Journal Information
Vol. 1. Issue 4.
Pages 197 (January 1990)
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Vol. 1. Issue 4.
Pages 197 (January 1990)
Nuevas perspectivas en el tratamiento biológico de los gliomas
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J. Vaquero, R. Martínez
Servicio de Neurocirugía. Clínica Puerta de Hierro. Madrid
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Resumen

En los últimos años, el descubrimiento de nuevos sistemas linfocitotóxicos, con capacidad de lisar in vivo células tumorales, abre nuevas perspectivas en el tratamiento de diversas neoplasias.

Las peculiares características inmunológicas del Sistema Nervioso y de los tumores que en él se desarrollan, hace que los gliomas malignos sean un atractivo campo para ensayar la posible aplicación clínica de las técnicas de inmunoterapia.

Aunque en el momento actual, la experiencia en este terreno es muy limitada y los resultados poco significativos, es indudable que el tratamiento biológico de los gliomas ofrece interesantes perspectivas de investigación y su eficacia real, en combinación con otras modalidades terapéuticas bien establecidas, merece ser estudiada.

Palabras clave:
Tumores cerebrales
Inmunoterapia
Linfocitos
Interferon
Células LAK
Células NK
Glioblastoma
Gliomas malignos
Summary

Recently, new lymphocytotoxic systems for lysing tumoral cells have led to consider modalities in the treatment of different neoplasms.

The peculiar immunological features of the Nervous System and its tumors, made the malignant gliomas a very atractive field for assaying immunotherapeutical procedures.

Although the very limited experience with these trials, and their poor significant results obtained at present, the biological treatment of brain tumors has to be considered.

Key words:
Brain tumors
Immunotherapy
Lymphocytes
Interferon
LAK-cells
NK-cells
Glioblastoma
Malignant gliomas

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