array:22 [
  "pii" => "S113014739071192X"
  "issn" => "11301473"
  "doi" => "10.1016/S1130-1473(90)71192-X"
  "estado" => "S300"
  "fechaPublicacion" => "1990-01-01"
  "aid" => "71192"
  "copyright" => "Sociedad Española de Neurocirugía"
  "copyrightAnyo" => "1990"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "fla"
  "cita" => "Neurocirugia. 1990;1:197"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 1763
    "formatos" => array:3 [
      "EPUB" => 10
      "HTML" => 897
      "PDF" => 856
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S1130147390711931"
    "issn" => "11301473"
    "doi" => "10.1016/S1130-1473(90)71193-1"
    "estado" => "S300"
    "fechaPublicacion" => "1990-01-01"
    "aid" => "71193"
    "copyright" => "Sociedad Española de Neurocirugía"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Neurocirugia. 1990;1:203-7"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 1809
      "formatos" => array:3 [
        "EPUB" => 11
        "HTML" => 784
        "PDF" => 1014
      ]
    ]
    "es" => array:9 [
      "idiomaDefecto" => true
      "titulo" => "Estimulación eléctrica intraoperatoria en Neurocirugía funcional"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "203"
          "paginaFinal" => "207"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "R.D. Lobato, J.J. Rivas, H. Sánchez Albisua, R. Sarabia"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "R.D."
              "apellidos" => "Lobato"
            ]
            1 => array:2 [
              "nombre" => "J.J."
              "apellidos" => "Rivas"
            ]
            2 => array:2 [
              "nombre" => "H."
              "apellidos" => "Sánchez Albisua"
            ]
            3 => array:2 [
              "nombre" => "R."
              "apellidos" => "Sarabia"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147390711931?idApp=UINPBA00004B"
    "url" => "/11301473/0000000100000004/v1_201305150958/S1130147390711931/v1_201305150958/es/main.assets"
  ]
  "es" => array:12 [
    "idiomaDefecto" => true
    "titulo" => "Nuevas perspectivas en el tratamiento biológico de los gliomas"
    "tieneTextoCompleto" => 0
    "paginas" => array:2 [
      0 => array:1 [
        "paginaInicial" => "197"
      ]
      1 => array:2 [
        "paginaInicial" => "200"
        "paginaFinal" => "201"
      ]
    ]
    "autores" => array:1 [
      0 => array:3 [
        "autoresLista" => "J. Vaquero, R. Martínez"
        "autores" => array:2 [
          0 => array:2 [
            "nombre" => "J."
            "apellidos" => "Vaquero"
          ]
          1 => array:2 [
            "nombre" => "R."
            "apellidos" => "Martínez"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:1 [
            "entidad" => "Servicio de Neurocirugía. Clínica Puerta de Hierro. Madrid"
          ]
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "PalabrasClave" => array:2 [
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec156546"
          "palabras" => array:8 [
            0 => "Tumores cerebrales"
            1 => "Inmunoterapia"
            2 => "Linfocitos"
            3 => "Interferon"
            4 => "Células LAK"
            5 => "Células NK"
            6 => "Glioblastoma"
            7 => "Gliomas malignos"
          ]
        ]
      ]
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Key words"
          "identificador" => "xpalclavsec156545"
          "palabras" => array:8 [
            0 => "Brain tumors"
            1 => "Immunotherapy"
            2 => "Lymphocytes"
            3 => "Interferon"
            4 => "LAK-cells"
            5 => "NK-cells"
            6 => "Glioblastoma"
            7 => "Malignant gliomas"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">En los &#250;ltimos a&#241;os&#44; el descubrimiento de nuevos sistemas linfocitot&#243;xicos&#44; con capacidad de lisar <span class="elsevierStyleItalic">in vivo</span> c&#233;lulas tumorales&#44; abre nuevas perspectivas en el tratamiento de diversas neoplasias&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Las peculiares caracter&#237;sticas inmunol&#243;gicas del Sistema Nervioso y de los tumores que en &#233;l se desarrollan&#44; hace que los gliomas malignos sean un atractivo campo para ensayar la posible aplicaci&#243;n cl&#237;nica de las t&#233;cnicas de inmunoterapia&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Aunque en el momento actual&#44; la experiencia en este terreno es muy limitada y los resultados poco significativos&#44; es indudable que el tratamiento biol&#243;gico de los gliomas ofrece interesantes perspectivas de investigaci&#243;n y su eficacia real&#44; en combinaci&#243;n con otras modalidades terap&#233;uticas bien establecidas&#44; merece ser estudiada&#46;</p>"
      ]
      "en" => array:2 [
        "titulo" => "Summary"
        "resumen" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Recently&#44; new lymphocytotoxic systems for lysing tumoral cells have led to consider modalities in the treatment of different neoplasms&#46;</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The peculiar immunological features of the Nervous System and its tumors&#44; made the malignant gliomas a very atractive field for assaying immunotherapeutical procedures&#46;</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Although the very limited experience with these trials&#44; and their poor significant results obtained at present&#44; the biological treatment of brain tumors has to be considered&#46;</p>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara">Vaquero&#44; J&#46;&#59; Mart&#237;nez&#44; R&#46;&#58; Nuevas perspectivas en el tratamiento biol&#243;gico de los gliomas&#46; Neurocirug&#237;a 1990&#59; 1&#58; 197&#8211;201&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Bibliograf&#237;a"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:40 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Immunological aspects of intrinsic glial tumors"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46;L&#46;J&#46; Apuzzo"
