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        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Presentamos un caso de tumor neuroectod&#233;rmico primitivo originado en el nervio ci&#225;tico&#44; en un paciente con un cuadro cl&#237;nico de ciatalgia intensa desencadenada siempre al sentarse y un abultamiento notable en la regi&#243;n gl&#250;tea derecha&#46; En la intervenci&#243;n quir&#250;rgica&#44; se identific&#243; en el tronco del nervio ci&#225;tico&#44; en el trayecto situado ligeramente por encima del pliegue gl&#250;teo&#44; una tumoraci&#243;n fusiforme de 8<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>12<span class="elsevierStyleHsp" style=""></span>cm&#44; que englobaba el nervio&#46; Histol&#243;gicamente&#44; el tumor estaba constituido por c&#233;lulas neopl&#225;sicas de n&#250;cleos redondeados&#44; relativamente uniformes y escaso citoplasma&#46; Junto a numerosas im&#225;genes de mitosis&#44; estaban significativamente representadas estructuras rosetoides&#44; en las que las c&#233;lulas neopl&#225;sicas se dispon&#237;an en corona con centros fibrilares &#40;Rosetas de Homer-Wright&#41;&#46; Con M&#46; E&#46; se observaron c&#233;lulas pobremente diferenciadas&#44; de peque&#241;o tama&#241;o&#44; con escasas prolongaciones citoplasm&#225;ticas&#44; raros microt&#250;bulos y aislados gr&#225;nulos electrodensos&#46; Con t&#233;cnicas de inmunohistoqu&#237;mia&#44; se detect&#243; inmunoreactividad d&#233;bil para NSE y moderada y zonal para sinaptofisina&#46; En conclusi&#243;n&#44; pensamos que se trata de una neoplasia maligna de nervio perif&#233;rico&#44; rara&#44; originada a partir de c&#233;lulas neuroepiteliales primitivas&#44; con caracter&#237;sticas microsc&#243;picas&#44; ultraestructurales e inmunohistoqu&#237;micas similares a las de los Tumores Neuroectod&#233;rmicos Primitivos del Sistema Nervioso Central&#46;</p>"
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        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A case of primitive neuroectodermal tumor arising in the sciatic nerve of a 30-year-old man is presented&#46; The patient was admitted to hospital with a sudden right-side sciatica and a tumoral mass in the right buttock&#46; At surgery a fusiform tumor of 8<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>12<span class="elsevierStyleHsp" style=""></span>cm was found in the proximal portion of the sciatic nerve&#46; An en block scission of tumoral mass with the segment of sciatic nerve affected was done&#46; The histological examination revealed a tumor composed of small cells with scanty cytoplasm and darkly-stained nuclei with fairly frequent mitoses&#46; In many areas the tumor cells were arranged in a well-marked rosette pattern with pale eosinophilic cores &#40;Homer-Wright rosettes&#41;&#46; Electron microscopy showed poorly differentiated cells with few cytoplasmic processes&#44; rare microtubules and isolated dense-core granules&#46; On immunohistochemical study&#44; a weak reaction with anti-NSE and a zonal positivity for synaptophisin were found&#46; We conclude that this tumor is a malignant peripheral neuroectodermal tumor derived from primitive neuroepithelio&#44; with microscopical&#44; ultrastructural imd immunohistochemical characteristics similar to Primitive Neuroectodermal Tumors of the Central Nervous System&#46;</p>"
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Vol. 4. Núm. 4.
Páginas 316-320 (enero 1992)
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Vol. 4. Núm. 4.
Páginas 316-320 (enero 1992)
Tumor neuroectodérmico primitivo del nervio ciático
Visitas
3080
M. Moreno, J. Rodríguez, S. Coca, J. Martos, A. Barcena
Servicios de Anatomía Patológica y Neurocirugía del Hospital Universitario del Aire. Madrid
Este artículo ha recibido
Información del artículo
Resumen

Presentamos un caso de tumor neuroectodérmico primitivo originado en el nervio ciático, en un paciente con un cuadro clínico de ciatalgia intensa desencadenada siempre al sentarse y un abultamiento notable en la región glútea derecha. En la intervención quirúrgica, se identificó en el tronco del nervio ciático, en el trayecto situado ligeramente por encima del pliegue glúteo, una tumoración fusiforme de 8×12cm, que englobaba el nervio. Histológicamente, el tumor estaba constituido por células neoplásicas de núcleos redondeados, relativamente uniformes y escaso citoplasma. Junto a numerosas imágenes de mitosis, estaban significativamente representadas estructuras rosetoides, en las que las células neoplásicas se disponían en corona con centros fibrilares (Rosetas de Homer-Wright). Con M. E. se observaron células pobremente diferenciadas, de pequeño tamaño, con escasas prolongaciones citoplasmáticas, raros microtúbulos y aislados gránulos electrodensos. Con técnicas de inmunohistoquímia, se detectó inmunoreactividad débil para NSE y moderada y zonal para sinaptofisina. En conclusión, pensamos que se trata de una neoplasia maligna de nervio periférico, rara, originada a partir de células neuroepiteliales primitivas, con características microscópicas, ultraestructurales e inmunohistoquímicas similares a las de los Tumores Neuroectodérmicos Primitivos del Sistema Nervioso Central.

Palabras clave:
Neuroepitelioma periférico
Tumor neuroectodérmico primitivo
Nervio ciático
Summary

A case of primitive neuroectodermal tumor arising in the sciatic nerve of a 30-year-old man is presented. The patient was admitted to hospital with a sudden right-side sciatica and a tumoral mass in the right buttock. At surgery a fusiform tumor of 8×12cm was found in the proximal portion of the sciatic nerve. An en block scission of tumoral mass with the segment of sciatic nerve affected was done. The histological examination revealed a tumor composed of small cells with scanty cytoplasm and darkly-stained nuclei with fairly frequent mitoses. In many areas the tumor cells were arranged in a well-marked rosette pattern with pale eosinophilic cores (Homer-Wright rosettes). Electron microscopy showed poorly differentiated cells with few cytoplasmic processes, rare microtubules and isolated dense-core granules. On immunohistochemical study, a weak reaction with anti-NSE and a zonal positivity for synaptophisin were found. We conclude that this tumor is a malignant peripheral neuroectodermal tumor derived from primitive neuroepithelio, with microscopical, ultrastructural imd immunohistochemical characteristics similar to Primitive Neuroectodermal Tumors of the Central Nervous System.

Key words:
Peripheral neuroepithelioma
Primitive neuroectodermal Tumor
Sciatic nerve

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