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Vol. 2. Issue 2.
Pages 107-110 (January 1991)
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Vol. 2. Issue 2.
Pages 107-110 (January 1991)
Significación pronóstica de la determinación del anticuerpo monoclonal Ki 67 en tumores cerebrales
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F.G. Salazar, C. Lacruz, R. Carrillo
Servicios de Neurocirugía y de Anatomía Patológica. Hospital «Gregario Marañón». Madrid
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Resumen

Uno de los principales fines de los estudios patológicos sobre un tumor extirpado es el de estimar el potencial proliferativo del tejido residual. Esto es muy importante para establecer un pronóstico del paciente y una eventual terapia postquirúrgica. La determinación del índice de Ki 67 ofrece un dato de máxima fiabilidad a la hora de cuantificar el potencial proliferativo de la neoplasia.

Nuestro estudio consiste en correlacionar el seguimiento de 20 pacientes intervenidos por tumores cerebrales de diversas estirpes y el índice de Ki 67 obtenido al valorar citológicamente las muestras obtenidas.

La evolución que han seguido las neoformaciones objeto de nuestro estudio se han correlacionado con los diferentes índices de Ki 67 obtenidos. De esta forma aquellos tumores con Ki 67 más alto han demostrado más tendencia a recidivar.

Palabras clave:
Ki 67
Actividad proliferativa
Tumor cerebral
Summary

The pathological examination of a brain tumor is important in order to determine the prognosis and the postoperative treatment. Ki-67 is a monoclonal antibody directed against a nuclear antigen present only in the proliferating cells. The Ki-67 positive cells percentage offers a good index of the proliferating capabilities of a tumor.

The specimens of 20 patients that were operated on from an intracranial tumor were analyzed and their Ki-67 index obtained in a cytologic smear. The follow-up correlated well with the Ki-67 index.

Key words:
Ki-67
Proliferating cells
Proliferating activity
Brain tumors

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