                            1 => "M&#46;S&#46; Mitchell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J&#46; Neurosurg&#46;"
                        "fecha" => "1981"
                        "volumen" => "51"
                        "paginaInicial" => "1"
                        "paginaFinal" => "18"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intratumoral LAK cell and interleukin-2 Therapy of human gliomas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "D&#46; Barba"
                            1 => "S&#46;C&#46; Saris"
                            2 => "C&#46; Holder"
                            3 => "S&#46;A&#46; Rosenberg"
                            4 => "E&#46;H&#46; Oldfield"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3171/jns.1989.70.2.0175"
                      "Revista" => array:6 [
                        "tituloSerie" => "J&#46; Neurosurg&#46;"
                        "fecha" => "1989"
                        "volumen" => "70"
                        "paginaInicial" => "175"
                        "paginaFinal" => "182"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2643685"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Autotransplantation of anaplastic astrocytoma into subcutaneous tissue of man"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46;F&#46; Batiista"
                            1 => "W&#46; Bloom"
                            2 => "M&#46; Loffman"
                            3 => "I&#46; Feigin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurology"
                        "fecha" => "1961"
                        "volumen" => "11"
                        "paginaInicial" => "977"
                        "paginaFinal" => "981"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/13865799"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Glioblastoma multiforme&#58; A controlled trial to assess the value of specific active immununotherapy in patients treated by radical surgery and radiotherapy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "H&#46;J&#46;G&#46; Bloom"
                            1 => "M&#46;J&#46; Peckham"
                            2 => "A&#46;E&#46; Richardson"
                            3 => "P&#46;A&#46; Alexander"
                            4 => "P&#46;M&#46; Payne"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Dr&#46; J&#46; C&#225;ncer"
                        "fecha" => "1973"
                        "volumen" => "27"
                        "paginaInicial" => "253"
                        "paginaFinal" => "267"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Autologous glioma transplantation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "W&#46;H&#46; Bloom"
                            1 => "K&#46;C&#46; Carstairs"
                            2 => "M&#46;R&#46; Crompton"
                            3 => "W&#46; Mc Kissock"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1960"
                        "volumen" => "2"
                        "paginaInicial" => "77"
                        "paginaFinal" => "78"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2885576"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Immune responses in patients with gliomas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "W&#46;H&#46; Brooks"
                            1 => "H&#46;D&#46; Cardwell"
                            2 => "R&#46;H&#46; Mortara"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Surg&#46; Neurol&#46;"
                        "fecha" => "1974"
                        "volumen" => "2"
                        "paginaInicial" => "419"
                        "paginaFinal" => "423"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4372736"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ultrastructure of human Natural Killer cells&#58; Nature of the cytolytic contacts in relation to cellular secretion"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "O&#46; Carpen"
                            1 => "I&#46; Virtanen"
                            2 => "E&#46; Saksela"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J&#46; Immunol&#46;"
                        "fecha" => "1982"
                        "volumen" => "128"
                        "paginaInicial" => "1&#46;697"
                        "paginaFinal" => "2&#46;691"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7077080"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Augmentation of mouse natural killer activity by interferon and interferon inducers"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46;Y&#46; Djeu"
                            1 => "J&#46;A&#46; Heinbaugh"
                            2 => "H&#46;T&#46; Holden"
                            3 => "R&#46;B&#46; Herberman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J&#46; Immunol&#46;"
                        "fecha" => "1979"
                        "volumen" => "122"
                        "paginaInicial" => "175"
                        "paginaFinal" => "181"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/310826"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Auto-radiographic and fluorescence antibody studies of the human host immune response to gliomas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "A&#46;E&#46; Egger"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurology"
                        "fecha" => "1972"
                        "volumen" => "22"
                        "paginaInicial" => "246"
                        "paginaFinal" => "250"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4334554"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Interferon and spontaneous cytotoxicity in man&#58; I&#46; Enhancement of the spontaneous cytotoxicity in man&#58; I&#46; Enhancement of the spontaneous cytotoxicity of peripheral lymphocites by human leukocyte interferon"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46; Einhorn"
