Journal Information
Vol. 33. Issue 4.
Pages 182-189 (July - August 2022)
Share
Share
Download PDF
More article options
Visits
11
Vol. 33. Issue 4.
Pages 182-189 (July - August 2022)
Review article
Neuromodulation of the anterior thalamic nucleus as a therapeutic option for difficult-to-control epilepsy
Neuromodulación del núcleo talámico anterior como opción terapéutica para epilepsia de difícil control
Visits
11
Juan Carlos Moreira-Holguína,b,
Corresponding author
, David Andrés Barahona-Moránb, José Hidalgo-Esmeraldasb, Cristian Guzmán-Rochinab
a Servicio de Neurocirugía, Hospital de Especialidades Guayaquil “Dr. Abel Gilbert Pontón”, Guayaquil, Ecuador
b Escuela de Medicina, Universidad de Guayaquil, Guayaquil, Ecuador
This item has received
Article information
Abstract
Full Text
Bibliography
Download PDF
Statistics
Figures (4)
Show moreShow less
Abstract

Deep brain stimulation (DBS) consists of the electrical stimulation of the subcortical structures by implanting electrodes connected to a pulse generator. The thalamus, being a structure that has multiple connections with various parts of the central nervous system, is a suitable target for DBS. The anterior thalamic nucleus (ANT) serves as an important relay site for the limbic system by receiving input from the hippocampus and mammillary bodies, and sending input to the cingulate gyrus; thus forming the Papez circuit. Due to these connections, the ANT constitutes an ideal route for the propagation of epileptogenic activity. ANT-DBS has excellent results in the control of complex partial seizures. The vast majority of patients with ANT-DBS have shown a significant reduction in the frequency of their seizures of more than 50%.

Keywords:
Anterior thalamic nucleus
Refractory epilepsy
Deep brain stimulation
Seizures
Resumen

La estimulación cerebral profunda (ECP) consiste en la estimulación eléctrica de las estructuras subcorticales mediante el implante de electrodos conectados a un generador de impulsos. El tálamo, al ser una estructura que posee múltiples conexiones con diversas partes del sistema nervioso central, es un target adecuado para la ECP. El núcleo talámico anterior (NA) sirve como un sitio de relevo importante para el sistema límbico al recibir aferencias desde el hipocampo y los cuerpos mamilares, y enviar eferencias hacia el giro del cíngulo; formando así el circuito de Papez. Debido a estas conexiones, el NA constituye una vía idónea para la propagación de la actividad epileptogénica. La ECP-NA tiene excelentes resultados en el control de las crisis parciales complejas. La gran mayoría de pacientes con ECP-NA han demostrado una reducción significativa en la frecuencia de sus crisis de más del 50%.

Palabras clave:
Núcleo talámico anterior
Epilepsia refractaria
Estimulación cerebral profunda
Convulsiones

Article

These are the options to access the full texts of the publication Neurocirugía (English edition)
Member
Member of the Sociedad Española de Neurocirugía

If it is the first time you have accessed you can obtain your credentials by contacting Elsevier Spain in suscripciones@elsevier.com or by calling our Customer Service at902 88 87 40 if you are calling from Spain or at +34 932 418 800 (from 9 to 18h., GMT + 1) if you are calling outside of Spain.

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option ¿I have forgotten my password¿.

Subscriber
Subscriber

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe
Subscribe to

Neurocirugía (English edition)

Purchase
Purchase article

Purchasing article the PDF version will be downloaded

Price 19.34 €

Purchase now
Contact
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
Email
Idiomas
Neurocirugía (English edition)
Article options
Tools
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?