotherapy &#40;median dose&#58; 60 Gy&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The median survival time was 11&#46;5 months&#44; and the 1 -and 2-year actuarial survival were 42&#46;5&#37; and 10&#46;6&#37; respectively&#46; Ten out of 18 patients &#40;55&#37;&#41; had tumor progression and the median time to tumor progression was 10 months &#40;range&#58; 1&#8211;14 months&#41;&#46; One patient &#40;5&#46;5&#37;&#41; developed severe toxicity&#46;</p> <span class="elsevierStyleSectionTitle">Conclusion</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">SRS is an attractive&#44; feasible and tolerable treatment modality for local intensification in malignant glioma&#44; lesser o equal than 5<span class="elsevierStyleHsp" style=""></span>cm in size&#46;</p>"
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        "nota" => "<p class="elsevierStyleNotepara">Ortiz de Urbina&#44; D&#46;&#59; Santos&#44; M&#46;&#59; Samblas&#44; J&#46;&#59; Delgado&#44; J&#46;M&#46;&#59; Bustos&#44; J&#46;C&#46;&#59; Guti&#233;rrez-D&#237;az&#44; J&#46;A&#46;&#44; Garc&#237;a-Berrocal&#44; I&#46;&#59; Rodr&#237;guez&#44; S&#46;&#59; Rubio&#44; M&#46;C&#46;&#59; Donckaster&#44; G&#46;&#59; Sansivirini&#44; F&#46;&#59; Calvo&#44; F&#46;A&#46;&#58; Tratamiento con radiocirug&#237;a estereot&#225;xica del glioma cerebral primario de alto grado&#46; Neurocirug&#237;a 1999&#59; 10&#58; 350&#8211;357&#46;</p>"
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Vol. 10. Núm. 5.
Páginas 350-357 (enero 1998)
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Vol. 10. Núm. 5.
Páginas 350-357 (enero 1998)
Tratamiento con radiocirugía estereotáxica del glioma cerebral primario de alto grado
Stereotactic radiosurgery in primary high grade malignat glioma
Visitas
2790
D. Ortiz de Urbina, M. Santos, J. Samblás, J.M. Delgado, J.C. Bustos, J.A. Gutiérrez-Díaz, I. García-Berrocal, S. Rodríguez, M.C. Rubio, G. Donckaster, F. Sansivirini, F.A. Calvo
Sanatorio San Francisco de Asís. Madrid
Este artículo ha recibido
Información del artículo
Resumen
Objetivo

Analizar en un estudio fase II el control local, tiempo a progresión y supervivencia (SPV) de pacientes con glioma cerebral primario de alto grado tratados con radiocirugía estereotáxica (RC), como tratamiento de intensificación local.

Material y métodos

Dieciocho pacientes, 8 astrocitomas anaplásicos y 10 glioblastomas multiformes de diámetro máximo menor o igual a 5cm, han sido tratados con RC, administrándose una dosis margen que incluye el volumen tumoral de 10–20 Gy (mediana: 15 Gy), alcanzando una dosis máxima intratumoral de 12.5–40 Gy (mediana 17 Gy). Catorce pacientes (78%) recibieron radioterapia externa fraccionada (mediana de dosis: 60 Gy).

Resultados

La mediana de SPV ha sido 11.5 meses y la SPV actuarial a 1 y 2 años de 42.5% y 10.6% respectivamente. Diez de 18 pacientes (55%) presentaron progresión tumoral con una mediana de tiempo a progresión de 10 meses (límites: 1–14 meses). Sólo 1 paciente (5.5%) desarrolló toxicidad severa.

Conclusiones

La RC es una atractiva modalidad de tratamiento de intensificación local en glioma maligno cerebral de tamaño menor o igual a 5cm, tolerable y factible.

Palabras clave:
Radiocirugía estereotáxica
Glioma cerebral de alto grado
Summary
Objective

To analyze in a phase II clinical trial the local control, time to progression and survival of patients with primary malignant glioma treated with stereotactic radiosurgery (SRS) as a treatment boost.

Methods and material A total of 18 patients, with anaplastic astrocytomas (8 cases) and glioblastoma multiformes (10 cases) (maximum diameter=5cm) have been treated with SRS, receiving a single marginal tumor dose of 10–20 Gy (median: 15 Gy), at 90% isodose line, and achieving a maximun tumor dose of 12.5–40 Gy (median: 17 Gy). Fourteen patients (78%) were treated with external beam radiotherapy (median dose: 60 Gy).

Results

The median survival time was 11.5 months, and the 1 -and 2-year actuarial survival were 42.5% and 10.6% respectively. Ten out of 18 patients (55%) had tumor progression and the median time to tumor progression was 10 months (range: 1–14 months). One patient (5.5%) developed severe toxicity.

Conclusion

SRS is an attractive, feasible and tolerable treatment modality for local intensification in malignant glioma, lesser o equal than 5cm in size.

Key words:
Stereotactic Radiosurgety
High grade glioma

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