                            1 => "H&#46; Blomgren"
                            2 => "H&#46; Strander"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Int&#46; J&#46; C&#225;ncer"
                        "fecha" => "1978"
                        "volumen" => "22"
                        "paginaInicial" => "405"
                        "paginaFinal" => "412"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/700895"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tumor autograft responses in patients with glioblastoma multiforme"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46;T&#46; Grace"
                            1 => "D&#46;M&#46; Perese"
                            2 => "R&#46;S&#46; Metzgar"
                            3 => "T&#46; Sasabe"
                            4 => "B&#46;S&#46; Holdrioge"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J&#46; Neurosurg&#46;"
                        "fecha" => "1961"
                        "volumen" => "18"
                        "paginaInicial" => "159"
                        "paginaFinal" => "167"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The lymphokine activated killer cell phenomenon Lysis of NK-resistant fresh solid tumor cells by IL-2 activated autologous human peripheral blood lymphocytes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "E&#46;A&#46; Grimm"
                            1 => "A&#46; Mazumder"
                            2 => "H&#46;Z&#46; Zhang"
                            3 => "S&#46;A&#46; Rosenberg"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J&#46; Exp&#46; Med&#46;"
                        "fecha" => "1982"
                        "volumen" => "155"
                        "paginaInicial" => "1&#46;823"
                        "paginaFinal" => "1&#46;841"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7077224"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lymphokine-activated killer phenomenon&#58; II&#46; The precursor phenotype is serologically distinct from peripheral T lymphocytes&#44; memory CTL&#44; and NK cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "E&#46;A&#46; Grimm"
                            1 => "K&#46; Ramsey"
                            2 => "A&#46; Mazunder"
                            3 => "D&#46;J&#46; Wilson"
                            4 => "J&#46;Y&#46; Djeu"
                            5 => "S&#46;A&#46; Rosenberg"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J&#46; Exp&#46; Med&#46;"
                        "fecha" => "1983"
                        "volumen" => "157"
                        "paginaInicial" => "884"
                        "paginaFinal" => "897"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6601174"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Immunotherapy of human glioma with Iymphokine-activated killer cells and interleukin-2"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "E&#46;A&#46; Grimm"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Advances in Neuro-Oncology"
                        "paginaInicial" => "515"
                        "paginaFinal" => "529"
                        "serieFecha" => "1988"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Augmentation by interferon of human natural and antibody-dependent cell-mediated cytotoxicity"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "R&#46;B&#46; Herberman"
                            1 => "J&#46;R&#46; Ortaldo"
                            2 => "G&#46;D&#46; Bonnard"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Nature"
                        "fecha" => "1979"
                        "volumen" => "277"
                        "paginaInicial" => "221"
                        "paginaFinal" => "223"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/95205"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "In vitro killing of human glioblastoma by interleukin-2-activated autologous lymphocytes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46;K&#46; Jacobs"
                            1 => "D&#46;J&#46; Wilson"
                            2 => "P&#46;L&#46; Kornblith"
                            3 => "E&#46;A&#46; Grimm"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3171/jns.1986.64.1.0114"
                      "Revista" => array:6 [
                        "tituloSerie" => "J&#46; Neurosurg&#46;"
                        "fecha" => "1986"
                        "volumen" => "64"
                        "paginaInicial" => "114"
                        "paginaFinal" => "117"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3001247"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Interleukin-2 and autologous lymphokine-activated killer cells in the treatment of malignant glioma&#46; Preliminary report"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46;K&#46; Jacobs"
                            1 => "D&#46;J&#46; Wilson"
                            2 => "P&#46;L&#46; Kornblith"
                            3 => "E&#46;A&#46; Grimm"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3171/jns.1986.64.5.0743"
                      "Revista" => array:6 [
                        "tituloSerie" => "J&#46; Neurosurg&#46;"
                        "fecha" => "1986"
                        "volumen" => "64"
                        "paginaInicial" => "743"
                        "paginaFinal" => "749"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3517250"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cell-mediated immunity and blocking factors in patients with tumours of the central nervous system"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "S&#46; Kumar"
                            1 => "G&#46; Taylor"
                            2 => "J&#46;K&#46; Steward"
                            3 => "M&#46;A&#46; Waghe"
                            4 => "P&#46; Mooris-Jones"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Int&#46; J&#46; C&#225;ncer"
                        "fecha" => "1973"
                        "volumen" => "12"
                        "paginaInicial" => "194"
                        "paginaFinal" => "205"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4364270"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Vascular invasion by glioma cells in man an electron microscopic study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "P&#46;C&#46; Kung"
                            1 => "J&#46;C&#46; Lee"
                            2 => "L&#46; Bakay"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3171/jns.1969.31.3.0339"
                      "Revista" => array:6 [
                        "tituloSerie" => "J&#46; Neurosurg&#46;"
                        "fecha" => "1969"
                        "volumen" => "31"
                        "paginaInicial" => "339"
                        "paginaFinal" => "345"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4309460"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Stereotactic injection of interferon-activated autologous lymphocytes in glioblastoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "R&#46; Mart&#237;nez"
                            1 => "J&#46; Vaquero"
                            2 => "S&#46; Oya"
                            3 => "G&#46; Bravo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Acta Neurochir&#46; &#40;Wien&#41;"
                        "fecha" => "1989"
                        "volumen" => "98"
                        "paginaInicial" => "94"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Adopptive immunotherapy for recurrent glioblastoma multiforme using lymphokine activated killer cells and recombinant interleukin-2"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "R&#46;E&#46; Merchant"
                            1 => "A&#46;J&#46; Grant"
                            2 => "L&#46;H&#46; Merchant"
                            3 => "H&#46;F&#46; Young"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "C&#225;ncer"
                        "fecha" => "1988"
                        "volumen" => "62"
                        "paginaInicial" => "665"
                        "paginaFinal" => "671"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2840186"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intralesional infusion of lymphokine-activated killer &#40;LAK&#41; cells and recombinant interleukin-2 &#40;rIL-2&#41; for the treatment of patients with malignant brain tumor"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "R&#46;E&#46; Merchant"
                            1 => "L&#46;H&#46; Merchant"
                            2 => "S&#46;H&#46;S&#46; Cook"
                            3 => "D&#46;W&#46; Mc Vicar"
                            4 => "H&#46;F&#46; Young"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurosurgery"
                        "fecha" => "1988"
                        "volumen" => "23"
                        "paginaInicial" => "725"
                        "paginaFinal" => "732"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2851116"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "An adoptive immunotherapy of patients with meduloblastoma by lymphokine-activated killer cells &#40;LAK&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "Y&#46; Okamoto"
                            1 => "K&#46; Shimizu"
                            2 => "Y&#46; Miyao"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Acta Neurochir&#46; &#40;Wien&#41;"
                        "fecha" => "1988"
                        "volumen" => "94"
                        "paginaInicial" => "47"
                        "paginaFinal" => "52"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Modificaciones ultraestructurales en glioblastoma tras inyecci&#243;n intratumoral de linfocitos aut&#243;logos"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "S&#46; Oya"
                            1 => "J&#46; Vaquero"
                            2 => "J&#46; Ramiro"
                            3 => "J&#46; Carrera"
                            4 => "F&#46;G&#46; Salazar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Arch&#46; Neurobiol&#46;"
                        "fecha" => "1988"
                        "volumen" => "1"
                        "paginaInicial" => "33"
                        "paginaFinal" => "34"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Observations on the systemic administration of autologous lymphokine-activated killer celis and recombinant interleukin-2 to patients with metastatic cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "S&#46;A&#46; Rosenberg"
                            1 => "M&#46;T&#46; Lotze"
                            2 => "L&#46;M&#46; Muul"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM198512263132601"
                      "Revista" => array:6 [
                        "tituloSerie" => "N&#46; Engl&#46; J&#46; Med&#46;"
                        "fecha" => "1985"
                        "volumen" => "313"
                        "paginaInicial" => "1&#46;485"
                        "paginaFinal" => "1&#46;492"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3906398"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
              "etiqueta" => "26&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cancer therapy with interleukin-2&#58; Immunologic manipulations can mediate the regression of cancer in humans"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "S&#46;A&#46; Rosenberg"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1200/jco.1988.6.3.403"
                      "Revista" => array:6 [
                        "tituloSerie" => "J&#46; Clin&#46; Oncol&#46;"
                        "fecha" => "1988"
                        "volumen" => "6"
                        "paginaInicial" => "403"
                        "paginaFinal" => "406"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3258361"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib27"
              "etiqueta" => "27&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Isolation and in vitro growth of glioma-infiltrating lymphocytes&#44; and an analysis of their surface phenotypes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "Y&#46; Sawamura"
                            1 => "H&#46; Abe"
                            2 => "T&#46; Aloa"
                            3 => "M&#46; Hosokawa"
                            4 => "H&#46; Kobayashi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3171/jns.1988.69.5.0745"
                      "Revista" => array:6 [
                        "tituloSerie" => "J&#46; Neurosurg&#46;"
                        "fecha" => "1988"
                        "volumen" => "69"
                        "paginaInicial" => "745"
                        "paginaFinal" => "750"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3054014"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib28"
              "etiqueta" => "28&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Adoptive immunotherapy of human meningeal gliomatosis and carcinomatosis with LAK cells and recombinant interleukin-2"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "K&#46; Shimlzu"
                            1 => "Y&#46; Okamoto"
                            2 => "Y&#46; Miyao"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3171/jns.1987.66.4.0519"
                      "Revista" => array:6 [
                        "tituloSerie" => "J&#46; Neurosurg&#46;"
                        "fecha" => "1987"
                        "volumen" => "66"
                        "paginaInicial" => "519"
                        "paginaFinal" => "521"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3494108"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib29"
              "etiqueta" => "29&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Adjuvant immunotherapy for malignant brain tumors in infants and children"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "K&#46; Takakura"
                            1 => "Y&#46; Miki"
                            2 => "O&#46; Kubo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Childs Brain"
                        "fecha" => "1975"
                        "volumen" => "1"
                        "paginaInicial" => "141"
                        "paginaFinal" => "147"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1102267"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib30"
              "etiqueta" => "30&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Immunotherapy of patients with advanced cancer using tumor-infiltrating-lymphocytes and recombinant interleukin-2&#58; A pilot study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "S&#46; Topalian"
                            1 => "D&#46; Solomon"
                            2 => "F&#46;P&#46; Avis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1200/jco.1988.6.5.839"
                      "Revista" => array:6 [
                        "tituloSerie" => "J&#46; Clin&#46; Oncol&#46;"
                        "fecha" => "1988"
                        "volumen" => "6"
                        "paginaInicial" => "839"
                        "paginaFinal" => "853"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3259261"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib31"
              "etiqueta" => "31&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Immunoth&#233;rapie active des tumeurs c&#233;rebrales&#46; A propos de 20 cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "P&#46; Trouillas"
                            1 => "C&#46; Lapras"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurochirurgie"
                        "fecha" => "1970"
                        "volumen" => "16"
                        "paginaInicial" => "143"
                        "paginaFinal" => "170"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4317954"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib32"
              "etiqueta" => "32&#46;"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Trouillas&#44; P&#46;&#58; Immunologie et immunoth&#233;rapie des tumeurs c&#233;rebrales &#40;&#224; propos de 43 observations&#41;&#46; Th&#232;se Doctoral&#44; Lyon&#44; 1971&#46;"
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib33"
              "etiqueta" => "33&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Immunologie et immunoth&#233;rapie des tumeurs c&#233;r&#233;brales&#44; &#233;tat actuel"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "P&#46; Trouillas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev&#46; Neurol&#46;"
                        "fecha" => "1973"
                        "volumen" => "128"
                        "paginaInicial" => "23"
                        "paginaFinal" => "38"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4367367"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib34"
              "etiqueta" => "34&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Presence and significance of NE-cells in glioblastomas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46; Vaquero"
                            1 => "S&#46; Coca"
                            2 => "R&#46; Mart&#237;nez"
                            3 => "J&#46; Ramiro"
                            4 => "P&#46;G&#46; Salazar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3171/jns.1989.70.5.0728"
                      "Revista" => array:7 [
                        "tituloSerie" => "J&#46; Neurosurg&#46;"
                        "fecha" => "1989"
                        "volumen" => "70"
                        "paginaInicial" => "728"
                        "paginaFinal" => "731"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2540292"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0016510708019883"
                          "estado" => "S300"
                          "issn" => "00165107"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib35"
              "etiqueta" => "35&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intrathecal injection of autologous leucocytes in glioblastoma&#46; Circulatory dynamics within the subarachnoid space and clinical results"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "J&#46; Vaquero"
                            1 => "R&#46; Mart&#237;nez"
                            2 => "L&#46; Barbolla"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Acta Neurochir&#46; &#40;Wien&#41;"
                        "fecha" => "1987"
                        "volumen" => "89"
                        "paginaInicial" => "37"
                        "paginaFinal" => "42"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib36"
              "etiqueta" => "36&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intratumoural injection of autologous lymphocytes plus human lymphoblastoid interferon for the treatment of glioblastoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "J&#46; Vaquero"
                            1 => "R&#46; Mart&#237;nez"
                            2 => "S&#46; Oya"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Acta Neurochir&#46; &#40;Wien&#41;"
                        "fecha" => "1989"
                        "volumen" => "98"
                        "paginaInicial" => "35"
                        "paginaFinal" => "41"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib37"
              "etiqueta" => "37&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Immunoterapia adoptiva en gliomas malignos&#58; Evidencia preliminar de respuesta a la inyecci&#243;n intratumoral de linfocitos aut&#243;logos"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46; Vaquero"
                            1 => "R&#46; Mart&#237;nez"
                            2 => "J&#46; Ramiro"
                            3 => "S&#46; Oya"
                            4 => "S&#46; Coca"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Neurolog&#237;a &#40;Esp&#46;&#41;"
                        "fecha" => "1987"
                        "volumen" => "1"
                        "numero" => "2 Supl&#46;"
                        "paginaInicial" => "10"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib38"
              "etiqueta" => "38&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evaluation of BCNU and&#47;or radiotherapy in the treatment of anaplastic gliomas&#46; A cooperative clinical trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "M&#46;D&#46; Walker"
                            1 => "E&#46; Alexander jr&#46;"
                            2 => "H&#46;E&#46; Hunt"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3171/jns.1978.49.3.0333"
                      "Revista" => array:6 [
                        "tituloSerie" => "J&#46; Neurosurg&#46;"
                        "fecha" => "1978"
                        "volumen" => "49"
                        "paginaInicial" => "333"
                        "paginaFinal" => "343"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/355604"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib39"
              "etiqueta" => "39&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Immunobiologic aspects of the brain and human gliomas&#46; A review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "C&#46;J&#46; Wikstrand"
                            1 => "D&#46;D&#46; Bigner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Am&#46; J&#46; Pathol&#46;"
                        "fecha" => "1980"
                        "volumen" => "98"
                        "paginaInicial" => "515"
                        "paginaFinal" => "567"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            39 => array:3 [
              "identificador" => "bib40"
              "etiqueta" => "40&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Immunotherapy with autologous white cell infusions &#40;&#171;lymphocytes&#187;&#41; in the treatment of recurrent glioblastoma&#46; A preliminary report"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "H&#46;F&#46; Young"
                            1 => "A&#46; Kaplan"
                            2 => "W&#46; Regelson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "C&#225;ncer"
                        "fecha" => "1977"
                        "volumen" => "40"
                        "paginaInicial" => "1&#46;037"
                        "paginaFinal" => "1&#46;044"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/589569"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "es"
  "url" => "/11301473/0000000100000004/v1_201305150958/S113014739071192X/v1_201305150958/es/main.assets"
  "Apartado" => null
  "PDF" => "https://static.elsevier.es/multimedia/11301473/0000000100000004/v1_201305150958/S113014739071192X/v1_201305150958/es/main.pdf?idApp=UINPBA00004B&text.app=https://revistaneurocirugia.com/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S113014739071192X?idApp=UINPBA00004B"
]
Compartir
Información de la revista
Vol. 1. Núm. 4.
Páginas 197 (enero 1990)
Compartir
Compartir
Descargar PDF
Más opciones de artículo
Vol. 1. Núm. 4.
Páginas 197 (enero 1990)
Nuevas perspectivas en el tratamiento biológico de los gliomas
Visitas
1758
J. Vaquero, R. Martínez
Servicio de Neurocirugía. Clínica Puerta de Hierro. Madrid
Este artículo ha recibido
Información del artículo
Resumen
Bibliografía
Descargar PDF
Estadísticas
Resumen

En los últimos años, el descubrimiento de nuevos sistemas linfocitotóxicos, con capacidad de lisar in vivo células tumorales, abre nuevas perspectivas en el tratamiento de diversas neoplasias.

Las peculiares características inmunológicas del Sistema Nervioso y de los tumores que en él se desarrollan, hace que los gliomas malignos sean un atractivo campo para ensayar la posible aplicación clínica de las técnicas de inmunoterapia.

Aunque en el momento actual, la experiencia en este terreno es muy limitada y los resultados poco significativos, es indudable que el tratamiento biológico de los gliomas ofrece interesantes perspectivas de investigación y su eficacia real, en combinación con otras modalidades terapéuticas bien establecidas, merece ser estudiada.

Palabras clave:
Tumores cerebrales
Inmunoterapia
Linfocitos
Interferon
Células LAK
Células NK
Glioblastoma
Gliomas malignos
Summary

Recently, new lymphocytotoxic systems for lysing tumoral cells have led to consider modalities in the treatment of different neoplasms.

The peculiar immunological features of the Nervous System and its tumors, made the malignant gliomas a very atractive field for assaying immunotherapeutical procedures.

Although the very limited experience with these trials, and their poor significant results obtained at present, the biological treatment of brain tumors has to be considered.

Key words:
Brain tumors
Immunotherapy
Lymphocytes
Interferon
LAK-cells
NK-cells
Glioblastoma
Malignant gliomas

Artículo

Opciones para acceder a los textos completos de la publicación Neurocirugía
Socio
Socio de la Sociedad Española de Neurocirugía

Si es la primera vez que accede a la web puede obtener sus claves de acceso poniéndose en contacto con Elsevier España en suscripciones@elsevier.com o a través de su teléfono de Atención al Cliente 902 88 87 40 si llama desde territorio español o del +34 932 418 800 (de 9 a 18h., GMT + 1) si lo hace desde el extranjero.

Si ya tiene sus datos de acceso, clique aquí.

Si olvidó su clave de acceso puede recuperarla clicando aquí y seleccionando la opción "He olvidado mi contraseña".

Suscriptor
Suscriptor de la revista

Si ya tiene sus datos de acceso, clique aquí.

Si olvidó su clave de acceso puede recuperarla clicando aquí y seleccionando la opción "He olvidado mi contraseña".
Suscribirse
Suscribirse a:

Neurocirugía

Comprar
Comprar acceso al artículo

Comprando el artículo el PDF del mismo podrá ser descargado

Precio 19,34 €

Comprar ahora
Contactar
Teléfono para suscripciones e incidencias
De lunes a viernes de 9h a 18h (GMT+1) excepto los meses de julio y agosto que será de 9 a 15h
Llamadas desde España
932 415 960
Llamadas desde fuera de España
+34 932 415 960
Email
Idiomas
Neurocirugía
Opciones de artículo
Herramientas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?